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- Chen, Lei, et al. Show all 4 Authors
- Biochemical and biophysical research communications 2013 v.435 pp. 514-519
- alkaline phosphatase; bone formation; bone morphogenetic proteins; calcification; gene expression; histopathology; messenger RNA; mineralization; models; osteocalcin; phosphatidylinositol 3-kinase; prostaglandins; rats; stem cells; tissues
- ... Tissue calcification is a typical histopathological feature of tendinopathy. The osteogenic differentiation of tendon stem cells (TSCs) induced by inflammatory mediators is believed to play a key role in this process. Previous studies showed that the major inflammatory mediator prostaglandin E2 (PGE2) induced osteogenic differentiation of TSCs via bone morphogenetic protein (BMP)-2 production. Usi ...