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- Loscher, Christine E., et al. Show all 6 Authors
- Biochemical and biophysical research communications 2013 v.440 pp. 163-167
- antigens; autoimmune diseases; humans; immune response; immunoglobulin E; myeloma; pathogens; patients; plasma cells; plasma membrane; protein transport; secretion
- ... The humoral immune system provides a crucial first defense against the invasion of microbial pathogens via the secretion of antigen specific immunoglobulins (Ig). The secretion of Ig is carried out by terminally differentiated B-lymphocytes called plasma cells. Despite the key role of plasma cells in the immune response, the mechanisms by which they constitutively traffic large volumes of Ig out o ...