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You searched for: Author "Du, Juan" Remove constraint Author: "Du, Juan" Journal Biochemical and biophysical research communications Remove constraint Journal: Biochemical and biophysical research communications Subject Human immunodeficiency virus 2 Remove constraint Subject: Human immunodeficiency virus 2 Subject proteins Remove constraint Subject: proteins
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1. HD domain of SAMHD1 influences Vpx-induced degradation at a post-interaction step

Author:
Du, Juan,   et al.   ; Kang, Jian; Hou, Jingwei; Zhao, Ke; Yu, Xiao-Fang;     Show all 5 Authors
Source:
Biochemical and biophysical research communications 2016 v.470 pp. 690-696
ISSN:
0006-291X
Subject:
Human immunodeficiency virus 1; Human immunodeficiency virus 2; chickens; humans; proteins; ubiquitin-protein ligase; viruses
Abstract:
... Primate SAMHD1 proteins are potent inhibitors of viruses, including retroviruses such as HIV-1, HIV-2, and SIV. Vpx, a distinctive viral protein expressed by HIV-2 and some SIVs, induces SAMHD1 degradation by forming a Vpx-DCAF1-based ubiquitin ligase complex. Either the N- or the C-terminus of SAMHD1 is critical for Vpx-induced degradation, depending on the types of SAMHD1 and Vpx proteins. Howev ...
DOI:
10.1016/j.bbrc.2016.01.080