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- Kim, Lark Kyun, et al. Show all 5 Authors
- Biochemical and biophysical research communications 2017
- Escherichia coli; acidification; antibacterial properties; bacteria; bacterial infections; cytokines; lectins; macrophages; mice; pathogenesis; peritonitis; phagocytosis; phagosomes; sepsis (infection); survival rate
- ... Sepsis is a life-threatening condition caused by an uncontrolled response to bacterial infection. Impaired bactericidal activity in the host is directly associated with severe sepsis; however, the underlying regulatory mechanism(s) is largely unknown. Here, we show that MCL (macrophage C-type lectin) plays a crucial role in killing bacteria during Escherichia coli-induced peritonitis. MCL-deficien ...