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- Ji, Chao; Yang, Bo; Yang, Zhi; Tu, Ying; Yang, Yan-li; He, Li; Bi, Zhi-Gang
- Biochemical and biophysical research communications 2012 v.425 no.4 pp. 825-829
- permeability; humans; cyclosporine; hydrogen peroxide; signal transduction; cysteine; keratinocytes; apoptosis; cyclophilins
- ... UVB-induced skin cell damage involves the opening of mitochondrial permeability transition pore (mPTP), which leads to both apoptotic and necrotic cell death. Cyclophilin D (Cyp-D) translocation to the inner membrane of mitochondrion acts as a key component to open the mPTP. Our Western-Blot results in primary cultured human skin keratinocytes and in HaCaT cell line demonstrated that UVB radiation ...