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You searched for: Journal Biochemical and biophysical research communications Remove constraint Journal: Biochemical and biophysical research communications Publication Year 2011 Remove constraint Publication Year: 2011 Source 2011 v.409 no.4 Remove constraint Source: 2011 v.409 no.4
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1. Activity-dependent SUMOylation of the brain-specific scaffolding protein GISP

Author:
Kantamneni, Sriharsha; Wilkinson, Kevin A.; Jaafari, Nadia; Ashikaga, Emi; Rocca, Daniel; Rubin, Philip; Jacobs, Susan C.; Nishimune, Atsushi; Henley, Jeremy M.
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 657-662
ISSN:
0006-291X
Subject:
G-protein coupled receptors; genes; mammals; neurons; post-translational modification; scaffolding proteins; two hybrid system techniques
Abstract:
... G-protein coupled receptor interacting scaffold protein (GISP) is a multi-domain, brain-specific protein derived from the A-kinase anchoring protein (AKAP)-9 gene. Using yeast two-hybrid screens to identify GISP interacting proteins we isolated the SUMO conjugating enzyme Ubc9. GISP interacts with Ubc9 in vitro, in heterologous cells and in neurons. SUMOylation is a post-translational modification ...
DOI:
10.1016/j.bbrc.2011.05.060
PubMed:
21616059
PubMed Central:
PMC3308138

2. Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family

Author:
Romero-Fernandez, Wilber; Borroto-Escuela, Dasiel O.; Tarakanov, Alexander O.; Mudó, Giuseppa; Narvaez, Manuel; Pérez-Alea, Mileidys; Agnati, Luigi F.; Ciruela, Francisco; Belluardo, Natale; Fuxe, Kjell
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 764-768
ISSN:
0006-291X
Subject:
agonists; bioinformatics; bioluminescence; energy; fibroblast growth factor receptor 1; genes; heparan sulfate; mitogen-activated protein kinase; phosphorylation; tyrosine
Abstract:
... Fibroblast growth factor receptor 1 (FGFR1) is known to be activated by homodimerization in the presence of both the FGF agonist ligand and heparan sulfate glycosaminoglycan. FGFR1 homodimers in turn trigger a variety of downstream signaling cascades via autophosphorylation of tyrosine residues in the cytoplasmic domain of FGFR1. By means of Bioluminescence Energy Resonance Transfer (BRET) as a si ...
DOI:
10.1016/j.bbrc.2011.05.085

3. Akt phosphorylates and regulates the function of Dlx5

Author:
Jeong, Hyung Min; Jin, Yun-Hye; Kim, Yeon-Jin; Yum, Jinah; Choi, You Hee; Yeo, Chang-Yeol; Lee, Kwang-Youl
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 681-686
ISSN:
0006-291X
Subject:
bone formation; post-translational modification; protein-serine-threonine kinases; serine; skeletal development; threonine; transcription (genetics); transcription factors
Abstract:
... Akt, a phosphoinositide-dependent serine/threonine protein kinase, acts as a key regulator in bone formation. Akt can be activated by several osteogenic signaling molecules, but its precise function and downstream targets in bone development are unknown. Dlx5 transcription factor plays important roles during bone development and osteoblast differentiation. Its expression is regulated by several os ...
DOI:
10.1016/j.bbrc.2011.05.064

4. ALCAPs induce mitochondrial apoptosis and activate DNA damage response by generating ROS and inhibiting topoisomerase I enzyme activity in K562 leukemia cell line

Author:
Bogurcu, Nuray; Sevimli-Gur, Canan; Ozmen, Besra; Bedir, Erdal; Korkmaz, Kemal Sami
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 738-744
ISSN:
0006-291X
Subject:
Alkanna; DNA damage; DNA topoisomerase; antioxidants; apoptosis; caspase-3; cell growth; doxorubicin; enzyme activity; enzyme inhibition; flow cytometry; landscapes; leukemia; neoplasm cells; phosphorylation; plasmids; therapeutics
Abstract:
... Endemic Alkanna cappadocica was used to isolate novel antitumor molecules from Turkish landscapes in our previous studies. In this study, deoxyalkannin (ALCAP1), β,β-dimethylacrylalkannin (ALCAP2), acetylalkannin (ALCAP3), and alkannin (ALCAP4) as well as the novel isolated compounds 5-methoxydeoxyalkannin (ALCAP5), 8-methoxydeoxyalkannin (ALCAP6), 5-methoxyacetylalkannin (ALCAP7), 5-methoxy-β,β-d ...
DOI:
10.1016/j.bbrc.2011.05.078

5. AMPK induces MUC5B expression via p38 MAPK in NCI-H292 airway epithelial cells

Author:
Bae, Chang Hoon; Kim, Jun Woo; Ye, Sang Baik; Song, Si-Youn; Kim, Yong-Woon; Park, So-Young; Kim, Yong-Dae
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 669-674
ISSN:
0006-291X
Subject:
AMP-activated protein kinase; dose response; epithelial cells; fatty acid metabolism; gene expression; glucose; humans; messenger RNA; metformin; mitogen-activated protein kinase; mucins; phosphorylation; secretion; serine; signal transduction; small interfering RNA; threonine
Abstract:
... Adenosine monophosphate-activated protein kinase (AMPK) is a well-known serine/threonine kinase that has been implicated in modulation of glucose and fatty acid metabolism. Recent reports have also implicated AMPK in modulation of mucin secretion. In this study, the effects and signaling pathways of AMPK on MUC5B expression were investigated in human NCI-H292 airway epithelial cells. Metformin, as ...
DOI:
10.1016/j.bbrc.2011.05.062

6. Casuarinin suppresses TNF-α-induced ICAM-1 expression via blockade of NF-κB activation in HaCaT cells

Author:
Kwon, Dong-Joo; Bae, Young-Soo; Ju, Sung Mi; Goh, Ah Ra; Choi, Soo Young; Park, Jinseu
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 780-785
ISSN:
0006-291X
Subject:
Hippophae rhamnoides; adhesion; anti-inflammatory activity; asthma; dose response; gene expression; humans; interleukin-1beta; interleukin-6; interleukin-8; keratinocytes; leaves; messenger RNA; mitogen-activated protein kinase; monocytes; skin diseases; traditional medicine; transcription factor NF-kappa B
Abstract:
... Hippophae rhamnoides has been extensively used in oriental traditional medicines for treatment of asthma, skin diseases, gastric ulcers, and lung disorders. In this study, we isolated casuarinin from the leaves of H.rhamnoides and examined the effect of casuarinin on the TNF-α-induced ICAM-1 expression in a human keratinocytes cell line HaCaT. Pretreatment with casuarinin inhibited TNF-α-induced p ...
DOI:
10.1016/j.bbrc.2011.05.088

7. Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species

Author:
Orellana, Juan A.; Díaz, Emilio; Schalper, Kurt A.; Vargas, Aníbal A.; Bennett, Michael V.L.; Sáez, Juan C.
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 603-609
ISSN:
0006-291X
Subject:
binding sites; cations; ethidium; fluorescence; nucleic acids; permeability; probability; propidium; toxicity
Abstract:
... Kinetics of permeation through connexin 43-EGFP hemichannels (Cx43-EGFP HCs) were evaluated in divalent cation-free solutions, which enhance HC open probability and thus, allow measurements during initial velocity. Three cations that become fluorescent upon binding to intracellular nucleic acids [ethidium (Etd), propidium (Prd) and 4′,6-diamidino-2-phenylindole (DAPI)] and Cx43-EGFP or Cx43 wild t ...
DOI:
10.1016/j.bbrc.2011.05.031
PubMed:
21600880
PubMed Central:
PMC3118918

8. Changes in carnitine octanoyltransferase activity induce alteration in fatty acid metabolism

Author:
Le Borgne, Françoise; Ben Mohamed, Amine; Logerot, Morgan; Garnier, Emilie; Demarquoy, Jean
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 699-704
ISSN:
0006-291X
Subject:
beta oxidation; carnitine; enzymes; fatty acid metabolism; gene overexpression; genes; messenger RNA; models; very long chain fatty acids
Abstract:
... The peroxisomal beta oxidation of very long chain fatty acids (VLCFA) leads to the formation of medium chain acyl-CoAs such as octanoyl-CoA. Today, it seems clear that the exit of shortened fatty acids produced by the peroxisomal beta oxidation requires their conversion into acyl-carnitine and the presence of the carnitine octanoyltransferase (CROT). Here, we describe the consequences of an overex ...
DOI:
10.1016/j.bbrc.2011.05.068

9. CPEB1 modulates lipopolysaccharide-mediated iNOS induction in rat primary astrocytes

Author:
Kim, Ki Chan; Hyun Joo, So; Shin, Chan Young
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 687-692
ISSN:
0006-291X
Subject:
astrocytes; binding proteins; brain; inducible nitric oxide synthase; inflammation; models; nitric oxide; phosphorylation; rats
Abstract:
... Upon CNS damage, astrocytes undergo a series of biological changes including increased proliferation, production of inflammatory mediators and morphological changes, in a response collectively called reactive gliosis. This process is an essential part of the brains response to injury, yet much is unknown about the molecular mechanism(s) that induce these changes. In this study, we investigated the ...
DOI:
10.1016/j.bbrc.2011.05.065

10. Dynamic changes in hair cell stereocilia and cochlear transduction after noise exposure

Author:
Wang, Hui; Yin, Shankai; Yu, Zhiping; Huang, Yanyan; Wang, Jian
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 616-621
ISSN:
0006-291X
Subject:
alopecia; brain stem; ears; guinea pigs; hearing; loci
Abstract:
... The structures of cochlear transduction include stereocilia at the apical surface of hair cells and their connection to the tectorial membrane. The transduction site is one of the loci for noise-induced cochlear damage. Although stereocilia are susceptible to noise, it has been found that in the inner ears of avians, this fragile structure is largely self-repairing and is associated with recovery ...
DOI:
10.1016/j.bbrc.2011.05.049

11. Electrogenic Na⁺/HCO₃⁻ co-transporter-1 is essential for the parathyroid hormone-stimulated intestinal HCO₃⁻ secretion

Author:
Charoenphandhu, Narattaphol; Laohapitakworn, Suparerk; Kraidith, Kamonshanok; Nakkrasae, La-iad; Jongwattanapisan, Prapaporn; Tharabenjasin, Phuntila; Krishnamra, Nateetip
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 775-779
ISSN:
0006-291X
Subject:
bicarbonates; body weight; colon; cystic fibrosis; epithelial cells; ileum; intravenous injection; jejunum; messenger RNA; nucleotide sequences; parathyroid hormone; quantitative polymerase chain reaction; rats; secretion; small interfering RNA; sodium; transporters
Abstract:
... Parathyroid hormone (PTH) was recently demonstrated to enhance the HCO₃ ⁻ secretion through the apical anion channel, cystic fibrosis transmembrane conductance regulator (CFTR), but how the HCO₃ ⁻ entered the epithelial cells was not well understood, in part, due to the lack of specific inhibitors of the basolateral HCO₃ ⁻ transporters. Moreover, the function of the PTH-stimulated HCO₃ ⁻ secretion ...
DOI:
10.1016/j.bbrc.2011.05.087

12. Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative – An investigation using behavioral tests battery of depression

Author:
Mahesh, Radhakrishnan; Jindal, Ankur; Gautam, Baldev; Bhatt, Shvetank; Pandey, Dilip
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 723-726
ISSN:
0006-291X
Subject:
5-hydroxytryptophan; amine oxidase (flavin-containing); animal models; brain; hypothermia; locomotion; metabolism; mice; neurotransmitters; rats
Abstract:
... Linezolid, an oxazolidinone class derivative is a reversible and nonselective inhibitor of monoamine oxidase (MAO), predominantly for MAO-A type. MAO-A is a key enzyme regulating the catabolism of catecholamine neurotransmitters in the brain. It is well known that the catecholaminergic neuronal systems are associated with depression and inhibition of MAO-A level in the brain could be used to treat ...
DOI:
10.1016/j.bbrc.2011.05.075

13. Evidence of tricellulin expression by immune cells, particularly microglia

Author:
Mariano, Cibelle; Silva, Sandra Leitão; Pereira, Pedro; Fernandes, Adelaide; Brites, Dora; Brito, Maria A.
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 799-802
ISSN:
0006-291X
Subject:
astrocytes; brain; dendritic cells; epithelial cells; gene expression; humans; immunohistochemistry; lymphocytes; macrophages; messenger RNA; monocytes; permeability; peroxidase; protein synthesis; proteins; quantitative polymerase chain reaction; rats; stomach; tight junctions
Abstract:
... Tight junctions (TJs) are elaborate structures located on the apical region of epithelial cells that limit paracellular permeability. Tricellulin is a recently discovered TJ protein, which is concentrated at the structurally specialized tricellular TJs but also present at bicellular contacts between epithelial cells, namely in the stomach. Interestingly, several TJ proteins have been found in othe ...
DOI:
10.1016/j.bbrc.2011.05.093

14. Fgf20b is required for the ectomesenchymal fate establishment of cranial neural crest cells in zebrafish

Author:
Yamauchi, Hajime; Goto, Mami; Katayama, Mika; Miyake, Ayumi; Itoh, Nobuyuki
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 705-710
ISSN:
0006-291X
Subject:
Danio rerio; apoptosis; fibroblast growth factor receptor 1; growth factors; metabolism; neural crest; polypeptides; skeletal development
Abstract:
... In cranial skeletal development, the establishment of the ectomesenchymal lineage within the cranial neural crest is of great significance. Fgfs are polypeptide growth factors with diverse functions in development and metabolism. Fgf20b knockdown zebrafish embryos showed dysplastic neurocranial and pharyngeal cartilages. Ectomesenchymal cells from cranial neural crest cells were significantly decr ...
DOI:
10.1016/j.bbrc.2011.05.069

15. Fluoride enhances transfection activity of carbonate apatite by increasing cytoplasmic stability of plasmid DNA

Author:
Chowdhury, E.H.
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 745-747
ISSN:
0006-291X
Subject:
RNA; Southern blotting; apatite; gene expression; gene silencing; genes; half life; human diseases; nanocrystals; nucleases; nucleotide sequences; plasmids; transfection
Abstract:
... Intracellular delivery of a functional gene or a nucleic acid sequence to specifically knockdown a harmful gene is a potential approach to precisely treat a critical human disease. The intensive efforts in the last few decades led to the development of a number of viral and non-viral synthetic vectors. However, an ideal delivery tool in terms of the safety and efficacy has yet to be established. R ...
DOI:
10.1016/j.bbrc.2011.05.079

16. Fucoxanthin exerts differing effects on 3T3-L1 cells according to differentiation stage and inhibits glucose uptake in mature adipocytes

Author:
Kang, Seong-Il; Ko, Hee-Chul; Shin, Hye-Sun; Kim, Hyo-Min; Hong, Youn-Suk; Lee, Nam-Ho; Kim, Se-Jae
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 769-774
ISSN:
0006-291X
Subject:
Petalonia; adipocytes; adipogenesis; adiponectin; dose response; gene expression; glucose; messenger RNA; phosphorylation; protein synthesis; signal transducing adaptor proteins; triacylglycerols
Abstract:
... Progression of 3T3-L1 preadipocyte differentiation is divided into early (days 0–2, D0–D2), intermediate (days 2–4, D2–D4), and late stages (day 4 onwards, D4-). In this study, we investigated the effects of fucoxanthin, isolated from the edible brown seaweed Petalonia binghamiae, on adipogenesis during the three differentiation stages of 3T3-L1 preadipocytes. When fucoxanthin was applied during t ...
DOI:
10.1016/j.bbrc.2011.05.086

17. Genes that integrate multiple adipogenic signaling pathways in human mesenchymal stem cells

Author:
Ito, Tomoya; Tsuruta, So; Tomita, Koki; Kikuchi, Kunio; Yokoi, Takahide; Aizawa, Yasunori
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 786-791
ISSN:
0006-291X
Subject:
adipogenesis; genes; humans; microarray technology; reverse transcriptase polymerase chain reaction; signal transduction; stem cells; transcription (genetics); transcription factors
Abstract:
... Adipogenesis is a well-characterized cell differentiation process. A large body of evidence has revealed the core transcription factors and signaling pathways that govern adipogenesis, but cross-talks between these cellular signals and its functional consequences have not been thoroughly investigated. We, therefore, sought to identify genes that are regulated by multiple signaling pathways during ...
DOI:
10.1016/j.bbrc.2011.05.089

18. Glutathione is a physiologic reservoir of neuronal glutamate

Author:
Koga, Minori; Serritella, Anthony V.; Messmer, Marcus M.; Hayashi-Takagi, Akiko; Hester, Lynda D.; Snyder, Solomon H.; Sawa, Akira; Sedlak, Thomas W.
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 596-602
ISSN:
0006-291X
Subject:
antioxidants; brain; cysteine; drugs; gamma-glutamyltransferase; glutamic acid; glutathione; memory; metabolism; neurons; oxidative stress; pathogenesis
Abstract:
... Glutamate, the principal excitatory neurotransmitter of the brain, participates in a multitude of physiologic and pathologic processes, including learning and memory. Glutathione, a tripeptide composed of the amino acids glutamate, cysteine, and glycine, serves important cofactor roles in antioxidant defense and drug detoxification, but glutathione deficits occur in multiple neuropsychiatric disor ...
DOI:
10.1016/j.bbrc.2011.04.087
PubMed:
21539809
PubMed Central:
PMC3923312

19. Human papillomavirus 16E6 suppresses major histocompatibility complex class I by upregulating lymphotoxin expression in human cervical cancer cells

Author:
Kim, Dong-Hern; Kim, Eun-Mi; Lee, Eun-Hee; Ji, Kon-Young; Yi, Jawoon; Park, Min; Kim, Kwang Dong; Cho, Yong-Yeon; Kang, Hyung-Sik
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 792-798
ISSN:
0006-291X
Subject:
Human papillomavirus 18; cytotoxic T-lymphocytes; gene expression regulation; humans; liver; lymphotoxin; major histocompatibility complex; mice; neoplasm cells; oncogenes; small interfering RNA; spleen; uterine cervical neoplasms
Abstract:
... Major histocompatibility complex (MHC) class I is a major host defense mechanism against viral infections such as type 16 and type 18 of the human papillomavirus (HPV). Here, we found that the E6 oncogene from HPV16, but not HPV18, suppressed MHC I expression. Ectopic expression of HPV16E6 in HeLa cells, which are infected with HPV18, suppressed MHC I expression, and that knockdown by antisense or ...
DOI:
10.1016/j.bbrc.2011.05.090

20. Inhibition of selenocysteine tRNA[Sᵉʳ]Sᵉᶜ aminoacylation provides evidence that aminoacylation is required for regulatory methylation of this tRNA

Author:
Kim, Jin Young; Carlson, Bradley A.; Xu, Xue-Ming; Zeng, Yu; Chen, Shawn; Gladyshev, Vadim N.; Lee, Byeong Jae; Hatfield, Dolph L.
Source:
Biochemical and biophysical research communications 2011 v.409 no.4 pp. 814-819
ISSN:
0006-291X
Subject:
Xenopus; aminoacylation; methylation; mutants; mutation; oocytes; selenium; selenocysteine; selenoproteins; serine; transfer RNA
Abstract:
... There are two isoforms of selenocysteine (Sec) tRNA[Sᵉʳ]Sᵉᶜ that differ by a single methyl group, Um34. The non-Um34 isoform supports the synthesis of a subclass of selenoproteins, designated housekeeping, while the Um34 isoform supports the expression of another subclass, designated stress-related selenoproteins. Herein, we investigated the relationship between tRNA[Sᵉʳ]Sᵉᶜ aminoacylation and Um3 ...
DOI:
10.1016/j.bbrc.2011.05.096
PubMed:
21624347
PubMed Central:
PMC3124823