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Biochemical and biophysical research communications
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infectious diseases
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- Author:
- Tadashi Mori; Masafumi Hidaka; Yi-Chin Lin; Ibuki Yoshizawa; Takayoshi Okabe; Shinichiro Egashira; Hirotatsu Kojima; Tetsuo Nagano; Mamoru Koketsu; Mari Takamiya; Takafumi Uchida
- Source:
- Biochemical and biophysical research communications 2011 v.406 no.3 pp. 439-443
- ISSN:
- 0006-291X
- Subject:
- Alzheimer disease; active sites; cell proliferation; cyclophilins; fluorescence; infectious diseases; peptidylprolyl isomerase; screening; surface plasmon resonance
- Abstract:
- ... Pin1, a peptidyl prolyl cis/trans isomerase (PPIase), is a potential target molecule for cancer, infectious disease, and Alzheimer’s disease. We established a high-throughput screening method for Pin1 inhibitors, which employs a real-time fluorescence detector. This screening method identified 66 compounds that inhibit Pin1 out of 9756 compounds from structurally diverse chemical libraries. Furthe ...
- DOI:
- 10.1016/j.bbrc.2011.02.066
- https://doi.org/10.1016/j.bbrc.2011.02.066
- Author:
- Bomi Hwang; Jaeyong Cho; In-sok Hwang; Hong-Guang Jin; Eun-Rhan Woo; Dong Gun Lee
- Source:
- Biochemical and biophysical research communications 2011 v.410 no.3 pp. 489-493
- ISSN:
- 0006-291X
- Subject:
- Candida albicans; Sambucus; antifungal properties; erythrocytes; flow cytometry; fluorescence; fungi; humans; infectious diseases; iodides; lipid bilayers; mechanism of action; medicinal plants; medicinal properties; plasma membrane; propidium
- Abstract:
- ... Lariciresinol is an enterolignan precursor isolated from the herb Sambucus williamsii, a folk medicinal plant used for its therapeutic properties. In this study, the antifungal properties and mode of action of lariciresinol were investigated. Lariciresinol displays potent antifungal properties against several human pathogenic fungal strains without hemolytic effects on human erythrocytes. To under ...
- DOI:
- 10.1016/j.bbrc.2011.06.004
- https://doi.org/10.1016/j.bbrc.2011.06.004
- Author:
- Saki Higurashi; Yusuke Machino; Emiko Suzuki; Mami Suzuki; Junya Kohroki; Yasuhiko Masuho
- Source:
- Biochemical and biophysical research communications 2012 v.417 no.2 pp. 794-799
- ISSN:
- 0006-291X
- Subject:
- antibodies; autoimmune diseases; complement; idiopathic diseases; immunoglobulin G; infectious diseases; intravenous injection; neutrophils; reactive oxygen species; surface antigens; thrombocytopenic purpura; tumor necrosis factor-alpha
- Abstract:
- ... Intravenous immunoglobulin (IVIG) is currently a very important therapeutic used for not only infectious diseases, but also for autoimmune diseases such as idiopathic thrombocytopenic purpura (ITP). Untoward reactions of IVIG have been thought to result from complement activation by aggregated IgG in IVIG. In addition, the aggregates have been known to activate neutrophils, which may result in the ...
- DOI:
- 10.1016/j.bbrc.2011.12.038
- https://doi.org/10.1016/j.bbrc.2011.12.038
4. A protective role of IL-30 via STAT and ERK signaling pathways in macrophage-mediated inflammation
- Author:
- Xiao Liu; Zhen Wang; Ning Ye; Zhongwen Chen; Xikun Zhou; Xiu Teng; Nongyu Huang; Ning Liu; Nannan Zhang; Ting Guan; Yongqiu Mao; Bin Kan; Yuquan Wei; Jiong Li
- Source:
- Biochemical and biophysical research communications 2013 v.435 pp. 306-312
- ISSN:
- 0006-291X
- Subject:
- animal models; anti-inflammatory activity; antioxidants; apoptosis; blood serum; dose response; enzyme activity; genes; glutathione; immune response; infectious diseases; inflammation; interferon-gamma; interleukin-1beta; interleukin-6; liver; liver diseases; macrophages; mitogen-activated protein kinase; protective effect; signal transduction; tumor necrosis factor-alpha
- Abstract:
- ... IL-30, the p28 subunit of IL-27, interacts with the Epstein–Barr virus-induced gene 3 (EBI3) to form IL-27, which modulates the inflammatory responses in autoimmune and infectious diseases. Several previous studies have provided evidence for the role of IL-30 in the anti-inflammatory process. However, the effect of IL-30 in macrophage-mediated immune responses is not well understood. With the rece ...
- DOI:
- 10.1016/j.bbrc.2013.03.136
- https://doi.org/10.1016/j.bbrc.2013.03.136
- Author:
- Uk Lee; Young Ran Nam; Jung Sook Ye; Kyoung Jin Lee; Nari Kim; Chul Hyun Joo
- Source:
- Biochemical and biophysical research communications 2014 v.450 pp. 1076-1082
- ISSN:
- 0006-291X
- Subject:
- Hepatitis C virus; acute course; chronic hepatitis; culture media; exocrine glands; gene expression regulation; genes; glycoproteins; hepatoma; humans; infectious diseases; liver cirrhosis; messenger RNA; mice; microarray technology; virus replication
- Abstract:
- ... Hepatitis C virus (HCV) affects 2–3% of the global population. Approximately one-quarter of acute infections cause chronic hepatitis that leads to liver cirrhosis or hepatocellular carcinoma. The major obstacle of current research is the extremely narrow host tropism of HCV. A single HCV strain can replicate in the Huh7 human hepatoma cell line. Huh7 cells can be adapted under selective pressure i ...
- DOI:
- 10.1016/j.bbrc.2014.06.106
- https://doi.org/10.1016/j.bbrc.2014.06.106
- Author:
- Sung Kyun Lee; Yoo Jung Park; Min Jung Ko; Ziyu Wang; Ha Young Lee; Young Whan Choi; Yoe-Sik Bae
- Source:
- Biochemical and biophysical research communications 2015 v.464 pp. 774-779
- ISSN:
- 0006-291X
- Subject:
- Allium sativum; apoptosis; garlic; infectious diseases; inflammation; interleukin-1beta; interleukin-6; macrophages; mice; models; reactive oxygen species; respiratory tract diseases; sepsis (infection); spleen; sucrose; survival rate; therapeutics; tumor necrosis factor-alpha
- Abstract:
- ... Sepsis is a serious, life-threatening, infectious disease. In this study, we demonstrate that sucrose methyl 3-formyl-4-methylpentanoate (SMFM), a novel natural compound isolated from garlic (Allium sativum L.), markedly enhances survival rates by inhibiting lung inflammation in a cecal ligation and puncture (CLP) experimental polymicrobial sepsis model. SMFM strongly reduced bacterial colony unit ...
- DOI:
- 10.1016/j.bbrc.2015.07.031
- https://doi.org/10.1016/j.bbrc.2015.07.031
- Author:
- Jun Mu; Yongtao Yang; Jin Chen; Ke Cheng; Qi Li; Yongdong Wei; Dan Zhu; Weihua Shao; Peng Zheng; Peng Xie
- Source:
- Biochemical and biophysical research communications 2015 v.466 pp. 689-695
- ISSN:
- 0006-291X
- Subject:
- Mycobacterium tuberculosis; bioinformatics; cerebrospinal fluid; databases; enzyme-linked immunosorbent assay; genes; immune system; infectious diseases; lipid metabolism; liquid chromatography; meningitis; pathogenesis; pathogens; patients; phenotype; proteins; proteomics; tandem mass spectrometry
- Abstract:
- ... Tuberculous meningitis (TBM) remains to be one of the most deadly infectious diseases. The pathogen interacts with the host immune system, the process of which is largely unknown. Various cellular processes of Mycobacterium tuberculosis (MTB) centers around lipid metabolism. To determine the lipid metabolism related proteins, a quantitative proteomic study was performed here to identify differenti ...
- DOI:
- 10.1016/j.bbrc.2015.08.036
- https://doi.org/10.1016/j.bbrc.2015.08.036
- Author:
- Esther H. Chang; Joe B. Harford; Michael A.W. Eaton; Patrick M. Boisseau; Admire Dube; Rose Hayeshi; Hulda Swai; Dong Soo Lee
- Source:
- Biochemical and biophysical research communications 2015 v.468 pp. 511-517
- ISSN:
- 0006-291X
- Subject:
- funding; industry; infectious diseases; nanomedicine; nanoparticles; poverty; professional societies; research and development; supply chain; therapeutics
- Abstract:
- ... Nanomedicine is an emerging and rapidly evolving field and includes the use of nanoparticles for diagnosis and therapy of a variety of diseases, as well as in regenerative medicine. In this mini-review, leaders in the field from around the globe provide a personal perspective on the development of nanomedicine. The focus lies on the translation from research to development and the innovation suppl ...
- DOI:
- 10.1016/j.bbrc.2015.10.136
- https://doi.org/10.1016/j.bbrc.2015.10.136
- Author:
- Hiroshi Hamana; Kiyomi Shitaoka; Hiroyuki Kishi; Tatsuhiko Ozawa; Atsushi Muraguchi
- Source:
- Biochemical and biophysical research communications 2016 v.474 pp. 709-714
- ISSN:
- 0006-291X
- Subject:
- gene therapy; infectious diseases; complementary DNA; T-lymphocytes; antigens; humans; neoplasms; immunotherapy; luciferase; reverse transcriptase polymerase chain reaction; transcription (genetics); mice; signal peptide; receptors; Human gammaherpesvirus 4
- Abstract:
- ... T-cell receptor (TCR) gene therapy is a promising approach for the treatment of infectious diseases and cancers. However, the paired cloning and functional assays of antigen-specific TCRα and TCRβ is time-consuming and laborious. In this study, we developed a novel, rapid and efficient antigen-specific TCR-cloning system by combining three technologies: multiplex one-step RT-PCR, transcriptionally ...
- DOI:
- 10.1016/j.bbrc.2016.05.015
- https://doi.org/10.1016/j.bbrc.2016.05.015
- Author:
- Bonsu Ku; Chae Won Keum; Hye Seon Lee; Hye-Yeoung Yun; Ho-Chul Shin; Bo Yeon Kim; Seung Jun Kim
- Source:
- Biochemical and biophysical research communications 2016 v.478 pp. 1217-1222
- ISSN:
- 0006-291X
- Subject:
- Streptococcus pyogenes; active sites; bacteria; crystal structure; dephosphorylation; genome; infectious diseases; molecular weight; protein-tyrosine-phosphatase; serine; threonine; tyrosine; virulence
- Abstract:
- ... Streptococcus pyogenes, or Group A Streptococcus (GAS), is a pathogenic bacterium that causes a variety of infectious diseases. The GAS genome encodes one protein tyrosine phosphatase, SP-PTP, which plays an essential role in the replication and virulence maintenance of GAS. Herein, we present the crystal structure of SP-PTP at 1.9 Å resolution. Although SP-PTP has been reported to have dual phosp ...
- DOI:
- 10.1016/j.bbrc.2016.08.097
- https://doi.org/10.1016/j.bbrc.2016.08.097
- Author:
- Takanori Shinjo; Misaki Iwashita; Akiko Yamashita; Tomomi Sano; Mitsudai Tsuruta; Hiroaki Matsunaga; Terukazu Sanui; Tomoichiro Asano; Fusanori Nishimura
- Source:
- Biochemical and biophysical research communications 2016 pp. -
- ISSN:
- 0006-291X
- Subject:
- IKappaB kinase; adipocytes; adipose tissue; autoimmune diseases; blood serum; chemokine CCL20; coculture; gene expression regulation; infectious diseases; inflammation; insulin; interleukin-17; interleukin-6; macrophages; messenger RNA; mice; mitogen-activated protein kinase; noninsulin-dependent diabetes mellitus; pathogenesis; secretion; synergism; tumor necrosis factor-alpha
- Abstract:
- ... Interleukin-17A (IL-17A) is known to induce inflammatory responses and to be involved in the pathogenesis of not only autoimmune diseases, but also several metabolic and infectious diseases. In this study, IL-17A is shown to induce IL-6 expression in 3T3-L1 mature adipocytes. Interestingly, we found that IL-17A synergistically amplified TNFα-induced secretion of IL-6 and upregulation of IL-17RA ex ...
- DOI:
- 10.1016/j.bbrc.2016.06.049
- https://doi.org/10.1016/j.bbrc.2016.06.049
- Author:
- Koichi Inoue; Eisuke Sakuma; Hiroyuki Morimoto; Hayato Asai; Yoshinori Koide; Tiandong Leng; Ikuo Wada; Zhi-Gang Xiong; Takatoshi Ueki
- Source:
- Biochemical and biophysical research communications 2016 v.478 no.1 pp. 53-59
- ISSN:
- 0006-291X
- Subject:
- T-lymphocytes; cell lines; cell viability; central nervous system; dendritic cells; inducible nitric oxide synthase; infectious diseases; inflammation; macrophages; neuroglia; phosphotransferases (kinases); schizophrenia; stroke; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... Microglia are derived from myelogenous cells and contribute to immunological and inflammatory responses in central nervous system. They play important roles not only in infectious diseases and inflammation after stroke, but also in psychiatric diseases such as schizophrenia. While recent studies suggest the significances of serum- and glucocorticoid-inducible kinases (SGKs) in other immune cells s ...
- DOI:
- 10.1016/j.bbrc.2016.07.094
- PubMed:
- 27457803
- PubMed Central:
- PMC4996278
- https://doi.org/10.1016/j.bbrc.2016.07.094
- Author:
- Aizhang Xu; Rong Wang; Andrew Freywald; Kristoffor Stewart; Suresh Tikoo; Jianqing Xu; Changyu Zheng; Jim Xiang
- Source:
- Biochemical and biophysical research communications 2017 pp. -
- ISSN:
- 0006-291X
- Subject:
- CD4-positive T-lymphocytes; agonists; antagonists; antibodies; cytotoxic T-lymphocytes; dendritic cells; genetically modified organisms; infectious diseases; interferon-gamma; mice; models; ovalbumin; vaccines
- Abstract:
- ... Expansion of PD-1-expressing CD8+ cytotoxic T lymphocytes (CTLs) and associated CTL exhaustion are chief issues for ineffective virus-elimination in chronic infectious diseases. PD-1 blockade using antagonistic anti-PD-L1 antibodies results in a moderate conversion of CTL exhaustion. We previously demonstrated that CD40L signaling of ovalbumin (OVA)-specific vaccine, OVA-Texo, converts CTL exhaust ...
- DOI:
- 10.1016/j.bbrc.2017.01.172
- https://doi.org/10.1016/j.bbrc.2017.01.172
- Author:
- Hitomi Matsushima; Yutaro Kumagai; Alexis Vandenbon; Hideo Kataoka; Miki Kadena; Haruka Fukamachi; Takafumi Arimoto; Hirobumi Morisaki; Nagatoshi Fujiwara; Nobuo Okahashi; Hirotaka Kuwata
- Source:
- Biochemical and biophysical research communications 2017 v.485 pp. 461-467
- ISSN:
- 0006-291X
- Subject:
- Streptococcus oralis; blood flow; cardiovascular diseases; gene expression; gene expression regulation; genes; hydrogen peroxide; hydrogen production; immunosuppression; infectious diseases; inflammation; innate immunity; interleukin-6; macrophages; microarray technology; mouth; mucosa; oxidative stress; pyruvate oxidase; quantitative polymerase chain reaction; signal transduction; stress response; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... Oral streptococci including mitis group streptococci are commensal residents and are also the first to colonize the oral cavity. However, various species of these oral streptococci have the potential to invade the host and occasionally lead to severe infectious disease such as cardiovascular diseases. Oral streptococci have close interactions with the host immune system including macrophages at th ...
- DOI:
- 10.1016/j.bbrc.2017.02.048
- https://doi.org/10.1016/j.bbrc.2017.02.048
- Author:
- Chun Wu; Gang Xu; Shang-Yi A. Tsai; William J. Freed; Chun-Ting Lee
- Source:
- Biochemical and biophysical research communications 2017 v.482 pp. 282-288
- ISSN:
- 0006-291X
- Subject:
- amino acid metabolism; apoptosis; databases; energy; gene expression; gene expression regulation; gene regulatory networks; genes; humans; infectious diseases; insulin; insulin resistance; muscles; noninsulin-dependent diabetes mellitus; oxidative phosphorylation; pathogenesis; patients; skeletal muscle; transcription (genetics); transcriptome
- Abstract:
- ... Skeletal muscle insulin resistance is considered to be the primary defect involved in type 2 diabetes mellitus (T2DM). Despite transcriptome studies in limited T2DM human subjects suggesting an association of T2DM with impaired oxidative phosphorylation in muscle, its molecular pathogenesis remains largely unknown. To identify dysregulated genes and gene networks that are associated with T2DM in h ...
- DOI:
- 10.1016/j.bbrc.2016.11.055
- https://doi.org/10.1016/j.bbrc.2016.11.055
- Author:
- Swanandi Pote; Sarah E. Pye; Tyler E. Sheahan; Anna Gawlicka-Chruszcz; Karolina A. Majorek; Maksymilian Chruszcz
- Source:
- Biochemical and biophysical research communications 2018 v.503 no.3 pp. 1993-1999
- ISSN:
- 0006-291X
- Subject:
- NADP (coenzyme); Neisseria gonorrhoeae; animal pathogens; antibiotics; bioinformatics; drug resistance; drugs; infectious diseases; oxidoreductases
- Abstract:
- ... Neisseria gonorrhoeae, an obligate human pathogen, is a leading cause of communicable diseases globally. Due to rapid development of drug resistance, the rate of successfully curing gonococcal infections is rapidly decreasing. Hence, research is being directed toward finding alternative drugs or drug targets to help eradicate these infections. 4-Hydroxy-tetrahydrodipicolinate reductase (DapB), an ...
- DOI:
- 10.1016/j.bbrc.2018.07.147
- PubMed:
- 30093108
- PubMed Central:
- PMC6192261
- https://doi.org/10.1016/j.bbrc.2018.07.147
- Author:
- Yixin Zhang; Yi Xiong; Peng Xie; Xiaogang Ao; Zheng Zheng; Xiaoqing Dong; Hao Li; Qingsong Yu; Zhimin Zhu; Meng Chen; Wenchuan Chen
- Source:
- Biochemical and biophysical research communications 2018 v.503 no.3 pp. 2040-2046
- ISSN:
- 0006-291X
- Subject:
- adjuvants; biofilm; bone resorption; decontamination; hemorrhage; infectious diseases; interleukin-10; interleukin-1beta; mouth; nonthermal processing; osteoclasts; pathogens; periodontitis; planning; rats; therapeutics; tumor necrosis factor-alpha
- Abstract:
- ... Periodontitis, a chronic infectious disease induced by microbial biofilm, is one of the most common diseases worldwide. Scaling and root planning (SRP) has always been recognized as the typical treatment. However, the therapeutic efficiency is often limited due to the intraoperative bleeding and the limitations of instruments. Non-thermal atmospheric plasma (NTP) appears to be a potential tool for ...
- DOI:
- 10.1016/j.bbrc.2018.07.154
- https://doi.org/10.1016/j.bbrc.2018.07.154
- Author:
- R. Manohar; N.H.V. Kutumbarao; Raghavendra Sashi Krishna Nagampalli; D. Velmurugan; K. Gunasekaran
- Source:
- Biochemical and biophysical research communications 2018 v.495 no.1 pp. 679-685
- ISSN:
- 0006-291X
- Subject:
- papain; fatty acids; infectious diseases; trypsin; antiviral properties; molecular models; serine; succinic acid; drugs; ligands; viruses; active sites; crystallization; Gibbs free energy; adverse effects; histidine
- Abstract:
- ... In the age of growing infectious diseases, there is a great demand for new inhibitors which can exhibit minimum side effects. Owing to the importance of proteases in life cycle and invasion, they have been projected as attractive targets for structure based drug designing against microbes including viruses. Here we report the inhibitory activity of a well known natural compound succinic acid again ...
- DOI:
- 10.1016/j.bbrc.2017.11.033
- https://doi.org/10.1016/j.bbrc.2017.11.033
- Author:
- Zhaoxiang Liu; Hua Zhang; Hong Xia; Baocheng Wang; Renwen Zhang; Qun Zeng; Lingzhi Guo; Kui Shen; BaTa Wang; Yanheng Zhong; Zhizhong Li; Guodong Sun
- Source:
- Biochemical and biophysical research communications 2019 v.512 no.2 pp. 367-372
- ISSN:
- 0006-291X
- Subject:
- CD8-positive T-lymphocytes; animal injuries; animal models; biotin; cerebrospinal fluid; cytokines; enzyme-linked immunosorbent assay; flow cytometry; humans; infectious diseases; inflammation; mice; permeability; spinal cord; staining
- Abstract:
- ... Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin after spinal cord injury (SCI) on secondary inflammation. Compared recovery from SCI in perforin knockout (Prf1−/−) and wild-type(WT)mice, WT mic ...
- DOI:
- 10.1016/j.bbrc.2019.03.002
- https://doi.org/10.1016/j.bbrc.2019.03.002
- Author:
- Hidetada Hirakawa; Ayako Takita; Mao Kato; Hanano Mizumoto; Haruyoshi Tomita
- Source:
- Biochemical and biophysical research communications 2020 v.521 no.3 pp. 555-561
- ISSN:
- 0006-291X
- Subject:
- bacteria; bacterial motility; bladder; cyclic AMP; epithelium; infectious diseases; mutants; pathogens; research; urinary tract diseases; uropathogenic Escherichia coli; virulence
- Abstract:
- ... Uropathogenic Escherichia coli (UPEC) is a major pathogen that causes urinary tract infection (UTI), a common bacterial infectious disease. This bacterium invades the urinary tract cells, where it aggregates, and subsequently forms multicellular colonies termed intracellular bacterial communities (IBCs). The motility of the bacteria plays a key role in the mechanism of virulence in the host bladde ...
- DOI:
- 10.1016/j.bbrc.2019.10.165
- https://doi.org/10.1016/j.bbrc.2019.10.165
- Author:
- Hyeryon Lee; Kyung-Hwa Baek; Trong-Nhat Phan; I Seul Park; Sangchul Lee; Jiho Kim; Joo Hwan No
- Source:
- Biochemical and biophysical research communications 2021 v.569 pp. 193-198
- ISSN:
- 0006-291X
- Subject:
- DNA topoisomerase; Leishmania donovani; antileishmanial properties; catalytic activity; drugs; enzyme activity; humans; infectious diseases; protein-protein interactions; research; synthetic peptides; therapeutics; toxicity; visceral leishmaniasis
- Abstract:
- ... Visceral leishmaniasis (VL) is a fatal infectious disease caused by viscerotropic parasitic species of Leishmania. Current treatment options are often ineffective and toxic, and more importantly, there are no clinically validated drug targets available to develop next generation therapeutics against VL. Topoisomerase IB (TopIB) is an essential enzyme for Leishmania survival. The enzyme is organize ...
- DOI:
- 10.1016/j.bbrc.2021.07.019
- https://doi.org/10.1016/j.bbrc.2021.07.019
- Author:
- Tian Zhao; Jiaqi Chen; Shuai Liu; Jie Yang; Juan Wu; Leiying Miao; Weibin Sun
- Source:
- Biochemical and biophysical research communications 2022 v.593 pp. 151-157
- ISSN:
- 0006-291X
- Subject:
- Fusobacterium nucleatum; amino acid metabolism; antibacterial properties; biofilm; biomarkers; carbohydrates; cell growth; dental plaque; gene expression; gene expression regulation; halitosis; infectious diseases; lysine; oxidative stress; periodontitis; plankton; research; reverse transcriptase polymerase chain reaction; sequence analysis; transcriptomics; virulence
- Abstract:
- ... As a chronic infectious disease, periodontitis can cause gum recession, loss of alveolar bone, loosening of teeth, and even loss of teeth. Dental plaque biofilm is the initiating factor for the occurrence and development of periodontitis. Fusobacterium nucleatum (F. nucleatum) plays a vital role in the structure and ecology of dental plaque biofilms. It is a bridge between early and late colonizat ...
- DOI:
- 10.1016/j.bbrc.2021.11.075
- https://doi.org/10.1016/j.bbrc.2021.11.075