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You searched for: Journal name Biochemical and biophysical research communications Remove constraint Journal name: Biochemical and biophysical research communications Publication Year 2020 Remove constraint Publication Year: 2020 Subject bone marrow Remove constraint Subject: bone marrow
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1. 17β-estradiol promotes bone marrow mesenchymal stem cell migration mediated by chemokine upregulation

Author:
Wenbi Zhang; Xiong Li; He Li; Xiang Lu; Junling Chen; Lu Li; Xiaoxi Sun; Congjian Xu
Source:
Biochemical and biophysical research communications 2020 v.530 no.2 pp. 381-388
ISSN:
0006-291X
Subject:
antagonists; bone marrow; cell movement; chemokines; chemotaxis; coculture; endometriosis; endometrium; gene expression; gene ontology; mesenchymal stromal cells; quantitative polymerase chain reaction; research; secretion; stem cells
Abstract:
... Bone marrow-derived cells engraft to the uterine endometrium and contribute to endometriosis. This study sought to further confirm that estrogen can promote the migration of bone marrow mesenchymal stem cells (BMSCs) and to investigate the function of estrogen on the secretion of chemokines during BMSC migration. BMSCs were treated with or without 17β-estradiol, cultured with or without endometria ...
DOI:
10.1016/j.bbrc.2020.07.135

2. Arsenite suppresses the transcriptional activity of EVI1 through the binding to CCHC-type Zn finger domain

Author:
Masatoshi Ogawa; Yasuko Okamoto; Seiichiro Himeno; Kazumi Suzukawa; Daigo Sumi
Source:
Biochemical and biophysical research communications 2020 v.529 no.4 pp. 910-915
ISSN:
0006-291X
Subject:
GATA transcription factors; alanine; arsenites; bone marrow; cysteine; dithiothreitol; gel electrophoresis; hematopoiesis; research; synthetic peptides; therapeutics; transcription (genetics); zinc finger motif
Abstract:
... Transcription factor EVI1 is essential for normal hematopoiesis in embryos but is aberrantly elevated in bone marrow cells of myelodysplastic syndrome (MDS) patients. EVI1 and its downstream GATA-2 appear to be a possible therapeutic target of MDS. Here we found that treatment of EVI1-expressing K562 cells with arsenite (As(III)) reduced the mRNA and protein levels of EVI1 and GATA-2. A gel shift ...
DOI:
10.1016/j.bbrc.2020.07.024

3. Astaxanthin improves osteopenia caused by aldehyde-stress resulting from Aldh2 mutation due to impaired osteoblastogenesis

Author:
Hiroko Hoshi; Fuka Monoe; Ikuroh Ohsawa; Shigeo Ohta; Takeshi Miyamoto
Source:
Biochemical and biophysical research communications 2020 v.527 no.1 pp. 270-275
ISSN:
0006-291X
Subject:
acetaldehyde; aldehyde dehydrogenase; astaxanthin; bone density; bone formation; bone marrow; catalytic activity; cell viability; femur; hip fractures; metabolism; mitochondria; osteoblasts; osteopenia; osteoporosis; research; single nucleotide polymorphism
Abstract:
... Aldehyde dehydrogenase 2 (ALDH2) plays major roles in aldehyde detoxification and in the catalysis of amino acids. ALDH2∗2, a dominant-negative transgenic expressing aldehyde dehydrogenase 2 (ALDH2) protein, is produced by a single nucleotide polymorphism (rs671) and is involved in the development of osteoporosis and hip fracture with aging. In a previous study, transgenic mice expressing Aldh2∗2( ...
DOI:
10.1016/j.bbrc.2020.04.013

4. Bone progeria diminished the therapeutic effects of bone marrow mesenchymal stem cells on retinal degeneration

Author:
Chun-Lei Deng; Cheng-Biao Hu; Bao-Ying Wang; Ye-Cheng Xiong; Tao Chen; Na Zhao; Li-Hui Bao; Rui Quan; Fang-Ying Du; Bing-Dong Sui; Xiao- Rui Yu
Source:
Biochemical and biophysical research communications 2020 v.531 no.2 pp. 180-186
ISSN:
0006-291X
Subject:
animal models; bone marrow; genes; research; retina; retinal degeneration; therapeutics
Abstract:
... Senescence is closely related to the occurrence of retinal degeneration. Recent studies have shown that bone marrow mesenchymal stem cells (BMMSCs) have significant therapeutic effects on retinal degeneration, While BMMSCs suffer from functional decline in bone aging. Whether senescence affects BMMSCs therapy on retinal degeneration remains unknown. Here, we applied the previously established bone ...
DOI:
10.1016/j.bbrc.2020.07.007

5. Caldecrin inhibits lipopolysaccharide-induced pro-inflammatory cytokines and M1 macrophage polarization through the immunoreceptor triggering receptor expressed in myeloid cells-2

Author:
Kenjiro Bandow; Hiroya Hasegawa; Mineko Tomomura; Akito Tomomura
Source:
Biochemical and biophysical research communications 2020 v.523 no.4 pp. 1027-1033
ISSN:
0006-291X
Subject:
CRISPR-Cas systems; blood serum; bone marrow; calcium; cell lines; cytokines; gene expression; genes; ligands; lipopolysaccharides; macrophages; mice; osteoclasts; pancreas; research
Abstract:
... Caldecrin was previously isolated as a serum calcium-decreasing factor from the pancreas and is known to suppress receptor activator of nuclear factor-κB ligand (RANKL)-induced calcium oscillation pathways in osteoclasts. Here, we explored the effects of caldecrin on lipopolysaccharide (LPS)–Toll-like receptor-4 (TLR-4) signaling pathways in macrophages. Caldecrin inhibited the LPS-induced gene ex ...
DOI:
10.1016/j.bbrc.2020.01.045

6. Chondrocytes-derived exosomal miR-8485 regulated the Wnt/β-catenin pathways to promote chondrogenic differentiation of BMSCs

Author:
Zeng Li; Yingjie Wang; Shuai Xiang; Zhibo Zheng; Yanyan Bian; Bin Feng; Xisheng Weng
Source:
Biochemical and biophysical research communications 2020 v.523 no.2 pp. 506-513
ISSN:
0006-291X
Subject:
bone marrow; cartilage; chondrocytes; coculture; microRNA; research
Abstract:
... In indirect co-culture system, chondrocytes can induce differentiation of bone marrow mesenchymal stem cells (BMSCs) to chondrocytes without additional inducer. The participation of microRNAs (miRNAs) may take part in the chondrogenic differentiation. Present study aimed to investigate the effect and mechanism of chondrocytes-derived exosomal miRNA in BMSCs chondrogenic differentiation. Our data s ...
DOI:
10.1016/j.bbrc.2019.12.065

7. Combination of gp130-targeting and TNF-targeting small molecules in alleviating arthritis through the down-regulation of Th17 differentiation and osteoclastogenesis

Author:
Yeon-Hwa Park; Hee Jung Kim; Kyeong Lee; Yongseok Choi; Tae-Hwe Heo
Source:
Biochemical and biophysical research communications 2020 v.522 no.4 pp. 1030-1036
ISSN:
0006-291X
Subject:
CD4-positive T-lymphocytes; bone formation; bone marrow; cartilage; cell proliferation; humans; inflammation; interleukin-6; mice; monocytes; osteoclasts; research; rheumatoid arthritis; secretion; splenocytes; therapeutics; tumor necrosis factors
Abstract:
... Rheumatoid arthritis (RA) is a systemic, chronic inflammatory disease that is characterized by T helper 17 (Th17) cell- and osteoclast-induced joint destruction and inflammation. In RA, several cytokines (interleukin (IL)-1, 6,17, and tumor necrosis factor (TNF)) are involved in almost all aspects of articular inflammation and destruction. This study aimed to evaluate the combinatorial effect of T ...
DOI:
10.1016/j.bbrc.2019.11.183

8. Downregulated miR-150 in bone marrow mesenchymal stem cells attenuates the apoptosis of LPS-stimulated RAW264.7 via MTCH2-dependent mitochondria transfer

Author:
Xiao Zhou; Keji Zhang; Zhengyu He; Yuxiao Deng; Yuan Gao
Source:
Biochemical and biophysical research communications 2020 v.526 no.3 pp. 560-567
ISSN:
0006-291X
Subject:
acute respiratory distress syndrome; apoptosis; bone marrow; caspase-3; genes; lipopolysaccharides; macrophages; membrane potential; mitochondria; mitochondrial membrane; nucleotidyltransferases; reactive oxygen species; research; therapeutics
Abstract:
... Mesenchymal stem cells (MSCs) are promising therapeutic cells for preventing apoptosis and abrogating cellular injury. Apoptosis of macrophages and the resulting dysfunction play a critical pathogenic role in acute respiratory distress syndrome (ARDS). Herein, the anti-apoptosis effects of bone marrow MSCs (BMSCs) on RAW264.7 were investigated by transwell assay. Compared to lipopolysaccharide (LP ...
DOI:
10.1016/j.bbrc.2020.03.098

9. Effects of cyclic fluid stress at different frequencies on behaviors of cells incubated on titanium alloy

Author:
Xing Lei; Hao Wu; Yue Song; Bin Liu; Shuai-Shuai Zhang; Jun-Qin Li; Long Bi; Guo-Xian Pei
Source:
Biochemical and biophysical research communications 2020 v.522 no.1 pp. 100-106
ISSN:
0006-291X
Subject:
alloys; bone marrow; collagen; fibroblasts; orthopedics; research; titanium
Abstract:
... The orthopedic external fixation is always in dynamic mechanical environment with the somatic movement. We used a self-designed mini oscillator to simulate this condition by providing the reciprocating cyclic fluid stress, and observed the behavioral responses of fibroblasts implanted on titanium alloy plane to the stress at different frequencies, including 0.2 Hz, 0.6 Hz, and 1.0 Hz. We found tha ...
DOI:
10.1016/j.bbrc.2019.11.070

10. Functional expression cloning of molecules inducing CD34 expression in bone marrow-derived stromal myofibroblasts

Author:
Takuji Matsuo; Haruko Tashiro; Ritsu Sumiyoshi; Sumiko Saito; Ryosuke Shirasaki; Naoki Shirafuji
Source:
Biochemical and biophysical research communications 2020 v.533 no.4 pp. 1283-1289
ISSN:
0006-291X
Subject:
blood; bone marrow; fibroblasts; genes; humans; interleukin-6; leukemia; phytohemagglutinin; research
Abstract:
... We have previously shown a fraction of stromal fibroblasts/myofibroblasts (Fibs) from leukemic bone marrow cells expresses leukemia-specific transcripts along with hematopoietic and Fib-related markers. Normal bone marrow-derived Fibs (nFibs) do not express CD34 or CD45; however, nFibs may express hematopoietic markers with some specific stimulations. CD34 expression was detected in nFib cultures ...
DOI:
10.1016/j.bbrc.2020.10.006

11. Hepatocellular HO-1 mediated iNOS-induced hepatoprotection against liver ischemia reperfusion injury

Author:
Yingli Qiao; Fei Xiao; Wenkai Li; Mingyong Yu; Peng Du; Zheping Fang; Jie Sun
Source:
Biochemical and biophysical research communications 2020 v.521 no.4 pp. 1095-1100
ISSN:
0006-291X
Subject:
bone marrow; heme oxygenase (biliverdin-producing); hepatoprotective effect; hypoxia; inducible nitric oxide synthase; ischemia; liver; reperfusion injury; research
Abstract:
... Hepatocyte-derived inducible nitric oxide synthase (iNOS) was proved to impart protection against liver ischemia reperfusion (I/R) injury in our prior analysis. However, the mechanism for this hepatoprotection remains incompletely understood. Bone marrow chimeric mice were generated using expression of iNOS in a hepatocyte-selective manner against an iNOS-knockout background. The function of heme ...
DOI:
10.1016/j.bbrc.2019.11.053

12. Human umbilical cord mesenchymal stem cell-derived exosomes act via the miR-1263/Mob1/Hippo signaling pathway to prevent apoptosis in disuse osteoporosis

Author:
Bao-cheng Yang; Ming-jie Kuang; Jia-yu Kang; Jie Zhao; Jian-xiong Ma; Xin-long Ma
Source:
Biochemical and biophysical research communications 2020 v. no. pp. -
ISSN:
0006-291X
Subject:
apoptosis; bone marrow; exosomes; hindlimbs; humans; luciferase; mesenchymal stromal cells; micro-computed tomography; microRNA; osteoporosis; rats; research; umbilical cord
Abstract:
... Disuse osteoporosis (DOP) is a common complication resulting from the lack of or disuse of mechanical loading and has been unsatisfactorily treated. We hypothesized that exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSCs) could reduce bone marrow mesenchymal stem cell (BMSC) apoptosis in rat DOP via the miR-1263/Mob1/Hippo signaling pathway.To evaluate the function of exoso ...
DOI:
10.1016/j.bbrc.2020.02.001

13. Impaired Vps34 complex activity-mediated autophagy inhibition contributes to endothelial progenitor cells damage in the ischemic conditions

Author:
Ru-chao Jiang; Xiao-ling Zhang; Qi-ai Zhang; Xue-ying Zheng; Hai-jie Shi; Yuan Qin; Gui-ping Zhang; Qing Xiao; Jian-dong Luo
Source:
Biochemical and biophysical research communications 2020 v.524 no.3 pp. 629-635
ISSN:
0006-291X
Subject:
apoptosis; autophagy; bone marrow; cell transplantation; glucose; hypoxia; ischemia; oxygen; peptides; rapamycin; research; stem cells
Abstract:
... Endothelial progenitor cells (EPCs) are widely accepted to be applied in ischemic diseases. However, the therapeutic potency is largely impeded because of its inviability in these ischemic conditions. Autophagy is recognized to be vital in cell activity. Therefore, we explore the role and the mechanism of autophagy in ischemic EPCs.We applied 7d-cultured bone marrow EPCs to investigate the autopha ...
DOI:
10.1016/j.bbrc.2020.01.133

14. Increased macrophage activation mediated by caspase recruitment domain 6 knockdown through negatively targeting AMPK

Author:
Fangyuan Chen; Juanli Li; Gang Tian; Zuyi Yuan
Source:
Biochemical and biophysical research communications 2020 v.525 no.2 pp. 412-417
ISSN:
0006-291X
Subject:
AMP-activated protein kinase; bone marrow; carcinogenesis; caspases; cholesterol; cytoplasm; fluorescent antibody technique; foam cells; loss-of-function mutation; macrophage activation; research
Abstract:
... Caspase recruitment domain 6 (CARD6) was initially implicated in the immune system and oncogenesis, which has also been emerged to play an important role in cardio-metabolic diseases. Nevertheless, the potential role of CARD6 on macrophage activation remains unknown. In the present study, we observed a decreased CARD6 expression in bone marrow derived macrophages (BMDMs) and mouse peritoneal macro ...
DOI:
10.1016/j.bbrc.2020.02.080

15. Inhibition of inflammation-mediated DPP-4 expression by linagliptin increases M2 macrophages in atherosclerotic lesions

Author:
Shuhei Nishida; Takeshi Matsumura; Takafumi Senokuchi; Saiko Murakami-Nishida; Norio Ishii; Yutaro Morita; Yoshitaka Yagi; Hiroyuki Motoshima; Tatsuya Kondo; Eiichi Araki
Source:
Biochemical and biophysical research communications 2020 v.524 no.1 pp. 8-15
ISSN:
0006-291X
Subject:
aorta; atherosclerosis; bone marrow; high fat diet; macrophages; mice; research
Abstract:
... Dipeptidyl peptidase-4 (DPP-4) inhibitors have been reported to suppress atherosclerosis progression in atherosclerotic mouse models through unclear mechanisms. In this study, we investigated the effect of the DPP-4 inhibitor, linagliptin, on macrophage polarization in vitro and in vivo.Mouse bone marrow macrophages (BMMs) were used in in vitro assays. High fat diet (HFD)-fed Apoe⁻/⁻ mice were tre ...
DOI:
10.1016/j.bbrc.2020.01.027

16. Inhibition of osteogenic and adipogenic potential in bone marrow-derived mesenchymal stem cells under osteoporosis

Author:
Tingben Huang; Zhou Yu; Qiong Yu; Ying Wang; Zhiwei Jiang; Huiming Wang; Guoli Yang
Source:
Biochemical and biophysical research communications 2020 v.525 no.4 pp. 902-908
ISSN:
0006-291X
Subject:
Western blotting; adipocytes; adipogenesis; bone formation; bone marrow; chondrocytes; females; integrins; mesenchymal stromal cells; microarray technology; osteoblasts; osteoporosis; ovariectomy; research; risk
Abstract:
... Osteoporosis, a prevalent systemic bone disease, has emerged as one of the most complicated health issues due to the risk of increased susceptibility to fractures. Bone-marrow mesenchymal stem cell (BMSC) has great potential of differentiating into several distinct cell types, including osteoblasts, adipocytes and chondrocytes. The present study analyzed the biological function changes of BMSCs un ...
DOI:
10.1016/j.bbrc.2020.03.035

17. Intracellular Ca2+ signaling mediates IGF-1-induced osteogenic differentiation in bone marrow mesenchymal stem cells

Author:
Liuzhong Wu; Guirong Zhang; Chuanbo Guo; Yaping Pan
Source:
Biochemical and biophysical research communications 2020 v.527 no.1 pp. 200-206
ISSN:
0006-291X
Subject:
Western blotting; alkaline phosphatase; bone formation; bone marrow; calcium; cell proliferation; endoplasmic reticulum; gene expression; insulin-like growth factor I; osteoblasts; osteocalcin; osteoporosis; quantitative polymerase chain reaction; research; surface area; transcription factors
Abstract:
... Insulin-like growth factor 1 (IGF-1), a multifunctional peptide that involves in cell proliferation and differentiation, can induce strong osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). However, it remains unknown whether intracellular Ca²⁺ signal contributes to the IGF-1-induced osteogenic differentiation of BMMSCs. In this study, we attempted to investigate the effect ...
DOI:
10.1016/j.bbrc.2020.04.048

18. K562 cell-derived exosomes suppress the adhesive function of bone marrow mesenchymal stem cells via delivery of miR-711

Author:
Yu-Huan Jiang; Jing Liu; Jin Lin; Shu-Qi Li; Yan-Mei Xu; Qing-Hua Min; Qiong-Hui Zhong; Fan Sun; Jing Li; Xia-Hong You; Kai-Li Liao; Ting-Yu Qin; Cui Zhao; Bo Huang; Xiao-Zhong Wang
Source:
Biochemical and biophysical research communications 2020 v.521 no.3 pp. 584-589
ISSN:
0006-291X
Subject:
adhesion; bone marrow; coculture; exosomes; leukemia; microRNA; research
Abstract:
... A failure of bone marrow mesenchymal stem cells (BM-MSCs) to adhere to hematopoietic cells is an essential cause of the progression of chronic myelogenous leukemia and is also a cause of failure of bone marrow (BM) transplantation, but the exact mechanisms of this have not been fully elucidated. Recent studies have indicated that microRNAs (miRNAs) are contained in leukemia-derived exosomes and ar ...
DOI:
10.1016/j.bbrc.2019.10.096

19. LncRNA HOTTIP enhances human osteogenic BMSCs differentiation via interaction with WDR5 and activation of Wnt/β-catenin signalling pathway

Author:
Ruiduan Liu; Zihao Li; Enhong Song; Panyong Hu; Qinghua Yang; Yiwen Hu; Hui Liu; Anmin Jin
Source:
Biochemical and biophysical research communications 2020 pp. -
ISSN:
0006-291X
Subject:
bone formation; bone marrow; humans; microarray technology; non-coding RNA; research; transcription factors
Abstract:
... To uncover the underlying molecular mechanism of long non-coding RNA in the osteogenic differentiation process of bone marrow mesenchymal stem cells (BMSCs), HOXA transcript at the distal tip (HOTTIP) was selected by using a lncRNA microarray assay. Results showed that HOTTIP was significantly upregulated during osteogenic differentiation of human BMSCs. Downregulation of HOTTIP by shRNA inhibited ...
DOI:
10.1016/j.bbrc.2020.02.034

20. Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm

Author:
Xu Zhang; Fangda Li; Wei Wang; Lei Ji; Bo Sun; Xue Xiao; Xiaoxiao Wang; Yuexin Chen; Bao Liu; Wei Ye; Cui Tian; Hongxia Wang; Yuehong Zheng
Source:
Biochemical and biophysical research communications 2020 v.533 no.4 pp. 1012-1020
ISSN:
0006-291X
Subject:
aneurysm; bone marrow; macrophages; pyroptosis; research
Abstract:
... Macrophages contribute to abdominal aortic aneurysm (AAA), but the effect of macrophage on AAA formation is not totally understood. Recent research proved that macrophage pyroptosis plays an important role in many cardiovascular disease. However, whether macrophage pyroptosis is involved in AAA and its mechanism remains unknown. In this study, we found that the pyroptosis significantly increased i ...
DOI:
10.1016/j.bbrc.2020.09.082