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- Yamashita, Shuntaro; Ogawa, Kaori; Ikei, Takahiro; Udono, Miyako; Fujiki, Tsukasa; Katakura, Yoshinori
- Biochemical and biophysical research communications 2012 v.417 no.1 pp. 630-634
- umbilical cord, etc ; transcriptional activation; longevity; humans; histones; resveratrol; genes; telomerase; fibroblasts; low calorie diet; Show all 10 Subjects
- ... SIRT1, the mammalian homolog of sirtuins, has emerged as a mediator of the beneficial effects of calorie restriction. Among them, we focused on the SIRT1-induced prevention of cellular senescence, and tried to reveal the molecular mechanisms that define the effects of SIRT1. Firstly in this study, we observed that overexpression of SIRT1 resulted in the prevention of cellular senescence of normal ...