Journal name: Biochemical and biophysical research communications / Subject: exosomes

1. GABA alleviates high glucose-induced podocyte injury through dynamically altering the expression of macrophage M1/M2-derived exosomal miR-21a-5p/miR-25-3p

Author:: Yibo Zhuang; Hongxue Zheng; Yong Yang; Huiping Ni
Source:: Biochemical and biophysical research communications 2022 v.618 pp. 38-45
ISSN:: 0006-291X
Subject:: apoptosis; exosomes; glucose; inflammation; kidney diseases; macrophages; phenotype; research
Abstract:: ... Podocyte injury is the main clinical pathological feature of diabetic kidney disease (DKD). The studies showed that DKD is associated with the polarization of macrophages to different types (M1 or M2) and the inflammatory processes which they mediate. It is a hot research topic in the treatment of DKD that find and intervene genes which related to M1/M2 phenotype. The potential anti-inflammatory e ...
DOI:: 10.1016/j.bbrc.2022.06.019
: https://doi.org/10.1016/j.bbrc.2022.06.019

2. LncRNA SNHG3 regulates the BMSC osteogenic differentiation in bone metastasis of breast cancer by modulating the miR-1273g-3p/BMP3 axis

Author:: Zijiu Sun; Jing Hu; Wei Ren; Yuting Fang; Kai Hu; Huomei Yu; Deyu Liao; Shiyan Liu; Lan Zhou; Tongchuan He; Yan Zhang
Source:: Biochemical and biophysical research communications 2022 v.594 pp. 117-123
ISSN:: 0006-291X
Subject:: bone formation; bone marrow; breast neoplasms; exosomes; luciferase; metastasis; neoplasm cells; reporter genes; research
Abstract:: ... Research on the role of lncRNAs in the process of bone metastasis in breast cancer (BM-BCa) has just begun at an early stage, and an increasing number of lncRNAs have been proved to play a regulatory role in the process of BM-BCa. Our study focused on the balance of osteogenic-osteoclast regulated by lncRNA-SNHG3 in bone metastasis microenvironment. SNHG3 level of clinical tissues and breast cance ...
DOI:: 10.1016/j.bbrc.2021.12.075
: https://doi.org/10.1016/j.bbrc.2021.12.075

3. RETRACTED: Serum exosomes mediate septic inflammation and liver and kidney injuries by up-regulating the expression of inflammatory factors

Author:: Liao Chen; Qunhang Shi; Xin Ma; Yafang Niu; Meng Chong; Li Ma
Source:: Biochemical and biophysical research communications 2022 pp. -
ISSN:: 0006-291X
Subject:: blood serum; cytokines; death; exosomes; inflammation; kidneys; liver; protein content; public health; research; therapeutics
Abstract:: ... Sepsis remains one of the major public health problems of widespread concern worldwide, and sepsis-related liver and kidney injuries are important causes of death in which excessive inflammatory response plays a key role. And serum exosomes as carriers of intercellular material exchange and communication may be closely associated with the development of inflammation-mediated liver and kidney injur ...
DOI:: 10.1016/j.bbrc.2022.02.110
: https://doi.org/10.1016/j.bbrc.2022.02.110

4. Transgenically expressed Helicobacter pylori CagA in vascular endothelial cells accelerates arteriosclerosis in mice

Author:: Kamrunnesa Tahmina; Narumi Hikawa; Atsushi Takahashi-Kanemitsu; Christopher Takaya Knight; Kengo Sato; Fumiko Itoh; Masanori Hatakeyama
Source:: Biochemical and biophysical research communications 2022 v.618 pp. 79-85
ISSN:: 0006-291X
Subject:: Helicobacter pylori; atherosclerosis; blood circulation; exosomes; gastritis; high fat diet; humans; inflammation; research; secretion; stomach neoplasms; transcription factors
Abstract:: ... Arteriosclerosis is intimately associated with cardiovascular diseases. Recently, evidence accumulated that infection with Helicobacter pylori cagA-positive strains, which causes gastritis, peptic ulceration, and gastric cancer, is also involved in the development of arteriosclerosis. The cagA-encoded CagA protein is injected into the attached gastric epithelial cells via the type IV secretion sys ...
DOI:: 10.1016/j.bbrc.2022.06.010
: https://doi.org/10.1016/j.bbrc.2022.06.010

5. ASCs -derived exosomes loaded with vitamin A and quercetin inhibit rapid senescence-like response after acute liver injury

Author:: Jia Fang; Wulong Liang
Source:: Biochemical and biophysical research communications 2021 v.572 pp. 125-130
ISSN:: 0006-291X
Subject:: exosomes; hepatocytes; liver; liver failure; liver transplant; mesenchymal stromal cells; quercetin; research; vitamin A
Abstract:: ... Acute liver injury is a short-term burst of liver cell damage, which has many causes and complex mechanisms. Despite the unique ability of the liver to heal itself, there is still no effective treatment except liver transplantation for chronic liver injury or even liver failure caused by acute liver injury. Stem cell-derived exosomes are ideal drug carriers due to their unique immunomodulatory eff ...
DOI:: 10.1016/j.bbrc.2021.07.059
: https://doi.org/10.1016/j.bbrc.2021.07.059

6. Secretion of signal peptides via extracellular vesicles

Author:: Kenji Ono; Mikio Niwa; Hiromi Suzuki; Nahoko Bailey Kobayashi; Tetsuhiko Yoshida; Makoto Sawada
Source:: Biochemical and biophysical research communications 2021 v.560 pp. 21-26
ISSN:: 0006-291X
Subject:: cell communication; endoplasmic reticulum; exosomes; genetic vectors; humans; mass spectrometry; particle size; peptides; research; secretion; signal peptide
Abstract:: ... Signal peptides (SPs) consist of short peptide sequences present at the N-terminal of newly synthesizing proteins and act as a zip code for the translocation of the proteins to the endoplasmic reticulum (ER). It was thought that the SPs are intracellularly degraded after translocation to the ER; however, recent studies showed cleaved SPs have diverse roles for controlling cell functions in auto- a ...
DOI:: 10.1016/j.bbrc.2021.04.073
: https://doi.org/10.1016/j.bbrc.2021.04.073

7. Tubular epithelial cells derived-exosomes containing CD26 protects mice against renal ischemia/reperfusion injury by maintaining proliferation and dissipating inflammation

Author:: Juan Du; Qiang Sun; Zhihao Wang; Feng Wang; Fangfang Chen; Hao Wang; Guokai Shang; Xiaomei Chen; Shifang Ding; Chen Li; Dawei Wu; Wei Zhang; Ming Zhong; Yihui Li
Source:: Biochemical and biophysical research communications 2021 v.553 pp. 134-140
ISSN:: 0006-291X
Subject:: acute kidney injury; bovine serum albumin; caudal vein; cell cycle; cell lines; chemokines; epithelial cells; epithelium; exosomes; fluorescent antibody technique; histology; inflammation; ischemia; kidneys; renal function; reperfusion injury; research; therapeutics
Abstract:: ... Ischemia-reperfusion injury (IR) is the leading cause of acute kidney injury (AKI). No effective drugs to treat IR-related AKI are currently available. Recent pre-clinical trials have evaluated the therapeutic potential of extracellular vesicles-exosomes to chronic kidney disease. Here, we found exosomes derived from the tubular epithelial cell in IR condition (Exoᴵᴿ) enriched CD26, compared with ...
DOI:: 10.1016/j.bbrc.2021.03.057
: https://doi.org/10.1016/j.bbrc.2021.03.057

8. miR-129–5p in exosomes inhibits diabetes-associated osteogenesis in the jaw via targeting FZD4

Author:: Jinhui Wang; Yanyun Xia; Jianhao Li; Wei Wang
Source:: Biochemical and biophysical research communications 2021 v.566 pp. 87-93
ISSN:: 0006-291X
Subject:: Western blotting; blood; bone formation; bone marrow; diabetes mellitus; exosomes; ligands; luciferase; microRNA; osteoblasts; research; skeletal development
Abstract:: ... Diabetes mellitus (DM) influence induces poor osseointegration. The osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is a critical factor in successful dental implants. Certain microRNAs play important roles during bone development, and others are deregulated in diabetes. This study investigated the roles of miR-129–5p in the osteoblast differentiation regulation. Exosomes ...
DOI:: 10.1016/j.bbrc.2021.05.072
: https://doi.org/10.1016/j.bbrc.2021.05.072

9. A targeted extracellular vesicles loaded with montelukast in the treatment of demyelinating diseases

Author:: Yun Xiao; Yuan Zhang; Yu-Han Gao; Zhuo-Hua Zhao; Jin He; Rui Gao; Yu-Xin Guo; Li-Bin Wang; Xing Li
Source:: Biochemical and biophysical research communications 2022 v.594 pp. 31-37
ISSN:: 0006-291X
Subject:: animal models; biocompatibility; central nervous system; drugs; exosomes; ligands; myelin sheath; oligodendroglia; research
Abstract:: ... The main pathological characteristics of demyelinating diseases are central nervous system (CNS) myelin damage, and the differentiation of oligodendrocyte precursor cells is the therapeutic target of myelin repair. Previous studies have found that a large number of platelet-derived growth factor receptor α(PDGFRα) positive oligodendrocyte progenitor cells (OPCs) accumulate in the lesion area of my ...
DOI:: 10.1016/j.bbrc.2022.01.051
: https://doi.org/10.1016/j.bbrc.2022.01.051

10. Administration of circRNA_0075932 shRNA exhibits a therapeutic effect on burn-associated infection in obese rats

Author:: Haidong Wu; Sheng He; Wei Zhang; Ying Huang; Qiang Zhang; Dan Liu
Source:: Biochemical and biophysical research communications 2022 v.608 pp. 82-89
ISSN:: 0006-291X
Subject:: adipose tissue; exosomes; heat stress; hospitals; inflammation; luciferase; obesity; quantitative polymerase chain reaction; rats; research; therapeutics; transcription factor NF-kappa B
Abstract:: ... miR-495 and miR-142–3p suppress inflammatory response. Circ_0075932 is overexpressed in the burned skin of obese individuals and is involved in the regulation of PUM2 and AuroraA kinase, thus activating the NF-kB pathway. Obesity significantly influences the length of hospital stay for paediatric burn patients, who present symptoms of slower healing or greater functional impairment. In this study, ...
DOI:: 10.1016/j.bbrc.2022.03.145
: https://doi.org/10.1016/j.bbrc.2022.03.145

11. Astrocytes increase exosomal secretion of oligodendrocyte precursor cells to promote their proliferation via integrin β4-mediated cell adhesion

Author:: Wenjin Zhang; Xiaoyan Zhang; Lei Zhang; Dan Xu; NanNan Cheng; Yong Tang; Yan Peng
Source:: Biochemical and biophysical research communications 2020 v.526 no.2 pp. 341-348
ISSN:: 0006-291X
Subject:: astrocytes; cell adhesion; central nervous system; direct contact; exosomes; gene ontology; integrins; interphase; myelination; oligodendroglia; research; secretion
Abstract:: ... Many degenerative diseases of the central nervous system (CNS) are associated with demyelination. Oligodendrocyte precursor cells (OPCs) are potential stem cells that can differentiate into oligodendrocytes (OLs) and promote myelination. Promoting the proliferation of OPCs is key to stimulating remyelination and treating neurodegenerative diseases. Herein, we report that astrocytes (ASTs) could in ...
DOI:: 10.1016/j.bbrc.2020.03.092
: https://doi.org/10.1016/j.bbrc.2020.03.092

12. Differential expression and sorting of exosomal microRNAs upon activation of the human monocyte-like cell line U937

Author:: Song-Yi Choi; Su-Hyung Hong; Heon-Jin Lee
Source:: Biochemical and biophysical research communications 2022 v.610 pp. 147-153
ISSN:: 0006-291X
Subject:: cell communication; eukaryotic cells; exosomes; gene expression regulation; humans; macrophages; mass spectrometry; microRNA; research
Abstract:: ... Extracellular vesicles such as exosomes in eukaryotes have drawn scrutiny due to their various roles in intercellular communication. Small RNAs, including microRNAs (miRNAs), are more abundant among the cargo of exosomes than other RNA types. MiRNAs loaded in secreted exosomes (or extracellular microRNAs) can be transported to recipient cells and may play a regulatory role although the miRNA loadi ...
DOI:: 10.1016/j.bbrc.2022.04.048
: https://doi.org/10.1016/j.bbrc.2022.04.048

13. Disruption of Core 1-mediated O-glycosylation oppositely regulates CD44 expression in human colon cancer cells and tumor-derived exosomes

Author:: Tianbo Gao; Tao Wen; Yang Ge; Jian Liu; Lei Yang; Yuliang Jiang; Xichen Dong; Heshu Liu; Jiannan Yao; Guangyu An
Source:: Biochemical and biophysical research communications 2020 v.521 no.2 pp. 514-520
ISSN:: 0006-291X
Subject:: antibodies; biomarkers; cell culture; colorectal neoplasms; exosomes; flow cytometry; gastrointestinal neoplasms; glycoproteins; glycosylation; humans; magnetism; neoplasm cells; research; secretion; therapeutics; transmission electron microscopy
Abstract:: ... Aberrant O-glycosylation truncates O-glycans and is known to be closely associated with colorectal cancer (CRC), a major gastrointestinal tumor. CD44 is one of the highly post-transcriptionally modified O-glycoproteins participating in a series of physiological and pathobiological processes. In this research, we aimed to investigate whether CD44 expression in cells and exosomes can be influenced b ...
DOI:: 10.1016/j.bbrc.2019.10.149
: https://doi.org/10.1016/j.bbrc.2019.10.149

14. Exosomal encapsulation of miR-125a-5p inhibited trophoblast cell migration and proliferation by regulating the expression of VEGFA in preeclampsia

Author:: Zhao Xueya; Li Yamei; Chen Sha; Chen Dan; Shen Hong; Yang Xingyu; Cheng Weiwei
Source:: Biochemical and biophysical research communications 2020 v.525 no.3 pp. 646-653
ISSN:: 0006-291X
Subject:: Western blotting; angiogenesis; blood; cell movement; cell proliferation; encapsulation; exosomes; flow cytometry; genes; humans; microRNA; pre-eclampsia; quantitative polymerase chain reaction; research; trophoblast; umbilical cord; vascular endothelial growth factor A
Abstract:: ... This study is aimed to examine the association between umbilical cord blood (UCB) derived exosomal microRNA (miRNA) with preeclampsia (PE) and to further explore the mechanism of a key differential gene (hsa-miR-125a-5p) in preeclampsia. Umbilical cord blood exosomal miRNA(exo-miRNA) from normal pregnant women and pregnant women with preeclampsia was processed via miRNA sequencing. Quantitative re ...
DOI:: 10.1016/j.bbrc.2020.02.137
: https://doi.org/10.1016/j.bbrc.2020.02.137

15. Exploring the potential of engineered exosomes as delivery systems for tumor-suppressor microRNA replacement therapy in ovarian cancer

Author:: Masaki Kobayashi; Kenjiro Sawada; Mayuko Miyamoto; Aasa Shimizu; Misa Yamamoto; Yasuto Kinose; Koji Nakamura; Mahiru Kawano; Michiko Kodama; Kae Hashimoto; Tadashi Kimura
Source:: Biochemical and biophysical research communications 2020 v.527 no.1 pp. 153-161
ISSN:: 0006-291X
Subject:: cancer therapy; cell proliferation; drug delivery systems; electroporation; exosomes; fibroblasts; microRNA; ovarian neoplasms; phosphorylation; research; xenotransplantation
Abstract:: ... MicroRNA (miRNA) plays a pivotal role in cancer biology. Therefore, tumor suppressor (TS) miRNAs are an attractive target for cancer therapy. However, clinical trials have failed due to the difficulties in miRNA delivery, warranting the development of a novel drug delivery system (DDS). Exosomes are stable in circulation and selectively picked up by cancer cells, indicating that they can serve as ...
DOI:: 10.1016/j.bbrc.2020.04.076
: https://doi.org/10.1016/j.bbrc.2020.04.076

16. Lipid membrane anchoring and highly specific fluorescence detection of cancer-derived exosomes based on postfunctionalized zirconium-metal-organic frameworks

Author:: Xuemei Wang; Yanzi Wu; Jingwen Shan; Wang Pan; Shuyun Pang; Yanan Chu; Xueping Ma; Bingjie Zou; Yujiao Li; Haiping Wu; Guohua Zhou
Source:: Biochemical and biophysical research communications 2022 v.609 pp. 69-74
ISSN:: 0006-291X
Subject:: adsorbents; biomarkers; breast neoplasms; cancer therapy; early diagnosis; exosomes; fluorescence; fluorescent dyes; lipids; magnetism; metastasis; neoplasm cells; research
Abstract:: ... Cancer-derived exosomes carry a variety of important biomarkers specific to the formation, invasion and metastasis of tumor tissue. Dynamic monitoring of exosomes originated from cancer cells has clinical significance. Here we proposed a novel method to employ zirconium-metal-organic frameworks (Zr-MOFs) for extracting and identifying exosomes from blood. At first UiO-66 was magnetically modified ...
DOI:: 10.1016/j.bbrc.2022.03.154
: https://doi.org/10.1016/j.bbrc.2022.03.154

17. Mechanical stress promotes angiogenesis through fibroblast exosomes

Author:: Fei Xie; Guannan Wen; Weidong Sun; Kewei Jiang; Ting Chen; Si Chen; Jianmin Wen
Source:: Biochemical and biophysical research communications 2020 v.533 no.3 pp. 346-353
ISSN:: 0006-291X
Subject:: angiogenesis; cell proliferation; cell viability; exosomes; fibroblasts; humans; mechanical stress; microRNA; research; secretion
Abstract:: ... Mechanical stress can induce multiple functional changes in vascular endothelial cells, including proliferation, differentiation, and migration. Furthermore, human fibroblasts are susceptible to external mechanical stress. In this work, we investigated whether mechanical stress can induce exosome secretion from fibroblasts to modulate angiogenesis.A CCK-8 cell proliferation assay was used to deter ...
DOI:: 10.1016/j.bbrc.2020.04.159
: https://doi.org/10.1016/j.bbrc.2020.04.159

18. Mesenchymal stem cells-derived exosomes prevent sepsis-induced myocardial injury by a CircRTN4/miR-497-5p/MG53 pathway

Author:: Jiang Li; Rui Jiang; Yuanyuan Hou; Aiqin Lin
Source:: Biochemical and biophysical research communications 2022 v.618 pp. 133-140
ISSN:: 0006-291X
Subject:: apoptosis; cardiomyocytes; cecum; cell viability; circular RNA; exosomes; fish; interleukin-6; oxidative stress; research; therapeutics
Abstract:: ... Sepsis is a life-threatening organ function dysfunction featured by stimulated oxidative stress and inflammatory responses, in which about 40%–60% of sepsis patients are accompanied with cardiac dysfunction. Mesenchymal stem cells (MSCs)-derived exosomes exert critical roles in the treatment of multiple diseases through transferring non-coding RNAs. Circular RNA (circRNA) is a novel form of functi ...
DOI:: 10.1016/j.bbrc.2022.05.094
: https://doi.org/10.1016/j.bbrc.2022.05.094

19. Neuroprotective effect of exosomes derived from bone marrow mesenchymal stem cells via activating TGR5 and suppressing apoptosis

Author:: Zhiqiang Liu; Xing Li; Zhongxing Ye; Hai Lin
Source:: Biochemical and biophysical research communications 2022 v.593 pp. 13-19
ISSN:: 0006-291X
Subject:: apoptosis; bone marrow; cell cycle; exosomes; glucose; immunohistochemistry; infarction; mortality; neuroprotective effect; oxygen; rats; research; therapeutics
Abstract:: ... Cerebral infarction has become one of the most common neurovascular diseases, and it leads to a high disability and death rate. The exosomes derived from bone marrow mesenchymal stem cells (BM-MSCs-exo) have been viewed as a potential therapeutic method for some diseases. However, the role of BM-MSCs-exo in cerebral infarction remains unclear. Middle cerebral artery occlusion (MCAO) rat and oxygen ...
DOI:: 10.1016/j.bbrc.2022.01.039
: https://doi.org/10.1016/j.bbrc.2022.01.039

20. Oil Red O based method for exosome labelling and detection

Author:: Shikha Bharati; Km Anjaly; Shivani Thoidingjam; Ashu Bhan Tiku
Source:: Biochemical and biophysical research communications 2022 v.611 pp. 179-182
ISSN:: 0006-291X
Subject:: color; cost effectiveness; dyes; exosomes; lipids; lipophilicity; micelles; therapeutics
Abstract:: ... With the realization of the role of exosomes in diseases, especially cancer, exosome research is gaining popularity in biomedical sciences. To understand exosome biology, their labelling and tracking studies are important. New and improved methods of exosome labelling for detection and tracking of exosomes need to be developed to harness their therapeutic and diagnostic potential. In this paper, w ...
DOI:: 10.1016/j.bbrc.2022.04.087
: https://doi.org/10.1016/j.bbrc.2022.04.087

21. A role for DIS3L2 over natural nonsense-mediated mRNA decay targets in human cells

Author:: Paulo J. da Costa; Juliane Menezes; Margarida Saramago; Juan F. García-Moreno; Hugo A. Santos; Margarida Gama-Carvalho; Cecília M. Arraiano; Sandra C. Viegas; Luísa Romão
Source:: Biochemical and biophysical research communications 2019 v.518 no.4 pp. 664-671
ISSN:: 0006-291X
Subject:: exosomes; humans; protein subunits; research; transferases; yeasts
Abstract:: ... The nonsense-mediated decay (NMD) pathway selectively degrades mRNAs carrying a premature translation-termination codon but also regulates the abundance of a large number of physiological mRNAs that encode full-length proteins. In human cells, NMD-targeted mRNAs are degraded by endonucleolytic cleavage and exonucleolytic degradation from both 5-’ and 3′-ends. This is done by a process not yet comp ...
DOI:: 10.1016/j.bbrc.2019.08.105
: https://doi.org/10.1016/j.bbrc.2019.08.105

22. Circ_0075932 in adipocyte-derived exosomes induces inflammation and apoptosis in human dermal keratinocytes by directly binding with PUM2 and promoting PUM2-mediated activation of AuroraA/NF-κB pathway

Author:: Xi Zhang; Lin Chen; Bo Xiao; Hengxin Liu; Yingjun Su
Source:: Biochemical and biophysical research communications 2019 v.511 no.3 pp. 551-558
ISSN:: 0006-291X
Subject:: RNA-binding proteins; adipocytes; adipose tissue; apoptosis; circular RNA; exons; exosomes; gene overexpression; humans; inflammation; keratinocytes; non-specific serine/threonine protein kinase; tissue repair; transcription factor NF-kappa B
Abstract:: ... It remains unclear why obese persons displayed a slower wound healing rate than the normal. In this study, we found that has_circ_0075932, a single-exon circular RNA, was outstandingly expressed in human normal adipose tissue and overexpressed in burned skin of obese persons compared with that of non-obese persons. Circ_0075932 overexpression or silencing in dermal keratinocytes had no obvious eff ...
DOI:: 10.1016/j.bbrc.2019.02.082
: https://doi.org/10.1016/j.bbrc.2019.02.082

23. Development of a DELFIA method to detect oncofetal antigen ROR1-positive exosomes

Author:: Hina Daikuzono; Masaya Yamazaki; Yoshifumi Sato; Takashi Takahashi; Kazuya Yamagata
Source:: Biochemical and biophysical research communications 2021 v.578 pp. 170-176
ISSN:: 0006-291X
Subject:: Western blotting; adults; antigens; blood serum; diagnostic techniques; europium; exosomes; fluorescence; fluorescent antibody technique; research; tyrosine
Abstract:: ... Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is highly expressed in a wide variety of hematological and solid cancers, but is low or absent in adult tissues. Here, we show that ROR1 is released with exosomes from ROR1-positive cancer cells. We also developed a simple dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) to detect cancer-derived ROR1-positive exosomes, which ...
DOI:: 10.1016/j.bbrc.2021.08.054
: https://doi.org/10.1016/j.bbrc.2021.08.054

24. Evidences against vesicle-dependent trafficking and involvement of extracellular proteasomes into cell-to-cell communications

Author:: Egor E. Diakonov; Anastasiia V. Selenina; Alexey N. Tomilin; Anna S. Tsimokha
Source:: Biochemical and biophysical research communications 2019 v.508 no.2 pp. 368-373
ISSN:: 0006-291X
Subject:: cell communication; exosomes; human cell lines; human diseases; humans; patients; proteasome endopeptidase complex; proteolysis; ubiquitin
Abstract:: ... The ubiquitin proteasome system is involved in the regulation of most basic intracellular processes, and deregulation of this system can results in certain kinds of human diseases. Proteolytic core this system, the 20S proteasome, has been found in physiological fluids of both healthy humans and patients suffering from a variety of inflammatory, autoimmune, and neoplastic diseases. The concentrati ...
DOI:: 10.1016/j.bbrc.2018.11.152
: https://doi.org/10.1016/j.bbrc.2018.11.152

25. Exosomal long non-coding RNA LIPCAR derived from oxLDL-treated THP-1 cells regulates the proliferation of human umbilical vein endothelial cells and human vascular smooth muscle cells

Author:: Nan Hu; Xixi Zeng; Feifei Tang; Sizheng Xiong
Source:: Biochemical and biophysical research communications 2021 v.575 pp. 65-72
ISSN:: 0006-291X
Subject:: apoptosis; atherosclerosis; biomarkers; cyclin-dependent kinase; exosomes; foam cells; humans; low density lipoprotein; non-coding RNA; oxidation; proliferating cell nuclear antigen; research; smooth muscle
Abstract:: ... It has been reported that long non-coding RNA (lncRNA) LIPCAR is involved in the progression of atherosclerosis. However, the mechanism underlying the effects of LIPCAR on regulating the occurrence and development of atherosclerosis remains unclear.Reverse transcription-quantitative PCR was performed to detect the levels of LIPCAR in the plasma of patients with atherosclerosis and in THP-1 macroph ...
DOI:: 10.1016/j.bbrc.2021.08.053
: https://doi.org/10.1016/j.bbrc.2021.08.053

26. Exosomal miR-301 derived from mesenchymal stem cells protects myocardial infarction by inhibiting myocardial autophagy

Author:: Yong Li; Rong Yang; Bingyan Guo; Hongbo Zhang; Hui Zhang; Suyun Liu; Yongjun Li
Source:: Biochemical and biophysical research communications 2019 v.514 no.1 pp. 323-328
ISSN:: 0006-291X
Subject:: Western blotting; autophagy; cardiac output; echocardiography; exosomes; flow cytometry; mesenchymal stromal cells; messenger RNA; models; myocardial infarction; protective effect; proteins; quantitative polymerase chain reaction; rats; reverse transcriptase polymerase chain reaction; staining
Abstract:: ... To investigate the protective effects of miR-301 in exosomes secreted by bone mesenchymal stem cells (BMSCs) on rats' myocardial infarction (MI).After isolation and culture, BMSCs were identified using flow cytometry. Then exosomes were then isolated. Rats MI models were established and they were divided into 4 groups: Sham group, Model group (injected with PBS), BMSC-Exos group (injected with exo ...
DOI:: 10.1016/j.bbrc.2019.04.138
: https://doi.org/10.1016/j.bbrc.2019.04.138

27. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acute liver failure by reducing the activity of the NLRP3 inflammasome in macrophages

Author:: Linrui Jiang; Shuqin Zhang; Huazhong Hu; Jing Yang; XiaoYan Wang; Yanyan Ma; JiaoHua Jiang; JinHong Wang; Lin Zhong; Ming Chen; Hong Wang; Yu Hou; RuiRui Zhu; Qun Zhang
Source:: Biochemical and biophysical research communications 2019 v.508 no.3 pp. 735-741
ISSN:: 0006-291X
Subject:: Western blotting; alanine transaminase; aspartate transaminase; caspase-1; enzyme-linked immunosorbent assay; exosomes; humans; inflammasomes; inflammation; interleukin-1beta; interleukin-6; liver; liver failure; macrophages; mesenchymal stromal cells; mice; models; umbilical cord
Abstract:: ... Human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-EXOs) play an important role in the regulation of the immune system and inflammatory responses; however, their role in acute liver failure (ALF) and related pathological conditions is unclear. In this study, we found that hUCMSC-EXOs can reduce the expression of the NLRP3 inflammasome and downstream inflammatory factors in acute l ...
DOI:: 10.1016/j.bbrc.2018.11.189
: https://doi.org/10.1016/j.bbrc.2018.11.189

28. Exosomes derived from miR-16-5p-overexpressing keratinocytes attenuates bleomycin-induced skin fibrosis

Author:: Yunyao Bo; Baiting Liu; Lijun Yang; Lin Zhang; Yuan Yan
Source:: Biochemical and biophysical research communications 2021 v.561 pp. 113-119
ISSN:: 0006-291X
Subject:: exosomes; fibroblasts; fibrosis; keratinocytes; microRNA; research; therapeutics
Abstract:: ... microRNAs have been shown to be associated with the development of skin fibrosis. Therefore, miRNA modulators play an important role in the management of cutaneous fibrotic diseases and are worthy of investigation. However, a major obstacle of miRNAs therapy is to deliver miRNAs to target cell types, tissues or organs. The study reported here investigated the effects of miR-16-5p delivery by kerat ...
DOI:: 10.1016/j.bbrc.2021.05.046
: https://doi.org/10.1016/j.bbrc.2021.05.046

29. Exosomes derived from tendon stem cells promote cell proliferation and migration through the TGF β signal pathway

Author:: Mingda Li; Jie Jia; Shanshan Li; Baocheng Cui; Jiao Huang; Zhaoming Guo; Kun Ma; Li Wang; Changhao Cui
Source:: Biochemical and biophysical research communications 2021 v.536 pp. 88-94
ISSN:: 0006-291X
Subject:: cell proliferation; exosomes; research; signal transduction
Abstract:: ... Tendon stem cells (TSCs) are a kind of progenitor cells found in tendon niches, which play a key role in the repair of tendon injuries. Exosomes that mediate cell communication are involved in physiological processes and various diseases, while the effect of exosomes derived from TSCs (TSC-exo) on TSCs is still unclear. The purpose of this study is to explore the effect of TSC-exo on TSCs. Analyzi ...
DOI:: 10.1016/j.bbrc.2020.12.057
: https://doi.org/10.1016/j.bbrc.2020.12.057

30. Extracellular αB-crystallin modulates the inflammatory responses

Author:: Yong-shun Guo; Pei-zhou Liang; Shen-zhao Lu; Rong Chen; Yan-qing Yin; Jia-wei Zhou
Source:: Biochemical and biophysical research communications 2019 v.508 no.1 pp. 282-288
ISSN:: 0006-291X
Subject:: astrocytes; autocrine signaling; cell lines; exosomes; heat shock proteins; inflammation; mice; neurodegenerative diseases; sclerosis
Abstract:: ... Neuroinflammation is considered a challenging clinical problem. Chronic inflammatory responses play important roles in the onset and progression of various neurodegenerative diseases, including multiple sclerosis (MS). Previous studies have shown that astrocytes express small heat shock protein αB-crystallin (CRYAB) which is capable of inhibiting inflammatory responses in astrocytes per se. Howeve ...
DOI:: 10.1016/j.bbrc.2018.11.024
: https://doi.org/10.1016/j.bbrc.2018.11.024

31. Gastric cancer derived exosomes mediate the delivery of circRNA to promote angiogenesis by targeting miR-29a/VEGF axis in endothelial cells

Author:: Shuang Li; Jialu Li; Haiyang Zhang; Yan Zhang; Xinyi Wang; Haiou Yang; Zhengyang Zhou; Xishan Hao; Guoguang Ying; Yi Ba
Source:: Biochemical and biophysical research communications 2021 v.560 pp. 37-44
ISSN:: 0006-291X
Subject:: angiogenesis; circular RNA; exosomes; gene expression; research; stomach neoplasms
Abstract:: ... Accumulating evidence has been found that circular RNA (circRNA) plays a critical role in the initiation and development of various diseases by modulating gene expression in the cytoplasm. However, the role of circ_0044366 (termed circ29) in gastric cancer (GC) has yet to be elusive. We detected that exosomal circ29 was confirmed to be highly expressed in GC and can significantly impair the prolif ...
DOI:: 10.1016/j.bbrc.2021.04.099
: https://doi.org/10.1016/j.bbrc.2021.04.099

32. Identification of myosin II as a cripto binding protein and regulator of cripto function in stem cells and tissue regeneration

Author:: Malachia Hoover; Farhana Runa; Evan Booker; Jolene K. Diedrich; Erika Duell; Blake Williams; Caroline Arellano-Garcia; Toni Uhlendorf; Sa La Kim; Wolfgang Fischer; James Moresco; Peter C. Gray; Jonathan A. Kelber
Source:: Biochemical and biophysical research communications 2019 v.509 no.1 pp. 69-75
ISSN:: 0006-291X
Subject:: Danio rerio; agonists; antagonists; binding proteins; cultured cells; exosomes; mesenchymal stromal cells; microfilaments; mitogen-activated protein kinase; models; myosin; stem cells; stress response; therapeutics; tissue repair; transforming growth factor beta
Abstract:: ... Cripto regulates stem cell function in normal and disease contexts via TGFbeta/activin/nodal, PI3K/Akt, MAPK and Wnt signaling. Still, the molecular mechanisms that govern these pleiotropic functions of Cripto remain poorly understood. We performed an unbiased screen for novel Cripto binding proteins using proteomics-based methods, and identified novel proteins including members of myosin II compl ...
DOI:: 10.1016/j.bbrc.2018.12.059
PubMed:: 30579599
PubMed Central:: PMC6855394
: https://doi.org/10.1016/j.bbrc.2018.12.059

33. Modification of exosomes with carbonate apatite and a glycan polymer improves transduction efficiency and target cell selectivity

Author:: Yuki Matsuki; Takayo Yanagawa; Hideaki Sumiyoshi; Jumpei Yasuda; Sachie Nakao; Mitsuaki Goto; Teiko Shibata-Seki; Toshihiro Akaike; Yutaka Inagaki
Source:: Biochemical and biophysical research communications 2021 v.583 pp. 93-99
ISSN:: 0006-291X
Subject:: apatite; carbonates; cytosol; cytotoxicity; drugs; exosomes; green fluorescent protein; hepatocytes; immunogenicity; luciferase; polymers; research
Abstract:: ... Exosomes are secreted from a variety of cells and transmit parental cell-derived biomolecules, such as nucleic acids and proteins, to recipient cells in distant organs. In addition to their important roles in both physiological and pathological conditions, exosomes are expected to serve as natural drug carriers without any cytotoxicity, immunogenicity, or tumorigenicity. However, the use of exosom ...
DOI:: 10.1016/j.bbrc.2021.10.063
: https://doi.org/10.1016/j.bbrc.2021.10.063

34. Primed mesenchymal stem cells package exosomes with metabolites associated with immunomodulation

Author:: Megan R. Showalter; Benjamin Wancewicz; Oliver Fiehn; Joehleen A. Archard; Shannon Clayton; Joseph Wagner; Peter Deng; Julian Halmai; Kyle D. Fink; Gerhard Bauer; Brian Fury; Nicholas H. Perotti; Michelle Apperson; Janelle Butters; Peter Belafsky; Gregory Farwell; Maggie Kuhn; Jan A. Nolta; Johnathon D. Anderson
Source:: Biochemical and biophysical research communications 2019 v.512 no.4 pp. 729-735
ISSN:: 0006-291X
Subject:: RNA; T-lymphocytes; cell communication; clinical trials; exosomes; glycolysis; humans; immunomodulation; macrophages; medicinal properties; mesenchymal stromal cells; metabolites; metabolomics; proteins; secretion; therapeutics
Abstract:: ... Mesenchymal stem cell (MSC) based therapies are currently being evaluated as a putative therapeutic in numerous human clinical trials. Recent reports have established that exosomes mediate much of the therapeutic properties of MSCs. Exosomes are nanovesicles which mediate intercellular communication, transmitting signals between cells which regulate a diverse range of biological processes. MSC-der ...
DOI:: 10.1016/j.bbrc.2019.03.119
PubMed:: 30926165
PubMed Central:: PMC6682414
: https://doi.org/10.1016/j.bbrc.2019.03.119

35. Talin-2 regulates integrin functions in exosomes

Author:: Zay Yar Soe; Onmanee Prajuabjinda; Phyoe Kyawe Myint; Arong Gaowa; Eiji Kawamoto; Eun Jeong Park; Motomu Shimaoka
Source:: Biochemical and biophysical research communications 2019 v.512 no.3 pp. 429-434
ISSN:: 0006-291X
Subject:: T-lymphocytes; cell adhesion; endothelial cells; exosomes; integrins; intercellular adhesion molecule-1; ligands; talin
Abstract:: ... Integrins on exosomes have been shown to mediate binding to recipient cells, potentially playing important roles in controlling exosomal internalization and organ distributions. Although the ability of cellular integrins to mediate cell adhesion is known to be regulated by the cytoplasmic adaptor protein talin, whether the activity of exosomal integrins is similarly regulated by talin remains to b ...
DOI:: 10.1016/j.bbrc.2019.03.027
: https://doi.org/10.1016/j.bbrc.2019.03.027

36. miRNAomics analysis reveals the promoting effects of cigarette smoke extract-treated Beas-2B-derived exosomes on macrophage polarization

Author:: Zhen Chen; Hao Wu; Rui Shi; Weiyang Fan; Jiashuo Zhang; Weiwei Su; Yonggang Wang; Peibo Li
Source:: Biochemical and biophysical research communications 2021 v.572 pp. 157-163
ISSN:: 0006-291X
Subject:: breathing; cigarettes; epithelium; exosomes; homeostasis; inflammation; interleukin-10; interleukin-6; lungs; macrophages; microRNA; prediction; research; secretion; smoke; therapeutics
Abstract:: ... Inhalation of cigarette smoke induces airway and parenchyma inflammation that predisposes smokers to multiple lung diseases such as COPD. Macrophage polarization, an important specifying feature of inflammation, is involved in the progression of pulmonary inflammation. Exosomes and their loaded miRNAs provide a medium for cross-talk between alveolar macrophages and lung epithelial cells to maintai ...
DOI:: 10.1016/j.bbrc.2021.07.093
: https://doi.org/10.1016/j.bbrc.2021.07.093

37. Brown adipocyte-derived exosomal miR-132-3p suppress hepatic Srebf1 expression and thereby attenuate expression of lipogenic genes

Author:: Yuichi Kariba; Tatsuya Yoshizawa; Yoshifumi Sato; Tomonori Tsuyama; Eiichi Araki; Kazuya Yamagata
Source:: Biochemical and biophysical research communications 2020 v.530 no.3 pp. 500-507
ISSN:: 0006-291X
Subject:: brown adipocytes; brown adipose tissue; coculture; cold; cold stress; exosomes; gene expression; lipogenesis; liver; microRNA; neurons; neurotransmitters; norepinephrine; research; sympathetic nervous system
Abstract:: ... Recent evidence has revealed a novel signaling mechanism through which brown adipose tissue (BAT)-derived exosomal microRNAs (miRNAs) influence hepatic gene expression. Here, we uncover neuronal control of these miRNAs and identify exosomal miR-132-3p as a regulator of hepatic lipogenesis under cold stress conditions. Norepinephrine, a sympathetic nervous system neurotransmitter mediating cold-ind ...
DOI:: 10.1016/j.bbrc.2020.05.090
: https://doi.org/10.1016/j.bbrc.2020.05.090

38. Deoxycholic acid-stimulated macrophage-derived exosomes promote spasmolytic polypeptide-expressing metaplasia in the stomach

Author:: Xianjun Xu; Jinnian Cheng; Shengzheng Luo; Xiaoyuan Gong; Dan Huang; Jingxian Xu; Yueqin Qian; Xinjian Wan; Hui Zhou
Source:: Biochemical and biophysical research communications 2020 v.524 no.3 pp. 649-655
ISSN:: 0006-291X
Subject:: bile; coculture; deoxycholic acid; exosomes; fluorescent antibody technique; inflammation; intestines; intragastric administration; lectins; macrophages; metaplasia; organoids; parasympatholytics; quantitative polymerase chain reaction; research; risk factors; stomach; stomach neoplasms; ultracentrifugation
Abstract:: ... Spasmolytic polypeptide-expressing metaplasia (SPEM) is an important risk factor for the occurrence of gastric cancer. It may be driven by a chronic inflammatory environment in which macrophage is involved. Studies have shown that intestinal metaplasia may originate from SPEM, and bile acid-induced chronic inflammation plays an important role in the process of intestinal metaplasia. However, wheth ...
DOI:: 10.1016/j.bbrc.2020.01.159
: https://doi.org/10.1016/j.bbrc.2020.01.159

39. Disrupted blood-brain barrier in 5×FAD mouse model of Alzheimer’s disease can be mimicked and repaired in vitro with neural stem cell-derived exosomes

Author:: Yanying Liu; Christa C. Huber; Hongmin Wang
Source:: Biochemical and biophysical research communications 2020 v.525 no.1 pp. 192-196
ISSN:: 0006-291X
Subject:: blood-brain barrier; cell culture; exosomes; humans; mice; neurodegenerative diseases; pathogenesis; research; therapeutics
Abstract:: ... Alzheimer’s disease (AD) is a devastating neurodegenerative disease and is associated with blood-brain barrier (BBB) disruption. AD mice and cell culture models play an essential role in understanding AD pathogenesis and validation of therapeutic reagents. One of the commonly used AD mice is the 5 × FAD mouse and previous studies have shown that BBB leakage occurs at 9 months of age in the mice. H ...
DOI:: 10.1016/j.bbrc.2020.02.074
: https://doi.org/10.1016/j.bbrc.2020.02.074

40. Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish

Author:: Hiroyuki Yatsuka; Kazumasa Hada; Hiroshi Shiraishi; Ryohei Umeda; Ikuko Morisaki; Hirotaro Urushibata; Nobuyuki Shimizu; Wulan Apridita Sebastian; Takatoshi Hikida; Tohru Ishitani; Reiko Hanada; Tatsuo Shimada; Kenichi Kimoto; Toshiaki Kubota; Toshikatsu Hanada
Source:: Biochemical and biophysical research communications 2020 v.533 no.4 pp. 1470-1476
ISSN:: 0006-291X
Subject:: Danio rerio; amyotrophic lateral sclerosis; death; exosomes; larvae; muscular atrophy; mutation; myelin sheath; pathogenesis; rapamycin; research; retinitis pigmentosa
Abstract:: ... Exosc2 is one of the components of the exosome complex involved in RNA 3′ end processing and degradation of various RNAs. Recently, EXOSC2 mutation has been reported in German families presenting short stature, hearing loss, retinitis pigmentosa, and premature aging. However, the in vivo function of EXOSC2 has been elusive. Herein, we generated Exosc2 knockout (exosc2⁻/⁻) zebrafish that showed lar ...
DOI:: 10.1016/j.bbrc.2020.10.044
: https://doi.org/10.1016/j.bbrc.2020.10.044

41. Exosomal miR-675 from metastatic osteosarcoma promotes cell migration and invasion by targeting CALN1

Author:: Liangzhi Gong; Qiyuan Bao; Chuanzhen Hu; Jun Wang; Qi Zhou; Li Wei; Lei Tong; Weibin Zhang; Yuhui Shen
Source:: Biochemical and biophysical research communications 2018 v.500 no.2 pp. 170-176
ISSN:: 0006-291X
Subject:: biomarkers; blood serum; cell culture; cell lines; cell movement; culture media; epithelium; exosomes; fibroblasts; gene expression regulation; genes; metastasis; microRNA; osteosarcoma; patients; phenotype; reverse transcriptase polymerase chain reaction; stromal cells
Abstract:: ... Exosomal microRNAs(miRNAs) transfer from tumor to stromal cells is reportedly associated with cancer progression and metastasis in various epithelial cancers. However, the role of exosomal miRNA in the metastasis of osteosarcoma(OS) -the most common bone malignancy-still largely remains unknown. In this study, we purified exosomes with a median size close to 100 nm from cell culture media as well ...
DOI:: 10.1016/j.bbrc.2018.04.016
: https://doi.org/10.1016/j.bbrc.2018.04.016

42. Exosomal proteome analysis of human plasma to monitor sepsis progression

Author:: Yan Xu; Xin Ku; Chunrong Wu; Chunlin Cai; Jianguo Tang; Wei Yan
Source:: Biochemical and biophysical research communications 2018 v.499 no.4 pp. 856-861
ISSN:: 0006-291X
Subject:: C-reactive protein; RNA; biomarkers; blood; blood sampling; body temperature; cell communication; clinical trials; correlation; disease course; exosomes; humans; immune response; mass spectrometry; metabolism; patients; proteome; sepsis (infection); sphingolipids; ultracentrifugation
Abstract:: ... Exosomes are cell-derived vesicles containing RNA, lipid, and protein, which act in body immune response, intercellular signaling and some other important biological processes. Exosomes have been extensively studied in the past several years on their disease related mechanisms and potential roles to monitor disease progression as biomarkers. Compared with analyzing exosome RNA, comprehensive prote ...
DOI:: 10.1016/j.bbrc.2018.04.006
: https://doi.org/10.1016/j.bbrc.2018.04.006

43. Exosome-mediated miR-9-5p promotes proliferation and migration of renal cancer cells both in vitro and in vivo by targeting SOCS4

Author:: Wenbin Song; Yule Chen; Guodong Zhu; Hongjun Xie; Zhishang Yang; Lei Li
Source:: Biochemical and biophysical research communications 2020 v.529 no.4 pp. 1216-1224
ISSN:: 0006-291X
Subject:: apoptosis; biomarkers; blood serum; cell lines; cell proliferation; cytokines; exosomes; humans; kidney neoplasms; kidneys; metastasis; microRNA; neoplasm cells; neoplasm progression; non-specific protein-tyrosine kinase; phosphorylation; research; therapeutics; transactivators
Abstract:: ... Exosomes secreted by cancer cells play important roles in tumor progression by interacting with cell receptors. Renal cancer derived exosomes contain miRNAs which are associated with cell proliferation and invasion. Micro RNA 9–5 (miR-9-5) is highly expressed in the serum of renal cancer patients with advanced (tumor size - node - metastasis) TNM stage and Fuhrman grade. miR-9-5p is extensively ex ...
DOI:: 10.1016/j.bbrc.2020.06.114
: https://doi.org/10.1016/j.bbrc.2020.06.114

44. Exosomes derived from breast cancer lung metastasis subpopulations promote tumor self-seeding

Author:: Hehai Huang; Xianchong Zheng; Changqing Cai; Zhuocheng Yao; Sitong Lu; Xiaojing Meng; Yutian Miao; Zhanxin He; Chunqing Cai; Fei Zou
Source:: Biochemical and biophysical research communications 2018 v.503 no.1 pp. 242-248
ISSN:: 0006-291X
Subject:: animal models; breast neoplasms; carcinoma; exosomes; flow cytometry; lungs; metastasis; neoplasm cells; patients; sowing
Abstract:: ... Lung metastasis is a primary obstacle in the clinical treatment of metastatic breast cancer. Most patients with lung metastasis eventually die of recurrence. Recurrence may be related to self-seeding, which occurs when circulating tumor cells re-seed into the tumors they originated from (metastasis or carcinoma in situ). Tumor-derived exosomes have been intensively revealed to promote the progress ...
DOI:: 10.1016/j.bbrc.2018.06.009
: https://doi.org/10.1016/j.bbrc.2018.06.009

45. Exosomes derived from human umbilical vein endothelial cells promote neural stem cell expansion while maintain their stemness in culture

Author:: Yi-Zhe Zhang; Fan Liu; Chang-Geng Song; Xiu-Li Cao; Yu-Fei Zhang; Hai-Ning Wu; Chen-Jun Guo; Yong-Qiang Li; Qi-Jun Zheng; Min-Hua Zheng; Hua Han
Source:: Biochemical and biophysical research communications 2018 v.495 no.1 pp. 892-898
ISSN:: 0006-291X
Subject:: adults; apoptosis; brain; cell communication; coculture; exosomes; gene expression regulation; genes; human umbilical vein endothelial cells; mice; stem cells
Abstract:: ... The neural stem cell (NSC) niche in subventricular zone (SVZ) of adult mammalian brain contains dense vascular plexus, where endothelial cells (ECs) regulate NSCs by releasing plenty of angiocrine factors. However, the role of ECs-derived exosomes, a novel type of mediators of intercellular communications, in the regulation of NSCs remains unclear. In the current study, primary NSCs isolated from ...
DOI:: 10.1016/j.bbrc.2017.11.092
: https://doi.org/10.1016/j.bbrc.2017.11.092

46. Exosomes of oral squamous cell carcinoma cells containing miR-181a-3p induce muscle cell atrophy and apoptosis by transmissible endoplasmic reticulum stress signaling

Author:: Ling Qiu; Wen Chen; Chenzhou Wu; Yihang Yuan; Yi Li
Source:: Biochemical and biophysical research communications 2020 v.533 no.4 pp. 831-837
ISSN:: 0006-291X
Subject:: RNA; apoptosis; cachexia; endoplasmic reticulum stress; exosomes; muscles; muscular atrophy; research; squamous cell carcinoma
Abstract:: ... Muscle atrophy is a major character of cancer cachexia, whose mechanism remains enigmatic. During cancer cachexia, the function of endoplasmic reticulum stress (ERS), which ubiquitously exists in invasive cancer, remains unclear in muscle remodeling. In addition, ERS can be transmitted to surrounding and distant cells, terming transmissible ERS (TERS), by certain soluble factors, which have not be ...
DOI:: 10.1016/j.bbrc.2020.09.066
: https://doi.org/10.1016/j.bbrc.2020.09.066

47. Exosomes secreted by placental stem cells selectively inhibit growth of aggressive prostate cancer cells

Author:: Taylor C. Peak; Prakash P. Praharaj; Gati K. Panigrahi; Michael Doyle; Yixin Su; Isabel R. Schlaepfer; Ravi Singh; Donald J. Vander Griend; Julie Alickson; Ashok Hemal; Anthony Atala; Gagan Deep
Source:: Biochemical and biophysical research communications 2018 v.499 no.4 pp. 1004-1010
ISSN:: 0006-291X
Subject:: antineoplastic activity; drug resistance; exosomes; human cell lines; humans; liver; mass spectrometry; nanoparticles; neoplasm cells; prostatic neoplasms; retinoic acid receptors; saturated fatty acids; stem cells; therapeutics; viability
Abstract:: ... The current paradigm in the development of new cancer therapies is the ability to target tumor cells while avoiding harm to noncancerous cells. Furthermore, there is a need to develop novel therapeutic options against drug-resistant cancer cells. Herein, we characterized the placental-derived stem cell (PLSC) exosomes (PLSCᴱˣᵒ) and evaluated their anti-cancer efficacy in prostate cancer (PCa) cell ...
DOI:: 10.1016/j.bbrc.2018.04.038
PubMed:: 29627574
PubMed Central:: PMC5929996
: https://doi.org/10.1016/j.bbrc.2018.04.038

48. Expression profiles and clinical value of plasma exosomal Tim-3 and Galectin-9 in non-small cell lung cancer

Author:: Jianwei Gao; Xiangyu Qiu; Xinying Li; Hang Fan; Fang Zhang; Tangfeng Lv; Yong Song
Source:: Biochemical and biophysical research communications 2018 v.498 no.3 pp. 409-415
ISSN:: 0006-291X
Subject:: T-lymphocytes; Western blotting; adenocarcinoma; biomarkers; enzyme-linked immunosorbent assay; exosomes; galectins; immune response; immunoglobulins; ligands; lung neoplasms; lungs; lymph nodes; metastasis; mucins; neoplasm cells; patients; protein content; squamous cell carcinoma; transmission electron microscopy; viruses
Abstract:: ... Exosomes are membrane-bound, virus-sized vesicles present in circulating blood. Tumor cells are avid producers of exosomes, which are thought to mimic molecular features of parent tumor cells. T-cell immunoglobulin- and mucin-domain-containing molecule 3 (Tim-3) is a the next-generation immune checkpoint that can be activated by its ligand Galectin-9 to negatively regulate the anti-tumor immune re ...
DOI:: 10.1016/j.bbrc.2018.02.114
: https://doi.org/10.1016/j.bbrc.2018.02.114

49. Human umbilical cord mesenchymal stem cell-derived exosomes act via the miR-1263/Mob1/Hippo signaling pathway to prevent apoptosis in disuse osteoporosis

Author:: Bao-cheng Yang; Ming-jie Kuang; Jia-yu Kang; Jie Zhao; Jian-xiong Ma; Xin-long Ma
Source:: Biochemical and biophysical research communications 2020 v. no. pp. -
ISSN:: 0006-291X
Subject:: apoptosis; bone marrow; exosomes; hindlimbs; humans; luciferase; mesenchymal stromal cells; micro-computed tomography; microRNA; osteoporosis; rats; research; umbilical cord
Abstract:: ... Disuse osteoporosis (DOP) is a common complication resulting from the lack of or disuse of mechanical loading and has been unsatisfactorily treated. We hypothesized that exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSCs) could reduce bone marrow mesenchymal stem cell (BMSC) apoptosis in rat DOP via the miR-1263/Mob1/Hippo signaling pathway.To evaluate the function of exoso ...
DOI:: 10.1016/j.bbrc.2020.02.001
: https://doi.org/10.1016/j.bbrc.2020.02.001

50. Hypoxic glioblastoma release exosomal VEGF-A induce the permeability of blood-brain barrier

Author:: Chen Zhao; Hongyan Wang; Chenghao Xiong; Yu Liu
Source:: Biochemical and biophysical research communications 2018 v.502 pp. 324-331
ISSN:: 0006-291X
Subject:: blood circulation; blood-brain barrier; endothelial cells; exosomes; models; neoplasm cells; occludins; permeability; vascular endothelial growth factor A
Abstract:: ... Exosomes are nano-vesicles released by tumor cells to modulate extracellular environment. Accumulating evidence revealed that glioblastoma derived exosomes contain multiple pro-angiogenic factors to induce the proliferation of endothelial cells. Here, we investigated the role of GBM-derived exosomes in inducing the permeability of the blood-brain barrier. We found that VEGF-A was over-expressed in ...
DOI:: 10.1016/j.bbrc.2018.05.140
: https://doi.org/10.1016/j.bbrc.2018.05.140

51. Intrauterine exosomes are required for bovine conceptus implantation

Author:: Kazuya Kusama; Keigo Nakamura; Rulan Bai; Kentaro Nagaoka; Toshihiro Sakurai; Kazuhiko Imakawa
Source:: Biochemical and biophysical research communications 2018 v.495 no.1 pp. 1370-1375
ISSN:: 0006-291X
Subject:: cattle; conceptus; endometrium; epithelial cells; exosomes; gene expression regulation; genes; pregnancy; protein synthesis; proteins
Abstract:: ... Exosomes, extracellular vesicles, are present in uterine flushing fluids (UFs), which are involved in conceptus-endometrial interactions during peri-implantation periods. Despite several studies on intrauterine exosomes conducted, the roles conceptus and endometrial exosomes play during peri-implantation periods have not been well characterized. To investigate the effect of bovine intrauterine exo ...
DOI:: 10.1016/j.bbrc.2017.11.176
: https://doi.org/10.1016/j.bbrc.2017.11.176

52. K562 cell-derived exosomes suppress the adhesive function of bone marrow mesenchymal stem cells via delivery of miR-711

Author:: Yu-Huan Jiang; Jing Liu; Jin Lin; Shu-Qi Li; Yan-Mei Xu; Qing-Hua Min; Qiong-Hui Zhong; Fan Sun; Jing Li; Xia-Hong You; Kai-Li Liao; Ting-Yu Qin; Cui Zhao; Bo Huang; Xiao-Zhong Wang
Source:: Biochemical and biophysical research communications 2020 v.521 no.3 pp. 584-589
ISSN:: 0006-291X
Subject:: adhesion; bone marrow; coculture; exosomes; leukemia; microRNA; research
Abstract:: ... A failure of bone marrow mesenchymal stem cells (BM-MSCs) to adhere to hematopoietic cells is an essential cause of the progression of chronic myelogenous leukemia and is also a cause of failure of bone marrow (BM) transplantation, but the exact mechanisms of this have not been fully elucidated. Recent studies have indicated that microRNAs (miRNAs) are contained in leukemia-derived exosomes and ar ...
DOI:: 10.1016/j.bbrc.2019.10.096
: https://doi.org/10.1016/j.bbrc.2019.10.096

53. Keratinocytes-derived exosomal miRNA regulates osteoclast differentiation in middle ear cholesteatoma

Author:: NingYue Gong; Weili Zhu; Runtong Xu; Zhenxiao Teng; Chang Deng; He Zhou; Ming Xia; Miaoqing Zhao
Source:: Biochemical and biophysical research communications 2020 v.525 no.2 pp. 341-347
ISSN:: 0006-291X
Subject:: cell communication; coculture; exosomes; fibroblasts; keratinocytes; microRNA; middle ear; osteoclasts; research
Abstract:: ... The occurrence and development of osteoclasts can directly affect the severity of bone destruction in middle ear cholesteatoma. At the same time, cell communication between keratinocytes and fibroblasts can stimulate osteoclast differentiation. However, the molecular mechanism of osteoclast differentiation in cholesteatoma is still poorly understood. In this study, we try to isolate the exosomes o ...
DOI:: 10.1016/j.bbrc.2020.02.058
: https://doi.org/10.1016/j.bbrc.2020.02.058

54. Matrine reduces the secretion of exosomal circSLC7A6 from cancer-associated fibroblast to inhibit tumorigenesis of colorectal cancer by regulating CXCR5

Author:: Chen Gu; Huigang Lu; Zhenghai Qian
Source:: Biochemical and biophysical research communications 2020 v.527 no.3 pp. 638-645
ISSN:: 0006-291X
Subject:: apoptosis; carcinogenesis; cell proliferation; colorectal neoplasms; exosomes; fibroblasts; research; secretion
Abstract:: ... Tumor microenvironment (e.g., stromal cells) has been suggested to be implicated in colorectal cancer (CRC) progression. Of which, cancer-associated fibroblasts (CAFs) are believed as one of the key stromal cells in tumors. Traditionally, matrine was used to treat cancers, including CRC. Unfortunately, little is known about whether matrine inhibited CRC progression via CAFs. In this research, we a ...
DOI:: 10.1016/j.bbrc.2020.04.142
: https://doi.org/10.1016/j.bbrc.2020.04.142

55. Neutrophil-derived exosome from systemic sclerosis inhibits the proliferation and migration of endothelial cells

Author:: Liya Li; Xiaoxia Zuo; Yizhi Xiao; Di Liu; Hui Luo; Honglin Zhu
Source:: Biochemical and biophysical research communications 2020 v.526 no.2 pp. 334-340
ISSN:: 0006-291X
Subject:: angiogenesis; autoimmune diseases; exosomes; fibrosis; humans; inflammation; neutrophils; quantitative polymerase chain reaction; research; sclerosis; transmission electron microscopy
Abstract:: ... Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, inflammation, and extensive fibrosis in multiple organs. Exosomes (EXOs) are cell-derived vesicles contained various DNAs, RNAs and proteins, and play important roles in various diseases. Here, we aimed to investigate the roles of SSc EXOs in angiogenesis related mechanisms.EXOs were isolated from plasma, cultured per ...
DOI:: 10.1016/j.bbrc.2020.03.088
: https://doi.org/10.1016/j.bbrc.2020.03.088

56. RASSF10 regulates bone invasion of growth hormone-secreting adenomas via exosomes

Author:: Tianyu Wang; Haibin Liu; Zhenhua Ji; Yin Cheng; Yucong Du; Huanhai Liu; Jianchun Liao; Hu Peng
Source:: Biochemical and biophysical research communications 2020 v.527 no.3 pp. 603-610
ISSN:: 0006-291X
Subject:: adenoma; apoptosis; calcium; coculture; early diagnosis; exosomes; methylation; osteoclasts; phenotype; research; resection; secretion; sequence analysis
Abstract:: ... Invasion of pituitary growth hormone-secreting adenoma into surrounding tissues poses a challenge for complete resection in surgery, which is the main reason for recurrence of this type of cancer. Studies have shown that abnormal methylation of RASSF10 can promote the expression of MDM2 and regulate the tumor microenvironment by affecting the secretion of exosomes. In the present study, we aim to ...
DOI:: 10.1016/j.bbrc.2020.04.131
: https://doi.org/10.1016/j.bbrc.2020.04.131

57. Regulation of hair follicle development by exosomes derived from dermal papilla cells

Author:: Lijuan Zhou; Han Wang; Jing Jing; Lijuan Yu; Xianjie Wu; Zhongfa Lu
Source:: Biochemical and biophysical research communications 2018 v.500 no.2 pp. 325-332
ISSN:: 0006-291X
Subject:: alopecia; cell cycle; exosomes; genes; growth and development; hair follicles; immunohistochemistry; messenger RNA; mice; neoplasms; protein content
Abstract:: ... Dermal papilla cells (DPCs) play a critical role in the regulation of hair follicle (HF) growth, formation, and cycling. DPCs are thought to regulate HF growth through a paracrine mechanism, in which exosomes may play a critical role.DPC-Exos were cutaneously injected into HFs at different HF cycle stages and the effects were evaluated by histological and immunohistochemical analyses. The effects ...
DOI:: 10.1016/j.bbrc.2018.04.067
: https://doi.org/10.1016/j.bbrc.2018.04.067

58. Schwann Cell-derived exosomes promote bone regeneration and repair by enhancing the biological activity of porous Ti6Al4V scaffolds

Author:: Zhigang Wu; Panjun Pu; Zhi Su; Xinchang Zhang; Linyang Nie; Yaoming Chang
Source:: Biochemical and biophysical research communications 2020 v.531 no.4 pp. 559-565
ISSN:: 0006-291X
Subject:: alloys; bioactive properties; biomedical research; bones; exosomes; mesenchymal stromal cells; nerve regeneration; therapeutics; tissue repair; titanium
Abstract:: ... Implants made of porous titanium alloy and fabricated by 3D printing are increasingly used in clinical research. However, porous titanium alloys do not integrate very well with surrounding bone tissue, and bone ingrowth into the implants is not substantial. Schwann cells (SCs) and SC-derived exosomes can effectively promote nerve regeneration, but their role in bone tissue regeneration and repair ...
DOI:: 10.1016/j.bbrc.2020.07.094
: https://doi.org/10.1016/j.bbrc.2020.07.094

59. The long non-coding RNA PCSEAT exhibits an oncogenic property in prostate cancer and functions as a competing endogenous RNA that associates with EZH2

Author:: Xiaohui Yang; Liang Wang; Rong Li; Yuhui Zhao; Yinmin Gu; Siying Liu; Tianyou Cheng; Kuohsiang Huang; Yi Yuan; Dalong Song; Shan Gao
Source:: Biochemical and biophysical research communications 2018 v.502 pp. 262-268
ISSN:: 0006-291X
Subject:: cell growth; cell proliferation; exosomes; males; non-coding RNA; oncogenes; patients; phenotype; prostatic neoplasms; therapeutics
Abstract:: ... Prostate cancer (PCa) is the most common malignancy and the leading cause of cancer deaths in males. Recent studies demonstrate that long non-coding RNAs (lncRNAs) are involved in many aspects of PCa. However, their biological roles in PCa remain imperfectly understood. Here,wecharacterized anlncRNA, PCaspecific expression and EZH2-associatedtranscript (PCSEAT, annotated as PRCAT38), which is spec ...
DOI:: 10.1016/j.bbrc.2018.05.157
: https://doi.org/10.1016/j.bbrc.2018.05.157

60. The role of actinin-4 (ACTN4) in exosomes as a potential novel therapeutic target in castration-resistant prostate cancer

Author:: Yu Ishizuya; Motohide Uemura; Ryohei Narumi; Eisuke Tomiyama; Yoko Koh; Makoto Matsushita; Kosuke Nakano; Yujiro Hayashi; Cong Wang; Taigo Kato; Koji Hatano; Atsunari Kawashima; Takeshi Ujike; Kazutoshi Fujita; Ryoichi Imamura; Jun Adachi; Takeshi Tomonaga; Norio Nonomura
Source:: Biochemical and biophysical research communications 2020 v.523 no.3 pp. 588-594
ISSN:: 0006-291X
Subject:: RNA; androgens; blood serum; cell lines; cell proliferation; death; exosomes; metastasis; neoplasm cells; patients; prognosis; prostatic neoplasms; proteomics; research; therapeutics; ultracentrifugation
Abstract:: ... Prostate cancer is the second leading cause of cancer death in men in the United States. Several novel therapeutic agents have been developed for castration-resistant prostate cancer (CRPC), but the prognosis for patients with CRPC remains poor. The identification of novel therapeutic targets for CRPC is an urgent issue. Exosomes are small vesicles secreted by a variety of cells, and exosomes deri ...
DOI:: 10.1016/j.bbrc.2019.12.084
: https://doi.org/10.1016/j.bbrc.2019.12.084

61. A serum exosomal microRNA panel as a potential biomarker test for gastric cancer

Author:: Ning Wang; Lina Wang; Yongjun Yang; Li Gong; Bin Xiao; Xin Liu
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: quantitative polymerase chain reaction; proteins; blood serum; stomach neoplasms; biomarkers; models; reverse transcriptase polymerase chain reaction; exosomes; metastasis; microRNA; neoplasm cells; patients; screening
Abstract:: ... The findings from several studies have suggested that circulating miRNAs are imbalanced with the genesis of gastric cancer (GC). Both normal and cancer cells can generate and secrete exosomes, which are nanosized membrane vesicles that can transport microRNAs and proteins. Emerging evidence indicates that the exosomes secreted by cancer cells can be released into the circulatory system. In this st ...
DOI:: 10.1016/j.bbrc.2017.10.003
: https://doi.org/10.1016/j.bbrc.2017.10.003

62. Adipose mesenchymal stem cell-derived exosomes ameliorate hypoxia/serum deprivation-induced osteocyte apoptosis and osteocyte-mediated osteoclastogenesis in vitro

Author:: Lin Ren; Zi-jun Song; Qing-wei Cai; Rui-xin Chen; Yang Zou; Qiang Fu; Yuan-yuan Ma
Source:: Biochemical and biophysical research communications 2019 v.508 no.1 pp. 138-144
ISSN:: 0006-291X
Subject:: acid phosphatase; age; apoptosis; blood serum; bone marrow; bone resorption; caspase-3; caspase-9; cell lines; cytochrome c; exosomes; genes; hypoxia; mesenchymal stromal cells; messenger RNA; models; monocytes; osteoclasts; protein content; staining; therapeutics
Abstract:: ... Age-related skeletal changes is closely associated with imbalanced bone remodeling characterized by elevated osteocyte apoptosis and osteoclast activation. Since osteocytes are the commander of bone remodeling, attenuating increased osteocyte apoptosis may improve age-related bone loss. Exosomes, derived from mesenchymal stem cells, hold promising potential for cell-free therapy due to multiple ab ...
DOI:: 10.1016/j.bbrc.2018.11.109
: https://doi.org/10.1016/j.bbrc.2018.11.109

63. Adipose tissue macrophage-derived exosomal miR-29a regulates obesity-associated insulin resistance

Author:: Ting Liu; Yu-Chen Sun; Peng Cheng; Hui-Ge Shao
Source:: Biochemical and biophysical research communications 2019 v.515 no.2 pp. 352-358
ISSN:: 0006-291X
Subject:: adipocytes; adipose tissue; agonists; exosomes; hepatocytes; insulin resistance; macrophages; mice; microRNA; myocytes; noninsulin-dependent diabetes mellitus; therapeutics
Abstract:: ... Obesity-associated insulin resistance is a forerunner of type 2 diabetes. Macrophages reside within adipose tissue (ATMs) have been reported to regulate insulin sensitivity through secreting miRNAs containing exosomes. Here, we show that miR-29a is increased in obese ATMs derived exosomes (ATMs-Exos) and can be transferred into adipocytes, myocytes and hepatocytes causing insulin resistance in vit ...
DOI:: 10.1016/j.bbrc.2019.05.113
: https://doi.org/10.1016/j.bbrc.2019.05.113

64. Exosomal and extracellular HMGB1 have opposite effects on SASH1 expression in rat astrocytes and glioma C6 cells

Author:: Chao Ma; Han Chen; Siming Zhang; Yingying Yan; Ronghua Wu; Yongjun Wang; Yan Liu; Liu Yang; Mei Liu
Source:: Biochemical and biophysical research communications 2019 v.518 no.2 pp. 325-330
ISSN:: 0006-291X
Subject:: Western blotting; astrocytes; cell adhesion; cell communication; cytokines; exosomes; gene ontology; glioma; mass spectrometry; nucleoproteins; rats; research
Abstract:: ... Exosomes are a type of extracellular vesicles derived from cells and mediators of intercellular communication. Different cell types have their own unique exosomes for exchanging information. We previously found that SASH1, a tumor suppressor, was lowly expressed or absent in glioma tissues and glioma C6 cells, but the structure and function of the corresponding exosomes had been unclear. Hence, we ...
DOI:: 10.1016/j.bbrc.2019.08.057
: https://doi.org/10.1016/j.bbrc.2019.08.057

65. Exosomal release through TRPML1-mediated lysosomal exocytosis is required for adipogenesis

Author:: Mi Seong Kim; Shmuel Muallem; Sung Hyun Kim; Kang Beom Kwon; Min Seuk Kim
Source:: Biochemical and biophysical research communications 2019 v.510 no.3 pp. 409-415
ISSN:: 0006-291X
Subject:: adipocytes; adipogenesis; calcium; cell membranes; endosomes; exocytosis; exosomes; genetic markers; lipids; lysosomes; obesity-related diseases
Abstract:: ... The lysosomal Ca2+ permeable channel TRPML1 (MCOLN1) plays key roles in lysosomal membrane trafficking, including the fusion of late endosomes to lysosomes and lysosomal exocytosis, both of which are essential for release of exosomes into the extracellular milieu. Multiple lines of evidence indicate that the contents of adipocyte-derived exosomes mediate diverse cellular responses, including adipo ...
DOI:: 10.1016/j.bbrc.2019.01.115
: https://doi.org/10.1016/j.bbrc.2019.01.115

66. Exosomes derived from mesenchymal stem cells attenuate the progression of atherosclerosis in ApoE−/- mice via miR-let7 mediated infiltration and polarization of M2 macrophage

Author:: Jiangbing Li; Hao Xue; Tingting Li; Xili Chu; Danqing Xin; Ye Xiong; Wei Qiu; Xiao Gao; Mingyu Qian; Jiangye Xu; Zhen Wang; Gang Li
Source:: Biochemical and biophysical research communications 2019 v.510 no.4 pp. 565-572
ISSN:: 0006-291X
Subject:: atherosclerosis; caudal vein; coronary artery disease; exosomes; high fat diet; immunosuppression; inflammation; macrophages; mesenchymal stromal cells; mice; risk; therapeutics
Abstract:: ... Atherosclerosis is a chronic inflammatory disease of the vasculature. Exosomes derived from mesenchymal stem cells (MSCs) exert immunomodulatory and immunosuppressive effects; however, the MSCs-exosomes administration on atherosclerosis was unknown. Here, our ApoE−/- mice were fed a high-fat diet and received intravenous injections of exosomes from MSCs for 12 weeks. After tail-vein injection, MSC ...
DOI:: 10.1016/j.bbrc.2019.02.005
: https://doi.org/10.1016/j.bbrc.2019.02.005

67. Exosomes derived from plasma of septic patients inhibit apoptosis of T lymphocytes by down-regulating bad via hsa-miR-7-5p

Author:: Jian-nan Deng; Yan-Qin Li; Yang Liu; Qi Li; Ye Hu; Jian-Qiao Xu; Tian-Yu Sun; Li-Xin Xie
Source:: Biochemical and biophysical research communications 2019 v.513 no.4 pp. 958-966
ISSN:: 0006-291X
Subject:: T-lymphocytes; apoptosis; caspase-3; exosomes; gene expression regulation; genes; high-throughput nucleotide sequencing; immunosuppression; lipopolysaccharides; luciferase; messenger RNA; mice; microRNA; models; mortality; patients; protein content; sepsis (infection); signal transduction
Abstract:: ... Immunosuppression is currently a vital pathophysiological characteristic and core problem of sepsis. Apoptosis of T lymphocyte contribute to immunosuppression by decreasing immune effector cells. A report has recently revealed the potential regulatory role of exosomal miRNAs derived from plasma of septic patients on immune system, but the underlying mechanism is unclear. We discovered the antiapop ...
DOI:: 10.1016/j.bbrc.2019.04.051
: https://doi.org/10.1016/j.bbrc.2019.04.051

68. Exosomes expressing carbonic anhydrase 9 promote angiogenesis

Author:: Kengo Horie; Kyojiro Kawakami; Yasunori Fujita; Maki Sugaya; Koji Kameyama; Kosuke Mizutani; Takashi Deguchi; Masafumi Ito
Source:: Biochemical and biophysical research communications 2017 v.492 no.3 pp. 356-361
ISSN:: 0006-291X
Subject:: angiogenesis; carbonate dehydratase; cell lines; density gradient centrifugation; disease course; exosomes; human umbilical vein endothelial cells; hypoxia; hypoxia-inducible factor 1; renal cell carcinoma; staining
Abstract:: ... Exosomes or microvesicles that are secreted from cells are considered to play important roles in tumor microenvironment. Carbonic anhydrase 9 (CA9), which is induced by hypoxia-inducible factor 1 (HIF1) in response to hypoxia, is overexpressed in many types of cancer including renal cell carcinoma (RCC). We examined the expression level of CA9 in several RCC cell lines and found that the basal lev ...
DOI:: 10.1016/j.bbrc.2017.08.107
: https://doi.org/10.1016/j.bbrc.2017.08.107

69. Glycan profiling analysis using evanescent-field fluorescence-assisted lectin array: Importance of sugar recognition for cellular uptake of exosomes from mesenchymal stem cells

Author:: Asako Shimoda; Yoshiro Tahara; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
Source:: Biochemical and biophysical research communications 2017 v.491 pp. 701-707
ISSN:: 0006-291X
Subject:: DNA; RNA; adipose tissue; antigen-presenting cells; exosomes; glycosylation; humans; immunoglobulins; in vivo studies; lectins; lipids; lymph nodes; membrane proteins; mice; physical properties; polysaccharides; stem cells; subcutaneous injection; sugars
Abstract:: ... Studies involving the functional analysis of exosomal contents including proteins, DNA, and RNA have been reported. Most membrane proteins and lipids are glycosylated, which controls their physical properties and functions, but little is known about glycans on exosomes owing to the difficulty of analysing them. To shed light on these issues, we collected exosomes from mesenchymal stem cells (MSCs) ...
DOI:: 10.1016/j.bbrc.2017.07.126
: https://doi.org/10.1016/j.bbrc.2017.07.126

70. Gut dysbiosis-derived exosomes trigger hepatic steatosis by transiting HMGB1 from intestinal to liver in mice

Author:: Yu Chen; Huanhuan Sun; Yang Bai; Fachao Zhi
Source:: Biochemical and biophysical research communications 2019 v.509 no.3 pp. 767-772
ISSN:: 0006-291X
Subject:: Streptomyces; dysbiosis; exosomes; fatty liver; high fat diet; intestinal microorganisms; intestines; liver; mice; nucleoproteins; ribosomal DNA; sequence analysis
Abstract:: ... In the past decade, research on the biology of the gut-liver axis has assisted in understanding the basic biology of nonalcoholic fatty liver disease (NAFLD). High mobility group box 1 (HMGB1) protein, in its role as a crucial injury-related molecule, displays a substantial correlation with the degree of liver steatosis. However, its underlying molecular mechanism remains unclear. In the current s ...
DOI:: 10.1016/j.bbrc.2018.12.180
: https://doi.org/10.1016/j.bbrc.2018.12.180

71. Induction of lipid droplets in non-macrophage cells as well as macrophages by liposomes and exosomes

Author:: Kazuyo Fujita; Masaharu Somiya; Shun'ichi Kuroda; Shuji Hinuma
Source:: Biochemical and biophysical research communications 2019 v.510 no.1 pp. 184-190
ISSN:: 0006-291X
Subject:: cell lines; droplets; exosomes; macrophages; mammals; nanoparticles; phosphatidylserines
Abstract:: ... It has been reported that phospholipid nanoparticles (PNPs) including liposomes and exosomes could efficiently induce lipid droplets (LDs) in macrophages. However, in non-macrophage cells, the effects of PNPs on the induction of LDs have not been thoroughly investigated. In this report, we directly compared non-macrophage and macrophage cell lines in terms of LD induction by various formulation of ...
DOI:: 10.1016/j.bbrc.2019.01.078
: https://doi.org/10.1016/j.bbrc.2019.01.078

72. Involvement of exosomes in dopaminergic neurodegeneration by microglial activation in midbrain slice cultures

Author:: Reiho Tsutsumi; Yuria Hori; Takahiro Seki; Yuki Kurauchi; Masahiro Sato; Mutsumi Oshima; Akinori Hisatsune; Hiroshi Katsuki
Source:: Biochemical and biophysical research communications 2019 pp. -
ISSN:: 0006-291X
Subject:: Parkinson disease; animal models; apoptosis; brain; culture media; dopamine; exosomes; interferon-gamma; microRNA; neuroglia; neurons; nitric oxide; nitric oxide synthase; patients; protective effect; proteins; sphingomyelins
Abstract:: ... Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive degeneration of dopamine neurons in the substantia nigra. Microglial activation is frequently observed in the brains of patients with PD and animal models. Interferon-γ (IFN-γ)/lipopolysaccharide (LPS) treatment triggers microglial activation and the reduction of dopamine neurons in midbrain slice cultures. W ...
DOI:: 10.1016/j.bbrc.2019.02.076
: https://doi.org/10.1016/j.bbrc.2019.02.076

73. Maternal exosomes in diabetes contribute to the cardiac development deficiency

Author:: Ruijing Shi; Lianbi Zhao; Wenbin Cai; Mengying Wei; Xueying Zhou; Guodong Yang; Lijun Yuan
Source:: Biochemical and biophysical research communications 2017 v.483 pp. 602-608
ISSN:: 0006-291X
Subject:: blood; diabetes mellitus; embryogenesis; exosomes; fluorescence; heart; mice; microRNA; nanogold; placenta; risk; sequence analysis; streptozotocin; tissues
Abstract:: ... Maternal diabetes mellitus induces an increased risk of congenital heart defects (CHD), however, the exact mechanisms are still not fully illustrated. In this study, diabetic pregnant C57BL/6 mice were induced by injection of streptozotocin before mating. Compared with the control normal mice, diabetic pregnant mice displayed significant changes of the exosomal miRNA contents in the blood, as reve ...
DOI:: 10.1016/j.bbrc.2016.12.097
: https://doi.org/10.1016/j.bbrc.2016.12.097

74. Oral keratinocyte-derived exosomes regulate proliferation of fibroblasts and epithelial cells

Author:: Sebastian Sjoqvist; Yoshiyuki Kasai; Daisuke Shimura; Taichi Ishikawa; Nadiah Ali; Takanori Iwata; Nobuo Kanai
Source:: Biochemical and biophysical research communications 2019 v.514 no.3 pp. 706-712
ISSN:: 0006-291X
Subject:: Western blotting; cell lines; cell proliferation; coculture; dexamethasone; epithelial cells; esophagus; exosomes; fibroblasts; fluorescent labeling; keratinocytes; mechanism of action; medicine; mucosa; neoplasm cells; therapeutics; tissue repair; transmission electron microscopy
Abstract:: ... Extracellular vesicles (EVs), including exosomes, are small membrane-bound particles released by cells. From a therapeutic point of view, EVs can often convey similar biological function as their parent cell. Grafts originating from oral mucosa have frequently been used in regenerative medicine, and we have previously described the use of oral cell sheets to prevent stricture formation of the esop ...
DOI:: 10.1016/j.bbrc.2019.04.202
: https://doi.org/10.1016/j.bbrc.2019.04.202

75. Reprogramming of cancer stem cells into non-tumorigenic cells using stem cell exosomes for cancer therapy

Author:: Kyoung Soo Lee; Ji Suk Choi; Yong Woo Cho
Source:: Biochemical and biophysical research communications 2019 v.512 no.3 pp. 511-516
ISSN:: 0006-291X
Subject:: ABC transporters; alkaline phosphatase; bone formation; breast neoplasms; drug resistance; exosomes; humans; metastasis; osteocalcin; resistance genes; reverse transcriptase polymerase chain reaction; stem cells; therapeutics; transcription factors
Abstract:: ... Cancer stem cells (CSCs) are a small population of cells with stem cell-like properties found in tumors. CSCs are closely associated with tumor heterogeneity, which influences tumor progress, metastasis, and drug resistance. Here, we propose a concept to enhance efficacy of cancer therapy through CSC reprogramming into non-tumorigenic cells using stem cell-derived exosomes with osteoinductive pote ...
DOI:: 10.1016/j.bbrc.2019.03.072
: https://doi.org/10.1016/j.bbrc.2019.03.072

76. Serum long non coding RNA MALAT-1 protected by exosomes is up-regulated and promotes cell proliferation and migration in non-small cell lung cancer

Author:: Rui Zhang; Yuhong Xia; Zhixin Wang; Jie Zheng; Yafei Chen; Xiaoli Li; Yu Wang; Huaikun Ming
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: apoptosis; biomarkers; blood serum; cell cycle; cell proliferation; exosomes; flow cytometry; humans; in vitro studies; lung neoplasms; metastasis; neoplasm cells; non-coding RNA; patients; prognosis; small interfering RNA
Abstract:: ... Circulating lncRNAs have been defined as a novel biomarker for non-small cell lung cancer (NSCLC), MALAT-1 was first identified lncRNA that was related to lung cancer metastasis. However, the relationship between exosomal lncRNAs and the diagnosis and prognosis of NSCLC was poorly understood. The aim of this study is to evaluate the clinical significance of serum exosomal MALAT-1 as a biomarker in ...
DOI:: 10.1016/j.bbrc.2017.06.055
: https://doi.org/10.1016/j.bbrc.2017.06.055

77. Structural insights into the specific recognition of DSR by the YTH domain containing protein Mmi1

Author:: Baixing Wu; Jinhao Xu; Shichen Su; Hehua Liu; Jianhua Gan; Jinbiao Ma
Source:: Biochemical and biophysical research communications 2017 v.491 pp. 310-316
ISSN:: 0006-291X
Subject:: Schizosaccharomyces pombe; crystal structure; exosomes; gene expression regulation; meiosis; messenger RNA; mitosis; mutation; proteins
Abstract:: ... Meiosis is one of the most dramatic differentiation programs accompanied by a striking change in gene expression profiles in fission yeast Schizosaccharomyces pombe. Whereas a number of meiosis-specific transcripts are expressed untimely in mitotic cells, and the entry of meiosis will be blocked as the accumulation of meiosis-specific mRNAs in the mitotic cells. A YTH domain containing protein Mmi ...
DOI:: 10.1016/j.bbrc.2017.07.104
: https://doi.org/10.1016/j.bbrc.2017.07.104

78. The exosomal compartment protects epidermal growth factor receptor from small molecule inhibitors

Author:: Yu Hung; Yuan-Liang Wang; You-Zhe Lin; Shu-Fen Chiang; Wan-Rong Wu; Shao-Chun Wang
Source:: Biochemical and biophysical research communications 2019 v.510 no.1 pp. 42-47
ISSN:: 0006-291X
Subject:: breast neoplasms; drug resistance; epidermal growth factor receptors; exosomes; lipids; metastasis; models; neoplasm cells; nucleic acids; signal transduction; stromal cells
Abstract:: ... Epidermal growth factor receptor (EGFR) plays a significant role in promoting breast cancer progression. However, targeting EGFR as a single treatment only resulted in moderate efficacy to the disease. The underlying mechanism of low responsiveness to EGFR inhibition remains largely unclear. Tumor-secreted extracellular vesicles (EVs) play a crucial role in mediating intercellular communication be ...
DOI:: 10.1016/j.bbrc.2018.12.187
: https://doi.org/10.1016/j.bbrc.2018.12.187

79. Activation of TLR3 and its adaptor TICAM-1 increases miR-21 levels in extracellular vesicles released from human cells

Author:: Yoshimi Fukushima; Masaaki Okamoto; Kana Ishikawa; Takahisa Kouwaki; Hirotake Tsukamoto; Hiroyuki Oshiumi
Source:: Biochemical and biophysical research communications 2018 v.500 no.3 pp. 744-750
ISSN:: 0006-291X
Subject:: Toll-like receptor 3; cell communication; dendritic cells; double-stranded RNA; exosomes; humans; innate immunity; macrophages; microRNA; small interfering RNA
Abstract:: ... Pattern-recognition receptors (PRRs) recognizes viral RNAs and trigger the innate immune responses. Toll-like receptor 3 (TLR3), a PRR, recognizes viral double-stranded RNA (dsRNA) in endolysosomes, whereas cytoplasmic dsRNA is sensed by another PRR, MDA5. TLR3 and MDA5 utilize TICAM-1 and MAVS, respectively, to trigger the signal for inducing innate immune responses. Extracellular vesicles (EVs) ...
DOI:: 10.1016/j.bbrc.2018.04.146
: https://doi.org/10.1016/j.bbrc.2018.04.146

80. Adipose mesenchymal stem cell-derived exosomes stimulated by hydrogen peroxide enhanced skin flap recovery in ischemia-reperfusion injury

Author:: Yun Bai; Yu-di Han; Xin-long Yan; Jing Ren; Quan Zeng; Xiao-dong Li; Xue-tao Pei; Yan Han
Source:: Biochemical and biophysical research communications 2018 v.500 no.2 pp. 310-317
ISSN:: 0006-291X
Subject:: angiogenesis; apoptosis; blood; coculture; eosin; exosomes; human umbilical vein endothelial cells; hydrogen peroxide; image analysis; immunohistochemistry; inflammation; ischemia; mesenchymal stromal cells; staining; stem cells; therapeutics
Abstract:: ... Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates for the treatment of ischemic disease or injury and may be an alternative treatment for cell therapy. This aim of the study was to evaluate whether exosomes derived from adipose mesenchymal stem cell (ADSC) can protect the skin flap during ischemia-reperfusion (I/R) injury and induce neovascularization.To investiga ...
DOI:: 10.1016/j.bbrc.2018.04.065
: https://doi.org/10.1016/j.bbrc.2018.04.065

81. Adipose tissue browning in cancer-associated cachexia can be attenuated by inhibition of exosome generation

Author:: Wenjun Hu; Zeyuan Ru; Wen Xiao; Zhiyong Xiong; Cheng Wang; Changfei Yuan; Xiaoping Zhang; Hongmei Yang
Source:: Biochemical and biophysical research communications 2018 v.506 no.1 pp. 122-129
ISSN:: 0006-291X
Subject:: adipocytes; adipose tissue; cachexia; enzyme inhibitors; exosomes; lipolysis; lung neoplasms; mice; muscular atrophy; neoplasm cells; skeletal muscle; weight loss
Abstract:: ... Cancer-associated cachexia (CAC) is a disorder characterized by unintended weight loss due to skeletal muscle wasting and adipose tissue loss. Although muscle atrophy in this condition has been well studied, the mechanisms underlying adipose tissue loss, which include browning, have not been investigated in detail. In this respect, though recent studies have shown that exosomes from cancer cells c ...
DOI:: 10.1016/j.bbrc.2018.09.139
: https://doi.org/10.1016/j.bbrc.2018.09.139

82. Cardiac-specific delivery by cardiac tissue-targeting peptide-expressing exosomes

Author:: Hyoeun Kim; Nuri Yun; Dasom Mun; Ji-Young Kang; Seung-Hyun Lee; Hyelim Park; Hyewon Park; Boyoung Joung
Source:: Biochemical and biophysical research communications 2018 v.499 no.4 pp. 803-808
ISSN:: 0006-291X
Subject:: RNA; cell lines; cell viability; exosomes; genetic engineering; glycosylation; heart; heart diseases; liver; mice; spleen; therapeutics; tissues; toxicity
Abstract:: ... Naturally occurring RNA carriers such as exosomes might be an untapped source of effective delivery vehicles. However, if exosomes are to be exploited for therapeutic applications, they must target specific tissues or cell types to avoid off-target effects. This study evaluated whether genetic modification of exosomes could enhance exosome delivery to heart cells and heart tissue without toxicity. ...
DOI:: 10.1016/j.bbrc.2018.03.227
: https://doi.org/10.1016/j.bbrc.2018.03.227

83. Co-transplantation of exosomes derived from hypoxia-preconditioned adipose mesenchymal stem cells promotes neovascularization and graft survival in fat grafting

Author:: Yu-di Han; Yun Bai; Xin-long Yan; Jing Ren; Quan Zeng; Xiao-dong Li; Xue-tao Pei; Yan Han
Source:: Biochemical and biophysical research communications 2018 v.497 no.1 pp. 305-312
ISSN:: 0006-291X
Subject:: adipocytes; angiogenesis; animal models; blood; exosomes; fluorescent antibody technique; human umbilical vein endothelial cells; immunohistochemistry; in vitro studies; inflammation; staining; stem cells; stromal cells; subcutaneous fat
Abstract:: ... Adipose-derived stromal cells (ADSCs)-derived exosomes (ADSC-Exos) account for the proangiogenic potential of stem cell. This study aimed to investigate the effect of ADSC-derived exosomes (ADSC-Exos) on the survival in fat grafting.A nude mouse model of subcutaneous fat grafting was adopted. Hypoxic preconditioned ADSC-Exos and ADSC-Exos were injected around the grafted tissue. The fat graft samp ...
DOI:: 10.1016/j.bbrc.2018.02.076
: https://doi.org/10.1016/j.bbrc.2018.02.076

84. Exosomal miR-93 promotes proliferation and invasion in hepatocellular carcinoma by directly inhibiting TIMP2/TP53INP1/CDKN1A

Author:: Xiaofeng Xue; Xiaona Wang; Yubin Zhao; Rongkuan Hu; Lei Qin
Source:: Biochemical and biophysical research communications 2018 v.502 pp. 515-521
ISSN:: 0006-291X
Subject:: algorithms; biomarkers; blood serum; cell lines; exosomes; hepatoma; mortality; patients; prediction; prognosis; quantitative polymerase chain reaction
Abstract:: ... Hepatocellular carcinoma (HCC) is a malignant cancer worldwide; lacking biomarkers for early prognostication contributes to its high lethality. Herein, we report a novel biomarker, exosome delivered miR-93, is up-regulated in HCC cell line media and serum samples of HCC patients. We measured the proliferation and invasion ability of HCC cell lines following exosomal miR-93 treatment. After predict ...
DOI:: 10.1016/j.bbrc.2018.05.208
: https://doi.org/10.1016/j.bbrc.2018.05.208

85. Exosomal microRNA-194 causes cardiac injury and mitochondrial dysfunction in obese mice

Author:: Hezhongrong Nie; Yong Pan; Yiwen Zhou
Source:: Biochemical and biophysical research communications 2018 v.503 no.4 pp. 3174-3179
ISSN:: 0006-291X
Subject:: adenosine triphosphate; animal disease models; cardiac output; cardiomyocytes; cardiomyopathy; exosomes; high fat diet; humans; mice; microRNA; mitochondria; morbidity; mortality; obesity; oxygen consumption; therapeutics
Abstract:: ... Obesity is associated with increased cardiovascular morbidity and mortality, but the effects of circulating factors on cardiac function is not fully elucidated. Present study aims to explore the pathophysiological role of microRNA (miR)-194, one of hepatic enriched miRs, in the process of obesity-related cardiomyopathy in human subjects and mice. The expression level of circulating exosomal miR-19 ...
DOI:: 10.1016/j.bbrc.2018.08.113
: https://doi.org/10.1016/j.bbrc.2018.08.113

86. Exosomal transfer of miR-214 mediates gefitinib resistance in non-small cell lung cancer

Author:: Yan Zhang; Min Li; Chengping Hu
Source:: Biochemical and biophysical research communications 2018 v.507 no.1-4 pp. 457-464
ISSN:: 0006-291X
Subject:: apoptosis; caspase-3; drug resistance; exosomes; flow cytometry; light scattering; lung neoplasms; microRNA; neoplasm cells; pro-apoptotic proteins; quantitative polymerase chain reaction; transmission electron microscopy; ultracentrifugation
Abstract:: ... Recent studies have demonstrated that exosomal miRNAs mediate as intercellular bio-messengers of drug resistance in lung cancer. Our objective was to investigate whether exosomes derived from gefitinib resistant non-small cell lung cancer cells could confer resistance to its recipient cells. Exosomes were successfully isolated by ultracentrifugation and exosomes morphologies and sizes were determi ...
DOI:: 10.1016/j.bbrc.2018.11.061
: https://doi.org/10.1016/j.bbrc.2018.11.061

87. Exosomes derived from pancreatic cancer cells induce activation and profibrogenic activities in pancreatic stellate cells

Author:: Atsushi Masamune; Naoki Yoshida; Shin Hamada; Tetsuya Takikawa; Tatsuhide Nabeshima; Tooru Shimosegawa
Source:: Biochemical and biophysical research communications 2018 v.495 no.1 pp. 71-77
ISSN:: 0006-291X
Subject:: actin; c-peptide; cell communication; exosomes; gene expression; genes; humans; messenger RNA; microarray technology; mitogen-activated protein kinase; muscles; neoplasm cells; pancreatic neoplasms; transforming growth factor beta 1; tumor necrosis factors
Abstract:: ... Pancreatic cancer cells (PCCs) interact with pancreatic stellate cells (PSCs), which play a pivotal role in pancreatic fibrogenesis, to develop the cancer-conditioned tumor microenvironment. Exosomes are membrane-enclosed nanovesicles, and have been increasingly recognized as important mediators of cell-to-cell communications. The aim of this study was to clarify the effects of PCC-derived exosome ...
DOI:: 10.1016/j.bbrc.2017.10.141
: https://doi.org/10.1016/j.bbrc.2017.10.141

88. Exosomes from C2C12 myoblasts enhance osteogenic differentiation of MC3T3-E1 pre-osteoblasts by delivering miR-27a-3p

Author:: Qian Xu; Yazhou Cui; Jing Luan; Xiaoyan Zhou; Haiying Li; Jinxiang Han
Source:: Biochemical and biophysical research communications 2018 v.498 no.1 pp. 32-37
ISSN:: 0006-291X
Subject:: beta catenin; bone formation; exosomes; microRNA; muscles; myoblasts; osteoblasts
Abstract:: ... Many regulators have been identified to participate in the cross-talk between muscle and bone, however, most previous studies focus on secreting proteins. In this study, we demonstrated that exosomes from myoblasts C2C12 can promote pre-osteoblasts MC3T3-E1 differentiation to osteoblasts. We revealed that the effect of C2C12 exosomes depended on its miR-27a-3p component, they can increase miR-27a- ...
DOI:: 10.1016/j.bbrc.2018.02.144
: https://doi.org/10.1016/j.bbrc.2018.02.144

89. IL- 1β/ATF3-mediated induction of Ski2 expression enhances hepatitis B virus x mRNA degradation

Author:: Fumihiro Shiromoto; Hussein H. Aly; Haruka Kudo; Koichi Watashi; Asako Murayama; Noriyuki Watanabe; Xin Zheng; Takanobu Kato; Kazuaki Chayama; Masamichi Muramatsu; Takaji Wakita
Source:: Biochemical and biophysical research communications 2018 v.503 no.3 pp. 1854-1860
ISSN:: 0006-291X
Subject:: Hepatitis B virus; exosomes; hepatoma; inflammation; interleukin-1beta; messenger RNA; transcription factors
Abstract:: ... Hepatitis B virus (HBV) -x protein is a transcriptional regulator required for the HBV life cycle. HBx also induces complications in the host such as hepatocellular carcinoma. We previously showed that HBx mRNA is degraded by the Ski2/RNA exosome complex. In the present study, we report the regulation of this system through the control of Ski2 expression. We identified interleukin (IL) -1β as an i ...
DOI:: 10.1016/j.bbrc.2018.07.126
: https://doi.org/10.1016/j.bbrc.2018.07.126

90. Induction of immune-related gene expression by seminal exosomes in the porcine endometrium

Author:: Rulan Bai; Zeinab Latifi; Kazuya Kusama; Keigo Nakamura; Masayuki Shimada; Kazuhiko Imakawa
Source:: Biochemical and biophysical research communications 2018 v.495 no.1 pp. 1094-1101
ISSN:: 0006-291X
Subject:: RNA; T-lymphocytes; boars; cell differentiation; chemokine CCL20; chemokine CXCL2; eggs; endometrium; epithelial cells; exosomes; gene expression; genes; interleukin-8; seminal plasma; signal transduction; spermatozoa
Abstract:: ... Seminal plasma (SP) is considered as a vehicle to carry sperm into female reproductive tract, of which functions have not been completely understood. This study aimed to identify the function of seminal exosomes on porcine endometrium. Exosomes were isolated from the sperm-rich fraction of boar semen and were confirmed by the expression of exosome marker HSP70 and size distribution using nano-sigh ...
DOI:: 10.1016/j.bbrc.2017.11.100
: https://doi.org/10.1016/j.bbrc.2017.11.100

91. Intraperitoneal injection of MSC-derived exosomes prevent experimental bronchopulmonary dysplasia

Author:: Rudolf K. Braun; Chandramu Chetty; Vivek Balasubramaniam; Ryan Centanni; Kristin Haraldsdottir; Peiman Hematti; Marlowe W. Eldridge
Source:: Biochemical and biophysical research communications 2018 v.503 no.4 pp. 2653-2658
ISSN:: 0006-291X
Subject:: angiogenesis; animal models; apoptosis; blood vessels; bronchopulmonary dysplasia; exosomes; heart; heart diseases; hyperoxia; hypertrophy; inflammation; intraperitoneal injection; lungs; neonates; oxygen; protein synthesis; vascular endothelial growth factors
Abstract:: ... Mesenchymal stromal cell (MSC) derived exosomes mediate tissue protection and regeneration in many injuries and diseases by modulating cell protein production, protecting from apoptosis, inhibiting inflammation, and increasing angiogenesis. In the present study, daily intraperitoneal injection of MSC-derived exosomes protected alveolarization and angiogenesis in a newborn rat model of bronchopulmo ...
DOI:: 10.1016/j.bbrc.2018.08.019
PubMed:: 30093115
PubMed Central:: PMC6398932
: https://doi.org/10.1016/j.bbrc.2018.08.019

92. Intravenous mesenchymal stem cell-derived exosomes ameliorate myocardial inflammation in the dilated cardiomyopathy

Author:: Xuan Sun; Anqi Shan; Zilun Wei; Biao Xu
Source:: Biochemical and biophysical research communications 2018 v.503 no.4 pp. 2611-2618
ISSN:: 0006-291X
Subject:: doxorubicin; cardiomyopathy; intravenous injection; staining; echocardiography; macrophages; inflammation; models; cardiomyocytes; cardiac output; exosomes; mice; stem cells; blood; apoptosis
Abstract:: ... Mesenchymal stem cells (MSCs) have been shown to be efficacy to attenuating cardiovascular inflammation; however, there are many limitations to stem cell treatment. Present study was to prove MSC-derived exosomes (MSC-Exos) could alleviating inflammatory cardiomyopathy by improving the inflammatory microenvironment of myocardium, especially by regulating the activity of macrophages. Mice were intr ...
DOI:: 10.1016/j.bbrc.2018.08.012
: https://doi.org/10.1016/j.bbrc.2018.08.012

93. Islet β cell: An endocrine cell secreting miRNAs

Author:: Aisen Zhang; Dameng Li; Yucheng Liu; Jing Li; Yujing Zhang; Chen-Yu Zhang
Source:: Biochemical and biophysical research communications 2018 v.495 no.2 pp. 1648-1654
ISSN:: 0006-291X
Subject:: arginine; blood glucose; cell culture; cell lines; culture media; exosomes; genes; glucose; insulin; insulin secretion; liver; metabolism; mice; microRNA; non-coding RNA; research
Abstract:: ... The pancreas is an important endocrine organ. Pancreatic beta (β) cells secrete insulin to regulate the metabolism of glucose and maintain the stability of blood glucose. MicroRNAs (miRNAs), small (20-25 nt) non-coding RNA molecules, function in target gene silencing through post-transcriptional patterns, and multiple miRNAs regulate insulin secretion, insulin signaling pathways in pancreatic β ce ...
DOI:: 10.1016/j.bbrc.2017.12.028
: https://doi.org/10.1016/j.bbrc.2017.12.028

94. Membrane proteins significantly restrict exosome mobility

Author:: Mikhail Skliar; Vasiliy S. Chernyshev; David M. Belnap; German V. Sergey; Samer M. Al-Hakami; Philip S. Bernard; Inge J. Stijleman; Rakesh Rachamadugu
Source:: Biochemical and biophysical research communications 2018 v.501 no.4 pp. 1055-1059
ISSN:: 0006-291X
Subject:: exosomes; extracellular matrix; hydrodynamics; membrane proteins; surface proteins
Abstract:: ... Exosomes are membrane nanovesicles implicated in cell-to-cell signaling in which they transfer their molecular cargo from the parent to the recipient cells. This role essentially depends on the exosomes' small size, which is the prerequisite for their rapid migration through the crowded extracellular matrix and into and out of circulation. Here we report much lower exosome mobility than expected f ...
DOI:: 10.1016/j.bbrc.2018.05.107
: https://doi.org/10.1016/j.bbrc.2018.05.107

95. MiR-130a-3p inhibits migration and invasion by regulating RAB5B in human breast cancer stem cell-like cells

Author:: Xiangjie Kong; Junfeng Zhang; Jia Li; Jianfeng Shao; Lin Fang
Source:: Biochemical and biophysical research communications 2018 v.501 no.2 pp. 486-493
ISSN:: 0006-291X
Subject:: blood; breast neoplasms; carcinogenesis; cell proliferation; disease progression; exosomes; humans; lymph nodes; metastasis; microRNA; oncogenes; research; therapeutics
Abstract:: ... Breast cancer stem cells (BCSCs) constitute a subpopulation of tumor cells that express stem cell-associated markers and have a high capacity for tumor generation in vivo. MicroRNAs (miRNAs) are involved in tumorigenesis by regulating specific oncogenes and tumor suppressor genes, and their roles in BCSCs are becoming more apparent. We try to reveal the mechanism by which specific miRNA plays its ...
DOI:: 10.1016/j.bbrc.2018.05.018
: https://doi.org/10.1016/j.bbrc.2018.05.018

96. Next-generation sequencing-based miRNA expression analysis in Parp1-deficient embryonic stem cell-derived exosomes

Author:: Tadashige Nozaki; Yuka Sasaki; Itsuko Fukuda; Mayu Isumi; Keitaro Nakamoto; Takae Onodera; Mitsuko Masutani
Source:: Biochemical and biophysical research communications 2018 v.499 pp. 410-415
ISSN:: 0006-291X
Subject:: DNA repair; NAD ADP-ribosyltransferase; cell death; cell differentiation; exosomes; gene expression regulation; gene ontology; genes; microRNA; mitogen-activated protein kinase; post-translational modification; quantitative analysis; signal transduction; small nuclear RNA; transfer RNA
Abstract:: ... Poly (ADP-ribose) polymerase family, member 1 (Parp1) has pleiotropic and disparate functions in multiple cellular signaling pathways through post-translational protein modification. It contributes to the regulation of various cellular processes, including DNA damage repair, cell death, and cell differentiation, genetically or epigenetically. Meanwhile, the functions of Parp1 in intercellular sign ...
DOI:: 10.1016/j.bbrc.2018.03.073
: https://doi.org/10.1016/j.bbrc.2018.03.073

97. Plasma exosomes regulate systemic blood pressure in rats

Author:: Kosuke Otani; Mai Yokoya; Tomoko Kodama; Kiko Hori; Kengo Matsumoto; Muneyoshi Okada; Hideyuki Yamawaki
Source:: Biochemical and biophysical research communications 2018 v.503 no.2 pp. 776-783
ISSN:: 0006-291X
Subject:: animal disease models; aorta; cell communication; collagen; exosomes; fibrosis; hypertension; laboratory animals; microRNA; prostaglandins; rats; smooth muscle; systolic blood pressure
Abstract:: ... Exosomes, the smallest extracellular vesicle, contain various molecules and mediate cell-cell communication. A number of studies demonstrate exosomes are involved in important physiological and pathological processes. Moreover, microRNA (miRNA) regulating hypertension development through the suppression of certain translation was recently reported. However, roles of exosomes containing various mol ...
DOI:: 10.1016/j.bbrc.2018.06.075
: https://doi.org/10.1016/j.bbrc.2018.06.075

98. AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74

Author:: Nobuhiro Hiraishi; Yo-ichi Ishida; Masami Nagahama
Source:: Biochemical and biophysical research communications 2015 v.467 pp. 534-540
ISSN:: 0006-291X
Subject:: RNA; RNA helicases; adenosinetriphosphatase; amino acid sequences; biogenesis; cell nucleolus; exosomes; protein subunits; proteomics; regulatory proteins; ribosomal proteins; ribosomes; sequence homology; yeasts
Abstract:: ... Nuclear VCP-like 2 (NVL2) is a chaperone-like nucleolar ATPase of the AAA (ATPase associated with diverse cellular activities) family, which exhibits a high level of amino acid sequence similarity with the cytosolic AAA-ATPase VCP/p97. These proteins generally act on macromolecular complexes to stimulate energy-dependent release of their constituents. We previously showed that NVL2 interacts with ...
DOI:: 10.1016/j.bbrc.2015.09.160
: https://doi.org/10.1016/j.bbrc.2015.09.160

99. Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulates rejuvenation of human skin

Author:: Yoon-Jin Kim; Sae mi Yoo; Hwan Hee Park; Hye Jin Lim; Yu-Lee Kim; Seunghee Lee; Kyung-Sun Kang; Kwang-Won Seo
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: blood; cell growth; cell movement; collagen; cosmetics; elastin; exosomes; fibroblasts; growth factors; humans; signal transduction; skin (animal); stem cells; therapeutics; tissue repair; umbilical cord
Abstract:: ... Human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) play an important role in cutaneous wound healing, and recent studies suggested that MSC-derived exosomes activate several signaling pathways, which are conducive in wound healing and cell growth. In this study, we investigated the roles of exosomes that are derived from USC-CM (USC-CM Exos) in cutaneous collagen synthesis and pe ...
DOI:: 10.1016/j.bbrc.2017.09.056
: https://doi.org/10.1016/j.bbrc.2017.09.056

100. Exosomes isolated from sera of mice fed Lactobacillus strains affect inflammatory cytokine production in macrophages in vitro

Author:: Ayako Aoki-Yoshida; Shinichi Saito; Takeshi Tsuruta; Arisa Ohsumi; Hinako Tsunoda; Kei Sonoyama
Source:: Biochemical and biophysical research communications 2017 v.489 pp. 248-254
ISSN:: 0006-291X
Subject:: Lactobacillus; anti-inflammatory activity; blood serum; exosomes; fluorescence; interleukin-6; macrophages; messenger RNA; mice; oral administration; tumor necrosis factor-alpha
Abstract:: ... Orally administered Lactobacillus strains, including L. plantarum No.14 and L. rhamnosus GG, reportedly reduce inflammatory cytokine production in mice. The present study tested our idea that circulating exosomes mediate the action of Lactobacillus strains. The lipopolysaccharide-induced production of TNF-α and IL-6 in vitro was attenuated in peritoneal exudate cells (PECs) isolated from C57BL/6N ...
DOI:: 10.1016/j.bbrc.2017.05.152
: https://doi.org/10.1016/j.bbrc.2017.05.152

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1. GABA alleviates high glucose-induced podocyte injury through dynamically altering the expression of macrophage M1/M2-derived exosomal miR-21a-5p/miR-25-3p

2. LncRNA SNHG3 regulates the BMSC osteogenic differentiation in bone metastasis of breast cancer by modulating the miR-1273g-3p/BMP3 axis

3. RETRACTED: Serum exosomes mediate septic inflammation and liver and kidney injuries by up-regulating the expression of inflammatory factors

4. Transgenically expressed Helicobacter pylori CagA in vascular endothelial cells accelerates arteriosclerosis in mice

5. ASCs -derived exosomes loaded with vitamin A and quercetin inhibit rapid senescence-like response after acute liver injury

6. Secretion of signal peptides via extracellular vesicles

7. Tubular epithelial cells derived-exosomes containing CD26 protects mice against renal ischemia/reperfusion injury by maintaining proliferation and dissipating inflammation

8. miR-129–5p in exosomes inhibits diabetes-associated osteogenesis in the jaw via targeting FZD4

9. A targeted extracellular vesicles loaded with montelukast in the treatment of demyelinating diseases

10. Administration of circRNA_0075932 shRNA exhibits a therapeutic effect on burn-associated infection in obese rats

11. Astrocytes increase exosomal secretion of oligodendrocyte precursor cells to promote their proliferation via integrin β4-mediated cell adhesion

12. Differential expression and sorting of exosomal microRNAs upon activation of the human monocyte-like cell line U937

13. Disruption of Core 1-mediated O-glycosylation oppositely regulates CD44 expression in human colon cancer cells and tumor-derived exosomes

14. Exosomal encapsulation of miR-125a-5p inhibited trophoblast cell migration and proliferation by regulating the expression of VEGFA in preeclampsia

15. Exploring the potential of engineered exosomes as delivery systems for tumor-suppressor microRNA replacement therapy in ovarian cancer

16. Lipid membrane anchoring and highly specific fluorescence detection of cancer-derived exosomes based on postfunctionalized zirconium-metal-organic frameworks

17. Mechanical stress promotes angiogenesis through fibroblast exosomes

18. Mesenchymal stem cells-derived exosomes prevent sepsis-induced myocardial injury by a CircRTN4/miR-497-5p/MG53 pathway

19. Neuroprotective effect of exosomes derived from bone marrow mesenchymal stem cells via activating TGR5 and suppressing apoptosis

20. Oil Red O based method for exosome labelling and detection

21. A role for DIS3L2 over natural nonsense-mediated mRNA decay targets in human cells

22. Circ_0075932 in adipocyte-derived exosomes induces inflammation and apoptosis in human dermal keratinocytes by directly binding with PUM2 and promoting PUM2-mediated activation of AuroraA/NF-κB pathway

23. Development of a DELFIA method to detect oncofetal antigen ROR1-positive exosomes

24. Evidences against vesicle-dependent trafficking and involvement of extracellular proteasomes into cell-to-cell communications

25. Exosomal long non-coding RNA LIPCAR derived from oxLDL-treated THP-1 cells regulates the proliferation of human umbilical vein endothelial cells and human vascular smooth muscle cells

26. Exosomal miR-301 derived from mesenchymal stem cells protects myocardial infarction by inhibiting myocardial autophagy

27. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acute liver failure by reducing the activity of the NLRP3 inflammasome in macrophages

28. Exosomes derived from miR-16-5p-overexpressing keratinocytes attenuates bleomycin-induced skin fibrosis

29. Exosomes derived from tendon stem cells promote cell proliferation and migration through the TGF β signal pathway

30. Extracellular αB-crystallin modulates the inflammatory responses

31. Gastric cancer derived exosomes mediate the delivery of circRNA to promote angiogenesis by targeting miR-29a/VEGF axis in endothelial cells

32. Identification of myosin II as a cripto binding protein and regulator of cripto function in stem cells and tissue regeneration

33. Modification of exosomes with carbonate apatite and a glycan polymer improves transduction efficiency and target cell selectivity

34. Primed mesenchymal stem cells package exosomes with metabolites associated with immunomodulation

35. Talin-2 regulates integrin functions in exosomes

36. miRNAomics analysis reveals the promoting effects of cigarette smoke extract-treated Beas-2B-derived exosomes on macrophage polarization

37. Brown adipocyte-derived exosomal miR-132-3p suppress hepatic Srebf1 expression and thereby attenuate expression of lipogenic genes

38. Deoxycholic acid-stimulated macrophage-derived exosomes promote spasmolytic polypeptide-expressing metaplasia in the stomach

39. Disrupted blood-brain barrier in 5×FAD mouse model of Alzheimer’s disease can be mimicked and repaired in vitro with neural stem cell-derived exosomes

40. Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish

41. Exosomal miR-675 from metastatic osteosarcoma promotes cell migration and invasion by targeting CALN1

42. Exosomal proteome analysis of human plasma to monitor sepsis progression

43. Exosome-mediated miR-9-5p promotes proliferation and migration of renal cancer cells both in vitro and in vivo by targeting SOCS4

44. Exosomes derived from breast cancer lung metastasis subpopulations promote tumor self-seeding

45. Exosomes derived from human umbilical vein endothelial cells promote neural stem cell expansion while maintain their stemness in culture

46. Exosomes of oral squamous cell carcinoma cells containing miR-181a-3p induce muscle cell atrophy and apoptosis by transmissible endoplasmic reticulum stress signaling

47. Exosomes secreted by placental stem cells selectively inhibit growth of aggressive prostate cancer cells

48. Expression profiles and clinical value of plasma exosomal Tim-3 and Galectin-9 in non-small cell lung cancer

49. Human umbilical cord mesenchymal stem cell-derived exosomes act via the miR-1263/Mob1/Hippo signaling pathway to prevent apoptosis in disuse osteoporosis

50. Hypoxic glioblastoma release exosomal VEGF-A induce the permeability of blood-brain barrier

51. Intrauterine exosomes are required for bovine conceptus implantation

52. K562 cell-derived exosomes suppress the adhesive function of bone marrow mesenchymal stem cells via delivery of miR-711

53. Keratinocytes-derived exosomal miRNA regulates osteoclast differentiation in middle ear cholesteatoma

54. Matrine reduces the secretion of exosomal circSLC7A6 from cancer-associated fibroblast to inhibit tumorigenesis of colorectal cancer by regulating CXCR5

55. Neutrophil-derived exosome from systemic sclerosis inhibits the proliferation and migration of endothelial cells

56. RASSF10 regulates bone invasion of growth hormone-secreting adenomas via exosomes

57. Regulation of hair follicle development by exosomes derived from dermal papilla cells

58. Schwann Cell-derived exosomes promote bone regeneration and repair by enhancing the biological activity of porous Ti6Al4V scaffolds

59. The long non-coding RNA PCSEAT exhibits an oncogenic property in prostate cancer and functions as a competing endogenous RNA that associates with EZH2

60. The role of actinin-4 (ACTN4) in exosomes as a potential novel therapeutic target in castration-resistant prostate cancer

61. A serum exosomal microRNA panel as a potential biomarker test for gastric cancer

62. Adipose mesenchymal stem cell-derived exosomes ameliorate hypoxia/serum deprivation-induced osteocyte apoptosis and osteocyte-mediated osteoclastogenesis in vitro

63. Adipose tissue macrophage-derived exosomal miR-29a regulates obesity-associated insulin resistance

64. Exosomal and extracellular HMGB1 have opposite effects on SASH1 expression in rat astrocytes and glioma C6 cells

65. Exosomal release through TRPML1-mediated lysosomal exocytosis is required for adipogenesis

66. Exosomes derived from mesenchymal stem cells attenuate the progression of atherosclerosis in ApoE−/- mice via miR-let7 mediated infiltration and polarization of M2 macrophage

67. Exosomes derived from plasma of septic patients inhibit apoptosis of T lymphocytes by down-regulating bad via hsa-miR-7-5p

68. Exosomes expressing carbonic anhydrase 9 promote angiogenesis

69. Glycan profiling analysis using evanescent-field fluorescence-assisted lectin array: Importance of sugar recognition for cellular uptake of exosomes from mesenchymal stem cells

70. Gut dysbiosis-derived exosomes trigger hepatic steatosis by transiting HMGB1 from intestinal to liver in mice