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- Chen, Xiang-Jun; Hu, Li-Dan; Yao, Ke; Yan, Yong-Bin
- Biochemical and biophysical research communications 2018 v.506 no.4 pp. 868-873
- 25-hydroxycholesterol; animal tissues; blindness; cataract; drug design; drugs; eye lens; humans; lanosterol; median effective concentration; patients; protein aggregates; surgery
- ... Cataract, a crystallin aggregation disease, is the leading cause of human blindness worldwide. Surgery is the only established treatment of cataracts and no anti-cataract drugs are available thus far. Recently lanosterol and 25-hydroxycholesterol have been reported to redissolve crystallin aggregates and partially restore lens transparency in animals. However, the efficacies of these two compounds ...
- Bari, Khandekar Jishan; Sharma, Shrikant; Chary, Kandala V.R.
- Biochemical and biophysical research communications 2018 v.506 no.4 pp. 862-867
- blindness; calcium; cataract; childhood; circular dichroism spectroscopy; cortex; differential scanning calorimetry; eye lens; fluorescence; fluorescence emission spectroscopy; homeostasis; humans; mutants; mutation; proteins; titration
- ... Infantile cataracts constitute one of the most important causes of childhood blindness worldwide. Human γS-crystallin is the most abundant protein in the eye lens cortex. A missense mutant of human γS-crystallin, Y67N (abbreviated hereafter as γS-Y67N) is recently reported to be associated with dominant infantile cataracts. To understand the structural basis for γS-Y67N to cause lens opacification ...