Journal name: Biochemical and biophysical research communications / Subject: leukemia / Text availability: Citation in PubAg

1. Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells

Author:: Shilpa Kuttikrishnan; Ajaz A. Bhat; Jericha M. Mateo; Fareed Ahmad; Feras Q. Alali; Tamam El-Elimat; Nicholas H. Oberlies; Cedric J. Pearce; Shahab Uddin
Source:: Biochemical and biophysical research communications 2022 v.601 pp. 59-64
ISSN:: 0006-291X
Subject:: antineoplastic activity; apoptosis; caspases; cell viability; fungi; leukemia; meroterpenoids; mitochondria; oncogenes; pro-apoptotic proteins; research; secondary metabolites; therapeutics
Abstract:: ... Neosetophomone B (NSP–B), a meroterpenoid fungal secondary metabolite, was investigated for its anticancer potential in leukemic cell lines (K562 and U937). NSP-B treatment of leukemic cells suppressed cell viability by triggering apoptotic cell death. Apoptosis induced by NSP-B is triggered by mitochondrial signaling and caspase activation. Additionally, NSP-B treatment of leukemic cells causes A ...
DOI:: 10.1016/j.bbrc.2022.02.071
: https://doi.org/10.1016/j.bbrc.2022.02.071

2. The CDK4/6-UCHL5-BRD4 axis confers resistance to BET inhibitors in MLL-rearranged leukemia cells by suppressing BRD4 protein degradation

Author:: Keigo Amari; Satoru Sasagawa; Natsuki Imayoshi; Yuki Toda; Shigekuni Hosogi; Toshihiko Imamura; Eishi Ashihara
Source:: Biochemical and biophysical research communications 2022 v.588 pp. 147-153
ISSN:: 0006-291X
Subject:: apoptosis; biomarkers; cell proliferation; cyclin-dependent kinase; isozymes; leukemia; prognosis; protein degradation; research; therapeutics; ubiquitinyl hydrolase 1
Abstract:: ... Among acute leukemias, mixed-lineage leukemia-rearranged (MLL-r) leukemia is associated with poor prognosis. Bromodomain and extra-terminal inhibitors (BETi) are promising agents for treatment of hematological malignancies; however, the mechanisms underlying sensitivity to BETi and biomarkers to predict sensitivity are yet to be clarified. Here, we established OTX015-resistant MLL-r cell lines (OT ...
DOI:: 10.1016/j.bbrc.2021.12.063
: https://doi.org/10.1016/j.bbrc.2021.12.063

3. Cyclophosphamide-induced GPX4 degradation triggers parthanatos by activating AIFM1

Author:: Liying Liu; Bingju Liu; Guotao Guan; Rui Kang; Yunpeng Dai; Daolin Tang
Source:: Biochemical and biophysical research communications 2022 v.606 pp. 68-74
ISSN:: 0006-291X
Subject:: alkylation agents; antineoplastic activity; autophagy; cyclophosphamide; ferroptosis; humans; leukemia; neoplasm cells; phospholipid-hydroperoxide glutathione peroxidase; phospholipids; protein degradation; research; xenotransplantation
Abstract:: ... Cyclophosphamide is an alkylating agent used to treat a variety of cancers, including leukemia. Here, we show a previously unrecognized role of cyclophosphamide in triggering the protein degradation of glutathione peroxidase 4 (GPX4), a phospholipid hydroperoxidase that protects cells from oxidative damage. Mechanistically, we found that the ubiquitin-proteasome system, but not autophagy, mediates ...
DOI:: 10.1016/j.bbrc.2022.03.098
: https://doi.org/10.1016/j.bbrc.2022.03.098

4. Highly polymerized proanthocyanidins (PAC) components from blueberry leaf and stem significantly inhibit SARS-CoV-2 infection via inhibition of ACE2 and viral 3CLpro enzymes

Author:: Kazuhiro Sugamoto; Yuri L. Tanaka; Akatsuki Saito; Yoh Goto; Takayuki Nakayama; Tamaki Okabayashi; Hisato Kunitake; Kazuhiro Morishita
Source:: Biochemical and biophysical research communications 2022 v.615 pp. 56-62
ISSN:: 0006-291X
Subject:: COVID-19 infection; Hepatitis C virus; Severe acute respiratory syndrome coronavirus 2; Vaccinium virgatum; antiviral properties; blueberries; cysteine proteinases; humans; leaves; leukemia; neutralization tests; pandemic; polymerization; proanthocyanidins; research; viruses
Abstract:: ... With the current worldwide pandemic of COVID-19, there is an urgent need to develop effective treatment and prevention methods against SARS-CoV-2 infection. We have previously reported that the proanthocyanidin (PAC) fraction in blueberry (BB) leaves has strong antiviral activity against hepatitis C virus (HCV) and human T-lymphocytic leukemia virus type 1 (HTLV-1). In this study, we used Kunisato ...
DOI:: 10.1016/j.bbrc.2022.04.072
: https://doi.org/10.1016/j.bbrc.2022.04.072

5. Promyelocytic leukemia protein is a restriction factor for Junín virus independently of Z matrix protein

Author:: Federico Giovannoni; Cecilia A. Vazquez; Pablo Thomas; Ricardo M. Gómez; Cybele C. García
Source:: Biochemical and biophysical research communications 2022 v.606 pp. 168-173
ISSN:: 0006-291X
Subject:: Argentine hemorrhagic fever; Lymphocytic choriomeningitis mammarenavirus; antiviral properties; antiviral proteins; cytoplasm; endemic diseases; etiological agents; humans; leukemia; mice; research; viruses; Argentina
Abstract:: ... The New World (NW) mammarenavirus Junín (JUNV) is the etiological agent of Argentine hemorrhagic fever, a human endemic disease of Argentina. Promyelocytic leukemia protein (PML) has been reported as a restriction factor for several viruses although the mechanism/s behind PML-mediated antiviral effect may be diverse and are a matter of debate. Previous studies have reported a nuclear to cytoplasm ...
DOI:: 10.1016/j.bbrc.2022.03.074
: https://doi.org/10.1016/j.bbrc.2022.03.074

6. Involvement of EZH2 inhibition in lenalidomide and pomalidomide-mediated growth suppression in HTLV-1-infected cells

Author:: Nobuyo Kondo; Yoshiko Nagano; Atsuhiko Hasegawa; Miku Ishizawa; Kuniko Katagiri; Takeru Yoneda; Takao Masuda; Mari Kannagi
Source:: Biochemical and biophysical research communications 2021 v.574 pp. 104-109
ISSN:: 0006-291X
Subject:: T-lymphocytes; adults; apoptosis; cell lines; histones; humans; leukemia; myeloma; research; substrate specificity; viruses
Abstract:: ... Immunomodulatory imide drugs (IMiDs), such as lenalidomide and pomalidomide, exert pleiotropic effects, e.g., antitumor effects in multiple myeloma, by binding the protein Cereblon and altering its substrate specificity. Lenalidomide is approved for the treatment of adult T-cell leukemia/lymphoma (ATL) caused by human T-cell leukemia virus type 1 (HTLV-1), although the precise mechanisms responsib ...
DOI:: 10.1016/j.bbrc.2021.08.051
: https://doi.org/10.1016/j.bbrc.2021.08.051

7. PML-II recruits ataxin-3 to PML-NBs and inhibits its deubiquitinating activity

Author:: Ying Zhang; An-wen Shao; Jun Tang; Yunyun Geng
Source:: Biochemical and biophysical research communications 2021 v.554 pp. 186-192
ISSN:: 0006-291X
Subject:: fluorescence microscopy; leukemia; research; ubiquitinyl hydrolase 1
Abstract:: ... Promyelocytic leukemia protein (PML) nuclear bodies (NBs) are dynamic and multiprotein complexes implicated in a variety of important biochemical events. Due to alternative mRNA splicing, PML has at least six nuclear isoforms that share a common N-terminus but differ in their C-terminal regions. However, the unique role of each PML isoform is not clear. Here, we report the characterization of the ...
DOI:: 10.1016/j.bbrc.2021.03.098
: https://doi.org/10.1016/j.bbrc.2021.03.098

8. A novel dipeptide type inhibitor of the Wnt/β-catenin pathway suppresses proliferation of acute myelogenous leukemia cells

Author:: Ryosuke Wakabayashi; Yasunao Hattori; Shigekuni Hosogi; Yuki Toda; Kazuyuki Takata; Eishi Ashihara
Source:: Biochemical and biophysical research communications 2021 v.535 pp. 73-79
ISSN:: 0006-291X
Subject:: Lampyridae; T-lymphocytes; apoptosis; carcinogenesis; cell cycle; dipeptides; dose response; gene expression; humans; idarubicin; leukemia; research; reverse transcriptase polymerase chain reaction
Abstract:: ... The Wnt/β-catenin pathway is an attractive target for the treatment of acute myelogenous leukemia (AML), since aberrant activation of the Wnt/β-catenin pathway contributes to carcinogenesis in various types of cancers including AML. Screening of an in-house compound library, constructed at Kyoto Pharmaceutical University, identified a novel compound designated “31” that was found to be an inhibito ...
DOI:: 10.1016/j.bbrc.2020.12.027
: https://doi.org/10.1016/j.bbrc.2020.12.027

9. Dasatinib, a second-generation tyrosine kinase inhibitor, induces melanogenesis via ERK-CREB-MITF-tyrosinase signaling in normal human melanocytes

Author:: Bogyeong Kang; Yeongeun Kim; Tae Jun Park; Hee Young Kang
Source:: Biochemical and biophysical research communications 2020 v.523 no.4 pp. 1034-1039
ISSN:: 0006-291X
Subject:: artificial skin; humans; leukemia; melanin; melanocytes; melanogenesis; phosphorylation; pigmentation; research; therapeutics; tyrosine
Abstract:: ... Dasatinib, a second-generation tyrosine kinase inhibitor, is indicated for the therapy of imatinib-resistant leukemia and also for the treatment of solid cancers. Here, we report a novel effect of dasatinib of inducing differentiation in normal human melanocytes. Treatment with dasatinib significantly increased the melanin content and tyrosinase activity through the up-regulation of MITF and tyros ...
DOI:: 10.1016/j.bbrc.2020.01.051
: https://doi.org/10.1016/j.bbrc.2020.01.051

10. Histone deacetylase 8 inhibition suppresses mantle cell lymphoma viability while preserving natural killer cell function

Author:: January M. Watters; Gabriela Wright; Matthew A. Smith; Bijal Shah; Kenneth L. Wright
Source:: Biochemical and biophysical research communications 2021 v.534 pp. 773-779
ISSN:: 0006-291X
Subject:: antibodies; apoptosis; cell cycle; clinical examination; cytokines; cytotoxicity; drug therapy; histone deacetylase; humans; interferon-gamma; leukemia; natural killer cells; non-Hodgkin lymphoma; post-translational modification; research; survival rate; viability
Abstract:: ... Mantle Cell Lymphoma (MCL) is a non-Hodgkin lymphoma with a median survival rate of five years. Standard treatment with high-dose chemotherapy plus rituximab (anti-CD20 antibody) has extended overall survival although, the disease remains incurable. Histone deacetylases (HDAC) are a family of enzymes that regulate multiple proteins and cellular pathways through post-translational modification. Bro ...
DOI:: 10.1016/j.bbrc.2020.11.001
: https://doi.org/10.1016/j.bbrc.2020.11.001

11. Identification and functional study of immortalized mouse thymic epithelial cells

Author:: Jia-Man Shen; Li Ma; Kai He; Wen-Qin Guo; Chuan Ding; Robert D. Hoffman; Bing-Qian He; Hong-Bin Zheng; Jian-Li Gao
Source:: Biochemical and biophysical research communications 2020 v.525 no.2 pp. 440-446
ISSN:: 0006-291X
Subject:: T-lymphocytes; agar; antigens; apoptosis; cell cycle; cell structures; coculture; epithelial cells; epithelium; flow cytometry; gentian violet; humans; interleukin-7; leukemia; mice; models; paclitaxel; photography; propidium; research; viruses
Abstract:: ... As the key cells in a three-dimensional scaffold within the thymus, Thymic epithelial cells (TECs) play critical roles in the homing, migration and differentiation of T cell precursors through adhesive interactions and the release of various cytokines. In this study, primary cultures of mouse TECs were isolated and identified with TEC-specific antibodies CK5 and CK8. These TECs were immortalized b ...
DOI:: 10.1016/j.bbrc.2020.02.083
: https://doi.org/10.1016/j.bbrc.2020.02.083

12. JAK2 inhibition in JAK2V617F-bearing leukemia cells enriches CD34+ leukemic stem cells that are abolished by the telomerase inhibitor GRN163L

Author:: Jenny Dahlström; Chuanyou Xia; Xiangling Xing; Xiaotian Yuan; Magnus Björkholm; Dawei Xu
Source:: Biochemical and biophysical research communications 2020 v.527 no.2 pp. 425-431
ISSN:: 0006-291X
Subject:: apoptosis; cell lines; leukemia; mice; research; stem cell factor; telomerase; therapeutics
Abstract:: ... The activating-mutation of JAK2V617F drives the development of myeloproliferative neoplasms (MPNs). Several JAK2 inhibitors such as ruxolitinib and gandotinib (LY2784544) currently in clinical trials and, provide improvements in MPNs including myelofibrosis. However, JAK2 inhibitors are non-curative and murine experiments show that JAK2 inhibitors don’t eradicate MPN stem cells and it is currently ...
DOI:: 10.1016/j.bbrc.2020.04.058
: https://doi.org/10.1016/j.bbrc.2020.04.058

13. NLS-RARα blocks cell differentiation by inhibiting the retinoic acid signalling pathway

Author:: Jian Li; Liang Zhong; Jiao Ye; Ling Xiong; Lihua Yu; Wenran Dan; Pengqiang Zhong; Zhen Yuan; Dongdong Liu; Juanjuan Yao; Junmei Liu; Beizhong Liu
Source:: Biochemical and biophysical research communications 2020 v.528 no.2 pp. 276-284
ISSN:: 0006-291X
Subject:: Western blotting; cell differentiation; elastase; genes; leukemia; neutrophils; research; retinoic acid; reverse transcriptase polymerase chain reaction; transcription (genetics); transcriptional activation
Abstract:: ... A majority of acute promyelocytic leukaemia (APL) cases are characterized by the PML-RARα fusion gene. Previous studies have shown that neutrophil elastase (NE) can cleave PML-RARα and is important for the development of APL. Here, we demonstrate that one of the cleavage products of PML-RARα, NLS-RARα, can block cell differentiation by repressing the expression of the target genes within the retin ...
DOI:: 10.1016/j.bbrc.2020.05.076
: https://doi.org/10.1016/j.bbrc.2020.05.076

14. Rosiglitazone binds to RXRα to induce RXRα tetramerization and NB4 cell differentiation

Author:: Fengyu Huang; Yihuan Li; Junjie Chen; Xiao-kun Zhang; Hu Zhou
Source:: Biochemical and biophysical research communications 2020 v.530 no.1 pp. 160-166
ISSN:: 0006-291X
Subject:: cell differentiation; cell proliferation; leukemia; ligands; research; therapeutics; transcription (genetics)
Abstract:: ... Rosiglitazone is a ligand of peroxisome proliferation-activated receptor gamma (PPARγ). However, it exerts biological activities and therapeutic effects through both PPARγ-dependent and independent mechanisms. In this study, we defined that rosiglitazone was also a ligand of retinoid X receptor alpha (RXRα) and displayed RXRα-dependent activities. We found that rosiglitazone directly bound to the ...
DOI:: 10.1016/j.bbrc.2020.06.134
: https://doi.org/10.1016/j.bbrc.2020.06.134

15. T618I CSF3R mutations in chronic neutrophilic leukemia induce oncogenic signals through aberrant trafficking and constitutive phosphorylation of the O-glycosylated receptor form

Author:: Andrea Price; Lawrence J. Druhan; Amanda Lance; Gavin Clark; C. Greer Vestal; Qing Zhang; David Foureau; Judy Parsons; Alicia Hamilton; Nury M. Steuerwald; Belinda R. Avalos
Source:: Biochemical and biophysical research communications 2020 v.523 no.1 pp. 208-213
ISSN:: 0006-291X
Subject:: colony-stimulating factors; dimerization; glycosylation; leukemia; ligands; mutants; mutation; phosphorylation; proteasome endopeptidase complex; research; tyrosine
Abstract:: ... Activating mutations in the membrane-proximal region of the colony-stimulating factor 3 receptor (CSF3R) are a hallmark of chronic neutrophilic leukemia (CNL) with the T618I mutation being most common. The mechanisms underlying constitutive activation of the T618I CSF3R and its signal propagation are poorly understood. Ligand-independent activation of the T618I CSF3R has previously been attributed ...
DOI:: 10.1016/j.bbrc.2019.12.030
: https://doi.org/10.1016/j.bbrc.2019.12.030

16. AFF4 enhances odontogenic differentiation of human dental pulp cells

Author:: Yuning Zhang; Qingyue Xiao; Zuping Wu; Ruoshi Xu; Shujuan Zou; Chenchen Zhou
Source:: Biochemical and biophysical research communications 2020 v.525 no.3 pp. 687-692
ISSN:: 0006-291X
Subject:: alkaline phosphatase; calcium; head; head and neck neoplasms; humans; leukemia; mineralization; research; scaffolding proteins; tooth pulp; tooth root
Abstract:: ... AFF4 is a component of super elongation complex (SECs) and functions as a scaffold protein to bridge the transcription elongation factors. It is associated with leukemia, HIV transcription, and head neck cancer. However, its role in odontogenic differentiation of dental pulp cells (DPCs) is unclear. Here, we show the expression of AFF4 is increased during odontogenesis. Depletion of AFF4 in human ...
DOI:: 10.1016/j.bbrc.2020.02.122
: https://doi.org/10.1016/j.bbrc.2020.02.122

17. CD47/SIRPα blocking enhances CD19/CD3-bispecific T cell engager antibody-mediated lysis of B cell malignancies

Author:: Lijun Xu; Shanlong Wang; Jie Li; Bingyu Li
Source:: Biochemical and biophysical research communications 2019 v.509 no.3 pp. 739-745
ISSN:: 0006-291X
Subject:: B-lymphocytes; T-lymphocytes; adaptive immunity; antibodies; cytotoxicity; humans; immunotherapy; leukemia; macrophages; mice; neoplasm cells; non-Hodgkin lymphoma; patients; phagocytosis
Abstract:: ... T cell immunotherapies are promising options in leukemia, among which the CD19/CD3-bispecific T cell engager antibody blinatumomab (MT103) has shown high response rates at very low doses in patients with lymphoma. However, the high CD47 expression in human lymphoma cells has limited the curative effects of blinatumomab other antibodies. Here we report the combined use of blinatumomab with a CD47-b ...
DOI:: 10.1016/j.bbrc.2018.12.175
: https://doi.org/10.1016/j.bbrc.2018.12.175

18. Characterization of the substrate specificity of the inositol 5-phosphatase SHIP1

Author:: Nina Nelson; Torsten Wundenberg; Hongying Lin; Christoph Rehbach; Stefan Horn; Sabine Windhorst; Manfred Jücker
Source:: Biochemical and biophysical research communications 2020 v.524 no.2 pp. 366-370
ISSN:: 0006-291X
Subject:: dyes; high performance liquid chromatography; hydrolysis; inositols; leukemia; phosphates; research; substrate specificity
Abstract:: ... SHIP1 is an inositol 5-phosphatase which is well established for its tumour suppressor potential in leukaemia. Enzymatically, two SHIP1 substrates, PtdIns(3,4,5)P₃ and Ins(1,3,4,5)P₄ have been identified to date. Additional substrates were found for the homologue SHIP2. In this study, we identified new inositol phosphate (InsP) substrates of SHIP1 by metal dye detection high-performance liquid chr ...
DOI:: 10.1016/j.bbrc.2020.01.012
: https://doi.org/10.1016/j.bbrc.2020.01.012

19. Functional expression cloning of molecules inducing CD34 expression in bone marrow-derived stromal myofibroblasts

Author:: Takuji Matsuo; Haruko Tashiro; Ritsu Sumiyoshi; Sumiko Saito; Ryosuke Shirasaki; Naoki Shirafuji
Source:: Biochemical and biophysical research communications 2020 v.533 no.4 pp. 1283-1289
ISSN:: 0006-291X
Subject:: blood; bone marrow; fibroblasts; genes; humans; interleukin-6; leukemia; phytohemagglutinin; research
Abstract:: ... We have previously shown a fraction of stromal fibroblasts/myofibroblasts (Fibs) from leukemic bone marrow cells expresses leukemia-specific transcripts along with hematopoietic and Fib-related markers. Normal bone marrow-derived Fibs (nFibs) do not express CD34 or CD45; however, nFibs may express hematopoietic markers with some specific stimulations. CD34 expression was detected in nFib cultures ...
DOI:: 10.1016/j.bbrc.2020.10.006
: https://doi.org/10.1016/j.bbrc.2020.10.006

20. Induction of human pluripotent stem cell-derived natural killer cells for immunotherapy under chemically defined conditions

Author:: Hiroyuki Matsubara; Akira Niwa; Tatsutoshi Nakahata; Megumu K. Saito
Source:: Biochemical and biophysical research communications 2019 v.515 no.1 pp. 1-8
ISSN:: 0006-291X
Subject:: allografting; antigens; blood serum; cattle; cell lines; cytotoxicity; humans; immunotherapy; leukemia; natural killer cells; neoplasm cells; phenotype; risk; stem cells
Abstract:: ... Natural killer (NK) cells are innate lymphocytes and show cytotoxicity against tumor cells without prior antigen specific stimulation. Because of their innate properties, NK cells are being considered for immunotherapies against various malignancies or leukemia. Human pluripotent stem cells (hPSCs) are capable of inducing enough NK cells for allogeneic transplantation. However, current induction p ...
DOI:: 10.1016/j.bbrc.2019.03.085
: https://doi.org/10.1016/j.bbrc.2019.03.085

21. Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells

Author:: Chisato Inoue; Sayaka Sobue; Yoshiyuki Kawamoto; Yuji Nishizawa; Masatoshi Ichihara; Akihiro Abe; Fumihiko Hayakawa; Motoshi Suzuki; Yoshinori Nozawa; Takahsi Murate
Source:: Biochemical and biophysical research communications 2020 v.525 no.4 pp. 1074-1080
ISSN:: 0006-291X
Subject:: D2 protein; apoptosis; cardiovascular diseases; cell lines; cyclins; cytotoxicity; dephosphorylation; leukemia; mutation; phosphatidylinositol 3-kinase; proteasome inhibitors; protein degradation; protein synthesis; research; synergism
Abstract:: ... T315I mutation found in chronic myelogenous leukemia (CML) and Ph + ALL patients is the most serious one among resistance against BCR/ABL kinase inhibitors including imatinib and is only responsive to ponatinib (PNT). However, the novel strategy is required to reduce life-threatening adverse effects of PNT including ischemic cardiovascular disease. We examined the mechanism of PNT-induced cytotoxi ...
DOI:: 10.1016/j.bbrc.2020.02.165
: https://doi.org/10.1016/j.bbrc.2020.02.165

22. JTE-607, a multiple cytokine production inhibitor, targets CPSF3 and inhibits pre-mRNA processing

Author:: Junya Kakegawa; Naoki Sakane; Kensuke Suzuki; Takayuki Yoshida
Source:: Biochemical and biophysical research communications 2019 v.518 no.1 pp. 32-37
ISSN:: 0006-291X
Subject:: affinity chromatography; cytokines; hydrolysis; leukemia; mechanism of action; messenger RNA; research
Abstract:: ... JTE-607 is a small molecule that was developed as an inflammatory cytokine inhibitor and also as an anti-leukemia reagent for monocytic leukemia. However, the mode of action of JTE-607 remains unknown. In this study, we identified JTE-607 to be a prodrug compound that is converted to an active form by ester hydrolysis. Furthermore, we determined that the active form of JTE-607 bound cleavage and p ...
DOI:: 10.1016/j.bbrc.2019.08.004
: https://doi.org/10.1016/j.bbrc.2019.08.004

23. K562 cell-derived exosomes suppress the adhesive function of bone marrow mesenchymal stem cells via delivery of miR-711

Author:: Yu-Huan Jiang; Jing Liu; Jin Lin; Shu-Qi Li; Yan-Mei Xu; Qing-Hua Min; Qiong-Hui Zhong; Fan Sun; Jing Li; Xia-Hong You; Kai-Li Liao; Ting-Yu Qin; Cui Zhao; Bo Huang; Xiao-Zhong Wang
Source:: Biochemical and biophysical research communications 2020 v.521 no.3 pp. 584-589
ISSN:: 0006-291X
Subject:: adhesion; bone marrow; coculture; exosomes; leukemia; microRNA; research
Abstract:: ... A failure of bone marrow mesenchymal stem cells (BM-MSCs) to adhere to hematopoietic cells is an essential cause of the progression of chronic myelogenous leukemia and is also a cause of failure of bone marrow (BM) transplantation, but the exact mechanisms of this have not been fully elucidated. Recent studies have indicated that microRNAs (miRNAs) are contained in leukemia-derived exosomes and ar ...
DOI:: 10.1016/j.bbrc.2019.10.096
: https://doi.org/10.1016/j.bbrc.2019.10.096

24. Megakaryocytic leukemia 1 (MKL1) mediates high glucose induced epithelial-mesenchymal transition by activating LOX transcription

Author:: Yuhua Ding; Huihui Xu; Luyang Li; Yibiao Yuan; Yong Xu
Source:: Biochemical and biophysical research communications 2019 v.509 no.3 pp. 633-640
ISSN:: 0006-291X
Subject:: actin; cadherins; chromatin; diabetic retinopathy; epigenetics; epithelial cells; epithelium; glucose; leukemia; small interfering RNA; smooth muscle; transcription (genetics); transcription factors; transcriptional activation
Abstract:: ... Diabetic retinopathy (DR) is one of the most devastating complications of diabetes mellitus. When exposed to high glucose (HG), retinal epithelial cells undergo profound alterations both morphologically and functionally in a well-conserved process known as epithelial-to-mesenchymal transition (EMT). The mechanism governing HG-induced EMT in retinal epithelial cells is not completely understood. He ...
DOI:: 10.1016/j.bbrc.2018.12.024
: https://doi.org/10.1016/j.bbrc.2018.12.024

25. PML modulates H3.3 targeting to telomeric and centromeric repeats in mouse fibroblasts

Author:: Jane Spirkoski; Akshay Shah; Andrew H. Reiner; Philippe Collas; Erwan Delbarre
Source:: Biochemical and biophysical research communications 2019 v.511 no.4 pp. 882-888
ISSN:: 0006-291X
Subject:: centromeres; fibroblasts; gene expression; genes; heterochromatin; histones; leukemia; mice; non-coding RNA; telomeres
Abstract:: ... Targeted deposition of histone variant H3.3 into chromatin is paramount for proper regulation of chromatin integrity, particularly in heterochromatic regions including repeats. We have recently shown that the promyelocytic leukemia (PML) protein prevents H3.3 from being deposited in large heterochromatic PML-associated domains (PADs). However, to what extent PML modulates H3.3 loading on chromatin ...
DOI:: 10.1016/j.bbrc.2019.02.087
: https://doi.org/10.1016/j.bbrc.2019.02.087

26. The novel small molecular BH3 mimetics SM3 and its regulation of cell apoptosis and autophagy

Author:: Yefan Wang; Shengjun Fan; Xin Li; Yilixiati Xiaokaiti; Yan Pan; Lu Tie; Xuejun Li
Source:: Biochemical and biophysical research communications 2019 v.517 no.1 pp. 15-22
ISSN:: 0006-291X
Subject:: antagonism; apoptosis; autophagy; cell viability; clinical trials; death; drugs; leukemia; pro-apoptotic proteins; proteins; screening; synergism
Abstract:: ... Bcl-2 family proteins play an important role in regulation of the cell survival and death. The inhibition of the anti-apoptotic proteins of Bcl-2 family leads to the apoptosis of cancer. BH3 mimetics have been developed targeting anti-apoptotic proteins of Bcl-2 family as small molecular drugs. It has been proved that BH3 mimetics has effect on apoptosis and proliferation in leukemia and some of t ...
DOI:: 10.1016/j.bbrc.2019.06.068
: https://doi.org/10.1016/j.bbrc.2019.06.068

27. IL- 10 gene-modified dendritic cells-induced type 1 T regulatory cells inhibit graft-versus-host disease while preserving graft-versus-leukemia effect

Author:: Jiangbo Wan; Fang Huang; Weiwei Hu; Siguo Hao
Source:: Biochemical and biophysical research communications 2018 v.507 no.1-4 pp. 122-127
ISSN:: 0006-291X
Subject:: CD4-positive T-lymphocytes; animal models; bone marrow transplant; dendritic cells; genes; interleukin-10; leukemia; mice
Abstract:: ... To explore the role of type 1 regulatory T (Tr1) cells in allogeneic bone marrow transplantation (allo-BMT), we generated Tr1 cells from naïve CD4+ T cells in donor mice that were subjected to stimulation of recipient interleukin (IL)-10 gene-modified dendritic cells (DCs). In animal models, the severity of graft-versus-host disease (GVHD) in the group co-infused with DC-induced Tr1 cells was mark ...
DOI:: 10.1016/j.bbrc.2018.10.183
: https://doi.org/10.1016/j.bbrc.2018.10.183

28. 4-Amino-2-Trifluoromethyl-Phenyl Retinate induced leukemia cell differentiation by decreasing eIF6

Author:: Ke Wang; Cong Wang; Chuan-Jun Zhu; Ge Li; Yue Li; Yu-Bin Feng; Jing-Jing Ruan; Fei Zhu; Yao Meng; Ren-Peng Zhou; Fei-Hu Chen
Source:: Biochemical and biophysical research communications 2018 v.503 no.3 pp. 2033-2039
ISSN:: 0006-291X
Subject:: carcinoma; cell cycle; cell differentiation; cell lines; cell proliferation; chrysin; leukemia; neoplasm cells; retinoic acid
Abstract:: ... 4-Amino-2-Trifluoromethyl-Phenyl Retinate (ATPR), an all-trans retinoic acid (ATRA) derivative, possesses the ability to relief several carcinoma. Here, we explored the potential molecular mechanism of eukaryotic translation initiation factor 6 (eIF6) in ATPR-induced leukemia cell differentiation. Our research showed that ATPR could inhibit cell proliferation and promote cell differentiation in se ...
DOI:: 10.1016/j.bbrc.2018.07.153
: https://doi.org/10.1016/j.bbrc.2018.07.153

29. Activation of Notch1 signaling by HTLV-1 Tax promotes proliferation of adult T-cell leukemia cells

Author:: Wenzhao Cheng; Tingjin Zheng; Yong Wang; Kun Cai; Wencai Wu; Tiejun Zhao; Ruian Xu
Source:: Biochemical and biophysical research communications 2019 v.512 no.3 pp. 598-603
ISSN:: 0006-291X
Subject:: Primate T-lymphotropic virus 1; T-lymphocytes; adults; cell lines; cell proliferation; half life; leukemia; neoplasm cells
Abstract:: ... Human T-cell leukemia virus 1 (HTLV-1), an oncogenic retrovirus, and Notch1 signaling, implicated in tumor formation and progression, are both associated with the development of adult T-cell leukemia (ATL). Here we explored the possibility of a mechanistic link between the two. We observed that the expression of Notch intracellular domain (NICD) was elevated in HTLV-1 infected cell lines. Knocking ...
DOI:: 10.1016/j.bbrc.2019.03.094
: https://doi.org/10.1016/j.bbrc.2019.03.094

30. Adenylate cyclase 7 regulated by miR-192 promotes ATRA-induced differentiation of acute promyelocytic leukemia cells

Author:: Bing He; Yanyan Chang; Chao Yang; Zhanglin Zhang; Guiping Xu; Xianqi Feng; Likun Zhuang
Source:: Biochemical and biophysical research communications 2018 v.506 no.3 pp. 543-547
ISSN:: 0006-291X
Subject:: adenylate cyclase; biomarkers; cell differentiation; cyclic AMP; disease course; leukemia; neoplasm cells; patients; retinoic acid; therapeutics
Abstract:: ... Adenylate cyclase 7 (AC7) has been reported to participate in various biological processes during cancer progression. However, the roles of AC7 in all-trans retinoic acid (ATRA)-induced differentiation of acute promyelocytic leukemia (APL) cells are still unknown. In this study, firstly, our results showed that AC7 affected intracellular cAMP level and influenced ATRA-induced differentiation of AP ...
DOI:: 10.1016/j.bbrc.2018.10.125
: https://doi.org/10.1016/j.bbrc.2018.10.125

31. E2f1 regulates the induction of promyelocytic leukemia zinc finger transcription in neuronal differentiation of pluripotent P19 embryonal carcinoma cells

Author:: Hsin-Chuan Lin; Chiung-Yuan Ko; Kuen-Haur Lee; I-Han Chen; Tzu-Jen Kao; Wen-Chang Chang; Tsung-I Hsu; Yi-Chao Lee
Source:: Biochemical and biophysical research communications 2019 v.512 no.3 pp. 629-634
ISSN:: 0006-291X
Subject:: binding sites; brain; leukemia; models; neoplasm cells; neural stem cells; neurons; transcription (genetics); transcription factors; transcription initiation site; zinc finger motif
Abstract:: ... During brain development, the expression of promyelocytic leukemia zinc finger (Plzf) in neural stem cells is precisely controlled to maintain the balance between neural stem cell self-renewal and differentiation. However, the mechanism underlying transcriptional regulation of Plzf in neural stem cell is still unclear. Herein, using P19 embryonal carcinoma cells as a model, we observed that Plzf e ...
DOI:: 10.1016/j.bbrc.2019.03.058
: https://doi.org/10.1016/j.bbrc.2019.03.058

32. Effect of trichostatin A on Burkitt's lymphoma cells: Inhibition of EPS8 activity through Phospho-Erk1/2 pathway

Author:: Peipei Sun; Xin Zhou; Yingzhi He; Huimin Liu; Yuxin Wang; Yiran Chen; Meifang Li; Yanjie He; Guowei Li; Yuhua Li
Source:: Biochemical and biophysical research communications 2018 v.497 pp. 990-996
ISSN:: 0006-291X
Subject:: B-cell lymphoma; apoptosis; cell proliferation; cell viability; enzyme inhibitors; epidermal growth factor receptors; epirubicin; histone deacetylase; leukemia; mice; neoplasm cells; prognosis
Abstract:: ... Histone deacetylase inhibitors (HDACi) manifest great potential for treatment of Burkitt's lymphoma (BL), an aggressive B-cell lymphoma. Epidermal growth factor receptor pathway substrate 8 (EPS8) is confirmed overexpressed and associated with poor prognosis in solid tumors and leukemia. However, EPS8 expression and the relationship between EPS8 and HDACi on BL remains obscure. Here, we hypothesiz ...
DOI:: 10.1016/j.bbrc.2018.02.128
: https://doi.org/10.1016/j.bbrc.2018.02.128

33. Elastic modulus and migration capability of drug treated leukemia cells K562

Author:: Kui Wang; Yuntian Xue; Ying Peng; Xiangchao Pang; Yuanjun Zhang; L.I. Ruiz-Ortega; Ye Tian; A.H.W. Ngan; Bin Tang
Source:: Biochemical and biophysical research communications 2019 v.516 no.1 pp. 177-182
ISSN:: 0006-291X
Subject:: biomechanics; bone marrow; cytoskeleton; dexamethasone; genes; hematopoietic stem cells; leukemia; modulus of elasticity; neoplasm cells; optical traps; protein synthesis; quantitative polymerase chain reaction; retinoic acid; tubulin; vimentin; viscoelasticity
Abstract:: ... Leukemia is a commonly seen disease caused by abnormal differentiation of hematopoietic stem cells and blasting in bone marrow. Despite drugs are used to treat the disease clinically, the influence of these drugs on leukemia cells’ biomechanical properties, which are closely related to complications like leukostasis or infiltration, is still unclear. Due to non-adherent and viscoelastic nature of ...
DOI:: 10.1016/j.bbrc.2019.06.024
: https://doi.org/10.1016/j.bbrc.2019.06.024

34. Identification of a point mutation PMLS214L-RARα that alters PML body organization, dynamics and SUMOylation

Author:: Shanshan Zhao; Peng Shi; Qihang Zhong; Shipeng Shao; Yuxing Huang; Yujie Sun; Congying Wu; Hong-Hu Zhu
Source:: Biochemical and biophysical research communications 2019 v.511 no.3 pp. 518-523
ISSN:: 0006-291X
Subject:: arsenic oxide; drug resistance; drug therapy; fluorescence recovery after photobleaching; leukemia; moieties; mutants; oncogene proteins; patients; point mutation; retinoic acid; retrospective studies; sumoylation
Abstract:: ... Genetic mutations on PML-RARα in acute promyelocytic leukemia (APL) are reported to associate with arsenic trioxide (ATO) or all-trans retinoic acid (ATRA) resistance. Here we performed a retrospective analysis of APL patients and identified that the patient with S214L mutation on the PML moiety of PML-RARα showed resistance to both ATO and ATRA. Super-resolution microcopy was used to examine the ...
DOI:: 10.1016/j.bbrc.2019.02.101
: https://doi.org/10.1016/j.bbrc.2019.02.101

35. Influence of acute promyelocytic leukemia therapeutic drugs on nuclear pore complex density and integrity

Author:: Anna Lång; Alexander Øye; Jens Eriksson; Alexander D. Rowe; Emma Lång; Stig Ove Bøe
Source:: Biochemical and biophysical research communications 2018 v.499 pp. 570-576
ISSN:: 0006-291X
Subject:: arsenic oxide; cell differentiation; cytoplasm; drugs; imports; leukemia; mitosis; nuclear pore; nuclear proteins; oncogene proteins; physiological transport; retinoic acid; stem cells; therapeutics
Abstract:: ... During cell division, a large number of nuclear proteins are released into the cytoplasm due to nuclear envelope breakdown. Timely nuclear import of these proteins following exit from mitosis is critical for establishment of the G1 nuclear environment. Dysregulation of post-mitotic nuclear import may affect the fate of newly divided stem or progenitor cells and may lead to cancer. Acute promyelocy ...
DOI:: 10.1016/j.bbrc.2018.03.191
: https://doi.org/10.1016/j.bbrc.2018.03.191

36. MicroRNA-3662 expression correlates with antiviral drug resistance in adult T-cell leukemia/lymphoma cells

Author:: Kiyoshi Yasui; Mai Izumida; Takeya Nakagawa; Yoshinao Kubo; Hideki Hayashi; Takashi Ito; Hiroaki Ikeda; Toshifumi Matsuyama
Source:: Biochemical and biophysical research communications 2018 v.501 no.4 pp. 833-837
ISSN:: 0006-291X
Subject:: T-lymphocytes; adults; antiviral agents; binding sites; cell lines; cell proliferation; drug resistance; interferon regulatory factors; leukemia; lymphoma; neoplasm cells; proto-oncogenes
Abstract:: ... Interferon regulatory factor (IRF) 4 and the proto-oncogene c-Rel cooperate in growth and antiviral drug resistance of adult T-cell leukemia/lymphoma (ATLL). To elucidate the target of IRF4 and c-Rel in ATLL, we determined the simultaneous binding sites of IRF4 and c-Rel using ChIP-seq technology. Nine genes were identified within 2 kb of binding sites, including MIR3662. Expression of miR-3662 wa ...
DOI:: 10.1016/j.bbrc.2018.04.159
: https://doi.org/10.1016/j.bbrc.2018.04.159

37. PATZ1 is required for efficient HIV-1 infection

Author:: Ishmael Dzigbordi Aziati; Takeshi Yoshida; Akiko Hamano; Kenjiro Maeda; Hiroaki Takeuchi; Shoji Yamaoka
Source:: Biochemical and biophysical research communications 2019 v.514 no.2 pp. 538-544
ISSN:: 0006-291X
Subject:: HIV infections; complementary DNA; humans; leukemia; mice; retroviral vectors; therapeutics; transcription factors; viruses; zinc finger motif
Abstract:: ... Successful HIV-1 infection and subsequent replication deeply depend on how the virus usurps the host cell machinery. Identification and functional characterization of these host factors may represent a critical strategy for developing novel anti-HIV-1 therapy. Here, expression cloning with a cDNA expression library identified as an inhibitor of HIV-1 infection, a carboxy-terminally truncated form ...
DOI:: 10.1016/j.bbrc.2019.04.175
: https://doi.org/10.1016/j.bbrc.2019.04.175

38. Resveratrol strongly enhances the retinoic acid-induced superoxide generating activity via up-regulation of gp91-phox gene expression in U937 cells

Author:: Hidehiko Kikuchi; Hitomi Mimuro; Futoshi Kuribayashi
Source:: Biochemical and biophysical research communications 2018 v.495 no.1 pp. 1195-1200
ISSN:: 0006-291X
Subject:: acetylation; chemical constituents of plants; chromatin; gene expression; gene expression regulation; genes; histones; humans; leukemia; phagocytes; promoter regions; protein content; resveratrol; retinoic acid; reverse transcriptase polymerase chain reaction; superoxide anion; transcription (genetics)
Abstract:: ... The membrane bound cytochrome b₅₅₈ composed of gp91-phox and p22-phox proteins, and cytosolic proteins p40-, p47-and p67-phox are important components of superoxide (O₂⁻)-generating system in phagocytes. Here, we describe that resveratrol, a pleiotropic phytochemical belonging to the stilbenoids, dramatically activates the O₂⁻-generating system during retinoic acid (RA)-induced differentiation of ...
DOI:: 10.1016/j.bbrc.2017.11.161
: https://doi.org/10.1016/j.bbrc.2017.11.161

39. Activation of Wnt signaling pathway by AF1q enriches stem-like population and enhance mammosphere formation of breast cells

Author:: Charlotte Olivia Tse; Soojin Kim; Jino Park
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: animal ovaries; breast neoplasms; leukemia; metastasis; oncogenes; ovarian neoplasms; prognosis; quercetin; signal transduction; stem cells
Abstract:: ... Wnt signaling pathway is believed to be responsible for control over various types of stem cells and may act as a niche factor to maintain stem cells in a self-renewing state. Moreover, dysregulated Wnt signaling pathway is strongly associated with several diseases including cancer. Previously, we have shown that AF1q associates with a poor prognosis in leukemia, myelodysplastic syndromes, multipl ...
DOI:: 10.1016/j.bbrc.2017.02.018
: https://doi.org/10.1016/j.bbrc.2017.02.018

40. BCL11B is frequently downregulated in HTLV-1-infected T-cells through Tax-mediated proteasomal degradation

Author:: Happy Kurnia Permatasari; Shingo Nakahata; Tomonaga Ichikawa; Kazuhiro Morishita
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: B-lymphocytes; Primate T-lymphotropic virus 1; T-lymphocytes; adults; cytoplasm; gene expression regulation; leukemia; lymphoma; messenger RNA; transcription (genetics); transcription factors; tumor suppressor genes; ubiquitination
Abstract:: ... Human T-cell leukemia virus type 1 (HTLV-1) is a causative agent of adult T-cell leukemia-lymphoma (ATLL). The HTLV-1-encoded protein Tax plays important roles in the proliferation of HTLV-1-infected T-cells by affecting cellular proteins. In this study, we showed that Tax transcriptionally and post-transcriptionally downregulates the expression of the tumor suppressor gene B-cell leukemia/lymphom ...
DOI:: 10.1016/j.bbrc.2017.06.172
: https://doi.org/10.1016/j.bbrc.2017.06.172

41. C/EBPβ contributes to transcriptional activation of long non-coding RNA NEAT1 during APL cell differentiation

Author:: Yewei Wang; Lei Fu; Ailian Sun; Doudou Tang; Yunxiao Xu; Zheyuan Li; Mingjie Chen; Guangsen Zhang
Source:: Biochemical and biophysical research communications 2018 v.499 no.2 pp. 99-104
ISSN:: 0006-291X
Subject:: binding sites; carcinogenesis; cell differentiation; chromatin; leukemia; luciferase; non-coding RNA; precipitin tests; retinoic acid; therapeutics; transcription factors; transcriptional activation
Abstract:: ... Emerging evidences have shown that long non-coding RNAs (lncRNAs) play critical roles in cancer development and cancer therapy. LncRNA Nuclear Enriched Abundant Transcript 1 (NEAT1) is indispensable during acute promyelocytic leukemia (APL) cell differentiation induced by all-trans retinoic acid (ATRA). However, the precise mechanism of NEAT1 upregulation has not been fully understood. In this stu ...
DOI:: 10.1016/j.bbrc.2017.10.137
: https://doi.org/10.1016/j.bbrc.2017.10.137

42. Characterization of goat inner cell mass derived cells in double kinase inhibition condition

Author:: Qiang Wei; Qihui Xi; Xiaokun Liu; Kai Meng; Xiaoe Zhao; Baohua Ma
Source:: Biochemical and biophysical research communications 2017 v.483 pp. 325-331
ISSN:: 0006-291X
Subject:: embryogenesis; embryonic stem cells; goats; humans; leukemia; mice; mitogen-activated protein kinase kinase; mitogen-activated protein kinase kinase kinase; tau-protein kinase
Abstract:: ... The identification of small molecular inhibitors, which were reported to promote the derivation of mouse and human embryonic stem cells (ESCs), provides a potential strategy for the derivation of domesticated ungulate ESCs. In present study, goat inner cell mass (ICM) derived cells in the double inhibition (2i) condition, in which, mitogen-activated protein kinase kinase (MAP2K) and glycogen synth ...
DOI:: 10.1016/j.bbrc.2016.12.144
: https://doi.org/10.1016/j.bbrc.2016.12.144

43. MOV10 inhibits replication of porcine reproductive and respiratory syndrome virus by retaining viral nucleocapsid protein in the cytoplasm of Marc-145 cells

Author:: Kuan Zhao; Li-Wei Li; Yu-Jiao Zhang; Yi-Feng Jiang; Fei Gao; Guo-Xin Li; Ling-Xue Yu; Wen-Ying Zhao; Tong-Ling Shan; Yan-Jun Zhou; Guang-Zhi Tong
Source:: Biochemical and biophysical research communications 2018 v.504 no.1 pp. 157-163
ISSN:: 0006-291X
Subject:: Porcine reproductive and respiratory syndrome virus; adsorption; control methods; cytoplasm; drugs; fluorescent antibody technique; leukemia; livestock production; nucleocapsid; nucleocapsid proteins; physiological transport; precipitin tests; protein content; swine; virus replication; viruses
Abstract:: ... Porcine reproductive and respiratory syndrome virus (PRRSV) has been a major threat to global industrial pig farming ever since its emergence in the late 1980s. Identification of sustainable and effective control measures against PRRSV transmission is a pressing problem. The nucleocapsid (N) protein of PRRSV is specifically localized in the cytoplasm and nucleus of virus-infected cells which is im ...
DOI:: 10.1016/j.bbrc.2018.08.148
: https://doi.org/10.1016/j.bbrc.2018.08.148

44. Novel biosensor using split-luciferase for detecting vitamin D receptor ligands based on the interaction between vitamin D receptor and coactivator

Author:: Hiroki Mano; Masashi Takano; Shinichi Ikushiro; Atsushi Kittaka; Toshiyuki Sakaki
Source:: Biochemical and biophysical research communications 2018 v.505 no.2 pp. 460-465
ISSN:: 0006-291X
Subject:: binding capacity; biosensors; calcitriol receptors; chemical interactions; leukemia; ligands; light intensity; luciferase; mutants; osteoporosis; psoriasis; rickets; vitamin D
Abstract:: ... Vitamin D receptor (VDR) ligands, such as 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] and its analogs, have been investigated for their potential clinical use in the treatment of various diseases such as type I rickets, osteoporosis, psoriasis, leukemia, and cancer. Previously, we reported a split-luciferase-based biosensor that can detect VDR ligands and assess their affinity for the ligand binding ...
DOI:: 10.1016/j.bbrc.2018.09.122
: https://doi.org/10.1016/j.bbrc.2018.09.122

45. CACUL1/CAC1 attenuates p53 activity through PML post-translational modification

Author:: Tomomi Fukuda; Yu Kigoshi-Tansho; Takao Naganuma; Akira Kazaana; Tomomi Okajima; Fuminori Tsuruta; Tomoki Chiba
Source:: Biochemical and biophysical research communications 2017 v.482 pp. 863-869
ISSN:: 0006-291X
Subject:: chromatin; gene expression; leukemia; post-translational modification; protein-protein interactions; transcription (genetics); tumor suppressor proteins
Abstract:: ... Promyelocytic leukaemia (PML) is a tumor suppressor protein covalently conjugated with SUMO family proteins, leading to the formation of PML nuclear bodies (NBs). PML-NBs provide a platform for efficient posttranslational modification of targets and protein-protein interaction, contributing to the adjustment of gene expression and chromatin integrity. Although PML SUMOylation is thought to play im ...
DOI:: 10.1016/j.bbrc.2016.11.125
: https://doi.org/10.1016/j.bbrc.2016.11.125

46. Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells

Author:: Jingyun Yao; Xing Wei; Yanhua Lu
Source:: Biochemical and biophysical research communications 2016 v.473 pp. 867-873
ISSN:: 0006-291X
Subject:: alkaloids; apoptosis; cytotoxicity; doxorubicin; drug resistance; humans; leukemia; messenger RNA; mitochondria; neoplasm cells; phosphorylation; reverse transcriptase polymerase chain reaction; signal transduction
Abstract:: ... Drug resistance limits leukemia treatment and chaetominine, a cytotoxic alkaloid that promotes apoptosis in a K562 human leukemia cell line via the mitochondrial pathway was studied with respect to chemoresistance in a K562/Adr human resistant leukemia cell line. Cytotoxicity assays indicated that K562/Adr resistance to adriamycin (ADR) did not occur in the presence of chaetominine and that chaeto ...
DOI:: 10.1016/j.bbrc.2016.03.141
: https://doi.org/10.1016/j.bbrc.2016.03.141

47. Detection of O-propargyl-puromycin with SUMO and ubiquitin by click chemistry at PML-nuclear bodies during abortive proteasome activities

Author:: Naoki Uozumi; Hotaru Matsumoto; Hisato Saitoh
Source:: Biochemical and biophysical research communications 2016 v.474 pp. 247-251
ISSN:: 0006-291X
Subject:: antibiotics; cell nucleolus; chemistry; homeostasis; leukemia; polypeptides; proteasome endopeptidase complex; puromycin; ribosomes; ubiquitin
Abstract:: ... The amino-nucleoside antibiotic, puromycin, acts by covalently linking to elongating polypeptide chains on ribosomes to generate prematurely terminated immature polypeptides. The trafficking of puromycin-conjugated (puromycylated) immature polypeptides within cell has, however, remained elusive. In this study, using O-propargyl-puromycin (OP-Puro), the distribution of puromycylated polypeptides wa ...
DOI:: 10.1016/j.bbrc.2016.03.155
: https://doi.org/10.1016/j.bbrc.2016.03.155

48. Development of a complete human IgG monoclonal antibody to transferrin receptor 1 targeted for adult T-cell leukemia/lymphoma

Author:: Shunsuke Shimosaki; Shingo Nakahata; Tomonaga Ichikawa; Akira Kitanaka; Takuro Kameda; Tomonori Hidaka; Yoko Kubuki; Gene Kurosawa; Lilin Zhang; Yukio Sudo; Kazuya Shimoda; Kazuhiro Morishita
Source:: Biochemical and biophysical research communications 2017 v.485 no.1 pp. 144-151
ISSN:: 0006-291X
Subject:: T-lymphocytes; adults; apoptosis; bacteriophages; cell growth; cell viability; cytotoxicity; flow cytometry; genes; humans; immunoglobulin G; in vivo studies; iron absorption; leukemia; lymphoma; monoclonal antibodies; neoplasm cells; therapeutics; transferrin
Abstract:: ... Iron is an essential nutrient for normal cell growth, and reprogramming of iron metabolism is essential to tumor cell survival and progression. HTLV-1-associated adult T-cell leukemia/lymphoma (ATLL) has no effective therapy and high levels of cell surface transferrin receptor 1 (TFR1) expression have been reported in ATLL by us and other groups. In this study, to develop a novel molecular-targete ...
DOI:: 10.1016/j.bbrc.2017.02.039
: https://doi.org/10.1016/j.bbrc.2017.02.039

49. HDAC9 regulates the alternative lengthening of telomere (ALT) pathway via the formation of ALT-associated PML bodies

Author:: Mohd. Raeed Jamiruddin; Taku Kaitsuka; Farzana Hakim; Atsushi Fujimura; Fan-Yan Wei; Hisato Saitoh; Kazuhito Tomizawa
Source:: Biochemical and biophysical research communications 2016 v.481 pp. 25-30
ISSN:: 0006-291X
Subject:: alanine transaminase; cell senescence; drugs; gene expression regulation; histone deacetylase; leukemia; neoplasm cells; proteins; small interfering RNA; telomerase; telomeres; therapeutics
Abstract:: ... Cancer cells overcome cellular senescence by activating the telomere maintenance mechanism, which can be either through telomerase or the alternative lengthening of telomeres (ALT). Being exclusive to cancer cells, targeting ALT is a more promising route for the development of drugs against cancer. The histone deacetylase (HDAC) family plays significant roles in various cellular processes. In addi ...
DOI:: 10.1016/j.bbrc.2016.11.026
: https://doi.org/10.1016/j.bbrc.2016.11.026

50. Human SMOOTHENED inhibits human immunodeficiency virus type 1 infection

Author:: Takeshi Yoshida; Akiko Hamano; Asuka Ueda; Hiroaki Takeuchi; Shoji Yamaoka
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: DNA; HIV infections; Human immunodeficiency virus 1; T-lymphocytes; human cell lines; humans; leukemia; messenger RNA; mice; quantitative polymerase chain reaction; retroviral vectors; reverse transcription; virus replication
Abstract:: ... Human SMOOTHENED (SMO) was identified by expression cloning as a new host factor that inhibits HIV-1 infection. Forced expression of SMO inhibited HIV-1 replication and infection with a single-round lentiviral vector, but not infection with a murine leukemia virus-based retroviral vector in human MT-4 T cells. Quantitative PCR analyses revealed that stable expression of SMO impaired formation of t ...
DOI:: 10.1016/j.bbrc.2017.09.063
: https://doi.org/10.1016/j.bbrc.2017.09.063

51. Hydroquinone induces DNA hypomethylation-independent overexpression of retroelements in human leukemia and hematopoietic stem cells

Author:: Anastasia Conti; Federica Rota; Enrico Ragni; Chiara Favero; Valeria Motta; Lorenza Lazzari; Valentina Bollati; Silvia Fustinoni; Giorgio Dieci
Source:: Biochemical and biophysical research communications 2016 v.474 pp. 691-695
ISSN:: 0006-291X
Subject:: DNA; DNA methylation; Retroviridae; benzene; blood; carcinogenesis; cultured cells; epigenetics; gene overexpression; genome; hematopoietic stem cells; humans; hydroquinone; inventories; leukemia; metabolites; neoplasm cells; retrotransposons; risk
Abstract:: ... Hydroquinone (HQ) is an important benzene-derived metabolite associated with acute myelogenous leukemia risk. Although altered DNA methylation has been reported in both benzene-exposed human subjects and HQ-exposed cultured cells, the inventory of benzene metabolite effects on the epigenome is only starting to be established. In this study, we used a monocytic leukemia cell line (THP-1) and hemato ...
DOI:: 10.1016/j.bbrc.2016.05.010
: https://doi.org/10.1016/j.bbrc.2016.05.010

52. Identification of miR-125b targets involved in acute promyelocytic leukemia cell proliferation

Author:: Yikai Zhang; Chengwu Zeng; Shuai Lu; Tianyu Qin; Lijian Yang; Shaohua Chen; Jie Chen; Yangqiu Li
Source:: Biochemical and biophysical research communications 2016 v.478 pp. 1758-1763
ISSN:: 0006-291X
Subject:: cell proliferation; leukemia; luciferase; mitogen-activated protein kinase; neoplasm cells; patients; signal transduction
Abstract:: ... Acute promyelocytic leukemia (APL) is characterized by the presence of the PML-RARα fusion protein. We have previously found that PML-RARα-regulated miR-125b is highly expressed in APL; however, the characteristics of the regulatory effects and mechanisms of miR-125b involved in APL proliferation have yet to be clarified. In this study, we demonstrate that miR-125b promotes the proliferation of AP ...
DOI:: 10.1016/j.bbrc.2016.09.020
: https://doi.org/10.1016/j.bbrc.2016.09.020

53. MOV10 interacts with Enterovirus 71 genomic 5′UTR and modulates viral replication

Author:: Huanru Wang; Liang Chang; Xiaohui Wang; Airong Su; Chunhong Feng; Yuxuan Fu; Deyan Chen; Nan Zheng; Zhiwei Wu
Source:: Biochemical and biophysical research communications 2016 v.479 pp. 571-577
ISSN:: 0006-291X
Subject:: 5' untranslated regions; Enterovirus A; antiviral properties; leukemia; parasites; proteins; ribosomes; virus replication; viruses
Abstract:: ... As a cytoplasmic parasite, RNA virus develops sophisticated mechanisms to counter host defense and utilize host proteins to facilitate its replication. Here we found Moloney leukemia virus 10 (MOV10), a highly conserved cellular protein belonging to SF1 helicase family, played critical roles in EV71 infection. Silencing cellular MOV10 could restrict EV71 replication, while over-expressing MOV10 re ...
DOI:: 10.1016/j.bbrc.2016.09.112
: https://doi.org/10.1016/j.bbrc.2016.09.112

54. Niclosamide suppresses RANKL-induced osteoclastogenesis and prevents LPS-induced bone loss

Author:: Yoon-Hee Cheon; Ju-Young Kim; Jong Min Baek; Sung-Jun Ahn; Hong-Seob So; Jaemin Oh
Source:: Biochemical and biophysical research communications 2016 v.470 pp. 343-349
ISSN:: 0006-291X
Subject:: bone resorption; breast neoplasms; cathepsin K; drugs; gene expression; genes; in vitro studies; integrins; leukemia; messenger RNA; neoplasm cells; niclosamide; non-specific serine/threonine protein kinase; osteoclasts; osteoporosis; phosphorylation; signal transduction; tapeworms; transactivators; transcription factor NF-kappa B
Abstract:: ... Niclosamide (5-chloro-salicyl-(2-chloro-4-nitro) anilide) is an oral anthelmintic drug used for treating intestinal infection of most tapeworms. Recently, niclosamide was shown to have considerable efficacy against some tumor cell lines, including colorectal, prostate, and breast cancers, and acute myelogenous leukemia. Specifically, the drug was identified as a potent inhibitor of signal transduc ...
DOI:: 10.1016/j.bbrc.2016.01.048
: https://doi.org/10.1016/j.bbrc.2016.01.048

55. Rho signaling inhibitor, CCG-1423, inhibits axonal elongation and dendritic complexity of rat cortical neurons

Author:: Keietsu Kikuchi; Jun Shiota; Tetsuya Yamada; Mitsuru Ishikawa; Daisuke Ihara; Mamoru Fukuchi; Masaaki Tsuda; Akiko Tabuchi
Source:: Biochemical and biophysical research communications 2017 v.492 no.3 pp. 474-479
ISSN:: 0006-291X
Subject:: actin; benzamides; cell viability; gene expression; homeodomain proteins; leukemia; neurites; rats; synapse
Abstract:: ... CCG-1423, a chemical inhibitor of Rho signaling, blocks serum response factor (SRF)/megakaryoblastic leukemia 1 (MKL1)-mediated gene expression by inhibiting the nuclear accumulation of MKL1. Several studies have suggested that CCG-1423 interacts not only with MKL1, which has a critical role in the regulation of neuronal morphology, but also with phosphatase and actin regulator 1 (Phactr1), which ...
DOI:: 10.1016/j.bbrc.2017.08.071
: https://doi.org/10.1016/j.bbrc.2017.08.071

56. The downregulation of miR-3173 in B-cell acute lymphoblastic leukaemia promotes cell invasion via PTK2

Author:: Lijun Tian; Junhua Cao; Qiang Ji; Chuanling Zhang; Tong Qian; Xianchuan Song; Baoshan Huang; Xinyi Tian
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: B-lymphocytes; Western blotting; cell lines; cell movement; cell proliferation; gene expression regulation; leukemia; luciferase; microRNA; pathogenesis; patients
Abstract:: ... MicroRNAs are important regulators of the pathogenesis of B-cell acute lymphoblastic leukaemia (B-ALL). In this study, we identified miR-3173 and its predicted target gene PTK2 were correspondingly differentially expressed in B-ALL patients. In B-ALL cell lines, CCK-8 proliferation assay revealed that miR-3173 could inhibit the cell proliferation. Moreover, transwell assay revealed that miR-3173 c ...
DOI:: 10.1016/j.bbrc.2017.10.013
: https://doi.org/10.1016/j.bbrc.2017.10.013

57. miR-320a regulates cell proliferation and apoptosis in multiple myeloma by targeting pre-B-cell leukemia transcription factor 3

Author:: Yinghao Lu; Depei Wu; Jishi Wang; Yan Li; Xiao Chai; Qian Kang
Source:: Biochemical and biophysical research communications 2016 v.473 pp. 1315-1320
ISSN:: 0006-291X
Subject:: apoptosis; cell growth; cell proliferation; cell viability; growth retardation; leukemia; mice; microRNA; models; myeloma; therapeutics; transcription factors
Abstract:: ... Aberrant expression of microRNAs (miRNAs) is implicated in cancer development and progression. While miR-320a is reported to be deregulated in many malignancy types, its biological role in multiple myeloma (MM) remains unclear. Here, we observed reduced expression of miR-320a in MM samples and cell lines. Ectopic expression of miR-320a dramatically suppressed cell viability and clonogenicity and i ...
DOI:: 10.1016/j.bbrc.2016.04.069
: https://doi.org/10.1016/j.bbrc.2016.04.069

58. Bovine leukemia virus nucleocapsid protein is an efficient nucleic acid chaperone

Author:: Dominic F. Qualley; Victoria L. Sokolove; James L. Ross
Source:: Biochemical and biophysical research communications 2015 v.458 pp. 687-692
ISSN:: 0006-291X
Subject:: Primate T-lymphotropic virus 1; Human immunodeficiency virus 1; T-lymphocytes; humans; leukemia; Bovine leukemia virus; thermodynamics; viruses; kinetics; nucleic acid annealing; nucleic acids; nucleocapsid proteins
Abstract:: ... Nucleocapsid proteins (NCs) direct the rearrangement of nucleic acids to form the most thermodynamically stable structure, and facilitate many steps throughout the life cycle of retroviruses. NCs bind strongly to nucleic acids (NAs) and promote NA aggregation by virtue of their cationic nature; they also destabilize the NA duplex via highly structured zinc-binding motifs. Thus, they are considered ...
DOI:: 10.1016/j.bbrc.2015.02.025
: https://doi.org/10.1016/j.bbrc.2015.02.025

59. Hispolon inhibits the growth of estrogen receptor positive human breast cancer cells through modulation of estrogen receptor alpha

Author:: Eun Hyang Jang; Soon Young Jang; In-Hye Cho; Darong Hong; Bom Jung; Min-Ju Park; Jong-Ho Kim
Source:: Biochemical and biophysical research communications 2015 v.463 pp. 917-922
ISSN:: 0006-291X
Subject:: Phellinus linteus; antineoplastic agents; breast neoplasms; cell growth; drug therapy; estrogen receptors; genes; humans; inflammation; leukemia; luciferase; lymphatic diseases; medicinal fungi; melanoma; messenger RNA; neoplasm cells; stomach neoplasms; transcription (genetics); urinary bladder neoplasms; Korean Peninsula
Abstract:: ... Human estrogen receptor α (ERα) is a nuclear transcription factor that is a major therapeutic target in breast cancer. The transcriptional activity of ERα is regulated by certain estrogen-receptor modulators. Hispolon, isolated from Phellinus linteus, a traditional medicinal mushroom called Sanghwang in Korea, has been used to treat various pathologies, such as inflammation, gastroenteric disorder ...
DOI:: 10.1016/j.bbrc.2015.06.035
: https://doi.org/10.1016/j.bbrc.2015.06.035

60. Integrin αVβ3 and αVβ5 are required for leukemia inhibitory factor-mediated the adhesion of trophoblast cells to the endometrial cells

Author:: Tae-Wook Chung; Mi-Ju Park; Hyung Sik Kim; Hee-Jung Choi; Ki-Tae Ha
Source:: Biochemical and biophysical research communications 2016 v.469 pp. 936-940
ISSN:: 0006-291X
Subject:: adhesion; antagonists; antibodies; embryo implantation; endometrium; gene expression; humans; integrins; leukemia; messenger RNA; neutralization; pregnancy; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; trophoblast
Abstract:: ... The embryo implantation including adhesion between trophoblast and endometrium is a crucial process for the successful pregnancy. LIF and adhesion molecules including integrins are known as significant factors for embryo implantation. However, the function of LIF on the regulation of adhesion molecule expression and promotion of trophoblast adhesion to endometrial cells has not been fully elucidat ...
DOI:: 10.1016/j.bbrc.2015.12.103
: https://doi.org/10.1016/j.bbrc.2015.12.103

61. Myricetin is a novel inhibitor of human inosine 5′-monophosphate dehydrogenase with anti-leukemia activity

Author:: Huiling Pan; Qian Hu; Jingyuan Wang; Zehui Liu; Dang Wu; Weiqiang Lu; Jin Huang
Source:: Biochemical and biophysical research communications 2016 pp. -
ISSN:: 0006-291X
Subject:: apoptosis; biochemical pathways; catalytic activity; cell proliferation; cytotoxicity; dose response; enzyme kinetics; fluorometry; guanine nucleotides; guanosine; humans; inhibitory concentration 50; leukemia; molecular models; myricetin; neoplasm cells; small fruits; tea; wines
Abstract:: ... Human inosine 5′-monophosphate dehydrogenase (hIMPDH) is a rate-limiting enzyme in the de novo biosynthetic pathway of purine nucleotides, playing crucial roles in cellular proliferation, differentiation, and transformation. Dysregulation of hIMPDH expression and activity have been found in a variety of human cancers including leukemia. In this study, we found that myricetin, a naturally occurring ...
DOI:: 10.1016/j.bbrc.2016.06.158
: https://doi.org/10.1016/j.bbrc.2016.06.158

62. PRDM14 maintains pluripotency of embryonic stem cells through TET-mediated active DNA demethylation

Author:: Naoki Okashita; Nao Sakashita; Ken Ito; Ayaka Mitsuya; Yoshiaki Suwa; Yoshiyuki Seki
Source:: Biochemical and biophysical research communications 2015 v.466 pp. 138-145
ISSN:: 0006-291X
Subject:: DNA; DNA methylation; DNA repair; blood serum; cultured cells; embryonic stem cells; gene expression; gene expression regulation; genes; germ cells; leukemia; mice; transcription (genetics); transcription factors
Abstract:: ... Pluripotency and self-renewal of mouse embryonic stem cells (ESCs) depend on a network of transcription factors maintained by exogenous leukaemia inhibitory factor (LIF). PR-domain containing transcriptional regulator 14 (PRDM14), is essential for maintenance of ESC self-renewal when the cells are cultured in serum plus LIF, but not in 2i medium plus LIF. Here, we show that pluripotency of ESCs is ...
DOI:: 10.1016/j.bbrc.2015.08.122
: https://doi.org/10.1016/j.bbrc.2015.08.122

63. RAD001 (everolimus) enhances TRAIL cytotoxicity in human leukemic Jurkat T cells by upregulating DR5

Author:: Myoung Woo Lee; Dae Seong Kim; Ji-Eun Eom; Young Jong Ko; Ki Woong Sung; Hong Hoe Koo; Keon Hee Yoo
Source:: Biochemical and biophysical research communications 2015 v.463 pp. 894-899
ISSN:: 0006-291X
Subject:: T-lymphocytes; antineoplastic agents; apoptosis; cytotoxicity; death; dose response; humans; leukemia; necrosis; pro-apoptotic proteins; receptors
Abstract:: ... Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), either alone or in combination with other anti-cancer agents, is a promising new strategy for the treatment of cancer. However, aberrant PI3K/Akt/mTOR survival signaling may confer TRAIL resistance by altering the balance between pro- and anti-apoptotic proteins. In the present study, we showed that the Akt/mTOR inhibitor RAD001 (eve ...
DOI:: 10.1016/j.bbrc.2015.05.133
: https://doi.org/10.1016/j.bbrc.2015.05.133

64. RETRACTION: miR-664 negatively regulates PLP2 and promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia

Author:: Hong Zhu; Mei-hua Miao; Xue-qiang Ji; Jun Xue; Xue-jun Shao
Source:: Biochemical and biophysical research communications 2015 v.459 no.2 pp. 340-345
ISSN:: 0006-291X
Subject:: T-lymphocytes; Western blotting; bioinformatics; cell movement; cell proliferation; gene expression; gene expression regulation; genes; leukemia; luciferase; microRNA; pathogenesis
Abstract:: ... This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).This article has been retracted at the request of the Editor-in-Chief.The Western blots from Figures 3A and 3D are similar to Western blots from Figures 3A and 3D of the article published by Yongfang Wang, Lianhong Xu and Lixin Jiang in Biochemical and Biophysical Res ...
DOI:: 10.1016/j.bbrc.2015.02.116
: https://doi.org/10.1016/j.bbrc.2015.02.116

65. Resveratrol-induced transcriptional up-regulation of ASMase (SMPD1) of human leukemia and cancer cells

Author:: Naoki Mizutani; Yukari Omori; Yoshiyuki Kawamoto; Sayaka Sobue; Masatoshi Ichihara; Motoshi Suzuki; Mamoru Kyogashima; Mitsuhiro Nakamura; Keiko Tamiya-Koizumi; Yoshinori Nozawa; Takashi Murate
Source:: Biochemical and biophysical research communications 2016 v.470 pp. 851-856
ISSN:: 0006-291X
Subject:: antineoplastic activity; cell proliferation; ceramides; chromatin; colorectal neoplasms; electrophoresis; enzyme activity; humans; leukemia; messenger RNA; metabolism; neoplasm cells; phytoalexins; pleiotropy; precipitin tests; resveratrol; sphingomyelins; transcription (genetics); transcription factors
Abstract:: ... Resveratrol (RSV) is a plant-derived phytoalexin present in plants, whose pleiotropic effects for health benefits have been previously reported. Its anti-cancer activity is among the current topics for novel cancer treatment. Here, effects of RSV on cell proliferation and the sphingolipid metabolism of K562, a human leukemia cell line, were analyzed. Some experiments were also performed in HCT116, ...
DOI:: 10.1016/j.bbrc.2016.01.134
: https://doi.org/10.1016/j.bbrc.2016.01.134

66. The Tax oncogene enhances ELL incorporation into p300 and P-TEFb containing protein complexes to activate transcription

Author:: Temesgen D. Fufa; Jung S. Byun; Clay Wakano; Alfonso G. Fernandez; Cynthia A. Pise-Masison; Kevin Gardner
Source:: Biochemical and biophysical research communications 2015 v.465 pp. 5-11
ISSN:: 0006-291X
Subject:: DNA-directed RNA polymerase; Primate T-lymphotropic virus 1; leukemia; oncogenes; transcription (genetics); transcription factor NF-kappa B; transcriptional activation
Abstract:: ... The eleven-nineteen lysine-rich leukemia protein (ELL) is a key regulator of RNA polymerase II mediated transcription. ELL facilitates RNA polymerase II transcription pause site entry and release by dynamically interacting with p300 and the positive transcription elongation factor b (P-TEFb). In this study, we investigated the role of ELL during the HTLV-1 Tax oncogene induced transactivation. We ...
DOI:: 10.1016/j.bbrc.2015.07.072
: https://doi.org/10.1016/j.bbrc.2015.07.072

67. 5-(2-Carboxyethenyl) isatin derivative induces G2/M cell cycle arrest and apoptosis in human leukemia K562 cells

Author:: Yao Zhou; Hong-Ye Zhao; Kai-Lin Han; Yao Yang; Bin-Bin Song; Qian-Nan Guo; Zhen-Chuan Fan; Yong-Min Zhang; Yu-Ou Teng; Peng Yu
Source:: Biochemical and biophysical research communications 2014 v.450 pp. 1650-1655
ISSN:: 0006-291X
Subject:: DNA; antineoplastic agents; apoptosis; caspase-3; cell cycle checkpoints; cyclins; cytotoxicity; flow cytometry; humans; inhibitory concentration 50; leukemia; membrane potential; mitochondria; mitochondrial membrane; staining
Abstract:: ... Our previous study successfully identified that the novel isatin derivative (E)-methyl 3-(1-(4-methoxybenzyl)-2,3-dioxoindolin-5-yl) acrylate (HKL 2H) acts as an anticancer agent at an inhibitory concentration (IC50) level of 3nM. In this study, the molecular mechanism how HKL 2H induces cytotoxic activity in the human chronic myelogenous leukemia K562 cells was investigated. Flow cytometric analy ...
DOI:: 10.1016/j.bbrc.2014.07.053
: https://doi.org/10.1016/j.bbrc.2014.07.053

68. Androgen-independent proliferation of LNCaP prostate cancer cells infected by xenotropic murine leukemia virus-related virus

Author:: Katsura Kakoki; Haruka Kamiyama; Mai Izumida; Yuka Yashima; Hideki Hayashi; Naoki Yamamoto; Toshifumi Matsuyama; Tsukasa Igawa; Hideki Sakai; Yoshinao Kubo
Source:: Biochemical and biophysical research communications 2014 v.447 pp. 216-222
ISSN:: 0006-291X
Subject:: Murine leukemia virus; androgen receptors; cell growth; etiology; human cell lines; humans; leukemia; mice; neoplasm cells; prostatic neoplasms; viruses
Abstract:: ... Xenotropic murine leukemia virus-related virus (XMRV) is a novel gammaretrovirus that was originally isolated from human prostate cancer. It is now believed that XMRV is not the etiologic agent of prostate cancer. An analysis of murine leukemia virus (MLV) infection in various human cell lines revealed that prostate cancer cell lines are preferentially infected by XMRV, and this suggested that XMR ...
DOI:: 10.1016/j.bbrc.2014.03.154
: https://doi.org/10.1016/j.bbrc.2014.03.154

69. Macrophage-derived microvesicles promote proliferation and migration of Schwann cell on peripheral nerve repair

Author:: Chuan Zhan; Cheng-bin Ma; Hong-mou Yuan; Bao-yuan Cao; Jia-jun Zhu
Source:: Biochemical and biophysical research communications 2015 v.468 pp. 343-348
ISSN:: 0006-291X
Subject:: Schwann cells; animal models; cell movement; interferon-gamma; interleukin-4; laminin; leukemia; macrophages; nerve growth factor; nerve tissue; phenotype; protein synthesis
Abstract:: ... Macrophages have been implicated in peripheral nerve regeneration. However, whether macrophages-derived microvesicles (MVs) are involved in this process remains unknown. In the present study, the effects of macrophages-derived MVs on proliferation and migration of Schwann cells (SCs) were evaluated in both in vitro and in vivo.Human monocytic leukaemia cell line (THP-1) was successfully driven to ...
DOI:: 10.1016/j.bbrc.2015.10.097
: https://doi.org/10.1016/j.bbrc.2015.10.097

70. PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction

Author:: Masaya Kato; Ryuta Muromoto; Sumihito Togi; Masashi Iwakami; Yuichi Kitai; Shigeyuki Kon; Kenji Oritani; Tadashi Matsuda
Source:: Biochemical and biophysical research communications 2015 v.461 pp. 366-371
ISSN:: 0006-291X
Subject:: cell growth; gene expression; hepatoma; interleukins; leukemia; phosphorylation; repressor proteins; transcriptional activation
Abstract:: ... The promyelocytic leukemia protein PML acts as a tumor suppressor by forming transcription–regulatory complexes with a variety of repressor proteins. In the present study, we found that endogenous PML suppresses interleukin (IL)-6-induced gene expression as well as phosphorylation and transcriptional activation of STAT3 in hepatoma cells. We also found that PML-mediated suppression of IL-6-induced ...
DOI:: 10.1016/j.bbrc.2015.04.040
: https://doi.org/10.1016/j.bbrc.2015.04.040

71. Pick1 modulates ephrinB1-induced junctional disassembly through an association with ephrinB1

Author:: Jungeun Son; Mi Seon Park; Inji Park; Hyun-Kyung Lee; Soo-Ho Lee; Byungwoo Kang; Byung-Hwa Min; Jaewoong Ryoo; Sanggyu Lee; Jong-Sup Bae; Sang-Hyun Kim; Mae-Ja Park; Hyun-Shik Lee
Source:: Biochemical and biophysical research communications 2014 v.450 pp. 659-665
ISSN:: 0006-291X
Subject:: cell adhesion; cell movement; dissociation; epithelial cells; gene overexpression; humans; leukemia; melanoma; metastasis; phenotype; prostatic neoplasms
Abstract:: ... Members of the Eph family have been implicated in the formation of cell–cell boundaries, cell movement, and positioning during development in the context of cancer progression. De-regulation of this signaling system is linked to the promotion of more aggressive and metastatic tumor phenotypes in a large variety of human cancers, including breast, lung, and prostate cancer, melanoma, and leukemia. ...
DOI:: 10.1016/j.bbrc.2014.06.027
: https://doi.org/10.1016/j.bbrc.2014.06.027

72. RNA polymerase III control elements are required for trans-activation by the murine retroviral long terminal repeat sequences

Author:: Yong-Woo Hwang; Na Kyung Yoo; Heung Mo Yang; Sang-Yun Choi
Source:: Biochemical and biophysical research communications 2015 v.456 pp. 110-115
ISSN:: 0006-291X
Subject:: DNA fragmentation; DNA-directed RNA polymerase; Murine leukemia virus; RNA; T-lymphocytes; Vaccinia virus; gel electrophoresis; genes; leukemia; lymphoma; mice; mutants; sequence analysis; terminal repeat sequences; transcription factors; transcriptional activation; viruses
Abstract:: ... RNA leukemia viruses induce T-cell lymphoblastic lymphomas or myeloid leukemias. Infection of cells with Moloney murine leukemia virus (M-MuLV) up-regulates the expression of a number of cellular genes, including those involved in T-lymphocyte activation. Previously, we demonstrated that this up-regulation occurs via the trans-activation activity of the M-MuLV long terminal repeat (LTR) sequences ...
DOI:: 10.1016/j.bbrc.2014.11.043
: https://doi.org/10.1016/j.bbrc.2014.11.043

73. Thiamet-G-mediated inhibition of O-GlcNAcase sensitizes human leukemia cells to microtubule-stabilizing agent paclitaxel

Author:: Ning Ding; Lingyan Ping; Yunfei Shi; Lixia Feng; Xiaohui Zheng; Yuqin Song; Jun Zhu
Source:: Biochemical and biophysical research communications 2014 v.453 pp. 392-397
ISSN:: 0006-291X
Subject:: cell viability; enzymes; epithelium; humans; inhibitory concentration 50; leukemia; microtubules; neoplasm cells; paclitaxel; phosphorylation; proteins; small interfering RNA; therapeutics; uridine diphosphate
Abstract:: ... Although the microtubule-stabilizing agent paclitaxel has been widely used for treatment of several cancer types, particularly for the malignancies of epithelia origin, it only shows limited efficacy on hematological malignancies. Emerging roles of O-GlcNAcylation modification of proteins in various cancer types have implicated the key enzymes catalyzing this reversible modification as targets for ...
DOI:: 10.1016/j.bbrc.2014.09.097
: https://doi.org/10.1016/j.bbrc.2014.09.097

74. Association of a murine leukaemia stem cell gene signature based on nucleostemin promoter activity with prognosis of acute myeloid leukaemia in patients

Author:: Mohamed A.E. Ali; Kazuhito Naka; Akiyo Yoshida; Kyoko Fuse; Atsuo Kasada; Takayuki Hoshii; Yuko Tadokoro; Masaya Ueno; Kumiko Ohta; Masahiko Kobayashi; Chiaki Takahashi; Atsushi Hirao
Source:: Biochemical and biophysical research communications 2014 v.450 pp. 837-843
ISSN:: 0006-291X
Subject:: binding proteins; cell cycle; gene expression regulation; genes; green fluorescent protein; guanosine triphosphate; humans; leukemia; messenger RNA; mice; models; patients; prognosis; stem cells
Abstract:: ... Acute myeloid leukaemia (AML) is a heterogeneous neoplastic disorder in which a subset of cells function as leukaemia-initiating cells (LICs). In this study, we prospectively evaluated the leukaemia-initiating capacity of AML cells fractionated according to the expression of a nucleolar GTP binding protein, nucleostemin (NS). To monitor NS expression in living AML cells, we generated a mouse AML m ...
DOI:: 10.1016/j.bbrc.2014.06.066
: https://doi.org/10.1016/j.bbrc.2014.06.066

75. Diacylglycerol kinase γ regulates antigen-induced mast cell degranulation by mediating Ca2+ influxes

Author:: Megumi Sakuma; Yasuhito Shirai; Takehiko Ueyama; Naoaki Saito
Source:: Biochemical and biophysical research communications 2014 v.445 pp. 340-345
ISSN:: 0006-291X
Subject:: allergens; calcium; crosslinking; diacylglycerol kinase; diacylglycerols; immunoglobulins; leukemia; mast cells; messenger RNA; rats; receptors; reverse transcriptase polymerase chain reaction; small interfering RNA
Abstract:: ... Diacylglycerol (DAG) is an important lipid that acts as a signaling messenger during mast cell degranulation after allergen cross-linking of immunoglobulin (Ig) E-bound FcεRI receptors. In this study, we determined the role of diacylglycerol kinase (DGK), which negatively regulates DAG-dependent signaling by converting DAG to phosphatidic acid (PA), in the regulation of mast cell degranulation. Tr ...
DOI:: 10.1016/j.bbrc.2014.01.197
: https://doi.org/10.1016/j.bbrc.2014.01.197

76. Differential role of thiopurine methyltransferase in the cytotoxic effects of 6-mercaptopurine and 6-thioguanine on human leukemia cells

Author:: Hazhar Karim; Aram Ghalali; Pierre Lafolie; Sigurd Vitols; Alan K. Fotoohi
Source:: Biochemical and biophysical research communications 2013 v.437 pp. 280-286
ISSN:: 0006-291X
Subject:: DNA; apoptosis; cytotoxicity; drugs; gene expression; gene expression regulation; genes; humans; leukemia; metabolism; metabolites; methylation; nucleotides; propidium; small interfering RNA; thiopurine S-methyltransferase
Abstract:: ... The thiopurine antimetabolites, 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are inactive pro-drugs that require intracellular metabolism for activation to cytotoxic metabolites. Thiopurine methyltransferase (TPMT) is one of the most important enzymes in this process metabolizing both 6-MP and 6-TG to different methylated metabolites including methylthioinosine monophosphate (meTIMP) and methy ...
DOI:: 10.1016/j.bbrc.2013.06.067
: https://doi.org/10.1016/j.bbrc.2013.06.067

77. Ell3 stimulates proliferation, drug resistance, and cancer stem cell properties of breast cancer cells via a MEK/ERK-dependent signaling pathway

Author:: Hee-Jin Ahn; Gwangil Kim; Kyung-Soon Park
Source:: Biochemical and biophysical research communications 2013 v.437 pp. 557-564
ISSN:: 0006-291X
Subject:: DNA-directed RNA polymerase; apoptosis; breast neoplasms; carcinogenesis; cell proliferation; drug resistance; embryonic stem cells; genes; leukemia; mice; neoplasm cells; signal transduction; testes
Abstract:: ... Ell3 is a RNA polymerase II transcription elongation factor that is enriched in testis. The C-terminal domain of Ell3 shows strong similarities to that of Ell (eleven−nineteen lysine-rich leukemia gene), which acts as a negative regulator of p53 and regulates cell proliferation and survival. Recent studies in our laboratory showed that Ell3 induces the differentiation of mouse embryonic stem cells ...
DOI:: 10.1016/j.bbrc.2013.06.114
: https://doi.org/10.1016/j.bbrc.2013.06.114

78. Establishment of a human cell line stably overexpressing mouse Nip45 and characterization of Nip45 subcellular localization

Author:: Kohtaro Hashiguchi; Masumi Ozaki; Isao Kuraoka; Hisato Saitoh
Source:: Biochemical and biophysical research communications 2013 v.430 pp. 72-77
ISSN:: 0006-291X
Subject:: T-lymphocytes; cell differentiation; cell-mediated immunity; human cell lines; humans; leukemia; mice; proteasome endopeptidase complex; proteins
Abstract:: ... The nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein, Nfatc2ip (Nip45), has been implicated as a crucial coordinator of the immune response and of cellular differentiation in humans and mice, and contains SUMO-like domains in its C-terminal region. However, the significance of its N-terminal region and its correlation to the SUMO modification pathway re ...
DOI:: 10.1016/j.bbrc.2012.11.020
: https://doi.org/10.1016/j.bbrc.2012.11.020

79. The F-box protein β-TrCP promotes ubiquitination of TRF1 and regulates the ALT-associated PML bodies formation in U2OS cells

Author:: Chong Wang; Haowen Xiao; Jie Ma; Yuanyuan Zhu; Jian Yu; Ling Sun; Hui Sun; Yanfang Liu; Changjiang Jin; He Huang
Source:: Biochemical and biophysical research communications 2013 v.434 pp. 728-734
ISSN:: 0006-291X
Subject:: F-box proteins; gene overexpression; leukemia; mammals; neoplasm cells; small interfering RNA; telomerase; telomeres; ubiquitin-protein ligase; ubiquitination
Abstract:: ... The telomeric repeat binding protein 1 (TRF1) is a major factor of the mammalian telosome/shelterin and negatively regulates telomere length by inhibiting access of telomerase at telomere termini in telomerase-positive cells. In telomerase-negative cancer cells, TRF1 also plays a critical role in the mechanism called alternative lengthening of telomeres (ALT) and is essential for formation of the ...
DOI:: 10.1016/j.bbrc.2013.03.096
: https://doi.org/10.1016/j.bbrc.2013.03.096

80. Insect peptide CopA3-induced protein degradation of p27Kip1 stimulates proliferation and protects neuronal cells from apoptosis

Author:: Seung Taek Nam; Dae Hong Kim; Min Bum Lee; Hyo Jung Nam; Jin Ku Kang; Mi Jung Park; Ik Hwan Lee; Heon Seok; Dong Gun Lee; Jae Sam Hwang; Ho Kim
Source:: Biochemical and biophysical research communications 2013 v.437 pp. 35-40
ISSN:: 0006-291X
Subject:: antibacterial proteins; anticarcinogenic activity; apoptosis; cell cycle; cell proliferation; dopamine; humans; immunoblotting; insects; leukemia; macrophage activation; mice; neurons; okadaic acid; protein degradation; stem cells; viability
Abstract:: ... We recently demonstrated that the antibacterial peptide, CopA3 (a D-type disulfide dimer peptide, LLCIALRKK), inhibits LPS-induced macrophage activation and also has anticancer activity in leukemia cells. Here, we examined whether CopA3 could affect neuronal cell proliferation. We found that CopA3 time-dependently increased cell proliferation by up to 31±2% in human neuroblastoma SH-SY5Y cells, an ...
DOI:: 10.1016/j.bbrc.2013.06.031
: https://doi.org/10.1016/j.bbrc.2013.06.031

81. Mitochondrial function is impaired in yeast and human cellular models of Shwachman Diamond syndrome

Author:: Adrianna L. Henson; Joseph B. Moore; Pascale Alard; Max M. Wattenberg; Johnson M. Liu; Steven R. Ellis
Source:: Biochemical and biophysical research communications 2013 v.437 pp. 29-34
ISSN:: 0006-291X
Subject:: biogenesis; bone marrow; carbon; chemotaxis; genes; humans; leukemia; membrane potential; mitochondrial membrane; mitotic spindle apparatus; models; neutropenia; oxygen consumption; pancreas; pathophysiology; protein synthesis; reactive oxygen species; ribosomes; translation (genetics); yeasts
Abstract:: ... Shwachman Diamond syndrome (SDS) is an inherited bone marrow failure syndrome typically characterized by neutropenia, exocrine pancreas dysfunction, metaphyseal chondrodysplasia, and predisposition to myelodysplastic syndrome and leukemia. SBDS, the gene affected in most cases of SDS, encodes a protein known to influence many cellular processes including ribosome biogenesis, mitotic spindle assemb ...
DOI:: 10.1016/j.bbrc.2013.06.028
: https://doi.org/10.1016/j.bbrc.2013.06.028

82. Pigment epithelium-derived factor (PEDF) inhibits survival and proliferation of VEGF-exposed multiple myeloma cells through its anti-oxidative properties

Author:: Ritsuko Seki; Sho-ichi Yamagishi; Takanori Matsui; Takafumi Yoshida; Takuji Torimura; Takato Ueno; Michio Sata; Takashi Okamura
Source:: Biochemical and biophysical research communications 2013 v.431 pp. 693-697
ISSN:: 0006-291X
Subject:: NAD(P)H oxidase (H2O2-forming); NADP (coenzyme); angiogenesis; animal models; apoptosis; bone marrow; cell culture; gene overexpression; glutathione peroxidase; humans; leukemia; mutants; myeloma; patients; reactive oxygen species; vascular endothelial growth factors
Abstract:: ... Vascular endothelial growth factor (VEGF) has been reported not only to induce angiogenesis within the bone marrow, but also directly stimulate the proliferation and survival of multiple myeloma cells, thus being involved in the development and progression of this second most common hematological malignancy. We, along with others, have found that pigment epithelium-derived factor (PEDF) has anti-a ...
DOI:: 10.1016/j.bbrc.2013.01.057
: https://doi.org/10.1016/j.bbrc.2013.01.057

83. Protocatechualdehyde possesses anti-cancer activity through downregulating cyclin D1 and HDAC2 in human colorectal cancer cells

Author:: Jin Boo Jeong; Seong-Ho Lee
Source:: Biochemical and biophysical research communications 2013 v.430 pp. 381-386
ISSN:: 0006-291X
Subject:: cell growth; leukemia; luciferase; genes; neoplasm cells; barley; dose response; gene expression; gene expression regulation; leaves; apoptosis; messenger RNA; humans; Vitis; transcription (genetics); growth retardation; in vitro studies; colorectal neoplasms; enzyme activity; cell proliferation; protein synthesis; histone deacetylase; bananas; anticarcinogenic activity
Abstract:: ... Protocatechualdehyde (PCA) is a naturally occurring polyphenol found in barley, green cavendish bananas, and grapevine leaves. Although a few studies reported growth-inhibitory activity of PCA in breast and leukemia cancer cells, the underlying mechanisms are still poorly understood. Thus, we performed in vitro study to investigate if treatment of PCA affects cell proliferation and apoptosis in hu ...
DOI:: 10.1016/j.bbrc.2012.11.018
: https://doi.org/10.1016/j.bbrc.2012.11.018

84. Pulsed extremely low-frequency magnetic fields stimulate microvesicle release from human monocytic leukaemia cells

Author:: Dan Stratton; Sigrun Lange; Jameel M. Inal
Source:: Biochemical and biophysical research communications 2013 v.430 pp. 470-475
ISSN:: 0006-291X
Subject:: apoptosis; biogenesis; calcium; electromagnetic field; ethylene glycol tetraacetic acid; humans; leukemia; magnetic fields; organelles; plasma membrane
Abstract:: ... Microvesicles are released from cell surfaces constitutively during early apoptosis or upon activation with various stimuli including sublytic membrane attack complex (MAC). This study shows that an alternating current, pulsed, extremely low-frequency electromagnetic field (0.3μT at 10Hz, 6V AC) induced transient plasma membrane damage that allowed calcium influx. This in turn caused a release of ...
DOI:: 10.1016/j.bbrc.2012.12.012
: https://doi.org/10.1016/j.bbrc.2012.12.012

85. The histone demethylase PHF8 is an oncogenic protein in human non-small cell lung cancer

Author:: Yuzhou Shen; Xufeng Pan; Heng Zhao
Source:: Biochemical and biophysical research communications 2014 v.451 pp. 119-125
ISSN:: 0006-291X
Subject:: DNA damage; apoptosis; cell growth; cell proliferation; genes; histones; humans; leukemia; lung neoplasms; neoplasm cells; prostatic neoplasms; squamous cell carcinoma; tissues
Abstract:: ... PHF8 is a JmjC domain-containing protein and erases repressive histone marks including H4K20me1 and H3K9me1/2. It binds to H3K4me3, an active histone mark usually located at transcription start sites (TSSs), through its plant homeo-domain, and is thus recruited and enriched in gene promoters. PHF8 is involved in the development of several types of cancer, including leukemia, prostate cancer, and e ...
DOI:: 10.1016/j.bbrc.2014.07.076
: https://doi.org/10.1016/j.bbrc.2014.07.076

86. The macroscopic structure of RADA16 peptide hydrogel stimulates monocyte/macrophage differentiation in HL60 cells via cholesterol synthesis

Author:: Yasutaka Kakiuchi; Noritaka Hirohashi; Kimiko Murakami-Murofushi
Source:: Biochemical and biophysical research communications 2013 v.433 pp. 298-304
ISSN:: 0006-291X
Subject:: cholesterol; cultured cells; gene expression; humans; hydrocolloids; leukemia; macrophages; monocytes; physical properties
Abstract:: ... Cells can sense physical properties of surrounding 3-dimensional (3D) culture substrata; however, the physiological influences of such sensing are not fully understood. Here, we studied the physiological characteristics and activities of the macroscopic structure of a routinely used 3D culture substrata, the RADA16 self-assembling peptide scaffold. We found that RADA16 exhibited three distinct ass ...
DOI:: 10.1016/j.bbrc.2013.02.105
: https://doi.org/10.1016/j.bbrc.2013.02.105

87. Ayanin diacetate-induced cell death is amplified by TRAIL in human leukemia cells

Author:: María Teresa Marrero; Sara Estévez; Gledy Negrín; José Quintana; Mariana López; Francisco J. Pérez; Jorge Triana; Francisco León; Francisco Estévez
Source:: Biochemical and biophysical research communications 2012 v.428 no.1 pp. 116-120
ISSN:: 0006-291X
Subject:: NAD ADP-ribosyltransferase; apoptosis; caspases; cell cycle; cytochrome c; death; flavonoids; humans; leukemia; lymphocytes; membrane potential; mitochondrial membrane; receptors
Abstract:: ... Here we demonstrate that the semi-synthetic flavonoid ayanin diacetate induces cell death selectively in leukemia cells without affecting the proliferation of normal lymphocytes. Incubation of human leukemia cells with ayanin diacetate induced G₂-M phase cell cycle arrest and apoptosis which was prevented by the non-specific caspase inhibitor z-VAD-fmk and reduced by the overexpression of Bcl-xL. ...
DOI:: 10.1016/j.bbrc.2012.10.017
: https://doi.org/10.1016/j.bbrc.2012.10.017

88. CRKL plays a pivotal role in tumorigenesis of head and neck squamous cell carcinoma through the regulation of cell adhesion

Author:: Hiroko Yanagi; Lei Wang; Hiroshi Nishihara; Taichi Kimura; Mishie Tanino; Teruki Yanagi; Satoshi Fukuda; Shinya Tanaka
Source:: Biochemical and biophysical research communications 2012 v.418 no.1 pp. 104-109
ISSN:: 0006-291X
Subject:: adhesion; carcinogenesis; cell adhesion; cell growth; fluorescent antibody technique; head; humans; leukemia; mice; neck; patients; precipitin tests; squamous cell carcinoma; tyrosine
Abstract:: ... The signaling adapter protein CRK is an indispensable molecule involved in regulating the malignant potential of human cancers. CRK-like (CRKL) is a hematopoietic cell-dominant homologue of CRK that is reported to be phosphorylated by BCR–ABL tyrosine kinase in chronic myelogenous leukemia patients, but its biological function in non-hematopoietic tumors remains unclear. In this study, we explored ...
DOI:: 10.1016/j.bbrc.2011.12.142
: https://doi.org/10.1016/j.bbrc.2011.12.142

89. Celastrol inhibits TGF-β1-induced epithelial–mesenchymal transition by inhibiting Snail and regulating E-cadherin expression

Author:: Hyereen Kang; Minjae Lee; Sung-Wuk Jang
Source:: Biochemical and biophysical research communications 2013 v.437 pp. 550-556
ISSN:: 0006-291X
Subject:: breast neoplasms; cell movement; dogs; epithelial cells; kidneys; leukemia; lung neoplasms; metastasis; neoplasm cells; transforming growth factor beta 1
Abstract:: ... The epithelial–mesenchymal transition (EMT) is a pivotal event in the invasive and metastatic potentials of cancer progression. Celastrol inhibits the proliferation of a variety of tumor cells including leukemia, glioma, prostate, and breast cancer; however, the possible role of celastrol in the EMT is unclear. We investigated the effect of celastrol on the EMT. Transforming growth factor-beta 1 ( ...
DOI:: 10.1016/j.bbrc.2013.06.113
: https://doi.org/10.1016/j.bbrc.2013.06.113

90. Combined treatment with fenretinide and indomethacin induces AIF-mediated, non-classical cell death in human acute T-cell leukemia Jurkat cells

Author:: Anna Hojka-Osinska; Ewa Ziolo; Andrzej Rapak
Source:: Biochemical and biophysical research communications 2012 v.419 no.3 pp. 590-595
ISSN:: 0006-291X
Subject:: DNA fragmentation; T-lymphocytes; additive effect; adverse effects; anti-inflammatory activity; apoptosis; cell membranes; clinical trials; cytotoxicity; death; humans; indomethacin; leukemia; mechanism of action; neoplasm cells; synergism; therapeutics
Abstract:: ... Currently used cytotoxic drugs in cancer therapy have a similar mechanism of action and low specificity. Applied simultaneously, they show an additive effect with strong side effects. Clinical trials with the use of different agents in cancer therapy show that the use of these compounds alone is not very effective in fighting cancer. An alternative solution could be to apply a combination of these ...
DOI:: 10.1016/j.bbrc.2012.02.092
: https://doi.org/10.1016/j.bbrc.2012.02.092

91. Histone post-translational modifications associated to BAALC expression in leukemic cells

Author:: Alessandra Franzoni; Nadia Passon; Dora Fabbro; Mario Tiribelli; Daniela Damiani; Giuseppe Damante
Source:: Biochemical and biophysical research communications 2012 v.417 no.2 pp. 721-725
ISSN:: 0006-291X
Subject:: acetylation; epigenetics; gene overexpression; genes; histones; leukemia; messenger RNA; post-translational modification; transcription (genetics)
Abstract:: ... BAALC expression is an indicator of aggressiveness in acute myelogenous leukemia (AML). Overexpression of this gene is associated to poor of clinical outcome. It is known that post-translational histone modifications control gene transcription. Thus, here we have investigated BAALC expression and post-translational histone modifications in leukemia cell lines. We show that Kasumi-6 and Kyo cells h ...
DOI:: 10.1016/j.bbrc.2011.12.013
: https://doi.org/10.1016/j.bbrc.2011.12.013

92. Honokiol induces caspase-independent paraptosis via reactive oxygen species production that is accompanied by apoptosis in leukemia cells

Author:: Yao Wang; Xiuping Zhu; Zehong Yang; Xiaojun Zhao
Source:: Biochemical and biophysical research communications 2013 v.430 pp. 876-882
ISSN:: 0006-291X
Subject:: Magnolia officinalis; apoptosis; caspases; chromatin; endoplasmic reticulum; honokiol; humans; leukemia; phosphatidylserines; plasma membrane; reactive oxygen species; therapeutics
Abstract:: ... Our previous report has shown that honokiol (HNK), a constituent of Magnolia officinalis, induces a novel form of non-apoptotic programmed cell death in human leukemia NB4 and K562 cells. In this study, we further explored the relationship between the cell death pathway and cytoplasmic vacuolization and studied the underlying mechanism of leukemia cell death mediated by honokiol. The results showe ...
DOI:: 10.1016/j.bbrc.2012.12.063
: https://doi.org/10.1016/j.bbrc.2012.12.063

93. Myc induced miR-144/451 contributes to the acquired imatinib resistance in chronic myelogenous leukemia cell K562

Author:: Li Liu; Sitao Wang; Renan Chen; Yanlan Wu; Bei Zhang; Siyong Huang; Jingyi Zhang; Fang Xiao; Meng Wang; Yingmin Liang
Source:: Biochemical and biophysical research communications 2012 v.425 no.2 pp. 368-373
ISSN:: 0006-291X
Subject:: cell proliferation; leukemia; therapeutics
Abstract:: ... Imatinib resistance remains the big hurdle for CML therapy. Previous study reveals that c-myc is important for bcr–abl CML cell proliferation, while its role in imatinib resistance is largely unknown. In this study, we first found that c-myc expression is upregulated in imatinib resistant K562R cells, which in turn enhances the expression of miR-144/451. Knockdown of c-myc or restoration of miR-14 ...
DOI:: 10.1016/j.bbrc.2012.07.098
: https://doi.org/10.1016/j.bbrc.2012.07.098

94. NMR study of xenotropic murine leukemia virus-related virus protease in a complex with amprenavir

Author:: Ayako Furukawa; Hideyasu Okamura; Ryo Morishita; Satoko Matsunaga; Naohiro Kobayashi; Takahisa Ikegami; Tsutomu Kodaki; Akifumi Takaori-Kondo; Akihide Ryo; Takashi Nagata; Masato Katahira
Source:: Biochemical and biophysical research communications 2012 v.425 no.2 pp. 284-289
ISSN:: 0006-291X
Subject:: amino acids; drugs; humans; leukemia; mice; neoplasm cells; nuclear magnetic resonance spectroscopy; prostatic neoplasms; protein subunits; proteinases; proviruses; titration; viral proteins; virus replication; wheat germ
Abstract:: ... Xenotropic murine leukemia virus-related virus (XMRV) is a virus created through recombination of two murine leukemia proviruses under artificial conditions during the passage of human prostate cancer cells in athymic nude mice. The homodimeric protease (PR) of XMRV plays a critical role in the production of functional viral proteins and is a prerequisite for viral replication. We synthesized XMRV ...
DOI:: 10.1016/j.bbrc.2012.07.083
: https://doi.org/10.1016/j.bbrc.2012.07.083

95. Prohibitins function as endogenous ligands for Siglec-9 and negatively regulate TCR signaling upon ligation

Author:: Hajime Yurugi; Shuhei Tanida; Kaoru Akita; Akiko Ishida; Munetoyo Toda; Hiroshi Nakada
Source:: Biochemical and biophysical research communications 2013 v.434 pp. 376-381
ISSN:: 0006-291X
Subject:: T-lymphocytes; antibodies; dendritic cells; immunotherapy; interleukin-2; leukemia; macrophages; mitogen-activated protein kinase; phosphorylation; receptors
Abstract:: ... Previously we demonstrated that prohibitin-1 and -2 (prohibitins) were expressed on the surface of T cell leukemia cell lines and activated T lymphocytes. In the present study, we found that prohibitins play a role as counter receptors for Siglec-9 expressed on macrophages and dendritic cells. Siglec-9 bound to prohibitins in a sialic acid-independent manner. Mutated Siglec-9 with Arg120 changed t ...
DOI:: 10.1016/j.bbrc.2013.03.085
: https://doi.org/10.1016/j.bbrc.2013.03.085

96. Quantitative multiplex quantum dot in-situ hybridisation based gene expression profiling in tissue microarrays identifies prognostic genes in acute myeloid leukaemia

Author:: Eleni Tholouli; Sarah MacDermott; Judith Hoyland; John Liu Yin; Richard Byers
Source:: Biochemical and biophysical research communications 2012 v.425 no.2 pp. 333-339
ISSN:: 0006-291X
Subject:: bone marrow; gene expression; genes; hybridization; image analysis; in situ hybridization; leukemia; microarray technology; oligonucleotides; patients; pellets; quantum dots
Abstract:: ... Measurement and validation of microarray gene signatures in routine clinical samples is problematic and a rate limiting step in translational research. In order to facilitate measurement of microarray identified gene signatures in routine clinical tissue a novel method combining quantum dot based oligonucleotide in situ hybridisation (QD-ISH) and post-hybridisation spectral image analysis was used ...
DOI:: 10.1016/j.bbrc.2012.07.092
: https://doi.org/10.1016/j.bbrc.2012.07.092

97. Sodium arsenite down-regulates the expression of X-linked inhibitor of apoptosis protein via translational and post-translational mechanisms in hepatocellular carcinoma

Author:: Hong Chen; Yuqing Hao; Lijing Wang; Dongwei Jia; Yuanyuan Ruan; Jianxin Gu
Source:: Biochemical and biophysical research communications 2012 v.422 no.4 pp. 721-726
ISSN:: 0006-291X
Subject:: antineoplastic agents; apoptosis; arsenic; cell cycle; cell growth; cell proliferation; cell viability; cytotoxicity; gene expression regulation; growth retardation; hepatoma; humans; leukemia; metastasis; patients; ribosomes; sodium; sodium arsenite; translation (genetics)
Abstract:: ... X-linked inhibitor of apoptosis protein (XIAP) is a member of the inhibitors of apoptosis protein (IAP) family, and has been reported to exhibit elevated expression levels in hepatocellular carcinoma (HCC) and promote cell survival, metastasis and tumor recurrence. Targeting XIAP has proven effective for the inhibition of cancer cell proliferation and restoration of cancer cell chemosensitivity. A ...
DOI:: 10.1016/j.bbrc.2012.05.066
: https://doi.org/10.1016/j.bbrc.2012.05.066

98. Toll-like receptor (TLR) 3 as a surrogate sensor of retroviral infection in human cells

Author:: Kosuke Miyauchi; Emiko Urano; Satoshi Takeda; Tsutomu Murakami; Yoshiaki Okada; Kui Cheng; Hang Yin; Masato Kubo; Jun Komano
Source:: Biochemical and biophysical research communications 2012 v.424 no.3 pp. 519-523
ISSN:: 0006-291X
Subject:: Toll-like receptor 3; Toll-like receptor 7; human diseases; humans; leukemia; mice; viruses
Abstract:: ... The toll-like receptor (TLR)-7 has been shown to sense the retroviral infection. However, a surrogate sensor has been implicated. We examined whether retrovirus serves as a TLR3 ligand in human cells by utilizing cell lines LNCaP and PC-3 lacking TLR7, and the xenotropic murine leukemia virus-relamoted virus (XMRV) insensitive to human tripartite motif-containing (TRIM) 5, a newly characterized pa ...
DOI:: 10.1016/j.bbrc.2012.06.148
: https://doi.org/10.1016/j.bbrc.2012.06.148

99. YM155 induces caspase-8 dependent apoptosis through downregulation of survivin and Mcl-1 in human leukemia cells

Author:: Weiying Feng; Akira Yoshida; Takanori Ueda
Source:: Biochemical and biophysical research communications 2013 v.435 pp. 52-57
ISSN:: 0006-291X
Subject:: apoptosis; caspase-3; caspase-8; cell growth; cytotoxicity; gene expression; humans; inhibitory concentration 50; leukemia; messenger RNA; protein synthesis
Abstract:: ... Survivin, a member of the inhibitor of apoptosis protein (IAP) family, is highly expressed in various kinds of tumors. In the present study, we investigated the cytotoxic mechanism of YM155, a unique small-molecule inhibitor of survivin, in human myelogenous leukemia cells. YM155 potently inhibited the cell growth of HL-60 and U937 cells with the half-maximal inhibitory concentration (IC50) value ...
DOI:: 10.1016/j.bbrc.2013.04.036
: https://doi.org/10.1016/j.bbrc.2013.04.036

100. A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line

Author:: Fabienne Godin; Sandrine Villette; Béatrice Vallée; Michel Doudeau; Séverine Morisset-Lopez; Maryvonne Ardourel; Tobias Hevor; Chantal Pichon; Hélène Bénédetti
Source:: Biochemical and biophysical research communications 2012 v.418 no.4 pp. 689-694
ISSN:: 0006-291X
Subject:: cognition; fluorescent antibody technique; genes; genetic disorders; leukemia; microfilaments; multiprotein complexes; mutation; nervous system
Abstract:: ... Neurofibromatosis type 1 is a common genetic disease that causes nervous system tumors, and cognitive deficits. It is due to mutations within the NF1 gene, which encodes the Nf1 protein. Nf1 has been shown to be involved in the regulation of Ras, cAMP and actin cytoskeleton dynamics. In this study, using immunofluorescence experiments, we have shown a partial nuclear localization of Nf1 in the ast ...
DOI:: 10.1016/j.bbrc.2012.01.079
: https://doi.org/10.1016/j.bbrc.2012.01.079

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1. Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells

2. The CDK4/6-UCHL5-BRD4 axis confers resistance to BET inhibitors in MLL-rearranged leukemia cells by suppressing BRD4 protein degradation

3. Cyclophosphamide-induced GPX4 degradation triggers parthanatos by activating AIFM1

4. Highly polymerized proanthocyanidins (PAC) components from blueberry leaf and stem significantly inhibit SARS-CoV-2 infection via inhibition of ACE2 and viral 3CLpro enzymes

5. Promyelocytic leukemia protein is a restriction factor for Junín virus independently of Z matrix protein

6. Involvement of EZH2 inhibition in lenalidomide and pomalidomide-mediated growth suppression in HTLV-1-infected cells

7. PML-II recruits ataxin-3 to PML-NBs and inhibits its deubiquitinating activity

8. A novel dipeptide type inhibitor of the Wnt/β-catenin pathway suppresses proliferation of acute myelogenous leukemia cells

9. Dasatinib, a second-generation tyrosine kinase inhibitor, induces melanogenesis via ERK-CREB-MITF-tyrosinase signaling in normal human melanocytes

10. Histone deacetylase 8 inhibition suppresses mantle cell lymphoma viability while preserving natural killer cell function

11. Identification and functional study of immortalized mouse thymic epithelial cells

12. JAK2 inhibition in JAK2V617F-bearing leukemia cells enriches CD34+ leukemic stem cells that are abolished by the telomerase inhibitor GRN163L

13. NLS-RARα blocks cell differentiation by inhibiting the retinoic acid signalling pathway

14. Rosiglitazone binds to RXRα to induce RXRα tetramerization and NB4 cell differentiation

15. T618I CSF3R mutations in chronic neutrophilic leukemia induce oncogenic signals through aberrant trafficking and constitutive phosphorylation of the O-glycosylated receptor form

16. AFF4 enhances odontogenic differentiation of human dental pulp cells

17. CD47/SIRPα blocking enhances CD19/CD3-bispecific T cell engager antibody-mediated lysis of B cell malignancies

18. Characterization of the substrate specificity of the inositol 5-phosphatase SHIP1

19. Functional expression cloning of molecules inducing CD34 expression in bone marrow-derived stromal myofibroblasts

20. Induction of human pluripotent stem cell-derived natural killer cells for immunotherapy under chemically defined conditions

21. Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells

22. JTE-607, a multiple cytokine production inhibitor, targets CPSF3 and inhibits pre-mRNA processing

23. K562 cell-derived exosomes suppress the adhesive function of bone marrow mesenchymal stem cells via delivery of miR-711

24. Megakaryocytic leukemia 1 (MKL1) mediates high glucose induced epithelial-mesenchymal transition by activating LOX transcription

25. PML modulates H3.3 targeting to telomeric and centromeric repeats in mouse fibroblasts

26. The novel small molecular BH3 mimetics SM3 and its regulation of cell apoptosis and autophagy

27. IL- 10 gene-modified dendritic cells-induced type 1 T regulatory cells inhibit graft-versus-host disease while preserving graft-versus-leukemia effect

28. 4-Amino-2-Trifluoromethyl-Phenyl Retinate induced leukemia cell differentiation by decreasing eIF6

29. Activation of Notch1 signaling by HTLV-1 Tax promotes proliferation of adult T-cell leukemia cells

30. Adenylate cyclase 7 regulated by miR-192 promotes ATRA-induced differentiation of acute promyelocytic leukemia cells

31. E2f1 regulates the induction of promyelocytic leukemia zinc finger transcription in neuronal differentiation of pluripotent P19 embryonal carcinoma cells

32. Effect of trichostatin A on Burkitt's lymphoma cells: Inhibition of EPS8 activity through Phospho-Erk1/2 pathway

33. Elastic modulus and migration capability of drug treated leukemia cells K562

34. Identification of a point mutation PMLS214L-RARα that alters PML body organization, dynamics and SUMOylation

35. Influence of acute promyelocytic leukemia therapeutic drugs on nuclear pore complex density and integrity

36. MicroRNA-3662 expression correlates with antiviral drug resistance in adult T-cell leukemia/lymphoma cells

37. PATZ1 is required for efficient HIV-1 infection

38. Resveratrol strongly enhances the retinoic acid-induced superoxide generating activity via up-regulation of gp91-phox gene expression in U937 cells

39. Activation of Wnt signaling pathway by AF1q enriches stem-like population and enhance mammosphere formation of breast cells

40. BCL11B is frequently downregulated in HTLV-1-infected T-cells through Tax-mediated proteasomal degradation

41. C/EBPβ contributes to transcriptional activation of long non-coding RNA NEAT1 during APL cell differentiation

42. Characterization of goat inner cell mass derived cells in double kinase inhibition condition

43. MOV10 inhibits replication of porcine reproductive and respiratory syndrome virus by retaining viral nucleocapsid protein in the cytoplasm of Marc-145 cells

44. Novel biosensor using split-luciferase for detecting vitamin D receptor ligands based on the interaction between vitamin D receptor and coactivator

45. CACUL1/CAC1 attenuates p53 activity through PML post-translational modification

46. Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells

47. Detection of O-propargyl-puromycin with SUMO and ubiquitin by click chemistry at PML-nuclear bodies during abortive proteasome activities

48. Development of a complete human IgG monoclonal antibody to transferrin receptor 1 targeted for adult T-cell leukemia/lymphoma

49. HDAC9 regulates the alternative lengthening of telomere (ALT) pathway via the formation of ALT-associated PML bodies

50. Human SMOOTHENED inhibits human immunodeficiency virus type 1 infection

51. Hydroquinone induces DNA hypomethylation-independent overexpression of retroelements in human leukemia and hematopoietic stem cells

52. Identification of miR-125b targets involved in acute promyelocytic leukemia cell proliferation

53. MOV10 interacts with Enterovirus 71 genomic 5′UTR and modulates viral replication

54. Niclosamide suppresses RANKL-induced osteoclastogenesis and prevents LPS-induced bone loss

55. Rho signaling inhibitor, CCG-1423, inhibits axonal elongation and dendritic complexity of rat cortical neurons

56. The downregulation of miR-3173 in B-cell acute lymphoblastic leukaemia promotes cell invasion via PTK2

57. miR-320a regulates cell proliferation and apoptosis in multiple myeloma by targeting pre-B-cell leukemia transcription factor 3

58. Bovine leukemia virus nucleocapsid protein is an efficient nucleic acid chaperone

59. Hispolon inhibits the growth of estrogen receptor positive human breast cancer cells through modulation of estrogen receptor alpha

60. Integrin αVβ3 and αVβ5 are required for leukemia inhibitory factor-mediated the adhesion of trophoblast cells to the endometrial cells

61. Myricetin is a novel inhibitor of human inosine 5′-monophosphate dehydrogenase with anti-leukemia activity

62. PRDM14 maintains pluripotency of embryonic stem cells through TET-mediated active DNA demethylation

63. RAD001 (everolimus) enhances TRAIL cytotoxicity in human leukemic Jurkat T cells by upregulating DR5

64. RETRACTION: miR-664 negatively regulates PLP2 and promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia

65. Resveratrol-induced transcriptional up-regulation of ASMase (SMPD1) of human leukemia and cancer cells

66. The Tax oncogene enhances ELL incorporation into p300 and P-TEFb containing protein complexes to activate transcription

67. 5-(2-Carboxyethenyl) isatin derivative induces G2/M cell cycle arrest and apoptosis in human leukemia K562 cells

68. Androgen-independent proliferation of LNCaP prostate cancer cells infected by xenotropic murine leukemia virus-related virus

69. Macrophage-derived microvesicles promote proliferation and migration of Schwann cell on peripheral nerve repair

70. PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction

27. IL- 10 gene-modified dendritic cells-induced type 1 T regulatory cells inhibit graft-versus-host disease while preserving graft-versus-leukemia effect

43. MOV10 inhibits replication of porcine reproductive and respiratory syndrome virus by retaining viral nucleocapsid protein in the cytoplasm of Marc-145 cells