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- Kageyama-Yahara, Natsuko; Wang, Xiaoyu; Katagiri, Tatsuo; Wang, Ping; Yamamoto, Takeshi; Tominaga, Makoto; Kadowaki, Makoto
- Biochemical and biophysical research communications 2011 v.416 no.3-4 pp. 283-288
- mast cells, etc ; bone marrow; calcium; cortex; food allergies; immunoglobulin E; phospholipase C; phosphorylation; tyrosine; Show all 9 Subjects
- ... Antigen-IgE-mediated mucosal mast-cell activation is critical in the development of food allergies. Cinnamaldehyde, a major constituent of Cinnamomi cortex, dose-dependently inhibited the antigen-IgE-induced degranulation of mucosal-type bone-marrow derived mast cells (mBMMCs) and RBL-2H3 cells. Cinnamaldehyde also suppressed the elevation of the intracellular Ca²⁺ level that is induced by the ext ...