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You searched for: Journal name Biochemical and biophysical research communications Remove constraint Journal name: Biochemical and biophysical research communications Subject cerebrospinal fluid Remove constraint Subject: cerebrospinal fluid
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1. Melatonin in ventricular and subarachnoid cerebrospinal fluid: Its function in the neural glymphatic network and biological significance for neurocognitive health

Author:
Russel J. Reiter; Ramaswamy Sharma; Sergio Rosales-Corral; Jasmine de Mange; William T. Phillips; Dun Xian Tan; Ryan D. Bitar
Source:
Biochemical and biophysical research communications 2022 v.605 pp. 70-81
ISSN:
0006-291X
Subject:
anti-inflammatory agents; antioxidants; blood; brain; cerebrospinal fluid; convection; decline; lymph; melatonin; neurotoxins; parenchyma (animal tissue); research; spinal cord; toxicity
Abstract:
... The central nervous system (CNS) is endowed with a specialized cerebrospinal fluid (CSF)/lymph network which removes toxic molecules and metabolic by-products from the neural parenchyma; collectively, this has been named the glymphatic system. It allows CSF located in the subarachnoid space which surrounds the CNS to enter the depths of the brain and spinal cord by means of Virchow-Robin perivascu ...
DOI:
10.1016/j.bbrc.2022.03.025

2. Spectral signature of multiple sclerosis. Preliminary studies of blood fraction by ATR FTIR technique

Author:
Magdalena Kołodziej; Karolina Chrabąszcz; Ewa Pięta; Natalia Piergies; Julia Rudnicka-Czerwiec; Halina Bartosik-Psujek; Czesława Paluszkiewicz; Marian Cholewa; Wojciech M. Kwiatek
Source:
Biochemical and biophysical research communications 2022 v.593 pp. 40-45
ISSN:
0006-291X
Subject:
Fourier transform infrared spectroscopy; blood sampling; blood serum; central nervous system; cerebrospinal fluid; chemometrics; diagnostic techniques; inflammation; magnetism; neurodegenerative diseases; research; sclerosis
Abstract:
... Multiple sclerosis (MS) is a chronic, neurodegenerative disease of central nervous system, characterized by inflammation, demyelination, and gliosis. It is commonly known the rapid and accurate diagnosis of MS determines treatment success. The standard diagnosis contains clinical symptoms observation, magnetic resonance imaging (MRI) of central nervous system (CNS), and analysis of cerebrospinal f ...
DOI:
10.1016/j.bbrc.2022.01.046

3. Tetraspanin heterogeneity of small extracellular vesicles in human biofluids and brain tissue

Author:
Mami Okada-Tsuchioka; Naoto Kajitani; Wataru Omori; Takashi Kurashige; Shuken Boku; Minoru Takebayashi
Source:
Biochemical and biophysical research communications 2022 v.627 pp. 146-151
ISSN:
0006-291X
Subject:
biomarkers; blood serum; brain; cerebrospinal fluid; exosomes; humans; lipid bilayers; research
Abstract:
... Extracellular vesicles (EVs) are particles released from most cell types delimited by a lipid bilayer. Small EVs (sEVs) are nanosized (<200 nm) and include exosomes. Brain-derived sEVs may provide a source for new biomarkers of brain status. CD9, CD63, and CD81 are major members of the tetraspanin family frequently used as sEV markers. However, according to a recent report, tetraspanins were not e ...
DOI:
10.1016/j.bbrc.2022.08.025

4. Adeno-associated virus-mediated in vivo suppression of expression of EPHX2 gene modulates the activity of paraventricular nucleus neurons in spontaneously hypertensive rats

Author:
Xiaoming Zhu; Kuibao Li; Yuanfeng Gao
Source:
Biochemical and biophysical research communications 2022 v.606 pp. 121-127
ISSN:
0006-291X
Subject:
astrocytes; cerebrospinal fluid; epoxide hydrolase; fluorescent antibody technique; genes; hypertension; hypothalamus; neurons; neuroprotective effect; pathogenesis; plasmids; rats; research; serine; serine racemase
Abstract:
... Hypertension can be attributed to increased sympathetic activities. Presympathetic neurons in the paraventricular nucleus (PVN) of the hypothalamus are capable of modulating sympathetic outflow, thus contributing to the pathogenesis of neurogenic hypertension. Epoxyeicosatrienoic acids (EETs) were reported to have anti-hypertensive effects, which could be degraded by soluble epoxide hydrolase (sEH ...
DOI:
10.1016/j.bbrc.2022.03.084

5. Galabiosylceramide is present in human cerebrospinal fluid

Author:
Hisako Akiyama; Mitsuko Ide; Toshiyuki Yamaji; Yasuaki Mizutani; Yoshiki Niimi; Tatsuro Mutoh; Hiroyuki Kamiguchi; Yoshio Hirabayashi
Source:
Biochemical and biophysical research communications 2021 v.536 pp. 73-79
ISSN:
0006-291X
Subject:
Fabry disease; Shiga toxin; ceramides; cerebrospinal fluid; constitutional isomers; humans; hydrocephalus; hydrophilic interaction chromatography; ionization; kidneys; liver; lysosomes; research; tandem mass spectrometry; urine
Abstract:
... Cerebrospinal fluid (CSF) contains glycosphingolipids, including lactosylceramide (LacCer, Galβ(1,4)Glcβ-ceramide). LacCer and its structural isomer, galabiosylceramide (Gb₂, Galα(1,4)Galβ-ceramide), are classified as ceramide dihexosides (CDH). Gb₂ is degraded by α-galactosidase A (GLA) in lysosomes, and genetic GLA deficiency causes Fabry disease, an X-linked lysosomal storage disorder. In patie ...
DOI:
10.1016/j.bbrc.2020.12.051

6. NLRP3 inflammasome of microglia promotes A1 astrocyte transformation, neo-neuron decline and cognition impairment in endotoxemia

Author:
Ting Xiao; Heyu Ji; Xuejuan Shangguan; Shuangquan Qu; Yulong Cui; Junmei Xu
Source:
Biochemical and biophysical research communications 2022 v.602 pp. 1-7
ISSN:
0006-291X
Subject:
astrocytes; cerebrospinal fluid; cognition; cognitive disorders; death; decline; endotoxemia; inflammasomes; lipopolysaccharides; medicine; mortality; pathogenesis; quality of life; research
Abstract:
... Infection, predominantly induced by gram-negative bacteria, is a critical health problem and a leading cause of death worldwide. Advance of techniques, such as antibiotics and life-supporting modality, allows a decreasing death rate of patients with infection in recent decades. Nevertheless, infection-associated complications, in particular cognitive dysfunction, largely influence the mortality of ...
DOI:
10.1016/j.bbrc.2022.02.092

7. Structural basis of the 24B3 antibody against the toxic conformer of amyloid β with a turn at positions 22 and 23

Author:
Yumi Irie; Yuka Matsushima; Akiko Kita; Kunio Miki; Tatsuya Segawa; Masahiro Maeda; Ryo C. Yanagita; Kazuhiro Irie
Source:
Biochemical and biophysical research communications 2022 v.621 pp. 162-167
ISSN:
0006-291X
Subject:
Alzheimer disease; amyloid; antibodies; cerebrospinal fluid; crystal structure; disulfide bonds; enzyme immunoassays; humans; immunization; research; toxicity
Abstract:
... Amyloid β-protein (Aβ) oligomers are involved in the early stages of Alzheimer's disease (AD) and antibodies against these toxic oligomers could be useful for accurate diagnosis of AD. We identified the toxic conformer of Aβ42 with a turn at positions 22/23, which has a propensity to form toxic oligomers. The antibody 24B3, developed by immunization of a toxic conformer surrogate E22P-Aβ9-35 in mi ...
DOI:
10.1016/j.bbrc.2022.07.010

8. A pilot study using proximity extension assay of cerebrospinal fluid and its extracellular vesicles identifies novel amyotrophic lateral sclerosis biomarker candidates

Author:
Sebastian Sjoqvist; Kentaro Otake
Source:
Biochemical and biophysical research communications 2022 v.613 pp. 166-173
ISSN:
0006-291X
Subject:
adhesion; amyotrophic lateral sclerosis; biomarkers; cerebrospinal fluid; chitinase; death; diagnostic techniques; gene expression regulation; myoglobin; research; support vector machines; tumor necrosis factor receptors
Abstract:
... Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder which is characterized by progressive degeneration of the motor system. Typically, the disease starts with focal weakness which spreads to involve most muscles and leads to death from respiratory failure within five years of diagnosis. Due to the heterogenic nature of the disease, diagnostics is complex, and it generally tak ...
DOI:
10.1016/j.bbrc.2022.04.127

9. Changed PGA and POSTN levels in choroid plexus are associated with depressive-like behaviors in mice

Author:
Jie Liu; Yong He; Ke Cheng; Peng Xie
Source:
Biochemical and biophysical research communications 2020 v.524 no.1 pp. 231-235
ISSN:
0006-291X
Subject:
Macaca fascicularis; brain; cerebrospinal fluid; choroid plexus; death; lipopolysaccharides; mental depression; pathogenesis; pepsin; research
Abstract:
... Major depressive disorder (MDD) has become a potential cause of death and disability among young people worldwide. Numerous studies have indicated that the different cerebrospinal fluid (CSF) proteins may be used as mediums for MDD. Given the emergent interest of CSF proteins in MDD, we validated proteins expression in the choroid plexus (CP), the brain region that produces CSF in the lateral vent ...
DOI:
10.1016/j.bbrc.2020.01.076

10. Characterization of the circadian oscillator in the choroid plexus of rats

Author:
Takeshi Yamaguchi; Toshiyuki Hamada; Toshiyuki Matsuzaki; Norio Iijima
Source:
Biochemical and biophysical research communications 2020 v.524 no.2 pp. 497-501
ISSN:
0006-291X
Subject:
aquaporins; bioluminescence; cerebrospinal fluid; choroid plexus; circadian rhythm; epithelium; hybridization; pineal body; quantitative polymerase chain reaction; research; secretion
Abstract:
... Circadian rhythms are a fundamental biological phenomena that control various physiological functions. The suprachiasmatic nucleus (SCN) is a master clock that integrates various peripheral clocks. Recently, the choroid plexus (CP) was reported to be one such peripheral clock, a circadian oscillator that might conversely affect the SCN. Hence, the principle aim of our study was to unravel the circ ...
DOI:
10.1016/j.bbrc.2020.01.125

11. Glioma-derived endothelial cells promote glioma cells migration via extracellular vesicles-mediated transfer of MYO1C

Author:
Yuan Tian; Zhixing Wang; Yuxin Wang; Bin Yin; Jiangang Yuan; Boqin Qiang; Wei Han; Xiaozhong Peng
Source:
Biochemical and biophysical research communications 2020 v.525 no.1 pp. 155-161
ISSN:
0006-291X
Subject:
biomarkers; biopsy; blood; cerebrospinal fluid; early diagnosis; gene expression regulation; glioma; humans; information exchange; neoplasm progression; research
Abstract:
... Extracellular vesicles (EV), as the intercellular information transfer molecules which can regulate the tumor microenvironment, promote migration and tumor progression. Previous studies reported that EV from endothelial cells was used to guide the fate and survival of gliomas, but many researches focus on normal human endothelial cells (NhEC) rather than tumor-derived endothelial cells. Our labora ...
DOI:
10.1016/j.bbrc.2020.02.017

12. Silencing IFNγ inhibits A1 astrocytes and attenuates neurogenesis decline and cognitive impairment in endotoxemia

Author:
Yanyan Lu; Yanliang Yang; Zhouyangfan Peng; Lingli Xie; Xiaoli Zhong; Fang Liang; Chuang Yuan; Ben Lu
Source:
Biochemical and biophysical research communications 2020 v.533 no.4 pp. 1519-1526
ISSN:
0006-291X
Subject:
astrocytes; bacterial infections; cerebrospinal fluid; cognition; cognitive disorders; decline; endotoxemia; hippocampus; homeostasis; humans; interferon-gamma; lipopolysaccharides; medicine; neurogenesis; neurons; research
Abstract:
... Cognitive impairment, acute or long-term, is a common complication in patients with severe bacterial infection. However, the underlying mechanisms are not fully verified and effective medicine is not available in clinics. Interferon gamma (IFNγ) is a pivotal cytokine against infection and is believed to be a tune in homeostasis of cognitive function. Here, we collected blood and cerebrospinal flui ...
DOI:
10.1016/j.bbrc.2020.10.084

13. Substrate-induced product-release mechanism of lipocalin-type prostaglandin D synthase

Author:
Shigeru Shimamoto; Yusuke Nakagawa; Yuji Hidaka; Takahiro Maruno; Yuji Kobayashi; Kazuki Kawahara; Takuya Yoshida; Tadayasu Ohkubo; Kosuke Aritake; Mahesh K. Kaushik; Yoshihiro Urade
Source:
Biochemical and biophysical research communications 2021 v.569 pp. 66-71
ISSN:
0006-291X
Subject:
brain; catalytic activity; cerebrospinal fluid; enzymes; ligands; prostaglandins; research; stoichiometry
Abstract:
... Prostaglandin D₂ (PGD₂), an endogenous somnogen, is a unique PG that is secreted into the cerebrospinal fluid. PGD₂ is a relatively fragile molecule and should be transported to receptors localized in the basal forebrain without degradation. However, it remains unclear how PGD₂ is stably carried to such remote receptors. Here, we demonstrate that the PGD₂-synthesizing enzyme, Lipocalin-type prosta ...
DOI:
10.1016/j.bbrc.2021.06.092

14. Neuropeptide S attenuates methamphetamine-induced stereotyped behavior in rats

Author:
Xing Li; Fan Jiang; Kai Yao; Lujia Yang; Xingyue Gao; Hongxia Chen; Xiaoli Wei; Ning Wu; Ru Zhou; Weixiu Yuan; Shuzhuo Zhang
Source:
Biochemical and biophysical research communications 2020 v.527 no.1 pp. 98-103
ISSN:
0006-291X
Subject:
cerebrospinal fluid; glutamic acid; hippocampus; methamphetamines; neuropeptides; research; stereotyped behavior
Abstract:
... Effective therapies for Methamphetamine (METH) induced stereotyped behavior are still being explored. It is unclear whether Neuropeptide S (NPS) is involved in the mechanism of METH-induced stereotyped behavior. In the contemporary behavioral study, pretreatment with NPS reduces stereotyped circling significantly, but didn’t have any impact on the total incidence of stereotypy and stereotyped snif ...
DOI:
10.1016/j.bbrc.2020.04.085

15. CD8 T cell-derived perforin aggravates secondary spinal cord injury through destroying the blood-spinal cord barrier

Author:
Zhaoxiang Liu; Hua Zhang; Hong Xia; Baocheng Wang; Renwen Zhang; Qun Zeng; Lingzhi Guo; Kui Shen; BaTa Wang; Yanheng Zhong; Zhizhong Li; Guodong Sun
Source:
Biochemical and biophysical research communications 2019 v.512 no.2 pp. 367-372
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; animal injuries; animal models; biotin; cerebrospinal fluid; cytokines; enzyme-linked immunosorbent assay; flow cytometry; humans; infectious diseases; inflammation; mice; permeability; spinal cord; staining
Abstract:
... Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin after spinal cord injury (SCI) on secondary inflammation. Compared recovery from SCI in perforin knockout (Prf1−/−) and wild-type(WT)mice, WT mic ...
DOI:
10.1016/j.bbrc.2019.03.002

16. CXCL1 promotes the proliferation of neural stem cells by stimulating the generation of reactive oxygen species in APP/PS1 mice

Author:
Yu Shang; Li Tian; Tianjiao Chen; Xiaoying Liu; Jilin Zhang; Dongxin Liu; Jiayi Wei; Wengang Fang; Yuhua Chen; Deshu Shang
Source:
Biochemical and biophysical research communications 2019 v.515 no.1 pp. 201-206
ISSN:
0006-291X
Subject:
Alzheimer disease; astrocytes; cell proliferation; cerebrospinal fluid; chemokine CXCL1; macrophages; mice; neural stem cells; patients; reactive oxygen species
Abstract:
... Elevated levels of CXCL1 were observed in the cerebrospinal fluid of patients with early Alzheimer's disease, which may affect neural stem cells in the subventricular zone. We used APP/PS1 mice and neural stem cells to elucidate the role of CXCL1 in Alzheimer's disease.We detected CXCL1 in cerebrospinal fluid (CSF), activated macrophages, and microglia suggesting that macrophages may contribute to ...
DOI:
10.1016/j.bbrc.2019.05.130

17. Cephalosporin antibiotics are weak blockers of GABAa receptor-mediated synaptic transmission in rat brain slices

Author:
Dmitry V. Amakhin; Elena B. Soboleva; Aleksey V. Zaitsev
Source:
Biochemical and biophysical research communications 2018 v.499 no.4 pp. 868-874
ISSN:
0006-291X
Subject:
brain; ceftriaxone; cerebrospinal fluid; cortex; gamma-aminobutyric acid; gamma-aminobutyric acid receptors; inhibitory concentration 50; neurons; patients; rats; renal failure; seizures; synaptic transmission
Abstract:
... Cephalosporins are beta-lactam antibiotics that are extensively used in medical practice and are reported to cause epileptic seizures in some patients. The primary cause of cephalosporin-induced convulsions is believed to be their ability to block GABAa receptors. However, direct evidence for the involvement of this mechanism has not yet been provided. The present study aims to investigate the abi ...
DOI:
10.1016/j.bbrc.2018.04.008

18. Cerebrospinal fluid CD4+ T lymphocyte-derived miRNA-let-7b can enhances the diagnostic performance of Alzheimer's disease biomarkers

Author:
Yaping Liu; Xiaojing He; Yanling Li; Tian Wang
Source:
Biochemical and biophysical research communications 2018 v.495 no.1 pp. 1144-1150
ISSN:
0006-291X
Subject:
Alzheimer disease; CD4-positive T-lymphocytes; biomarkers; cerebrospinal fluid; correlation; microRNA; models; neurodegenerative diseases; regression analysis; screening
Abstract:
... Alzheimer's disease is very difficult to clinically diagnose. miRNAs constitute the promising next generation of Alzheimer's disease (AD) biomarkers and have the potential to diagnose neurodegenerative diseases. In this study, 94 subjects underwent extensive dementia screening. Let-7b miRNA was found to increase in association with the progression of AD, and the increase in let-7b miRNA was mainly ...
DOI:
10.1016/j.bbrc.2017.11.122

19. Increased cerebrospinal fluid complement C5 levels in major depressive disorder and schizophrenia

Author:
Takashi Ishii; Kotaro Hattori; Tomoko Miyakawa; Kentaro Watanabe; Shinsuke Hidese; Daimei Sasayama; Miho Ota; Toshiya Teraishi; Hiroaki Hori; Sumiko Yoshida; Akihiko Nunomura; Kazuyuki Nakagome; Hiroshi Kunugi
Source:
Biochemical and biophysical research communications 2018 v.497 no.2 pp. 683-688
ISSN:
0006-291X
Subject:
body mass index; brain; cerebrospinal fluid; complement; enzyme-linked immunosorbent assay; inflammation; males; mental depression; nationalities and ethnic groups; pathogenesis; patients; schizophrenia
Abstract:
... Inflammation has been implicated in a variety of psychiatric disorders. We aimed to determine whether levels of complement C5 protein in the cerebrospinal fluid (CSF), which may reflect activation of the complement system in the brain, are altered in patients with major psychiatric disorders. Additionally, we examined possible associations of CSF C5 levels with clinical variables. Subjects compris ...
DOI:
10.1016/j.bbrc.2018.02.131

20. Elongation affinity, activation barrier, and stability of Aβ42 oligomers/fibrils in physiological saline

Author:
Roberto A. Rodriguez; Liao Y. Chen; Germán Plascencia-Villa; George Perry
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
Alzheimer disease; cerebrospinal fluid; heparan sulfate; models; neurotoxicity; peptides; proteoglycans; thermodynamics
Abstract:
... Amyloid-beta (Aβ) peptides, Aβ40 and the more neurotoxic Aβ42, have been the subject of many research efforts for Alzheimer's disease. In two recent independent investigations, the atomistic structure of Aβ42 fibril has been clearly established in the S-shaped conformation consisting of three β-sheets stabilized by salt bridges formed between the Lys28 sidechain and the C-terminus of Ala42. This s ...
DOI:
10.1016/j.bbrc.2017.04.084
PubMed:
28427941
PubMed Central:
PMC5489073