Journal name: Biochemical and biophysical research communications / Subject: bone marrow

1. 17β-estradiol promotes bone marrow mesenchymal stem cell migration mediated by chemokine upregulation

Author:: Wenbi Zhang; Xiong Li; He Li; Xiang Lu; Junling Chen; Lu Li; Xiaoxi Sun; Congjian Xu
Source:: Biochemical and biophysical research communications 2020 v.530 no.2 pp. 381-388
ISSN:: 0006-291X
Subject:: antagonists; bone marrow; cell movement; chemokines; chemotaxis; coculture; endometriosis; endometrium; gene expression; gene ontology; mesenchymal stromal cells; quantitative polymerase chain reaction; research; secretion; stem cells
Abstract:: ... Bone marrow-derived cells engraft to the uterine endometrium and contribute to endometriosis. This study sought to further confirm that estrogen can promote the migration of bone marrow mesenchymal stem cells (BMSCs) and to investigate the function of estrogen on the secretion of chemokines during BMSC migration. BMSCs were treated with or without 17β-estradiol, cultured with or without endometria ...
DOI:: 10.1016/j.bbrc.2020.07.135
: https://doi.org/10.1016/j.bbrc.2020.07.135

2. IL- 1R1 blockade attenuates liver injury through inhibiting the recruitment of myeloid-derived suppressor cells in sepsis

Author:: Minjie Luo; Hao Wang; Ke Liu; Meidong Liu; Sipin Tan; Yaxi Zhu; Huali Zhang
Source:: Biochemical and biophysical research communications 2022 v.620 pp. 21-28
ISSN:: 0006-291X
Subject:: antagonists; bone marrow; humans; liver; macrophages; phenotype; prognosis; protective effect; research
Abstract:: ... Myeloid-derived suppressor cells (MDSCs) mobilize and migrate from bone marrow to peripheral tissues or immune organs, which is associated with poor prognosis in sepsis. Intervention of MDSCs might be a potential target for the effective treatment of sepsis. In the present study, we demonstrated that IL-1R1 blockade with either recombinant human IL-1R antagonist Anakinra or IL-1R1 deficiency had a ...
DOI:: 10.1016/j.bbrc.2022.06.038
: https://doi.org/10.1016/j.bbrc.2022.06.038

3. 25-hydroxycholesterol promotes RANKL-induced osteoclastogenesis through coordinating NFATc1 and Sp1 complex in the transcription of miR-139-5p

Author:: Lishan Zhang; Yinping Lv; Guozhe Xian; Yanliang Lin
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: T-lymphocytes; binding capacity; bone marrow; chromatin; immune response; ligands; lipid metabolism; macrophage colony-stimulating factor; macrophages; mice; monocytes; precipitin tests; transcription (genetics); transcription factor NF-kappa B
Abstract:: ... 25-hydroxycholesterol (25-HC) is implicated in many processes, including lipid metabolism and the immune response. However, the role of 25-HC in RANKL-induced osteoclastogenesis remains largely unknown. Our results showed that 25-HC inhibited miR-139-5p expression in mouse bone marrow macrophages (BMMs) cultured in receptor activator of NF-κB ligand (RANKL) and monocyte macrophage colony-stimulati ...
DOI:: 10.1016/j.bbrc.2017.02.118
: https://doi.org/10.1016/j.bbrc.2017.02.118

4. IL- 37 impairs host resistance to Listeria infection by suppressing macrophage function

Author:: Mengmeng Zhao; Yongguang Hu; Juanjuan Shou; Shao Bo Su; Jianhua Yang; Tianshu Yang
Source:: Biochemical and biophysical research communications 2016 pp. -
ISSN:: 0006-291X
Subject:: Listeria monocytogenes; anti-inflammatory activity; apoptosis; bacteria; blood serum; bone marrow; colony-stimulating factors; immune response; listeriosis; liver; macrophages; mice; microbial load; models
Abstract:: ... Listeria monocytogenes is a Gram-positive intracellular bacterium that was transmitted through contaminated food and causes sepsis and even death. IL-37 has been described as an important anti-inflammatory factor, but little is known about the function of IL-37 in host defense against Liseria monocytogenes (Lm) infection. In mice model of systemic infection, we found that mice treated with IL-37 w ...
DOI:: 10.1016/j.bbrc.2016.11.002
: https://doi.org/10.1016/j.bbrc.2016.11.002

5. APOBEC3B is preferentially expressed at the G2/M phase of cell cycle

Author:: Shigeki Hirabayashi; Kotaro Shirakawa; Yoshihito Horisawa; Tadahiko Matsumoto; Hiroyuki Matsui; Hiroyuki Yamazaki; Anamaria Daniela Sarca; Yasuhiro Kazuma; Ryosuke Nomura; Yoshinobu Konishi; Suguru Takeuchi; Emani Stanford; Hideya Kawaji; Yasuhiro Murakawa; Akifumi Takaori-Kondo
Source:: Biochemical and biophysical research communications 2021 v.546 pp. 178-184
ISSN:: 0006-291X
Subject:: bone marrow; carcinogenesis; cytosine; cytosine deaminase; myeloma; research; sequence analysis; single-stranded DNA; uracil
Abstract:: ... APOBEC3B (A3B) is a cytosine deaminase that converts cytosine to uracil in single-stranded DNA. Cytosine-to-thymine and cytosine-to-guanine base substitution mutations in trinucleotide motifs (APOBEC mutational signatures) were found in various cancers including lymphoid hematological malignancies such as multiple myeloma and A3B has been shown to be an enzymatic source of mutations in those cance ...
DOI:: 10.1016/j.bbrc.2021.02.008
: https://doi.org/10.1016/j.bbrc.2021.02.008

6. ATP turnover and glucose dependency in hematopoietic stem/progenitor cells are increased by proliferation and differentiation

Author:: Shintaro Watanuki; Hiroshi Kobayashi; Yuriko Sorimachi; Masamichi Yamamoto; Shinichiro Okamoto; Keiyo Takubo
Source:: Biochemical and biophysical research communications 2019 v.514 no.1 pp. 287-294
ISSN:: 0006-291X
Subject:: adenosine triphosphate; bone marrow; cell cycle; cell differentiation; glucose; glycolysis; hematopoietic stem cells; monitoring; monocytes; nutrient requirements; oxidative phosphorylation
Abstract:: ... Hematopoietic stem cells (HSCs) are quiescent cells in the bone marrow niche and are relatively dependent on glycolytic ATP production. On the other hand, differentiated cells, including hematopoietic progenitor cells (HPCs), preferentially generate ATP via oxidative phosphorylation. However, it is unclear how cellular differentiation and the cell cycle status affect nutritional requirements and A ...
DOI:: 10.1016/j.bbrc.2019.04.123
: https://doi.org/10.1016/j.bbrc.2019.04.123

7. ATP6V1H regulates the growth and differentiation of bone marrow stromal cells

Author:: Lin Li; Shaoqing Yang; Yanli Zhang; Dongrui Ji; Zuolin Jin; Xiaohong Duan
Source:: Biochemical and biophysical research communications 2018 v.502 no.1 pp. 84-90
ISSN:: 0006-291X
Subject:: Danio rerio; H-transporting ATP synthase; bone formation; bone marrow; bone resorption; cell cycle checkpoints; gene expression; histology; humans; messenger RNA; mice; stromal cells; transforming growth factor beta 1; transforming growth factor beta receptors
Abstract:: ... ATP6V1H encodes subunit H of vacuolar ATPase (V-ATPase) and may regulate osteoclastic function. The deficiency of ATP6V1H caused bone loss in human, mouse and zebrafish. In this report, we identified the mechanisms by which ATP6V1H regulates proliferation and differentiation of bone marrow stromal cells (BMSCs). We found that ATP6V1H was expressed in BMSCs, and Atp6v1h+/- BMSCs exhibited the lower ...
DOI:: 10.1016/j.bbrc.2018.05.124
: https://doi.org/10.1016/j.bbrc.2018.05.124

8. Accelerated apoptosis of peripheral blood monocytes in Cebpb-deficient mice

Author:: Akihiro Tamura; Hideyo Hirai; Asumi Yokota; Atsushi Sato; Tsukimi Shoji; Takahiro Kashiwagi; Masaki Iwasa; Aya Fujishiro; Yasuo Miura; Taira Maekawa
Source:: Biochemical and biophysical research communications 2015 v.464 pp. 654-658
ISSN:: 0006-291X
Subject:: apoptosis; bone marrow; bone marrow cells; flow cytometry; hematopoiesis; macrophages; mice; monocytes; transcription factors
Abstract:: ... The CCAAT/enhancer-binding protein β (C/EBPβ) transcription factor is required for granulopoiesis under stress conditions. However, little is known about its roles in steady state hematopoiesis. Here, we analyzed the peripheral blood and bone marrow of Cebpb−/− mice at steady state by flow cytometry and unexpectedly found that the number of peripheral blood monocytes was severely reduced, while th ...
DOI:: 10.1016/j.bbrc.2015.07.045
: https://doi.org/10.1016/j.bbrc.2015.07.045

9. Acid sphingomyelinase regulates osteoclastogenesis by modulating sphingosine kinases downstream of RANKL signaling

Author:: Xilinqiqige Bao; Takuya Ogawa; Satoru Se; Motofusa Akiyama; Anton Bahtiar; Tatsuo Takeya; Norihiro Ishida-Kitagawa
Source:: Biochemical and biophysical research communications 2011 v.405 no.4 pp. 533-537
ISSN:: 0006-291X
Subject:: bone marrow; genes; macrophages; osteoclasts; phosphotransferases (kinases); sphingosine
Abstract:: ... Acid sphingomyelinase (ASM) was identified as a gene induced by NFAT2 activation in osteoclasts. Suppression of ASM expression in bone marrow macrophages by knockdown enhanced c-Fos/NFAT2 expression, increasing the number of TRAP-positive multinucleated cells in vitro. SphK1 was upregulated during the late stage of osteoclastogenesis, while SphK2 expression remained constant. SphK1 was downregulat ...
DOI:: 10.1016/j.bbrc.2011.01.061
: https://doi.org/10.1016/j.bbrc.2011.01.061

10. Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells

Author:: Weimin Qiu; Li Chen; Moustapha Kassem
Source:: Biochemical and biophysical research communications 2011 v.413 no.1 pp. 98-104
ISSN:: 0006-291X
Subject:: DNA microarrays; adipocytes; bone marrow; gene expression regulation; humans; mitogen-activated protein kinase; mutation; signal transduction; stem cells
Abstract:: ... The canonical Wnt signaling pathway can determine human bone marrow stromal (mesenchymal) stem cell (hMSC) differentiation fate into osteoblast or adipocyte lineages. However, its downstream targets in MSC are not well characterized. Thus, using DNA microarrays, we compared global gene expression patterns induced by Wnt3a treatment in two hMSC lines: hMSC-LRP5ᵀ²⁵³ and hMSC-LRP5ᵀ²⁴⁴ cells carrying ...
DOI:: 10.1016/j.bbrc.2011.08.061
: https://doi.org/10.1016/j.bbrc.2011.08.061

11. Activation of protein kinase C accelerates murine osteoclastogenesis partly via transactivation of RANK gene through functional AP-1 responsive element in RANK gene promoter

Author:: Riko Kitazawa; Satomi Kinto-Shibahara; Ryuma Haraguchi; Yukihiro Kohara; Sohei Kitazawa
Source:: Biochemical and biophysical research communications 2019 v.515 no.2 pp. 268-274
ISSN:: 0006-291X
Subject:: DNA; antibodies; binding sites; bone marrow; cold; gene expression; genes; genetic vectors; ligands; macrophages; mice; mutagenesis; oligonucleotides; osteoclasts; promoter regions; protein binding; protein kinase C; small interfering RNA; transcription (genetics); transcription factor NF-kappa B; transcriptional activation
Abstract:: ... Receptor activator of NF-κB (RANK) expressed on osteoclasts and their precursors is a receptor for RANK ligand (RANKL). Signals transduced by RANKL-RANK interaction induce genes essential for the differentiation and function of osteoclasts. We have cloned a basic promoter region of the mouse RANK gene and have analyzed the transcription machinery by transcription factors such as PU.1 (−480), and M ...
DOI:: 10.1016/j.bbrc.2019.05.144
: https://doi.org/10.1016/j.bbrc.2019.05.144

12. Adipose mesenchymal stem cell-derived exosomes ameliorate hypoxia/serum deprivation-induced osteocyte apoptosis and osteocyte-mediated osteoclastogenesis in vitro

Author:: Lin Ren; Zi-jun Song; Qing-wei Cai; Rui-xin Chen; Yang Zou; Qiang Fu; Yuan-yuan Ma
Source:: Biochemical and biophysical research communications 2019 v.508 no.1 pp. 138-144
ISSN:: 0006-291X
Subject:: acid phosphatase; age; apoptosis; blood serum; bone marrow; bone resorption; caspase-3; caspase-9; cell lines; cytochrome c; exosomes; genes; hypoxia; mesenchymal stromal cells; messenger RNA; models; monocytes; osteoclasts; protein content; staining; therapeutics
Abstract:: ... Age-related skeletal changes is closely associated with imbalanced bone remodeling characterized by elevated osteocyte apoptosis and osteoclast activation. Since osteocytes are the commander of bone remodeling, attenuating increased osteocyte apoptosis may improve age-related bone loss. Exosomes, derived from mesenchymal stem cells, hold promising potential for cell-free therapy due to multiple ab ...
DOI:: 10.1016/j.bbrc.2018.11.109
: https://doi.org/10.1016/j.bbrc.2018.11.109

13. Ameliorating replicative senescence of human bone marrow stromal cells by PSMB5 overexpression

Author:: Li Lu; Hui-Fang Song; Jiao-Long Wei; Xue-Qin Liu; Wen-Hui Song; Ba-Yi Yan; Gui-Jiao Yang; Ang Li; Wu-Lin Yang
Source:: Biochemical and biophysical research communications 2014 v.443 pp. 1182-1188
ISSN:: 0006-291X
Subject:: bone marrow; cell growth; cell proliferation; cell senescence; cell viability; cyclins; humans; hydrogen peroxide; medicine; oxidative stress; phenotype; stromal cells; therapeutics
Abstract:: ... Multipotent human bone marrow stromal cells (hBMSCs) potentially serve as a source for cell-based therapy in regenerative medicine. However, in vitro expansion was inescapably accompanied with cell senescence, characterized by inhibited proliferation and compromised pluripotency. We have previously demonstrated that this aging process is closely associated with reduced 20S proteasomal activity, wi ...
DOI:: 10.1016/j.bbrc.2013.12.113
: https://doi.org/10.1016/j.bbrc.2013.12.113

14. Ameloblastin and enamelin prevent osteoclast formation by suppressing RANKL expression via MAPK signaling pathway

Author:: Wichida Chaweewannakorn; Wataru Ariyoshi; Toshinori Okinaga; Kazumasa Morikawa; Katsura Saeki; Kenshi Maki; Tatsuji Nishihara
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: bone marrow; calcitriol; cell differentiation; coculture; dexamethasone; enamel; genes; humans; ligands; messenger RNA; mice; mineralization; mitogen-activated protein kinase; osteoclasts; phosphorylation; protein synthesis; signal transduction; stromal cells
Abstract:: ... Ameloblastin (Ambn) and enamelin (Enam) play a pivotal role in enamel mineralization. Previous studies have demonstrated that these enamel-related gene products also affect bone growth and remodeling; however, the underlying mechanisms have not been elucidated. In the present study, we examined the effects of Ambn and Enam on the receptor activator of nuclear factor kappa-B ligand (RANKL) expressi ...
DOI:: 10.1016/j.bbrc.2017.01.181
: https://doi.org/10.1016/j.bbrc.2017.01.181

15. Analysis of the stem cell characteristics of adult stem cells from Arbas white Cashmere goat

Author:: Yu Ren; Haiqing Wu; Xiao Wang; Na Xue; Hao Liang; Dongjun Liu
Source:: Biochemical and biophysical research communications 2014 v.448 pp. 121-128
ISSN:: 0006-291X
Subject:: GATA transcription factors; Western blotting; adult stem cells; adults; appendages; biomarkers; bone marrow; embryonic stem cells; gene expression; goats; immunocytochemistry; in vitro culture; interleukin-6; messenger RNA; mice; neoplasms; reverse transcriptase polymerase chain reaction
Abstract:: ... Studies have shown that multipotent adult stem cells possess differentiation characteristics similar to embryonic stem cells and pluripotent stem cells. We aimed to explore these similarities further by examining the expression of the pluripotency and stemness biomarkers, AKP, IL-6, Nanog, Oct-4, Rex-1, Sox-2 and TERT, as well as the triploblastic biomarkers, Sox-1, Myod1 and Gata-6 in adipose-der ...
DOI:: 10.1016/j.bbrc.2013.12.044
: https://doi.org/10.1016/j.bbrc.2013.12.044

16. Angiopoietin1 contributes to the maintenance of cell quiescence in EVI1ʰⁱᵍʰ leukemia cells

Author:: Emi Ichihara; Kazuko Kaneda; Yusuke Saito; Norio Yamakawa; Kazuhiro Morishita
Source:: Biochemical and biophysical research communications 2011 v.416 no.3-4 pp. 239-245
ISSN:: 0006-291X
Subject:: antineoplastic agents; bone marrow; bone marrow cells; cell cycle; drug resistance; gene expression regulation; genes; humans; mice; myeloid leukemia; prognosis; quantitative polymerase chain reaction; stem cells; transcription factors
Abstract:: ... Ecotropic viral integration site-1 (EVI1) is an oncogenic transcription factor in human acute myeloid leukemia (AML) associated with poor prognosis. Because the drug-resistance of leukemia cells is partly dependent on cell quiescence in the bone marrow niche, EVI1 may be involved in cell cycle regulation in leukemia cells. As a candidate regulator of the cell cycle in leukemia cells with high EVI1 ...
DOI:: 10.1016/j.bbrc.2011.10.061
: https://doi.org/10.1016/j.bbrc.2011.10.061

17. Anthelmintic drug niclosamide enhances the sensitivity of chronic myeloid leukemia cells to dasatinib through inhibiting Erk/Mnk1/eIF4E pathway

Author:: Zhong Liu; Yong Li; Cao Lv; Li Wang; Hongping Song
Source:: Biochemical and biophysical research communications 2016 v.478 no.2 pp. 893-899
ISSN:: 0006-291X
Subject:: apoptosis; bone marrow; cell lines; drugs; enzyme inhibitors; myeloid leukemia; neoplasm cells; niclosamide; phosphorylation; signal transduction; stem cells; therapeutics; toxicity; tyrosine
Abstract:: ... Chronic myeloid leukemia (CML) responds well to BCR-ABL tyrosine kinase inhibitors (TKI), but becomes resistant to TKIs after it progresses to blast phase (BP). Here we show that niclosamide, a FDA-approved anthelmintic drug, enhances the sensitivity of BP-CML cells to dasatinib (2nd generation of BCR-ABL TKI) through inhibiting Erk/Mnk1/eIF4E signaling pathway. Niclosamide dose-dependently inhibi ...
DOI:: 10.1016/j.bbrc.2016.08.047
: https://doi.org/10.1016/j.bbrc.2016.08.047

18. Anti-ATR001 monoclonal antibody ameliorates atherosclerosis through beta-arrestin2 pathway

Author:: Yingxuan Wang; Zhiran Fan; Chanjuan Xu; Xiaole Yan; Yanzhao Zhou; Zhihua Qiu; Qingchen Yuan; Jiayu Zheng; Yuhua Liao; Xiao Chen
Source:: Biochemical and biophysical research communications 2021 v.544 pp. 1-7
ISSN:: 0006-291X
Subject:: atherosclerosis; bone marrow; calcium; low density lipoprotein; macrophages; mice; monoclonal antibodies; peptides; phosphorylation; protective effect; renin-angiotensin system; research; signal transduction; transcription factor NF-kappa B; vaccines
Abstract:: ... Our previous study developed ATRQβ-001 vaccine, which targets peptide ATR001 from angiotensin Ⅱ (Ang Ⅱ) receptor type 1 (AT1R). The ATRQβ-001 vaccine could induce the production of anti-ATR001 monoclonal antibody (McAb-ATR) and inhibit atherosclerosis without feedback activation of the renin-angiotensin system (RAS). This study aims at investigating the underexploited mechanisms of McAb-ATR in ame ...
DOI:: 10.1016/j.bbrc.2021.01.054
: https://doi.org/10.1016/j.bbrc.2021.01.054

19. Anti-adipogenic effects of sesamol on human mesenchymal stem cells

Author:: Min Kim; Yoo-Jung Lee; Seung-Cheol Jee; Inho Choi; Jung-Suk Sung
Source:: Biochemical and biophysical research communications 2016 v.469 pp. 49-54
ISSN:: 0006-291X
Subject:: adipocytes; adipogenesis; adults; anemia; antioxidant activity; bone marrow; chondrocytes; gene expression; genes; humans; lipids; lipolysis; mitogen-activated protein kinase; neurons; osteoblasts; osteoporosis; sesame oil; stem cells; stromal cells
Abstract:: ... Human mesenchymal stem cells (hMSCs) from adult bone marrow are able to differentiate into adipocytes, osteoblasts, chondrocytes and neuronal cells. Adipocytes in bone marrow are primarily responsible for the maintenance of bone structure by maintaining cell number balance with other stromal cells. However, the number of adipocytes in the bone marrow increases with age, leading to an imbalance of ...
DOI:: 10.1016/j.bbrc.2015.11.070
: https://doi.org/10.1016/j.bbrc.2015.11.070

20. Antibiotic anisomycin selectively targets leukemia cell lines and patient samples through suppressing Wnt/β-catenin signaling

Author:: Yong Li; Jialin Hu; Hongping Song; Tao Wu
Source:: Biochemical and biophysical research communications 2018 v.505 no.3 pp. 858-864
ISSN:: 0006-291X
Subject:: antibiotics; apoptosis; bone marrow; cell differentiation; cell lines; developmental stages; dose response; drugs; enzyme inhibitors; mechanism of action; mitogen-activated protein kinase; myeloid leukemia; neoplasm cells; patients; stem cells; tyrosine
Abstract:: ... Chronic myeloid leukemia (CML) responds well to BCR-ABL tyrosine kinase inhibitors (TKI), such as imatinib and dasatinib. However, these inhibitors have been less effective as single agents in the blast phase-CML. In this work, we show that anisomycin, a clinically available drug, targets CML cells at all stages of development and enhances BCR-ABL TKIs’ efficacy. Anisomycin at nanomolar concentrat ...
DOI:: 10.1016/j.bbrc.2018.09.183
: https://doi.org/10.1016/j.bbrc.2018.09.183

21. Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress

Author:: Jiaqiao Wang; Yanhua Xu; Huihui Wan; June Hu
Source:: Biochemical and biophysical research communications 2018 v.497 no.1 pp. 241-247
ISSN:: 0006-291X
Subject:: antibiotics; antioxidants; apoptosis; blood; bone marrow; cell lines; drugs; enzyme inhibitors; hematopoietic stem cells; ivermectin; mitochondria; myeloid leukemia; oxidative stress; tyrosine
Abstract:: ... Mitochondria has been a promising target in blood cancer given their unique dependencies on mitochondrial functions compared to normal hematopoietic cells. In line with this concept, we show that an anthelminthic drug ivermectin selectively kills chronic myeloid leukemia (CML) cells via inducing mitochondrial dysfunctions and oxidative stress. Ivermectin is significantly more effective in inducing ...
DOI:: 10.1016/j.bbrc.2018.02.063
: https://doi.org/10.1016/j.bbrc.2018.02.063

22. Apolipoprotein E plays crucial roles in maintaining bone mass by promoting osteoblast differentiation via ERK1/2 pathway and by suppressing osteoclast differentiation via c-Fos, NFATc1, and NF-κB pathway

Author:: Takaaki Noguchi; Kosuke Ebina; Makoto Hirao; Satoru Otsuru; Adam J. Guess; Ryota Kawase; Tohru Ohama; Shizuya Yamashita; Yuki Etani; Gensuke Okamura; Hideki Yoshikawa
Source:: Biochemical and biophysical research communications 2018 v.503 no.2 pp. 644-650
ISSN:: 0006-291X
Subject:: T-lymphocytes; alkaline phosphatase; apolipoprotein E; bone density; bone marrow; bone metabolism; cathepsin K; dose response; females; femur; gene expression; gene expression regulation; genes; homozygosity; hyperlipidemia; lipid metabolism; macrophages; mice; micro-computed tomography; mitogen-activated protein kinase; osteoblasts; osteoclasts; osteoporosis; risk; transcription factor NF-kappa B; transmembrane proteins
Abstract:: ... Apolipoprotein E (ApoE) plays crucial roles not only in lipid metabolism but also in bone metabolism. Specifically ApoE4, one of major ApoE isoforms, has been demonstrated to be associated with increased risk of developing osteoporosis compared to another major isoform ApoE3. However, the detailed mechanism of how the different ApoE isoforms affect bone metabolism remains unclear. Micro-CT analyse ...
DOI:: 10.1016/j.bbrc.2018.06.055
: https://doi.org/10.1016/j.bbrc.2018.06.055

23. Arsenite suppresses the transcriptional activity of EVI1 through the binding to CCHC-type Zn finger domain

Author:: Masatoshi Ogawa; Yasuko Okamoto; Seiichiro Himeno; Kazumi Suzukawa; Daigo Sumi
Source:: Biochemical and biophysical research communications 2020 v.529 no.4 pp. 910-915
ISSN:: 0006-291X
Subject:: GATA transcription factors; alanine; arsenites; bone marrow; cysteine; dithiothreitol; gel electrophoresis; hematopoiesis; research; synthetic peptides; therapeutics; transcription (genetics); zinc finger motif
Abstract:: ... Transcription factor EVI1 is essential for normal hematopoiesis in embryos but is aberrantly elevated in bone marrow cells of myelodysplastic syndrome (MDS) patients. EVI1 and its downstream GATA-2 appear to be a possible therapeutic target of MDS. Here we found that treatment of EVI1-expressing K562 cells with arsenite (As(III)) reduced the mRNA and protein levels of EVI1 and GATA-2. A gel shift ...
DOI:: 10.1016/j.bbrc.2020.07.024
: https://doi.org/10.1016/j.bbrc.2020.07.024

24. Astaxanthin improves osteopenia caused by aldehyde-stress resulting from Aldh2 mutation due to impaired osteoblastogenesis

Author:: Hiroko Hoshi; Fuka Monoe; Ikuroh Ohsawa; Shigeo Ohta; Takeshi Miyamoto
Source:: Biochemical and biophysical research communications 2020 v.527 no.1 pp. 270-275
ISSN:: 0006-291X
Subject:: acetaldehyde; aldehyde dehydrogenase; astaxanthin; bone density; bone formation; bone marrow; catalytic activity; cell viability; femur; hip fractures; metabolism; mitochondria; osteoblasts; osteopenia; osteoporosis; research; single nucleotide polymorphism
Abstract:: ... Aldehyde dehydrogenase 2 (ALDH2) plays major roles in aldehyde detoxification and in the catalysis of amino acids. ALDH2∗2, a dominant-negative transgenic expressing aldehyde dehydrogenase 2 (ALDH2) protein, is produced by a single nucleotide polymorphism (rs671) and is involved in the development of osteoporosis and hip fracture with aging. In a previous study, transgenic mice expressing Aldh2∗2( ...
DOI:: 10.1016/j.bbrc.2020.04.013
: https://doi.org/10.1016/j.bbrc.2020.04.013

25. Augmented neutrophil extracellular traps formation promotes atherosclerosis development in socially defeated apoE−/− mice

Author:: Keita Yamamoto; Hiroyuki Yamada; Noriyuki Wakana; Masakazu Kikai; Kensuke Terada; Naotoshi Wada; Shinichiro Motoyama; Makoto Saburi; Takeshi Sugimoto; Daisuke Kami; Takehiro Ogata; Masakazu Ibi; Chihiro Yabe-Nishimura; Satoaki Matoba
Source:: Biochemical and biophysical research communications 2018 v.500 no.2 pp. 490-496
ISSN:: 0006-291X
Subject:: aorta; atherosclerosis; blood pressure; bone marrow; cages; deoxyribonuclease I; genes; high fat diet; histones; lipid composition; males; mice; monocytes; myeloperoxidase; neutrophils; reactive oxygen species; risk factors; social behavior; suppressor cells
Abstract:: ... Depression is an independent risk factor of cardiovascular disease (CVD); however, the causal association remains undefined. We exposed mice to repeated social defeat (RSD) to precipitate depressive-like behaviors, and investigated the effects on atherosclerosis. Eight-week-old male apoE−/− mice were exposed to RSD by housing with a larger CD-1 mouse in a shared home cage. They were subjected to v ...
DOI:: 10.1016/j.bbrc.2018.04.115
: https://doi.org/10.1016/j.bbrc.2018.04.115

26. Autophagy activation facilitates mechanical stimulation-promoted osteoblast differentiation and ameliorates hindlimb unloading-induced bone loss

Author:: Zezhu Zhou; Guixun Shi; Xinfeng Zheng; Shengdan Jiang; Leisheng Jiang
Source:: Biochemical and biophysical research communications 2018 v.498 no.3 pp. 667-673
ISSN:: 0006-291X
Subject:: autophagy; bone formation; bone marrow; bone resorption; mesenchymal stromal cells; models; osteoblasts; osteoporosis; rapamycin
Abstract:: ... Autophagy has been indicated to be involved in regulating bone metabolism. However, little is known about the role of autophagy in mechanical stimulation-influenced osteoblast differentiation and bone formation. In the present study, we first demonstrated that autophagy activation was essential for cyclic mechanical stretching-promoted osteoblast differentiation of bone marrow mesenchymal stem cel ...
DOI:: 10.1016/j.bbrc.2018.03.040
: https://doi.org/10.1016/j.bbrc.2018.03.040

27. Autophagy exerts pivotal roles in regulatory effects of 1α,25-(OH)2D3 on the osteoclastogenesis

Author:: Lianmei Ji; Jie Gao; Ruina Kong; Ying Gao; Xiaofan Ji; Dongbao Zhao
Source:: Biochemical and biophysical research communications 2019 v.511 no.4 pp. 869-874
ISSN:: 0006-291X
Subject:: autophagy; bone marrow; cholecalciferol; drugs; gene overexpression; genes; macrophages; osteoclasts; osteoporosis
Abstract:: ... As an active form of vitamin D₃, 1α,25-(OH)₂D₃ has a positive therapeutical effect on osteoporosis. However, 1α,25-(OH)₂D₃ can not only promote the osteoclastogenesis, but also inhibit the proliferation of osteoclast precursors (OCPs). Autophagy is regulated by 1α,25-(OH)₂D₃ and is considered to promote the osteoclastogenesis. Nevertheless, the role of 1α,25-(OH)₂D₃ in OCPs' autophagy remains unkn ...
DOI:: 10.1016/j.bbrc.2019.02.114
: https://doi.org/10.1016/j.bbrc.2019.02.114

28. Autophagy mediates enhancement of proangiogenic activity by hypoxia in mesenchymal stromal/stem cells

Author:: Seul-Gi Lee; Young Ae Joe
Source:: Biochemical and biophysical research communications 2018 v.501 no.4 pp. 941-947
ISSN:: 0006-291X
Subject:: angiogenin; autophagy; bone marrow; chloroquine; cytokines; human umbilical vein endothelial cells; hypoxia; hypoxia-inducible factor 1; ischemia; secretion; small interfering RNA; stem cells; therapeutics; vascular endothelial growth factors
Abstract:: ... Mesenchymal stromal/stem cells (MSCs) have been promising source for regenerative cell therapy in ischemic diseases. To improve efficacy of MSC therapy, various priming methods have been developed, and hypoxic priming has been reported to enhance therapeutic efficacy of MSCs by increasing secretion level of growth factors and cytokines. Recently, it has been reported that bone marrow MSCs primed w ...
DOI:: 10.1016/j.bbrc.2018.05.086
: https://doi.org/10.1016/j.bbrc.2018.05.086

29. Autophagy promotes osteogenic differentiation of human bone marrow mesenchymal stem cell derived from osteoporotic vertebrae

Author:: Yongxian Wan; Naiqiang Zhuo; Yulin Li; Weikang Zhao; Dianming Jiang
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: autophagy; bone density; bone formation; bone marrow; humans; mice; osteoporosis; patients; phenotype; stem cells; vertebrae
Abstract:: ... Osteoporosis is one of the most prevalent age-related diseases worldwide, of which vertebral fracture is by far the most common osteoporotic fracture. Reduced bone formation caused by senescence is a main cause for senile osteoporosis, however, how to improve the osteogenic differentiation of osteoporotic bone marrow mesenchymal stem cells (BMSCs) remains a challenge. This study aimed to investiga ...
DOI:: 10.1016/j.bbrc.2017.05.004
: https://doi.org/10.1016/j.bbrc.2017.05.004

30. BST-2 is a potential activator of invasion and migration in tamoxifen-resistant breast cancer cells

Author:: Eun Hee Yi; Hyouna Yoo; Kum Hee Noh; Songhee Han; Haeri Lee; Jin-Ku Lee; Cheolhee Won; Byung-Hak Kim; Myoung-Hwan Kim; Chung-Hyun Cho; Sang-kyu Ye
Source:: Biochemical and biophysical research communications 2013 v.435 pp. 685-690
ISSN:: 0006-291X
Subject:: animal models; antigens; bone marrow; breast neoplasms; humans; melanoma; metastasis; neoplasm cells; signal transduction; tissue repair; transcription factors
Abstract:: ... Bone marrow stromal cell antigen 2 (BST-2) is a type II transmembrane protein that is known to be a therapeutic target in several types of cancer. However, despite its clinical importance, the roles of BST-2 expression have remained elusive. Here, we found that BST-2 expression is up-regulated in tamoxifen-resistant MCF-7 human breast cancer (TRM-7) cells, resulting in enhanced invasiveness and mi ...
DOI:: 10.1016/j.bbrc.2013.05.043
: https://doi.org/10.1016/j.bbrc.2013.05.043

31. Bergapten suppresses RANKL-induced osteoclastogenesis and ovariectomy-induced osteoporosis via suppression of NF-κB and JNK signaling pathways

Author:: Guiping Chen; Qiang Xu; Min Dai; Xuqiang Liu
Source:: Biochemical and biophysical research communications 2019 v.509 no.2 pp. 329-334
ISSN:: 0006-291X
Subject:: Cnidium monnieri; Oriental traditional medicine; actin; bergapten; bone marrow; bone resorption; cytotoxicity; gene expression; genes; ingredients; ligands; macrophages; medicinal properties; messenger RNA; mitogen-activated protein kinase; osteoporosis; postmenopause; signal transduction; transcription factor NF-kappa B
Abstract:: ... Bergapten (BP), derived from Cnidium monnieri (L.) Cusson, is an ingredient widely used in traditional Chinese medicine and has important biological and pharmacological activities. However, the effect of BP on ovariectomy-induced osteoporosis and the underlying mechanism are not entirely clear. In this study, we investigated the effects of BP on ovariectomy-induced osteoporosis and receptor activa ...
DOI:: 10.1016/j.bbrc.2018.12.112
: https://doi.org/10.1016/j.bbrc.2018.12.112

32. Bio-active molecules modified surfaces enhanced mesenchymal stem cell adhesion and proliferation

Author:: Rezvan Mobasseri; Lingling Tian; Masoud Soleimani; Seeram Ramakrishna; Hossein Naderi-Manesh
Source:: Biochemical and biophysical research communications 2017 v.483 pp. 312-317
ISSN:: 0006-291X
Subject:: adhesion; bone marrow; cell adhesion; cell culture; cell proliferation; collagen; confocal microscopy; cultured cells; extracellular matrix; fibronectins; glass; peptides; pseudopodia; scanning electron microscopy; signal transduction; stem cells; tissue culture; tissue engineering
Abstract:: ... Surface modification of the substrate as a component of in vitro cell culture and tissue engineering, using bio-active molecules including extracellular matrix (ECM) proteins or peptides derived ECM proteins can modulate the surface properties and thereby induce the desired signaling pathways in cells. The aim of this study was to evaluate the behavior of human bone marrow mesenchymal stem cells ( ...
DOI:: 10.1016/j.bbrc.2016.12.146
: https://doi.org/10.1016/j.bbrc.2016.12.146

33. Blockade of plasminogen activator inhibitor-1 empties bone marrow niche sufficient for donor hematopoietic stem cell engraftment without myeloablative conditioning

Author:: Abd Aziz Ibrahim; Takashi Yahata; Yukari Muguruma; Toshio Miyata; Kiyoshi Ando
Source:: Biochemical and biophysical research communications 2019 v.516 no.2 pp. 500-505
ISSN:: 0006-291X
Subject:: bone marrow; cell differentiation; cell movement; cell transplantation; drug therapy; hematopoietic stem cells; irradiation; mice; mortality; niches; patients; plasminogen activator inhibitors
Abstract:: ... Upon hematopoietic stem cell transplantation (HSCT), the availability of recipients' niches in the bone marrow (BM) is one of the factors that influence donor HSC engraftment and hematopoietic reconstitution. Therefore, myeloablative conditioning, such as irradiation and/or chemotherapy, which creates empty niches in the recipients' BM, is required for the success of HSCT. However, the conventiona ...
DOI:: 10.1016/j.bbrc.2019.06.076
: https://doi.org/10.1016/j.bbrc.2019.06.076

34. Bone marrow NLRP3 inflammasome-IL-1β signal regulates post-myocardial infarction megakaryocyte development and platelet production

Author:: You Wang; Hong Jiang; Xiaorong Hu; Wenwen Fu
Source:: Biochemical and biophysical research communications 2021 v.585 pp. 96-102
ISSN:: 0006-291X
Subject:: atherosclerosis; bone marrow; flow cytometry; fluorescent antibody technique; infarction; myocardial infarction; research; secretion; survival rate; therapeutics
Abstract:: ... Platelet plays an important role in the progression of atherosclerosis. Recently it has been reported that myocardial infarction (MI) triggers megakaryopoiesis and thrombopoiesis in the bone marrow and leads to increased circulating platelets, which might contribute to the aggravation of atherosclerosis. However, the underlying mechanisms remain unclear. Here, we analyzed post-MI bone marrow tissu ...
DOI:: 10.1016/j.bbrc.2021.11.031
: https://doi.org/10.1016/j.bbrc.2021.11.031

35. Bone marrow mesenchymal stem cells ameliorate colitis-associated tumorigenesis in mice

Author:: Zexian Chen; Xiaowen He; Xiaosheng He; Xiuting Chen; Xutao Lin; Yifeng Zou; Xiaojian Wu; Ping Lan
Source:: Biochemical and biophysical research communications 2014 v.450 pp. 1402-1408
ISSN:: 0006-291X
Subject:: azoxymethane; bone marrow; carcinogenesis; colitis; colon; colorectal neoplasms; dextran; flow cytometry; interleukin-1beta; interleukin-6; mice; models; patients; phosphorylation; risk; sodium sulfate; spleen; stem cells; tumor necrosis factor-alpha; weight loss
Abstract:: ... Bone marrow-derived mesenchymal stem cell (MSC) is widely studied in inflammatory bowel disease (IBD) in basic and clinical research. However, patients with IBD have higher risk of developing colorectal cancer and MSC has dual effect on tumorigenesis. This study aims to evaluate the role of MSC on tumorigenesis of IBD.MSCs were isolated from the bone marrow of allogenic mice and identified by flow ...
DOI:: 10.1016/j.bbrc.2014.07.002
: https://doi.org/10.1016/j.bbrc.2014.07.002

36. Bone marrow sympathetic activation regulates post-myocardial infarction megakaryocyte expansion but not platelet production

Author:: Wenwen Fu; Guannan Meng; Xiaomeng Yang; Lilei Yu; Hong Jiang
Source:: Biochemical and biophysical research communications 2019 v.513 no.1 pp. 99-104
ISSN:: 0006-291X
Subject:: Western blotting; alpha-2 adrenergic receptors; antagonists; blood platelet count; blood platelets; bone marrow; enzyme-linked immunosorbent assay; exercise; infarction; mice; myocardial infarction; nerve tissue; patients; staining; sympathetic nervous system
Abstract:: ... After myocardial infarction (MI), increased platelet number and size are inversely related to the outcomes of patients. Our previous study confirmed an excessive thrombopoiesis taking place in the bone marrow after MI. However, the mechanisms remain unknown. It has been reported that the sympathetic stimulation by noise or exercise can promote megakaryocyte (MK) producing platelets which is mediat ...
DOI:: 10.1016/j.bbrc.2019.03.160
: https://doi.org/10.1016/j.bbrc.2019.03.160

37. Bone morphogenetic protein (BMP)1-3 enhances bone repair

Author:: Lovorka Grgurevic; Boris Macek; Mladen Mercep; Mislav Jelic; Tomislav Smoljanovic; Igor Erjavec; Ivo Dumic-Cule; Stefan Prgomet; Dragan Durdevic; Drazen Vnuk; Marija Lipar; Marko Stejskal; Vera Kufner; Jelena Brkljacic; Drazen Maticic; Slobodan Vukicevic
Source:: Biochemical and biophysical research communications 2011 v.408 no.1 pp. 25-31
ISSN:: 0006-291X
Subject:: biomarkers; bone marrow; bone morphogenetic proteins; collagen; extracellular matrix; genes; humans; metalloproteinases; mineralization; morphogenesis; neutralization; osteocalcin; patients; polyclonal antibodies; rabbits; rats; stem cells; transforming growth factor beta; ulna
Abstract:: ... Members of the astacin family of metalloproteinases such as human bone morphogenetic protein 1 (BMP-1) regulate morphogenesis by processing precursors to mature functional extracellular matrix (ECM) proteins and several growth factors including TGFβ, BMP2, BMP4 and GFD8. We have recently discovered that BMP1-3 isoform of the Bmp-1 gene circulates in the human plasma and is significantly increased ...
DOI:: 10.1016/j.bbrc.2011.03.109
: https://doi.org/10.1016/j.bbrc.2011.03.109

38. Bone progeria diminished the therapeutic effects of bone marrow mesenchymal stem cells on retinal degeneration

Author:: Chun-Lei Deng; Cheng-Biao Hu; Bao-Ying Wang; Ye-Cheng Xiong; Tao Chen; Na Zhao; Li-Hui Bao; Rui Quan; Fang-Ying Du; Bing-Dong Sui; Xiao- Rui Yu
Source:: Biochemical and biophysical research communications 2020 v.531 no.2 pp. 180-186
ISSN:: 0006-291X
Subject:: animal models; bone marrow; genes; research; retina; retinal degeneration; therapeutics
Abstract:: ... Senescence is closely related to the occurrence of retinal degeneration. Recent studies have shown that bone marrow mesenchymal stem cells (BMMSCs) have significant therapeutic effects on retinal degeneration, While BMMSCs suffer from functional decline in bone aging. Whether senescence affects BMMSCs therapy on retinal degeneration remains unknown. Here, we applied the previously established bone ...
DOI:: 10.1016/j.bbrc.2020.07.007
: https://doi.org/10.1016/j.bbrc.2020.07.007

39. Bone stroma-derived cells change coregulators recruitment to androgen receptor and decrease cell proliferation in androgen-sensitive and castration-resistant prostate cancer cells

Author:: Marcelo A. Villagran; Francisco A. Gutierrez-Castro; Diego F. Pantoja; Jose C. Alarcon; Macarena A. Fariña; Romina F. Amigo; Natalia A. Muñoz-Godoy; Mabel G. Pinilla; Eduardo A. Peña; Ivan Gonzalez-Chavarria; Jorge R. Toledo; Coralia I. Rivas; Juan C. Vera; Eileen M. McNerney; Sergio A. Onate
Source:: Biochemical and biophysical research communications 2015 v.467 pp. 1039-1045
ISSN:: 0006-291X
Subject:: androgen receptors; androgens; bone marrow; cell cycle; cell proliferation; coculture; dissociation; genes; humans; metastasis; monocytes; neoplasm cells; osteoblasts; osteoclasts; osteosarcoma; prostatic neoplasms; transcription (genetics); transcriptional activation
Abstract:: ... Prostate cancer (CaP) bone metastasis is an early event that remains inactive until later-stage progression. Reduced levels of circulating androgens, due to andropause or androgen deprivation therapies, alter androgen receptor (AR) coactivator expression. Coactivators shift the balance towards enhanced AR-mediated gene transcription that promotes progression to androgen-resistance. Disruptions in ...
DOI:: 10.1016/j.bbrc.2015.10.009
: https://doi.org/10.1016/j.bbrc.2015.10.009

40. Bortezomib enhances the osteogenic differentiation capacity of human mesenchymal stromal cells derived from bone marrow and placental tissues

Author:: Tanwarat Sanvoranart; Aungkura Supokawej; Pakpoom Kheolamai; Yaowalak U-pratya; Nuttha Klincumhom; Sirikul Manochantr; Methichit Wattanapanitch; Surapol Issaragrisil
Source:: Biochemical and biophysical research communications 2014 v.447 pp. 580-585
ISSN:: 0006-291X
Subject:: alizarin; alkaline phosphatase; bone formation; bone marrow; drug therapy; gene expression regulation; genetic markers; human diseases; humans; mice; mineralization; myeloma; osteoblasts; osteopenia; patients; placenta; staining; stem cells; stromal cells
Abstract:: ... Bortezomib (BZB) is a chemotherapeutic agent approved for treating multiple myeloma (MM) patients. In addition, there are several reports showing that bortezomib can induce murine mesenchymal stem cells (MSCs) to undergo osteogenic differentiation and increase bone formation in vivo. MSCs are the multipotent stem cells that have capacity to differentiate into several mesodermal derivatives includi ...
DOI:: 10.1016/j.bbrc.2014.04.044
: https://doi.org/10.1016/j.bbrc.2014.04.044

41. COMP-angiopoietin 1 increases proliferation, differentiation, and migration of stem-like cells through Tie-2-mediated activation of p38 MAPK and PI3K/Akt signal transduction pathways

Author:: Sung-Ho Kook; Shin-Saeng Lim; Eui-Sic Cho; Young-Hoon Lee; Seong-Kyu Han; Kyung-Yeol Lee; Jungkee Kwon; Jae-Won Hwang; Cheol-Hyeon Bae; Young-Kwon Seo; Jeong-Chae Lee
Source:: Biochemical and biophysical research communications 2014 v.455 pp. 371-377
ISSN:: 0006-291X
Subject:: CXCR4 receptor; angiogenesis; angiopoietin-1; antagonists; bone marrow; cartilage; humans; ligaments; messenger RNA; mitogen-activated protein kinase; osteoblasts; phosphatidylinositol 3-kinase; phosphorylation; rats; signal transduction; stem cells; transcription factors
Abstract:: ... Recombinant COMP-Ang1, a chimera of angiopoietin-1 (Ang1) and a short coiled-coil domain of cartilage oligomeric matrix protein (COMP), is under consideration as a therapeutic agent capable of inducing the homing of cells with increased angiogenesis. However, the potentials of COMP-Ang1 to stimulate migration of mesenchymal stem cells (MSCs) and the associated mechanisms are not completely underst ...
DOI:: 10.1016/j.bbrc.2014.11.025
: https://doi.org/10.1016/j.bbrc.2014.11.025

42. CSTA plays a role in osteoclast formation and bone resorption by mediating the DAP12/TREM2 pathway

Author:: Rui Wei; Lin Zhang; Wei Hu; Jie Wu; Wei Zhang
Source:: Biochemical and biophysical research communications 2022 v.627 pp. 12-20
ISSN:: 0006-291X
Subject:: bone formation; bone marrow; bone resorption; cysteine proteinase inhibitors; fluorescent antibody technique; mice; osteoclasts; osteoporosis; postmenopause; precipitin tests; research; therapeutics
Abstract:: ... Cystatin A (CSTA) is a cysteine protease inhibitor that is expressed highly during osteoporosis. However, the exact role of CSTA in osteoporosis remains unknown. In this study, we examined the role of CSTA in the formation, differentiation, and bone resorption of osteoclasts. We extracted bone marrow cells from 8-week-old wildtype mice to obtain RANKL and M–CSF–induced osteoclasts. We performed CS ...
DOI:: 10.1016/j.bbrc.2022.08.033
: https://doi.org/10.1016/j.bbrc.2022.08.033

43. Caldecrin inhibits lipopolysaccharide-induced pro-inflammatory cytokines and M1 macrophage polarization through the immunoreceptor triggering receptor expressed in myeloid cells-2

Author:: Kenjiro Bandow; Hiroya Hasegawa; Mineko Tomomura; Akito Tomomura
Source:: Biochemical and biophysical research communications 2020 v.523 no.4 pp. 1027-1033
ISSN:: 0006-291X
Subject:: CRISPR-Cas systems; blood serum; bone marrow; calcium; cell lines; cytokines; gene expression; genes; ligands; lipopolysaccharides; macrophages; mice; osteoclasts; pancreas; research
Abstract:: ... Caldecrin was previously isolated as a serum calcium-decreasing factor from the pancreas and is known to suppress receptor activator of nuclear factor-κB ligand (RANKL)-induced calcium oscillation pathways in osteoclasts. Here, we explored the effects of caldecrin on lipopolysaccharide (LPS)–Toll-like receptor-4 (TLR-4) signaling pathways in macrophages. Caldecrin inhibited the LPS-induced gene ex ...
DOI:: 10.1016/j.bbrc.2020.01.045
: https://doi.org/10.1016/j.bbrc.2020.01.045

44. Celastrol inhibits vasculogenesis by suppressing the VEGF-induced functional activity of bone marrow-derived endothelial progenitor cells

Author:: Shuai Huang; Yubo Tang; Xingdong Cai; Xinsheng Peng; Xingmo Liu; Longjuan Zhang; Yucheng Xiang; Dechun Wang; Xi Wang; Tao Pan
Source:: Biochemical and biophysical research communications 2012 v.423 no.3 pp. 467-472
ISSN:: 0006-291X
Subject:: Oriental traditional medicine; adhesion; bone marrow; cell adhesion; cell viability; cytokines; endothelial nitric oxide synthase; mechanism of action; medicinal plants; phosphorylation; secretion; stem cells; vascular endothelial growth factor receptor-2; vascular endothelial growth factors
Abstract:: ... Bone marrow (BM)-derived endothelial progenitor cells (EPCs) play a critical role in tumor vasculogenesis because they provide both instructive (release of pro-angiogenic cytokines, such as VEGF) and structural (vessel incorporation and stabilization) functions. Celastrol, derived from Trypterygium wilfordii Hook F., a traditional Chinese medicine plant, has been studied for its antitumorigenic pr ...
DOI:: 10.1016/j.bbrc.2012.05.143
: https://doi.org/10.1016/j.bbrc.2012.05.143

45. Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells

Author:: Jinyeong Yu; Hye Min Kim; Kwang Pyo Kim; Youngsook Son; Min-Sik Kim; Ki-Sook Park
Source:: Biochemical and biophysical research communications 2019 v.508 no.2 pp. 361-367
ISSN:: 0006-291X
Subject:: blood; bone marrow; cadherins; cell movement; ceramides; chemotaxis; cytokines; mesenchymal stromal cells; metabolites; phosphates; phosphotransferases (kinases); sphingosine; stem cells; substance P; transforming growth factor beta
Abstract:: ... Endogenous bone marrow-derived mesenchymal stem cells (BM-MSCs) are mobilized into peripheral blood and injured tissues by various growth factors and cytokines that are expressed in the injured tissues, such as substance P (SP), stromal cell derived factor-1 (SDF-1), and transforming growth factor-beta (TGF-β). Extracellular bioactive lipid metabolites such as ceramide-1-phosphate and sphingosine- ...
DOI:: 10.1016/j.bbrc.2018.11.154
: https://doi.org/10.1016/j.bbrc.2018.11.154

46. Chondrocytes-derived exosomal miR-8485 regulated the Wnt/β-catenin pathways to promote chondrogenic differentiation of BMSCs

Author:: Zeng Li; Yingjie Wang; Shuai Xiang; Zhibo Zheng; Yanyan Bian; Bin Feng; Xisheng Weng
Source:: Biochemical and biophysical research communications 2020 v.523 no.2 pp. 506-513
ISSN:: 0006-291X
Subject:: bone marrow; cartilage; chondrocytes; coculture; microRNA; research
Abstract:: ... In indirect co-culture system, chondrocytes can induce differentiation of bone marrow mesenchymal stem cells (BMSCs) to chondrocytes without additional inducer. The participation of microRNAs (miRNAs) may take part in the chondrogenic differentiation. Present study aimed to investigate the effect and mechanism of chondrocytes-derived exosomal miRNA in BMSCs chondrogenic differentiation. Our data s ...
DOI:: 10.1016/j.bbrc.2019.12.065
: https://doi.org/10.1016/j.bbrc.2019.12.065

47. Co-culture with neurotrophic factor secreting cells induced from adipose-derived stem cells: Promotes neurogenic differentiation

Author:: Shahnaz Razavi; Mohamad Reza Razavi; Mahsa Kheirollahi-Kouhestani; Mohammad Mardani; Fatemeh Sadat Mostafavi
Source:: Biochemical and biophysical research communications 2013 v.440 pp. 381-387
ISSN:: 0006-291X
Subject:: bone marrow; coculture; enzyme-linked immunosorbent assay; humans; nerve growth factor; neurodegenerative diseases; reverse transcriptase polymerase chain reaction; secretion; stem cells
Abstract:: ... Adipose-derived stem cells (ADSCs) and bone marrow stem cells (BMSCs) can be equally proper in the treatment of neurodegenerative diseases. However, ADSCs have practical benefits. In this study, we attempted to induce the secretion of neurotrophic factors (NTF) in human ADSCs. We then evaluated the effects of co-culture with NTF secreting cells in neural differentiation of human ADSCs. Isolated hu ...
DOI:: 10.1016/j.bbrc.2013.09.069
: https://doi.org/10.1016/j.bbrc.2013.09.069

48. Coculture in vitro with endothelial cells induces cytarabine resistance of acute myeloid leukemia cells in a VEGF-A/VEGFR-2 signaling–independent manner

Author:: Shuichiro Okamoto; Kei Miyano; Keisuke Kitakaze; Hitomi Kato; Akira Yamauchi; Mizuho Kajikawa; Momoe Itsumi; Chikage Kawai; Futoshi Kuribayashi
Source:: Biochemical and biophysical research communications 2022 v.587 pp. 78-84
ISSN:: 0006-291X
Subject:: CRISPR-Cas systems; antineoplastic agents; apoptosis; bone marrow; cell movement; coculture; endothelial cells; humans; myeloid leukemia; phosphorylation; research; vascular endothelial growth factor A; vascular endothelial growth factor receptor-2
Abstract:: ... An interaction between acute myeloid leukemia (AML) cells and endothelial cells in the bone marrow seems to play a critical role in chemosensitivity on leukemia treatment. The endothelial niche reportedly enhances the paracrine action of the soluble secretory proteins responsible for chemoresistance in a vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 (VEGFR-2) signaling pathway–depe ...
DOI:: 10.1016/j.bbrc.2021.11.090
: https://doi.org/10.1016/j.bbrc.2021.11.090

49. Cofilin-1 promotes fibrocyte differentiation and contributes to pulmonary fibrosis

Author:: Wei Guo; Ting Guo; Qianhui Zhou; Yaomei Long; Man Luo; Qinxue Shen; Wang Duan; Xiaoli Ouyang; Hong Peng
Source:: Biochemical and biophysical research communications 2021 v.565 pp. 43-49
ISSN:: 0006-291X
Subject:: bone marrow; cell proliferation; fibrosis; lungs; monocytes; pathogenesis; pulmonary fibrosis; research
Abstract:: ... Fibrocytes originate from the bone marrow monocyte lineage and participate in the pathogenesis of pulmonary fibrosis. Research providing a comprehensive picture of fibrocytes is still limited. Cofilin-1 (CFL-1) is an important protein that regulates cell proliferation, migration and differentiation. Whether CFL-1 can induce monocyte differentiation into fibrocytes and promote the process of pulmon ...
DOI:: 10.1016/j.bbrc.2021.05.085
: https://doi.org/10.1016/j.bbrc.2021.05.085

50. Combination of gp130-targeting and TNF-targeting small molecules in alleviating arthritis through the down-regulation of Th17 differentiation and osteoclastogenesis

Author:: Yeon-Hwa Park; Hee Jung Kim; Kyeong Lee; Yongseok Choi; Tae-Hwe Heo
Source:: Biochemical and biophysical research communications 2020 v.522 no.4 pp. 1030-1036
ISSN:: 0006-291X
Subject:: CD4-positive T-lymphocytes; bone formation; bone marrow; cartilage; cell proliferation; humans; inflammation; interleukin-6; mice; monocytes; osteoclasts; research; rheumatoid arthritis; secretion; splenocytes; therapeutics; tumor necrosis factors
Abstract:: ... Rheumatoid arthritis (RA) is a systemic, chronic inflammatory disease that is characterized by T helper 17 (Th17) cell- and osteoclast-induced joint destruction and inflammation. In RA, several cytokines (interleukin (IL)-1, 6,17, and tumor necrosis factor (TNF)) are involved in almost all aspects of articular inflammation and destruction. This study aimed to evaluate the combinatorial effect of T ...
DOI:: 10.1016/j.bbrc.2019.11.183
: https://doi.org/10.1016/j.bbrc.2019.11.183

51. Comparison of the bone regeneration ability between stem cells from human exfoliated deciduous teeth, human dental pulp stem cells and human bone marrow mesenchymal stem cells

Author:: Kengo Nakajima; Ryo Kunimatsu; Kazuyo Ando; Toshinori Ando; Yoko Hayashi; Takuya Kihara; Tomoka Hiraki; Yuji Tsuka; Takaharu Abe; Masato Kaku; Hiroki Nikawa; Takashi Takata; Kazuo Tanne; Kotaro Tanimoto
Source:: Biochemical and biophysical research communications 2018 v.497 pp. 876-882
ISSN:: 0006-291X
Subject:: bone formation; bone marrow; collagen; congenital abnormalities; histology; humans; medicine; mice; palate; patients; pulp; skull; stem cells; tissue engineering; tooth pulp
Abstract:: ... Cleft lip and palate is the most common congenital anomaly in the orofacial region. Autogenous iliac bone graft, in general, has been employed for closing the bone defect at the alveolar cleft. However, such iliac bone graft provides patients with substantial surgical and psychological invasions. Consequently, development of a less invasive method has been highly anticipated. Stem cells from human ...
DOI:: 10.1016/j.bbrc.2018.02.156
: https://doi.org/10.1016/j.bbrc.2018.02.156

52. Construction of EMSC-islet co-localizing composites for xenogeneic porcine islet transplantation

Author:: Jung-Sik Kim; Hyunwoo Chung; Nari Byun; Seong-Jun Kang; Sunho Lee; Jun-Seop Shin; Chung-Gyu Park
Source:: Biochemical and biophysical research communications 2018 v.497 no.2 pp. 506-512
ISSN:: 0006-291X
Subject:: angiogenesis; bone marrow; fibrin; humans; insulin-dependent diabetes mellitus; islets of Langerhans; mice; patients; stem cells; swine; xenotransplantation
Abstract:: ... Pancreatic islet transplantation is an ultimate solution for treating patients with type 1 diabetes (T1D). The pig is an ideal donor of islets for replacing scarce human islets. Besides immunological hurdles, non-immunological hurdles including fragmentation and delayed engraftment of porcine islets need solutions to succeed in porcine islet xenotransplantation. In this study, we suggest a simple ...
DOI:: 10.1016/j.bbrc.2018.02.057
: https://doi.org/10.1016/j.bbrc.2018.02.057

53. Contact-dependent abrogation of bone marrow-derived plasmacytoid dendritic cell differentiation by murine mesenchymal stem cells

Author:: Holger Hackstein; Inna Tschipakow; Gregor Bein; Philipp Nold; Cornelia Brendel; Nelli Baal
Source:: Biochemical and biophysical research communications 2016 v.476 pp. 15-20
ISSN:: 0006-291X
Subject:: Toll-like receptor 9; adaptive immunity; bone marrow; cell differentiation; coculture; dendritic cells; interferon-alpha; mice; stem cells
Abstract:: ... Plasmacytoid dendritic cells (pDCs) are rare central regulators of antiviral immunity and unsurpassed producers of interferon-α (IFN-α). Despite their crucial role as a link between innate and adaptive immunity, little is known about the modulation of pDC differentiation by other bone marrow (BM) cells. In this study, we investigated the modulation of pDC differentiation in Flt-3 ligand (Flt3L)-su ...
DOI:: 10.1016/j.bbrc.2016.05.108
: https://doi.org/10.1016/j.bbrc.2016.05.108

54. Contribution of PDGFRα lineage cells in adult mouse hematopoiesis

Author:: Asaka Miura; Takashi Shimbo; Tomomi Kitayama; Yuya Ouchi; Sho Yamazaki; Mami Nishida; Eiichi Takaki; Ryoma Yamamoto; Edward Wijaya; Katsuto Tamai
Source:: Biochemical and biophysical research communications 2021 v.534 pp. 186-192
ISSN:: 0006-291X
Subject:: adults; blood; bone marrow; embryogenesis; flow cytometry; hematopoiesis; mice; platelet-derived growth factor receptor alpha; research; sequence analysis; transcriptomics
Abstract:: ... Platelet-derived growth factor receptor alpha (PDGFRα) is a dominant marker of mesodermal mesenchymal cells in mice. Previous studies demonstrated that PDGFRα-positive (PDGFRα+) mesodermal cells develop not only into mesenchymal cells but also into a subset of total hematopoietic cells (HCs) in the limited period during mouse embryogenesis. However, the precise characteristics of the PDGFRα lineag ...
DOI:: 10.1016/j.bbrc.2020.11.114
: https://doi.org/10.1016/j.bbrc.2020.11.114

55. Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity

Author:: Tsubasa Ochiai; Yuka Sasaki; Hiroshi Kuwata; Yoshihito Nakatani; Chieko Yokoyama; Shuntaro Hara
Source:: Biochemical and biophysical research communications 2021 v.546 pp. 124-129
ISSN:: 0006-291X
Subject:: bone marrow; dermis; ears; edema; histology; histopathology; hypersensitivity; metabolites; models; prostacyclin; prostaglandin synthase; prostaglandin-I synthase; research
Abstract:: ... Microsomal prostaglandin (PG) E synthase-1 (mPGES-1) and prostacyclin (PGI₂) synthase (PGIS) are PG terminal synthases that work downstream of cyclooxygenase and synthesize PGE₂ and PGI₂, respectively. Although the involvement of PG receptors in acquired cutaneous immune responses was recently shown, the roles of these PG terminal synthases remain unclear. To identify the pathophysiological roles ...
DOI:: 10.1016/j.bbrc.2021.02.004
: https://doi.org/10.1016/j.bbrc.2021.02.004

56. Crystal structure of CD38 in complex with daratumumab, a first-in-class anti-CD38 antibody drug for treating multiple myeloma

Author:: Hyun Tae Lee; Yujin Kim; Ui Beom Park; Tae Jun Jeong; Sang Hyung Lee; Yong-Seok Heo
Source:: Biochemical and biophysical research communications 2021 v.536 pp. 26-31
ISSN:: 0006-291X
Subject:: Food and Drug Administration; active sites; antibodies; bone marrow; crystal structure; drugs; epitopes; glycoproteins; mechanism of action; myeloma; research
Abstract:: ... Multiple myeloma is a blood cancer characterized by the plasma cell malignancy in the bone marrow, resulting in the destruction of bone tissue. Recently, the US FDA approved two antibody drugs for the treatment of multiple myeloma, daratumumab and isatuximab, targeting CD38, a type II transmembrane glycoprotein highly expressed in plasma cells and multiple myeloma cells. Here, we report the crysta ...
DOI:: 10.1016/j.bbrc.2020.12.048
: https://doi.org/10.1016/j.bbrc.2020.12.048

57. Cyclosporin A inhibits adipogenic differentiation and regulates immunomodulatory functions of murine mesenchymal stem cells

Author:: Ying Qu; Qiwang Lin; Yan Yuan; Zhengxu Sun; Pengfei Li; Fen Wang; Hua Jiang; Tong Chen
Source:: Biochemical and biophysical research communications 2018 v.498 no.3 pp. 516-522
ISSN:: 0006-291X
Subject:: T-lymphocytes; adipogenesis; anemia; apoptosis; bone marrow; cyclosporine; gene expression; immunosuppression; interleukin-6; mesenchymal stromal cells; mice; transcription factors
Abstract:: ... Aplastic anemia (AA) is generally considered as an immune-mediated bone marrow failure syndrome. Several studies show that bone marrow mesenchymal stem cells (BM-MSCs), as key cellular components of the bone marrow microenvironment, are also involved in the pathogenic mechanism of AA. Cyclosporin A (CsA) is a classic immunosuppressive drug for AA, and it specifically inhibits mammalian T cells by ...
DOI:: 10.1016/j.bbrc.2018.03.012
: https://doi.org/10.1016/j.bbrc.2018.03.012

58. DCIR3 and DCIR4 are co-expressed on inflammatory and patrolling monocytes

Author:: Yu Hsu; Ryo Okada; Takashi Nishimura; Norihito Kawasaki; Kazuo Yamamoto; Naoki Matsumoto
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: bone marrow; eosinophils; immunologic receptors; mice; monoclonal antibodies; monocytes; neutrophils; pathophysiology; protein synthesis; spleen
Abstract:: ... Dendritic cell inhibitory receptor 3 (DCIR3) is a member of dendritic immuno-receptor family, of which protein expression has been unknown. We established a specific monoclonal antibody against mouse DCIR3 and investigated the expression of DCIR3 on immune cells of various immune organs. We found that DCIR3 was expressed on monocytes, but not on eosinophils and neutrophils. We also found the exist ...
DOI:: 10.1016/j.bbrc.2017.10.067
: https://doi.org/10.1016/j.bbrc.2017.10.067

59. DGCR5 induces osteogenic differentiation by up-regulating Runx2 through miR-30d-5p

Author:: Zhi-hao Wu; Kai-hua Huang; Kang Liu; Guan-tong Wang; Qiang Sun
Source:: Biochemical and biophysical research communications 2018 v.505 no.2 pp. 426-431
ISSN:: 0006-291X
Subject:: Western blotting; bone density; bone formation; bone marrow; bone resorption; developmental orthopedic disease; gene expression regulation; humans; mesenchymal stromal cells; messenger RNA; osteoblasts; osteoclasts; osteoporosis; patients; postmenopause; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; transcription factors
Abstract:: ... Postmenopausal osteoporosis (PMOP) is a metabolic bone disease caused by unbalance between osteoblast bone formation and osteoclast bone resorption. In this study, the moderating effect of DGCR5 on osteogenic differentiation and its role in PMOP was assessed.The expression levels of DGCR5, miR-30d-5p, and Runt-related transcription factor 2 (Runx2) mRNA and protein were determined by qRT-PCR and w ...
DOI:: 10.1016/j.bbrc.2018.09.033
: https://doi.org/10.1016/j.bbrc.2018.09.033

60. DLX3 regulates osteogenic differentiation of bone marrow mesenchymal stem cells via Wnt/β-catenin pathway mediated histone methylation of DKK4

Author:: Shichen Sun; Miao Yu; Zhuangzhuang Fan; I-Ting Yeh; Hailan Feng; Haochen Liu; Dong Han
Source:: Biochemical and biophysical research communications 2019 v.516 no.1 pp. 171-176
ISSN:: 0006-291X
Subject:: Lentivirus; Western blotting; alizarin; alkaline phosphatase; bone formation; bone marrow; chromatin; gene overexpression; histones; lysine; mesenchymal stromal cells; methylation; precipitin tests; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; staining; transcription factors
Abstract:: ... Distal-less homeobox 3 (DLX3) is an important transcription factor involved in the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). However, the underlying mechanism is not clear. This study investigated the underlying mechanism of DLX3 in osteogenic differentiation.DLX3 overexpression and knockdown in cells were achieved using lentiviruses. The osteogenic differentiation ...
DOI:: 10.1016/j.bbrc.2019.06.029
: https://doi.org/10.1016/j.bbrc.2019.06.029

61. Dendritic cell inhibitory receptor 4 (DCIR4) is preferentially expressed on inflammatory and patrolling monocytes

Author:: Yosuke Kameda; Motoki Hanayama; Atsushi Kishimoto; Masahiko Kume; Kazuo Yamamoto; Naoki Matsumoto
Source:: Biochemical and biophysical research communications 2016 v.480 pp. 215-221
ISSN:: 0006-291X
Subject:: bone marrow; dendritic cells; immunologic receptors; lectins; lymph nodes; macrophages; mice; monoclonal antibodies; monocytes; screening; spleen
Abstract:: ... Dendritic cell inhibitory receptor 4 (DCIR4, Clec4a1) is a lectin receptor and a member of mouse dendritic cell immunoreceptor family. Due to the lack of antibodies against DCIR4, expression of DCIR4 protein remains unknown. In this study, we established a specific monoclonal antibody against DCIR4 and investigated the expression of DCIR4 among immune cells. We found that DCIR4 was expressed on no ...
DOI:: 10.1016/j.bbrc.2016.10.030
: https://doi.org/10.1016/j.bbrc.2016.10.030

62. Dexamethasone treatment alters function of adipocytes from a mesenchymal stromal cell line

Author:: James C. Johnston; Azeb Haile; Dongqing Wang; Gabriele Ronnett; Lynne C. Jones
Source:: Biochemical and biophysical research communications 2014 v.451 pp. 473-479
ISSN:: 0006-291X
Subject:: adipocytes; adiponectin; adrenal cortex hormones; bone marrow; dexamethasone; enzyme-linked immunosorbent assay; gene expression; hypoxia-inducible factor 1; interleukin-6; leptin; messenger RNA; mice; osteoporosis; pathogenesis; pathophysiology; protein synthesis; quantitative polymerase chain reaction; stromal cells; tumor necrosis factor-alpha; vascular endothelial growth factors; viability
Abstract:: ... Osteoporosis and osteonecrosis are associated with corticosteroid treatment, but the pathophysiologies are unclear. We hypothesized that mature adipocytes present within the bone marrow compartment play a key role in the development of both diseases. Adipocytes have recognized regulatory effects on bone viability and healing by releasing signaling molecules called adipokines. Our purpose was to ev ...
DOI:: 10.1016/j.bbrc.2014.07.063
: https://doi.org/10.1016/j.bbrc.2014.07.063

63. Dickkopf (Dkk)-2 is a beige fat-enriched adipokine to regulate adipogenesis

Author:: Jing Yang; Bing-yin Shi
Source:: Biochemical and biophysical research communications 2021 v.548 pp. 211-216
ISSN:: 0006-291X
Subject:: Adenoviridae; adipogenesis; adipokines; adipose tissue; bone marrow; gain-of-function mutation; human health; ligands; liver; metabolism; obesity; research; subcutaneous fat; therapeutics
Abstract:: ... In the past decades, remarkable efforts have been made to unravel the regulation of adipose tissue metabolism, given the increasing prevalence of obesity and its huge impact on human health. Wnt signaling pathway is closely involved in this entity. As extracellular inhibitors to Wnt signaling, secreted protein Dickkopfs (Dkks) may be potential targets to combat obesity and related metabolic disord ...
DOI:: 10.1016/j.bbrc.2021.02.068
: https://doi.org/10.1016/j.bbrc.2021.02.068

64. Differentiation of GFP-Bcl-2-engineered mesenchymal stem cells towards a nucleus pulposus-like phenotype under hypoxia in vitro

Author:: Zhong Fang; Qin Yang; Wei Luo; Guang-hui Li; Jun Xiao; Feng Li; Wei Xiong
Source:: Biochemical and biophysical research communications 2013 v.432 pp. 444-450
ISSN:: 0006-291X
Subject:: anaerobic conditions; apoptosis; bone marrow; cell proliferation; cell transplantation; cell viability; collagen; genes; glycosaminoglycans; hypoxia; intervertebral disks; phenotype; proteoglycans; rats; reverse transcriptase polymerase chain reaction; stem cells
Abstract:: ... Differentiation of bone marrow-derived mesenchymal stem cells (MSCs) into a nucleus pulposus-like phenotype under hypoxia has been proposed as a potential therapeutic approach for intervertebral disc degeneration. However, limited cell viability under hypoxic conditions has restricted MSC differentiation capacity and thus restricted its clinical application. In this study, we genetically modified ...
DOI:: 10.1016/j.bbrc.2013.01.127
: https://doi.org/10.1016/j.bbrc.2013.01.127

65. Direct contacts with colon cancer cells regulate the differentiation of bone marrow mesenchymal stem cells into tumor associated fibroblasts

Author:: Yanan Peng; Zongwei Li; Peng Yang; Ian P. Newton; Hua Ren; Lichao Zhang; Haili Wu; Zhuoyu Li
Source:: Biochemical and biophysical research communications 2014 v.451 pp. 68-73
ISSN:: 0006-291X
Subject:: actin; bone marrow; coculture; colorectal neoplasms; fibroblasts; models; muscles; neoplasm cells; signal transduction; stem cells
Abstract:: ... Tumor–stroma interactions are referred to as essential events in tumor progression. There has been growing attention that bone marrow-derived mesenchymal stem cells (BMSCs) can travel to tumor stroma, where they differentiate into tumor-associated fibroblast (TAF)-like cells, a predominant tumor-promoting stromal cell. However, little is definitively known about the contributors for this transitio ...
DOI:: 10.1016/j.bbrc.2014.07.074
: https://doi.org/10.1016/j.bbrc.2014.07.074

66. Direct induction of hepatocyte-like cells from immortalized human bone marrow mesenchymal stem cells by overexpression of HNF4α

Author:: Xiaojun Hu; Peiyi Xie; Weiqiang Li; Zhengran Li; Hong Shan
Source:: Biochemical and biophysical research communications 2016 v.478 no.2 pp. 791-797
ISSN:: 0006-291X
Subject:: albumins; bone marrow; cell transplantation; culture media; glycogen; hepatocytes; humans; liver; messenger RNA; mice; secretion; stem cells; transcription factors; urea
Abstract:: ... Hepatocytes from human bone marrow-derived mesenchymal stem cells (hBM-MSCs) are expected to be a useful source for cell transplantation. However, relatively low efficiency and repeatability of hepatic differentiation of human BM-MSCs remains an obstacle for clinical translation. Hepatocyte nuclear factor 4 alpha (HNF4α), a critical transcription factor, plays an essential role in the entire proce ...
DOI:: 10.1016/j.bbrc.2016.08.026
: https://doi.org/10.1016/j.bbrc.2016.08.026

67. Distorted antibody repertoire developed in the absence of pre-B cell receptor formation

Author:: Lin Sun; Naoko Kono; Takeyuki Shimizu; Hiroyuki Toh; Hanbing Xue; Osamu Numata; Manabu Ato; Shigeyuki Itamura; Kazuo Ohnishi
Source:: Biochemical and biophysical research communications 2018 v.495 no.1 pp. 1411-1417
ISSN:: 0006-291X
Subject:: B-lymphocytes; arginine; autoantibodies; bone marrow; genes; high-throughput nucleotide sequencing; immunoglobulins; mice; spleen
Abstract:: ... The pre-B cell receptor (pre-BCR), consisting of the μ heavy chain (μHC) and the surrogate light chain (SLC, Vpre-B and λ5), plays important roles during B cell development. The formation of the pre-BCR, which enables the nascent immunoglobulin HC to associate with the SLC, is considered a prerequisite for B cell development. However, a significant number of peripheral mature (leaky) B cells exist ...
DOI:: 10.1016/j.bbrc.2017.11.171
: https://doi.org/10.1016/j.bbrc.2017.11.171

68. Dll1/Notch activation contributes to bortezomib resistance by upregulating CYP1A1 in multiple myeloma

Author:: Dehui Xu; Jinsong Hu; Elke De Bruyne; Eline Menu; Rik Schots; Karin Vanderkerken; Els Van Valckenborgh
Source:: Biochemical and biophysical research communications 2012 v.428 no.4 pp. 518-524
ISSN:: 0006-291X
Subject:: animal models; bone marrow; cytochrome P-450; drug resistance; humans; mice; myeloma; pharmacokinetics; receptors; stromal cells; therapeutics
Abstract:: ... One of the greatest challenges in multiple myeloma (MM) treatment is to overcome drug resistance. Many pathways are involved including Notch signaling. Notch receptors are expressed by MM cells and Notch ligand Dll1 is present on bone marrow (BM) stromal cells. In this study, we demonstrate that Dll1 can activate Notch signaling mostly through Notch2 receptor and can contribute to drug resistance ...
DOI:: 10.1016/j.bbrc.2012.10.071
: https://doi.org/10.1016/j.bbrc.2012.10.071

69. Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia

Author:: Shuhei Kajikawa; Yuu Taguchi; Tadayoshi Hayata; Yoichi Ezura; Ryo Ueta; Sumimasa Arimura; Jun-ichiro Inoue; Masaki Noda; Yuji Yamanashi
Source:: Biochemical and biophysical research communications 2018 v.498 no.4 pp. 967-974
ISSN:: 0006-291X
Subject:: bone density; bone formation; bone marrow; cell fusion; homeostasis; macrophages; mice; monocytes; osteoblasts; osteoclasts; osteopenia; resorption; signal transduction
Abstract:: ... Bone mass is determined by coordinated acts of osteoblasts and osteoclasts, which control bone formation and resorption, respectively. Osteoclasts are multinucleated, macrophage/monocyte lineage cells from bone marrow. The Dok-family adaptors Dok-1, Dok-2 and Dok-3 are expressed in the macrophage/monocyte lineage and negatively regulate many signaling pathways, implying roles in osteoclastogenesis ...
DOI:: 10.1016/j.bbrc.2018.03.090
: https://doi.org/10.1016/j.bbrc.2018.03.090

70. Downregulated miR-150 in bone marrow mesenchymal stem cells attenuates the apoptosis of LPS-stimulated RAW264.7 via MTCH2-dependent mitochondria transfer

Author:: Xiao Zhou; Keji Zhang; Zhengyu He; Yuxiao Deng; Yuan Gao
Source:: Biochemical and biophysical research communications 2020 v.526 no.3 pp. 560-567
ISSN:: 0006-291X
Subject:: acute respiratory distress syndrome; apoptosis; bone marrow; caspase-3; genes; lipopolysaccharides; macrophages; membrane potential; mitochondria; mitochondrial membrane; nucleotidyltransferases; reactive oxygen species; research; therapeutics
Abstract:: ... Mesenchymal stem cells (MSCs) are promising therapeutic cells for preventing apoptosis and abrogating cellular injury. Apoptosis of macrophages and the resulting dysfunction play a critical pathogenic role in acute respiratory distress syndrome (ARDS). Herein, the anti-apoptosis effects of bone marrow MSCs (BMSCs) on RAW264.7 were investigated by transwell assay. Compared to lipopolysaccharide (LP ...
DOI:: 10.1016/j.bbrc.2020.03.098
: https://doi.org/10.1016/j.bbrc.2020.03.098

71. Dual expression of hTERT and VEGF prolongs life span and enhances angiogenic ability of aged BMSCs

Author:: Hao Tang; Yongsheng Xiang; Xiaodan Jiang; Yiquan Ke; Zongyu Xiao; Yang Guo; Qiujing Wang; Mouxuan Du; Linsha Qin; Yuxi Zou; Yingqian Cai; Zhenzhou Chen; Ruxiang Xu
Source:: Biochemical and biophysical research communications 2013 v.440 pp. 502-508
ISSN:: 0006-291X
Subject:: bone marrow; elderly; genes; genetic engineering; humans; ischemia; longevity; patients; stromal cells; therapeutics; vascular endothelial growth factors
Abstract:: ... Previous studies have confirmed the therapeutic effects of bone marrow stromal cells (BMSCs) transplantation on cerebral ischemia. However, the proliferative, differentiative, and homing capacity of BMSC from the elderly are significantly reduced, especially after several passages expansion in vitro. In this study, by introducing lentivirus-mediated hTERT and VEGF genes to modify human BMSCs from ...
DOI:: 10.1016/j.bbrc.2013.09.053
: https://doi.org/10.1016/j.bbrc.2013.09.053

72. EEN regulates the proliferation and survival of multiple myeloma cells by potentiating IGF-1 secretion

Author:: Er-Wen Huang; Sheng-Jiang Xue; Xiao-Yan Li; Suo-Wen Xu; Jian-Ding Cheng; Jin-Xiang Zheng; He Shi; Guo-Li Lv; Zhi-Gang Li; Yue Li; Chang-Hui Liu; Xiao-Hui Chen; Hong Liu; Jie Li; Chao Liu
Source:: Biochemical and biophysical research communications 2014 v.447 pp. 271-277
ISSN:: 0006-291X
Subject:: apoptosis; bone marrow; cell proliferation; cyclin-dependent kinase; gene overexpression; insulin-like growth factor I; interphase; myeloma; neutralization; phenotype; plasma cells; secretion
Abstract:: ... The molecular mechanisms of multiple myeloma are not well defined. EEN is an endocytosis-regulating molecule. Here we report that EEN regulates the proliferation and survival of multiple myeloma cells, by regulating IGF-1 secretion. In the present study, we observed that EEN expression paralleled with cell proliferation, EEN accelerated cell proliferation, facilitated cell cycle transition from G1 ...
DOI:: 10.1016/j.bbrc.2014.03.127
: https://doi.org/10.1016/j.bbrc.2014.03.127

73. Early osteoinductive human bone marrow mesenchymal stromal/stem cells support an enhanced hematopoietic cell expansion with altered chemotaxis- and adhesion-related gene expression profiles

Author:: Noriko Sugino; Yasuo Miura; Hisayuki Yao; Masaki Iwasa; Aya Fujishiro; Sumie Fujii; Hideyo Hirai; Akifumi Takaori-Kondo; Tatsuo Ichinohe; Taira Maekawa
Source:: Biochemical and biophysical research communications 2016 v.469 pp. 823-829
ISSN:: 0006-291X
Subject:: bone marrow; cell adhesion; cell transplantation; chemokine CXCL12; gene expression; genes; hematopoiesis; humans; mice; microarray technology; mineralization; stem cells; stromal cells
Abstract:: ... Bone marrow (BM) microenvironment has a crucial role in supporting hematopoiesis. Here, by using a microarray analysis, we demonstrate that human BM mesenchymal stromal/stem cells (MSCs) in an early osteoinductive stage (e-MSCs) are characterized by unique hematopoiesis-associated gene expression with an enhanced hematopoiesis-supportive ability. In comparison to BM-MSCs without osteoinductive tre ...
DOI:: 10.1016/j.bbrc.2015.12.061
: https://doi.org/10.1016/j.bbrc.2015.12.061

74. Echinocystic acid inhibits RANKL-induced osteoclastogenesis by regulating NF-κB and ERK signaling pathways

Author:: Jian-hui Yang; Qiong Wu; Jian-guo Lv; Hui-Yong Nie
Source:: Biochemical and biophysical research communications 2016 pp. -
ISSN:: 0006-291X
Subject:: Gleditsia sinensis; transcription factor NF-kappa B; osteoclasts; fruits; macrophages; signal transduction; ovariectomy; bone density; bone marrow; triterpenoids; osteoporosis; rats; phosphorylation; mitogen-activated protein kinase
Abstract:: ... Receptor activator of nuclear factor-κB ligand (RANKL) is a key factor in the differentiation and activation of osteoclasts. Echinocystic acid (EA), a pentacyclic triterpene isolated from the fruits of Gleditsia sinensis Lam, was reported to prevent reduction of bone mass and strength and improve the cancellous bone structure and biochemical properties in ovariectomy rats. However, the molecular m ...
DOI:: 10.1016/j.bbrc.2016.06.118
: https://doi.org/10.1016/j.bbrc.2016.06.118

75. Effect of 5-aminolevulinic acid on erythropoiesis: A preclinical in vitro characterization for the treatment of congenital sideroblastic anemia

Author:: Tohru Fujiwara; Koji Okamoto; Ryoyu Niikuni; Kiwamu Takahashi; Yoko Okitsu; Noriko Fukuhara; Yasushi Onishi; Kenichi Ishizawa; Ryo Ichinohasama; Yukio Nakamura; Motowo Nakajima; Tohru Tanaka; Hideo Harigae
Source:: Biochemical and biophysical research communications 2014 v.454 pp. 102-108
ISSN:: 0006-291X
Subject:: aminolevulinic acid; anemia; bone marrow; dose response; erythropoiesis; gamma-aminobutyric acid; gene expression regulation; genes; glycine (amino acid); heme; heme oxygenase (biliverdin-producing); hemoglobin; humans; induced pluripotent stem cells; mitochondria; mutation; neurotransmitters; peptide transporters; reverse transcriptase polymerase chain reaction; solutes; staining; symporters
Abstract:: ... Congenital sideroblastic anemia (CSA) is a hereditary disorder characterized by microcytic anemia and bone marrow sideroblasts. The most common form of CSA is attributed to mutations in the X-linked gene 5-aminolevulinic acid synthase 2 (ALAS2). ALAS2 is a mitochondrial enzyme, which utilizes glycine and succinyl-CoA to form 5-aminolevulinic acid (ALA), a crucial precursor in heme synthesis. There ...
DOI:: 10.1016/j.bbrc.2014.10.050
: https://doi.org/10.1016/j.bbrc.2014.10.050

76. Effects of cyclic fluid stress at different frequencies on behaviors of cells incubated on titanium alloy

Author:: Xing Lei; Hao Wu; Yue Song; Bin Liu; Shuai-Shuai Zhang; Jun-Qin Li; Long Bi; Guo-Xian Pei
Source:: Biochemical and biophysical research communications 2020 v.522 no.1 pp. 100-106
ISSN:: 0006-291X
Subject:: alloys; bone marrow; collagen; fibroblasts; orthopedics; research; titanium
Abstract:: ... The orthopedic external fixation is always in dynamic mechanical environment with the somatic movement. We used a self-designed mini oscillator to simulate this condition by providing the reciprocating cyclic fluid stress, and observed the behavioral responses of fibroblasts implanted on titanium alloy plane to the stress at different frequencies, including 0.2 Hz, 0.6 Hz, and 1.0 Hz. We found tha ...
DOI:: 10.1016/j.bbrc.2019.11.070
: https://doi.org/10.1016/j.bbrc.2019.11.070

77. Effects of strontium on proliferation and differentiation of rat bone marrow mesenchymal stem cells

Author:: Yunfeng Li; Jihua Li; Songsong Zhu; En Luo; Ge Feng; Qianming Chen; Jing Hu
Source:: Biochemical and biophysical research communications 2012 v.418 no.4 pp. 725-730
ISSN:: 0006-291X
Subject:: Western blotting; adipocytes; alkaline phosphatase; bone formation; bone marrow; bone resorption; drugs; flow cytometry; lipoprotein lipase; messenger RNA; osteoblasts; osteocalcin; osteoporosis; protein synthesis; rats; reverse transcriptase polymerase chain reaction; stem cells; strontium
Abstract:: ... Strontium ranelate (SrR) was an effective anti-osteoporotic drug to increase bone formation and decrease bone resorption. However, reports about the effect of SR on osteoblastic and adipocytic differentiation from bone marrow mesenchymal stem cells (BMMSCs) are limited. The purpose of this study is to evaluate whether SrR affects the ability of BMMSCs to differentiate into osteoblasts or adipocyte ...
DOI:: 10.1016/j.bbrc.2012.01.088
: https://doi.org/10.1016/j.bbrc.2012.01.088

78. Elastic modulus and migration capability of drug treated leukemia cells K562

Author:: Kui Wang; Yuntian Xue; Ying Peng; Xiangchao Pang; Yuanjun Zhang; L.I. Ruiz-Ortega; Ye Tian; A.H.W. Ngan; Bin Tang
Source:: Biochemical and biophysical research communications 2019 v.516 no.1 pp. 177-182
ISSN:: 0006-291X
Subject:: biomechanics; bone marrow; cytoskeleton; dexamethasone; genes; hematopoietic stem cells; leukemia; modulus of elasticity; neoplasm cells; optical traps; protein synthesis; quantitative polymerase chain reaction; retinoic acid; tubulin; vimentin; viscoelasticity
Abstract:: ... Leukemia is a commonly seen disease caused by abnormal differentiation of hematopoietic stem cells and blasting in bone marrow. Despite drugs are used to treat the disease clinically, the influence of these drugs on leukemia cells’ biomechanical properties, which are closely related to complications like leukostasis or infiltration, is still unclear. Due to non-adherent and viscoelastic nature of ...
DOI:: 10.1016/j.bbrc.2019.06.024
: https://doi.org/10.1016/j.bbrc.2019.06.024

79. Endogenous ROS levels are increased in replicative senescence in human bone marrow mesenchymal stromal cells

Author:: Sin-Gu Jeong; Goang-Won Cho
Source:: Biochemical and biophysical research communications 2015 v.460 pp. 971-976
ISSN:: 0006-291X
Subject:: adipocytes; proteins; DNA damage; humans; catalase; stromal cells; energy metabolism; cell senescence; reactive oxygen species; superoxide dismutase; lipids; stem cells; bone marrow; ascorbic acid
Abstract:: ... Cellular senescence is characterized by functional decline induced by cumulative damage to DNA, proteins, lipids, and carbohydrates. Previous studies have reported that replicative senescence is caused by excessive amounts of reactive oxygen species (ROS) produced as a result of aerobic energy metabolism. In this study, we established human bone marrow mesenchymal stromal cells (hBM-MSCs) in repli ...
DOI:: 10.1016/j.bbrc.2015.03.136
: https://doi.org/10.1016/j.bbrc.2015.03.136

80. Engineering tubular bone using mesenchymal stem cell sheets and coral particles

Author:: Wenxin Geng; Dongyang Ma; Xingrong Yan; Liangqi Liu; Jihong Cui; Xin Xie; Hongmin Li; Fulin Chen
Source:: Biochemical and biophysical research communications 2013 v.433 pp. 595-601
ISSN:: 0006-291X
Subject:: bioreactors; bone formation; bone marrow; cell culture; corals; explants; extracellular matrix; in vivo studies; mechanical properties; mice; skeletal development; stem cells; tissue engineering
Abstract:: ... The development of bone tissue engineering has provided new solutions for bone defects. However, the cell-scaffold-based approaches currently in use have several limitations, including low cell seeding rates and poor bone formation capacity. In the present study, we developed a novel strategy to engineer bone grafts using mesenchymal stem cell sheets and coral particles. Rabbit bone marrow mesench ...
DOI:: 10.1016/j.bbrc.2013.03.034
: https://doi.org/10.1016/j.bbrc.2013.03.034

81. Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells

Author:: Yoshiko Matsumoto Ikushima; Fumio Arai; Yuka Nakamura; Kentaro Hosokawa; Yoshiaki Kubota; Masanori Hirashima; Hirofumi Toyama; Toshio Suda
Source:: Biochemical and biophysical research communications 2013 v.430 pp. 20-25
ISSN:: 0006-291X
Subject:: angiopoietin-1; blood; bone marrow; crossing; genetically modified organisms; hematopoiesis; mice; osteoblasts; stem cells
Abstract:: ... Angiopoietin-1 (Angpt1) signaling via the Tie2 receptor regulates vascular and hematopoietic systems. To investigate the role of Angpt1-Tie2 signaling in hematopoiesis, we prepared conditionally inducible transgenic (Tg) mice expressing a genetically engineered Angpt1, cartridge oligomeric matrix protein (COMP)-Angpt1. The effects of COMP-Angpt1 overexpression in osteoblasts on hematopoiesis were ...
DOI:: 10.1016/j.bbrc.2012.11.002
: https://doi.org/10.1016/j.bbrc.2012.11.002

82. Enhanced Nox1 expression and oxidative stress resistance in c-kit-positive hematopoietic stem/progenitor cells

Author:: Yoshishige Urata; Shinji Goto; Lan Luo; Hanako Doi; Yuriko Kitajima; Shinya Masuda; Yusuke Ono; Tao-Sheng Li
Source:: Biochemical and biophysical research communications 2014 v.454 pp. 376-380
ISSN:: 0006-291X
Subject:: bone marrow; catalase; gene expression; hematopoietic stem cells; mice; oxidative stress; peroxidase; reactive oxygen species; stress tolerance
Abstract:: ... Although stem cells are generally thought to be resistant to oxidative stress, the fact and in detail molecular mechanism are still to be clearly identified. We herein tried to understand the overall characterization of redox regulatory signaling in hematopoietic stem cells. We purified c-kit-positive hematopoietic stem/progenitor cells from the bone marrow of healthy mice, and then evaluated thei ...
DOI:: 10.1016/j.bbrc.2014.10.090
: https://doi.org/10.1016/j.bbrc.2014.10.090

83. Enhanced accumulation of adipocytes in bone marrow stromal cells in the presence of increased extracellular and intracellular [Ca²⁺]

Author:: Ryota Hashimoto; Youichi Katoh; Kyoko Nakamura; Seigo Itoh; Takafumi Iesaki; Hiroyuki Daida; Yuji Nakazato; Takao Okada
Source:: Biochemical and biophysical research communications 2012 v.423 no.4 pp. 672-678
ISSN:: 0006-291X
Subject:: adipocytes; bone marrow; bone resorption; calcium; chelating agents; dexamethasone; glycerol-3-phosphate dehydrogenase; insulin; mice; osteoblasts; stem cells; stromal cells
Abstract:: ... The bone marrow stroma contains osteoblasts and adipocytes that have a common precursor: the pluripotent mesenchymal stem cell found in bone marrow stromal cells (BMSCs). Local bone marrow Ca²⁺ levels can reach high concentrations due to bone resorption, which is one of the notable features of the bone marrow stroma. Here, we describe the effects of high [Ca²⁺]ₒ on the accumulation of adipocytes i ...
DOI:: 10.1016/j.bbrc.2012.06.010
: https://doi.org/10.1016/j.bbrc.2012.06.010

84. Epidermis–dermis junction as a novel location for bone marrow-derived cells to reside in response to ionizing radiation

Author:: Junko Okano; Hideto Kojima; Miwako Katagi; Yuki Nakae; Tomoya Terashima; Takahiko Nakagawa; Takeshi Kurakane; Naoki Okamoto; Keita Morohashi; Hiroshi Maegawa; Jun Udagawa
Source:: Biochemical and biophysical research communications 2015 v.461 pp. 695-701
ISSN:: 0006-291X
Subject:: bone marrow; green fluorescent protein; inflammation; ionizing radiation; mice; transgenic animals
Abstract:: ... Bone marrow-derived cells (BMDCs) can migrate into the various organs in the mice irradiated by ionizing radiation (IR). However, it may not be the case in the skin. While IR is used for bone marrow (BM) transplantation, studying with the epidermal sheets demonstrated that the BMDC recruitment is extraordinarily rare in epidermis in the mouse. Herein, using the chimera mice with BM from green fluo ...
DOI:: 10.1016/j.bbrc.2015.04.094
: https://doi.org/10.1016/j.bbrc.2015.04.094

85. Epigenetic identification of ZNF545 as a functional tumor suppressor in multiple myeloma via activation of p53 signaling pathway

Author:: Yu Fan; Qian Zhan; Hongying Xu; Lili Li; Chen Li; Qian Xiao; Shili Xiang; Tianli Hui; Tingxiu Xiang; Guosheng Ren
Source:: Biochemical and biophysical research communications 2016 v.474 pp. 660-666
ISSN:: 0006-291X
Subject:: apoptosis; biomarkers; bone marrow; carcinogenesis; epigenetics; methylation; myeloma; signal transduction; suppressor genes; therapeutics; transcription (genetics)
Abstract:: ... The KRAB–zinc-finger protein ZNF545 was recently identified as a potential suppressor gene in several tumors. However, the regulatory mechanisms of ZNF545 in tumorigenesis remain unclear. In this study, we investigated the expression and roles of ZNF545 in multiple myeloma (MM). ZNF545 was frequently downregulated in MM tissues compared with non-tumor bone marrow tissues. ZNF545 expression was sil ...
DOI:: 10.1016/j.bbrc.2016.04.146
: https://doi.org/10.1016/j.bbrc.2016.04.146

86. Establishment of adipose-derived mesenchymal stem cell lines from a p53-knockout mouse

Author:: Akihiko Komine; Motoko Abe; Toshiyuki Saeki; Takahiro Terakawa; Chiyoko Uchida; Takafumi Uchida
Source:: Biochemical and biophysical research communications 2012 v.426 no.4 pp. 468-474
ISSN:: 0006-291X
Subject:: adipocytes; hepatocytes; liver; muscles; caudal vein; cartilage; mice; osteoblasts; bone marrow; stem cells; chondrocytes
Abstract:: ... Mesenchymal stem cells (MSCs) can differentiate into a variety of cell types. MSCs exist in several tissues such as the bone marrow, adipose, muscle, cartilage, and tendon. This differentiation potential makes MSCs candidates for cell-based therapeutic strategies for mesenchymal tissue injuries. MSCs can be prepared from bone marrow (BM-MSCs) and adipose (AD-MSCs); however, these MSCs exhibit sene ...
DOI:: 10.1016/j.bbrc.2012.08.094
: https://doi.org/10.1016/j.bbrc.2012.08.094

87. Exendin-4 promotes bone formation in diabetic states via HDAC1-Wnt/β-catenin axis

Author:: Ying Deng; Wenyi Zhu; Anhua lin; Chenxiu Wang; Changhui Xiong; Fanghua Xu; Jinfeng Li; Shuijin Huang; Na Zhang; Yanan Huo
Source:: Biochemical and biophysical research communications 2021 v.544 pp. 8-14
ISSN:: 0006-291X
Subject:: Western blotting; alizarin; blood glucose; body weight; bone density; bone formation; bone marrow; bone resorption; glycemic effect; high fat diet; histone deacetylase; noninsulin-dependent diabetes mellitus; research; streptozotocin; tibia; transcription factors; wnt proteins
Abstract:: ... Exendin-4 has been found to have hypoglycemic effect and prevent bone loss in diabetic patients, but its mechanism of preventing bone loss is still unclear. In this study, high-fat diet combined with streptozotocin was used to establish type 2 diabetes mellitus (T2DM) mice, and bone marrow mesenchyme stem cells (BMSCs) were isolated for osteogenic induction in vitro. Alizarin red staining and ALP ...
DOI:: 10.1016/j.bbrc.2021.01.039
: https://doi.org/10.1016/j.bbrc.2021.01.039

88. Exosomes from bone marrow mesenchymal stem cells decrease chemosensitivity of acute myeloid leukemia cells via delivering miR-10a

Author:: Juan Wu; Yaqin Zhang; Xiaoyu Li; Jingyi Ren; Ling Chen; Jiadi Chen; Yingping Cao
Source:: Biochemical and biophysical research communications 2022 v.622 pp. 149-156
ISSN:: 0006-291X
Subject:: bone marrow; coculture; exosomes; myeloid leukemia; research
Abstract:: ... Bone marrow mesenchymal stem cells (BMSCs) are an integral part of the acute myeloid leukemia (AML) bone marrow microenvironment and contribute to AML progression. In this study, we explored the communication between BMSCs and AML cells via exosomes. The AML cells co-cultured with BMSCs-Exos were found to have lower chemosensitivity exposed to cytarabine, suggesting that BMSCs-Exos could protect A ...
DOI:: 10.1016/j.bbrc.2022.07.017
: https://doi.org/10.1016/j.bbrc.2022.07.017

89. Expression profiling of N6-methyladenosine modified circRNAs in acute myeloid leukemia

Author:: Mohammed Awal Issah; Dansen Wu; Feng Zhang; Weili Zheng; Yanquan Liu; Rong Chen; Guilan Lai; Jianzhen Shen
Source:: Biochemical and biophysical research communications 2022 v.601 pp. 137-145
ISSN:: 0006-291X
Subject:: bioinformatics; bone marrow; gene expression regulation; methylation; microarray technology; myeloid leukemia; prognosis; relapse; research
Abstract:: ... Acute myeloid leukemia (AML) is the most common acute leukemia in adults, associated with poor prognosis and easy relapse of disease. Circular RNAs (circRNAs) were detected to be m⁶A modified and the role of m⁶A circRNAs has been reported in other diseases including cancers, however, their role has not been elucidated in AML yet. In the present study, we aimed to investigate the expression profili ...
DOI:: 10.1016/j.bbrc.2022.02.087
: https://doi.org/10.1016/j.bbrc.2022.02.087

90. Extracellular calcium influx promotes antibacterial autophagy in Escherichia coli infected murine macrophages via CaMKKβ dependent activation of ERK1/2, AMPK and FoxO1

Author:: Xin Liu; Ning Wang; Yuanfeng Zhu; Yongjun Yang; Xiaoli Chen; Qian Chen; Hong Zhou; Jiang Zheng
Source:: Biochemical and biophysical research communications 2016 v.469 pp. 639-645
ISSN:: 0006-291X
Subject:: Escherichia coli; RNA interference; antibacterial properties; autophagy; bacteria; bone marrow; calcium; macrophages; mice; mitogen-activated protein kinase; signal transduction
Abstract:: ... Autophagy induction has been found as an alternative mechanism for ultimate elimination of invaded bacteria in innate immune cells. However, underlying mechanisms for the regulation of antibacterial autophagy require further elucidation. The present study mainly explores calcium dependent regulation of autophagy and its contribution to bactericidal activity in Escherichia coli (E. coli) infected m ...
DOI:: 10.1016/j.bbrc.2015.12.052
: https://doi.org/10.1016/j.bbrc.2015.12.052

91. Extracellular signal-regulated kinase (ERK) dictates osteogenic and/or chondrogenic lineage commitment of mesenchymal stem cells under dynamic compression

Author:: Daniel Pelaez; Nestor Arita; Herman S. Cheung
Source:: Biochemical and biophysical research communications 2012 v.417 no.4 pp. 1286-1291
ISSN:: 0006-291X
Subject:: alkaline phosphatase; bone formation; bone marrow; cartilage; chondrogenesis; collagen; fibrin; gels; glycosaminoglycans; mitogen-activated protein kinase; osteocalcin; reverse transcriptase polymerase chain reaction; stem cells
Abstract:: ... Elucidating the intracellular signaling cascades which lead to differentiation programs can be a daunting but necessary task. Even more so when the nature of the differentiating stimuli can elicit different biochemical responses yet achieve the same functional outcome. In the field of cartilage and bone regeneration the importance of the extracellular signal-regulated kinase (ERK) pathway has been ...
DOI:: 10.1016/j.bbrc.2011.12.131
: https://doi.org/10.1016/j.bbrc.2011.12.131

92. FANCD2 protects against bone marrow injury from ferroptosis

Author:: Xinxin Song; Yangchun Xie; Rui Kang; Wen Hou; Xiaofang Sun; Michael W. Epperly; Joel S. Greenberger; Daolin Tang
Source:: Biochemical and biophysical research communications 2016 v.480 no.3 pp. 443-449
ISSN:: 0006-291X
Subject:: DNA damage; DNA repair; Fanconi anemia; adverse effects; autophagy; bone marrow; drug therapy; genes; glutathione; iron; iron absorption; lipid peroxidation; malondialdehyde; neoplasms; proteins; stromal cells
Abstract:: ... Bone marrow injury remains a serious concern in traditional cancer treatment. Ferroptosis is an iron- and oxidative-dependent form of regulated cell death that has become part of an emerging strategy for chemotherapy. However, the key regulator of ferroptosis in bone marrow injury remains unknown. Here, we show that Fanconi anemia complementation group D2 (FANCD2), a nuclear protein involved in DN ...
DOI:: 10.1016/j.bbrc.2016.10.068
PubMed:: 27773819
PubMed Central:: PMC6591579
: https://doi.org/10.1016/j.bbrc.2016.10.068

93. FGF7 supports hematopoietic stem and progenitor cells and niche-dependent myeloblastoma cells via autocrine action on bone marrow stromal cells in vitro

Author:: Ruri Ishino; Kaori Minami; Satowa Tanaka; Mami Nagai; Keiji Matsui; Natsumi Hasegawa; Robert G. Roeder; Shigetaka Asano; Mitsuhiro Ito
Source:: Biochemical and biophysical research communications 2013 v.440 pp. 125-131
ISSN:: 0006-291X
Subject:: antibodies; bone marrow; coculture; fibroblast growth factors; fibroblasts; mice; stem cells; stromal cells; transcription (genetics)
Abstract:: ... FGF1 and FGF2 support hematopoietic stem and progenitor cells (HSPCs) under stress conditions. In this study, we show that fibroblast growth factor (FGF7) may be a novel niche factor for HSPC support and leukemic growth. FGF7 expression was attenuated in mouse embryonic fibroblasts (MEFs) deficient for the MED1 subunit of the Mediator transcriptional coregulator complex. When normal mouse bone mar ...
DOI:: 10.1016/j.bbrc.2013.09.044
: https://doi.org/10.1016/j.bbrc.2013.09.044

94. Fas/S1P1 crosstalk via NF-κB activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis

Author:: Islamy Rahma Hutami; Takashi Izawa; Akiko Mino-Oka; Takehiro Shinohara; Hiroki Mori; Akihiko Iwasa; Eiji Tanaka
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: animal models; bone density; bone formation; bone marrow; bone resorption; cartilage; ligands; macrophages; maximum residue limits; mice; mitogen-activated protein kinase; osteoclasts; pathogenesis; phosphorylation; rheumatoid arthritis; sphingosine; transcription factor NF-kappa B
Abstract:: ... Enhanced turnover of subchondral trabecular bone is a hallmark of rheumatoid arthritis (RA) and it results from an imbalance between bone resorption and bone formation activities. To investigate the formation and activation of osteoclasts which mediate bone resorption, a Fas-deficient MRL/lpr mouse model which spontaneously develops autoimmune arthritis and exhibits decreased bone mass was studied ...
DOI:: 10.1016/j.bbrc.2017.07.006
: https://doi.org/10.1016/j.bbrc.2017.07.006

95. Fibromatosis stem cells rather than bone-marrow mesenchymal stem cells recapitulate a murine model of fibromatosis

Author:: Jung-Pan Wang; Yun-Ju Hui; Shih-Tien Wang; Yi-Chao Huang; En-Rung Chiang; Chien-Lin Liu; Tain-Hsiung Chen; Shih-Chieh Hung
Source:: Biochemical and biophysical research communications 2011 v.408 no.2 pp. 269-275
ISSN:: 0006-291X
Subject:: actin; animal models; bone marrow; collagen; etiology; excision; humans; in vivo studies; muscles; stem cells
Abstract:: ... Palmar fibromatosis is a benign fibroproliferative tumor of unknown etiology, with a high rate of recurrence after excision. The offending cells of palmar fibromatosis are myofibroblasts and the cellular origin of other myofibroblasts has previously been reported to be the bone marrow. However, further clarification of the relationship between bone marrow precursors and palmar fibromatosis is requ ...
DOI:: 10.1016/j.bbrc.2011.04.011
: https://doi.org/10.1016/j.bbrc.2011.04.011

96. Functional expression cloning of molecules inducing CD34 expression in bone marrow-derived stromal myofibroblasts

Author:: Takuji Matsuo; Haruko Tashiro; Ritsu Sumiyoshi; Sumiko Saito; Ryosuke Shirasaki; Naoki Shirafuji
Source:: Biochemical and biophysical research communications 2020 v.533 no.4 pp. 1283-1289
ISSN:: 0006-291X
Subject:: blood; bone marrow; fibroblasts; genes; humans; interleukin-6; leukemia; phytohemagglutinin; research
Abstract:: ... We have previously shown a fraction of stromal fibroblasts/myofibroblasts (Fibs) from leukemic bone marrow cells expresses leukemia-specific transcripts along with hematopoietic and Fib-related markers. Normal bone marrow-derived Fibs (nFibs) do not express CD34 or CD45; however, nFibs may express hematopoietic markers with some specific stimulations. CD34 expression was detected in nFib cultures ...
DOI:: 10.1016/j.bbrc.2020.10.006
: https://doi.org/10.1016/j.bbrc.2020.10.006

97. Functional expression of P2X family receptors in macrophages is affected by microenvironment in mouse T cell acute lymphoblastic leukemia

Author:: Shayan Chen; Wenli Feng; Xiao Yang; Wanzhu Yang; Yongxin Ru; Jinfeng Liao; Lina Wang; Yongmin Lin; Qian Ren; Guoguang Zheng
Source:: Biochemical and biophysical research communications 2014 v.446 pp. 1002-1009
ISSN:: 0006-291X
Subject:: T-lymphocytes; apoptosis; bone marrow; calcium; cell communication; electron microscopy; hematopoiesis; image analysis; ion channels; lymphocytic leukemia; macrophages; mice; nucleotides; plasma membrane; quantitative polymerase chain reaction; receptors; spleen
Abstract:: ... Nucleotides are important players in intercellular signaling communication network. P2X family receptors (P2XRs) are ATP-gated plasma membrane ion channels with diverse biological functions. Macrophages are important components in the microenvironment of hematopoiesis participating in both physiological and pathological processes. However, the role of P2XRs in macrophages in leukemia has not been ...
DOI:: 10.1016/j.bbrc.2014.03.048
: https://doi.org/10.1016/j.bbrc.2014.03.048

98. GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro

Author:: Christian David Schmid; Kai Schledzewski; Carolin Mogler; Nina Waldburger; Viktoria Kalna; Alexander Marx; Anna Maria Randi; Cyrill Géraud; Sergij Goerdt; Philipp-Sebastian Koch
Source:: Biochemical and biophysical research communications 2018 v.497 no.1 pp. 32-38
ISSN:: 0006-291X
Subject:: G-protein coupled receptors; GATA transcription factors; bone marrow; calcium signaling; endothelial cells; hepatoma; humans; liver; luciferase; lymph nodes; microarray technology; mitogen-activated protein kinase; permeability; spleen; transcription (genetics)
Abstract:: ... Endothelial cells (EC) along the vascular tree exhibit organ-specific angiodiversity. Compared to most other ECs, liver sinusoidal endothelial cells (LSEC) that constitute the organ-specific microvasculature of the liver are morphologically and functionally unique. Previously, we showed that transcription factor Gata4 acts as a master regulator controlling LSEC differentiation. Upon analysis of th ...
DOI:: 10.1016/j.bbrc.2018.01.185
: https://doi.org/10.1016/j.bbrc.2018.01.185

99. GPR35 regulates osteogenesis via the Wnt/GSK3β/β-catenin signaling pathway

Author:: Yao Zhang; Tingwang Shi; Yaohua He
Source:: Biochemical and biophysical research communications 2021 v.556 pp. 171-178
ISSN:: 0006-291X
Subject:: G-protein coupled receptors; agonists; bone density; bone formation; bone marrow; bone resorption; chronic diseases; osteoporosis; ovariectomy; research
Abstract:: ... It is well known that osteoporosis is a significant chronic disease with the increase of the aging population. Here, we report that expression of G protein-coupled receptor 35 (GPR35) in bone marrow mesenchymal stem cells (BMSCs) is suppressed in diagnosed osteoporosis patients and osteoporotic mice. The expression of GPR35 on BMSCs is enhanced during osteogenic differentiation. GPR35 knockout sup ...
DOI:: 10.1016/j.bbrc.2021.03.084
: https://doi.org/10.1016/j.bbrc.2021.03.084

100. GRP78 secreted by tumor cells stimulates differentiation of bone marrow mesenchymal stem cells to cancer-associated fibroblasts

Author:: Yanan Peng; Zongwei Li; Zhuoyu Li
Source:: Biochemical and biophysical research communications 2013 v.440 pp. 558-563
ISSN:: 0006-291X
Subject:: actin; bone marrow; endoplasmic reticulum; fibroblasts; humans; mice; muscles; neoplasm cells; phosphorylation; signal transduction; stem cells; stromal cells; transforming growth factor beta
Abstract:: ... Cancer-associated fibroblasts (CAFs), one type of tumor-associated stromal cells, have been shown to provide a favorable environment for the malignant tumor progression. Extensive reports have demonstrated that mesenchymal stem cells (MSCs) can function as precursors for CAFs. However, the mechanisms by which tumor cells induce the transition of MSCs to CAFs have not been well established. GRP78, ...
DOI:: 10.1016/j.bbrc.2013.09.108
: https://doi.org/10.1016/j.bbrc.2013.09.108

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1. 17β-estradiol promotes bone marrow mesenchymal stem cell migration mediated by chemokine upregulation

2. IL- 1R1 blockade attenuates liver injury through inhibiting the recruitment of myeloid-derived suppressor cells in sepsis

3. 25-hydroxycholesterol promotes RANKL-induced osteoclastogenesis through coordinating NFATc1 and Sp1 complex in the transcription of miR-139-5p

4. IL- 37 impairs host resistance to Listeria infection by suppressing macrophage function

5. APOBEC3B is preferentially expressed at the G2/M phase of cell cycle

6. ATP turnover and glucose dependency in hematopoietic stem/progenitor cells are increased by proliferation and differentiation

7. ATP6V1H regulates the growth and differentiation of bone marrow stromal cells

8. Accelerated apoptosis of peripheral blood monocytes in Cebpb-deficient mice

9. Acid sphingomyelinase regulates osteoclastogenesis by modulating sphingosine kinases downstream of RANKL signaling

10. Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells

11. Activation of protein kinase C accelerates murine osteoclastogenesis partly via transactivation of RANK gene through functional AP-1 responsive element in RANK gene promoter

12. Adipose mesenchymal stem cell-derived exosomes ameliorate hypoxia/serum deprivation-induced osteocyte apoptosis and osteocyte-mediated osteoclastogenesis in vitro

13. Ameliorating replicative senescence of human bone marrow stromal cells by PSMB5 overexpression

14. Ameloblastin and enamelin prevent osteoclast formation by suppressing RANKL expression via MAPK signaling pathway

15. Analysis of the stem cell characteristics of adult stem cells from Arbas white Cashmere goat

16. Angiopoietin1 contributes to the maintenance of cell quiescence in EVI1ʰⁱᵍʰ leukemia cells

17. Anthelmintic drug niclosamide enhances the sensitivity of chronic myeloid leukemia cells to dasatinib through inhibiting Erk/Mnk1/eIF4E pathway

18. Anti-ATR001 monoclonal antibody ameliorates atherosclerosis through beta-arrestin2 pathway

19. Anti-adipogenic effects of sesamol on human mesenchymal stem cells

20. Antibiotic anisomycin selectively targets leukemia cell lines and patient samples through suppressing Wnt/β-catenin signaling

21. Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress

22. Apolipoprotein E plays crucial roles in maintaining bone mass by promoting osteoblast differentiation via ERK1/2 pathway and by suppressing osteoclast differentiation via c-Fos, NFATc1, and NF-κB pathway

23. Arsenite suppresses the transcriptional activity of EVI1 through the binding to CCHC-type Zn finger domain

24. Astaxanthin improves osteopenia caused by aldehyde-stress resulting from Aldh2 mutation due to impaired osteoblastogenesis

25. Augmented neutrophil extracellular traps formation promotes atherosclerosis development in socially defeated apoE−/− mice

26. Autophagy activation facilitates mechanical stimulation-promoted osteoblast differentiation and ameliorates hindlimb unloading-induced bone loss

27. Autophagy exerts pivotal roles in regulatory effects of 1α,25-(OH)2D3 on the osteoclastogenesis

28. Autophagy mediates enhancement of proangiogenic activity by hypoxia in mesenchymal stromal/stem cells

29. Autophagy promotes osteogenic differentiation of human bone marrow mesenchymal stem cell derived from osteoporotic vertebrae

30. BST-2 is a potential activator of invasion and migration in tamoxifen-resistant breast cancer cells

31. Bergapten suppresses RANKL-induced osteoclastogenesis and ovariectomy-induced osteoporosis via suppression of NF-κB and JNK signaling pathways

32. Bio-active molecules modified surfaces enhanced mesenchymal stem cell adhesion and proliferation

33. Blockade of plasminogen activator inhibitor-1 empties bone marrow niche sufficient for donor hematopoietic stem cell engraftment without myeloablative conditioning

34. Bone marrow NLRP3 inflammasome-IL-1β signal regulates post-myocardial infarction megakaryocyte development and platelet production

35. Bone marrow mesenchymal stem cells ameliorate colitis-associated tumorigenesis in mice

36. Bone marrow sympathetic activation regulates post-myocardial infarction megakaryocyte expansion but not platelet production

37. Bone morphogenetic protein (BMP)1-3 enhances bone repair

38. Bone progeria diminished the therapeutic effects of bone marrow mesenchymal stem cells on retinal degeneration

39. Bone stroma-derived cells change coregulators recruitment to androgen receptor and decrease cell proliferation in androgen-sensitive and castration-resistant prostate cancer cells

40. Bortezomib enhances the osteogenic differentiation capacity of human mesenchymal stromal cells derived from bone marrow and placental tissues

41. COMP-angiopoietin 1 increases proliferation, differentiation, and migration of stem-like cells through Tie-2-mediated activation of p38 MAPK and PI3K/Akt signal transduction pathways

42. CSTA plays a role in osteoclast formation and bone resorption by mediating the DAP12/TREM2 pathway

43. Caldecrin inhibits lipopolysaccharide-induced pro-inflammatory cytokines and M1 macrophage polarization through the immunoreceptor triggering receptor expressed in myeloid cells-2

44. Celastrol inhibits vasculogenesis by suppressing the VEGF-induced functional activity of bone marrow-derived endothelial progenitor cells

45. Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells

46. Chondrocytes-derived exosomal miR-8485 regulated the Wnt/β-catenin pathways to promote chondrogenic differentiation of BMSCs

47. Co-culture with neurotrophic factor secreting cells induced from adipose-derived stem cells: Promotes neurogenic differentiation

48. Coculture in vitro with endothelial cells induces cytarabine resistance of acute myeloid leukemia cells in a VEGF-A/VEGFR-2 signaling–independent manner

49. Cofilin-1 promotes fibrocyte differentiation and contributes to pulmonary fibrosis

50. Combination of gp130-targeting and TNF-targeting small molecules in alleviating arthritis through the down-regulation of Th17 differentiation and osteoclastogenesis

51. Comparison of the bone regeneration ability between stem cells from human exfoliated deciduous teeth, human dental pulp stem cells and human bone marrow mesenchymal stem cells

52. Construction of EMSC-islet co-localizing composites for xenogeneic porcine islet transplantation

53. Contact-dependent abrogation of bone marrow-derived plasmacytoid dendritic cell differentiation by murine mesenchymal stem cells

54. Contribution of PDGFRα lineage cells in adult mouse hematopoiesis

55. Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity

56. Crystal structure of CD38 in complex with daratumumab, a first-in-class anti-CD38 antibody drug for treating multiple myeloma

57. Cyclosporin A inhibits adipogenic differentiation and regulates immunomodulatory functions of murine mesenchymal stem cells

58. DCIR3 and DCIR4 are co-expressed on inflammatory and patrolling monocytes

59. DGCR5 induces osteogenic differentiation by up-regulating Runx2 through miR-30d-5p

60. DLX3 regulates osteogenic differentiation of bone marrow mesenchymal stem cells via Wnt/β-catenin pathway mediated histone methylation of DKK4

61. Dendritic cell inhibitory receptor 4 (DCIR4) is preferentially expressed on inflammatory and patrolling monocytes

62. Dexamethasone treatment alters function of adipocytes from a mesenchymal stromal cell line

63. Dickkopf (Dkk)-2 is a beige fat-enriched adipokine to regulate adipogenesis

64. Differentiation of GFP-Bcl-2-engineered mesenchymal stem cells towards a nucleus pulposus-like phenotype under hypoxia in vitro

65. Direct contacts with colon cancer cells regulate the differentiation of bone marrow mesenchymal stem cells into tumor associated fibroblasts

66. Direct induction of hepatocyte-like cells from immortalized human bone marrow mesenchymal stem cells by overexpression of HNF4α

67. Distorted antibody repertoire developed in the absence of pre-B cell receptor formation

68. Dll1/Notch activation contributes to bortezomib resistance by upregulating CYP1A1 in multiple myeloma

69. Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia

70. Downregulated miR-150 in bone marrow mesenchymal stem cells attenuates the apoptosis of LPS-stimulated RAW264.7 via MTCH2-dependent mitochondria transfer