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- Du, Juan, et al. Show all 5 Authors
- Biochemical and biophysical research communications 2016 v.470 pp. 690-696
- Human immunodeficiency virus 1; Human immunodeficiency virus 2; chickens; humans; proteins; ubiquitin-protein ligase; viruses
- ... Primate SAMHD1 proteins are potent inhibitors of viruses, including retroviruses such as HIV-1, HIV-2, and SIV. Vpx, a distinctive viral protein expressed by HIV-2 and some SIVs, induces SAMHD1 degradation by forming a Vpx-DCAF1-based ubiquitin ligase complex. Either the N- or the C-terminus of SAMHD1 is critical for Vpx-induced degradation, depending on the types of SAMHD1 and Vpx proteins. Howev ...
- Du, Juan, et al. Show all 7 Authors
- Biochemical and biophysical research communications 2019 v.510 no.4 pp. 551-557
- Retroviridae; antiviral properties; cytoplasm; digitonin; fractionation; humans; mutants; nuclear localization signals; nucleocytoplasmic transport; nucleoside-triphosphate phosphatase; retrotransposons
- ... Currently, SAMHD1 is the only known dNTPase in human cells. It also suppresses the replication of both retroviruses and retroelements. SAMHD1 contains a classic nuclear localization sequence (NLS) and resides in the nucleus in live or fixed cells. It has been reported that alteration or removal of NLS does not affect the dNTPase or the antiviral activity of SAMHD1. However, it was unclear whether ...