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- Li, Huizi Keiko; Hasegawa, Sumitaka; Nakajima, Nakako Izumi; Morokoshi, Yukie; Minegishi, Katsuyuki; Nagatsu, Kotaro
- Biochemical and biophysical research communications 2018 v.506 no.4 pp. 1078-1084
- animal models; antibodies; blood platelets; body weight changes; cytotoxicity; erythrocytes; humans; immunoglobulin G; immunologic receptors; leukopenia; ligands; major histocompatibility complex; mice; neoplasm cells; osteosarcoma; therapeutics; thrombocytopenia; tissues
- ... Major histocompatibility complex class I chain-related protein A and B (MICA/B) are ligands of the immune receptor, natural-killer group 2 member D. MICA/B expression is often found in several types of cancer but is restricted in normal tissues. Here, we show that an α-particle emitting astatine-211 (211At)-labeled antibody targeting MICA/B (211At-anti MICA/B Ab) efficiently ablates cancer cells i ...
- Han, Hao; Yang, Shu; Liang, Yu; Zeng, Peng; Liu, Lipei; Yang, Xiaoxiao; Duan, Yajun; Han, Jihong; Chen, Yuanli
- Biochemical and biophysical research communications 2018 v.506 no.4 pp. 1040-1046
- DNA topoisomerase (ATP-hydrolysing); actin; atherosclerosis; calcification; carotid arteries; gene expression regulation; genes; humans; mice; muscle protein; myocytes; osteopontin; phenotype; platelet-derived growth factor; smooth muscle
- ... The switch of vascular smooth muscle cells (SMCs) from the contractile phenotype to proliferative one can make contributions to atherosclerosis and neointima formation. MiR-21 can prevent the rupture of advanced lesion plaques. We previously reported the protection of DNA topoisomerase II (Topo II) inhibitors against atherosclerosis and vascular calcification. However, it remains unknown if Topo I ...