U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Journal name Biochemical and biophysical research communications Remove constraint Journal name: Biochemical and biophysical research communications Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
Start Over

Search

19,581  Search Results

« Previous | 1 - 100 of 19,581 |
Number of results to display per page

Search Results

1. 1-, 2- and 3-AG as substrates of the endocannabinoid enzymes and endogenous ligands of the cannabinoid receptor 1

Author:
Shrouq I. Farah; Samantha Hilston; Ngan Tran; Nikolai Zvonok; Alexandros Makriyannis
Source:
Biochemical and biophysical research communications 2022 v.591 pp. 31-36
ISSN:
0006-291X
Subject:
acylglycerol lipase; agonists; amide hydrolases; cannabinoid receptors; cannabinoids; enantiomers; fatty acids; hydrolysis; isomerization; ligands; monoacylglycerols; research; serine; stereochemistry
Abstract:
... 2-Arachidonoylglycerol (2-AG) is the most potent and abundant endocannabinoid that acts as a full agonist at the cannabinoid 1 (CB1) and 2 (CB2) receptors. It serves as a substrate for several serine hydrolases, including monoacylglycerol lipase (MGL), α/β hydrolase domain 6 (ABHD6) and fatty acid amide hydrolase (FAAH). However, 2-AG's rapid conversion to 1-AG (the S stereoisomer) and 3-AG (the R ...
DOI:
10.1016/j.bbrc.2021.12.105

2. IL- 17A promotes vascular calcification in an ex vivo murine aorta culture

Author:
Sumie Hiramatsu-Asano; Tomoyuki Mukai; Takahiko Akagi; Haruhito A. Uchida; Shunichi Fujita; Kazuhisa Nakano; Yoshitaka Morita
Source:
Biochemical and biophysical research communications 2022 v.604 pp. 83-87
ISSN:
0006-291X
Subject:
aorta; calcification; histology; inflammation; interleukin-17; interleukin-6; mice; micro-computed tomography; mineralization; mortality; phosphates; psoriasis; research; risk
Abstract:
... Vascular calcification is characterized by mineral deposition in the vasculature, which is triggered by chronic systemic inflammation, including psoriasis. Psoriasis is an IL-17A-mediated inflammatory skin disease that is associated with exacerbated vascular calcification and high cardiovascular mortality. Although previous studies have shown that IL-17A induces vascular dysfunction in murine psor ...
DOI:
10.1016/j.bbrc.2022.03.051

3. 17β-estradiol inhibits vascular proliferation and inflammation by reducing NF-κB expression induced by increased crosstalk between KLF5 and ERα

Author:
Man-li Zhang; Man-na Zhang; Wen-li Wang; Hui Chen; Xia Wang; Xuan Li; Li Li; Fei Tong
Source:
Biochemical and biophysical research communications 2022 pp. -
ISSN:
0006-291X
Subject:
Western blotting; cardiovascular system; cell proliferation; chromatin immunoprecipitation; fluorescent antibody technique; inflammation; luciferase; research; smooth muscle
Abstract:
... Pathological vascular remodeling and cell proliferation play vital roles in many proliferative vascular diseases. Estrogen can protect the cardiovascular system, but its exact molecular mechanism is unknown. Here we report that 17β-estradiol (E2) suppressed vascular smooth muscle cells (VSMCs) proliferation and inflammation. qRT-PCR and western blot demonstrated that E2 decreased NF-κB p50 express ...
DOI:
10.1016/j.bbrc.2022.07.054

4. IL- 1R1 blockade attenuates liver injury through inhibiting the recruitment of myeloid-derived suppressor cells in sepsis

Author:
Minjie Luo; Hao Wang; Ke Liu; Meidong Liu; Sipin Tan; Yaxi Zhu; Huali Zhang
Source:
Biochemical and biophysical research communications 2022 v.620 pp. 21-28
ISSN:
0006-291X
Subject:
antagonists; bone marrow; humans; liver; macrophages; phenotype; prognosis; protective effect; research
Abstract:
... Myeloid-derived suppressor cells (MDSCs) mobilize and migrate from bone marrow to peripheral tissues or immune organs, which is associated with poor prognosis in sepsis. Intervention of MDSCs might be a potential target for the effective treatment of sepsis. In the present study, we demonstrated that IL-1R1 blockade with either recombinant human IL-1R antagonist Anakinra or IL-1R1 deficiency had a ...
DOI:
10.1016/j.bbrc.2022.06.038

5. 2D-DIGE based urinary proteomics and functional enrichment studies to reveal novel Mycobacterium tuberculosis and human protein biomarker candidates for pulmonary tuberculosis

Author:
Amit Kaushik; Sabyasachi Bandyopadhyay; Chhavi Porwal; Alagiri Srinivasan; Lokesh A. Rukmangadachar; Gururao Hariprasad; Srujana Kola; Jitender Kataria; Urvashi B. Singh
Source:
Biochemical and biophysical research communications 2022 v.619 pp. 15-21
ISSN:
0006-291X
Subject:
Mycobacterium tuberculosis; Streptococcus; adenosinetriphosphatase; biomarkers; cell walls; extracellular space; gel electrophoresis; gene expression regulation; genes; humans; immune response; liquid chromatography; pathogenicity; plasma membrane; pneumonia; protein-protein interactions; proteome; proteomics; research; tandem mass spectrometry; tuberculosis; urine
Abstract:
... In the absence of a sensitive and specific diagnostic modality capable of detecting all forms of tuberculosis (TB), proteomics may identify specific Mycobacterium tuberculosis (M.tb) proteins in urine, with a potential as biomarkers. To identify candidate biomarkers for TB, proteome profile of urine from pulmonary TB patients was compared with non-disease controls (NDC) and disease controls (DC, S ...
DOI:
10.1016/j.bbrc.2022.06.021

6. 3-Hydroxyacyl-CoA dehydratase 2 deficiency confers resistance to diet-induced obesity and glucose intolerance

Author:
Lengyun Wei; Shengmei Weng; Xuyang Lu; Shenglong Zhu; Qin Yang; Yong Q. Chen
Source:
Biochemical and biophysical research communications 2022 v.605 pp. 134-140
ISSN:
0006-291X
Subject:
diabetes; energy expenditure; enzymes; fatty acids; fatty liver; glucose; liver; obesity; pandemic; research; therapeutics
Abstract:
... Obesity and associated complications are becoming a pandemic. Inhibiting fatty acid synthesis and elongation is an important intervention for the treatment of obesity. Despite intensive investigations, many potential therapeutic targets have yet to be discovered. In this study, decreased expression of Hacd2 (a newly found enzyme in fatty acid elongation) was found in HFD induced mice and loss of H ...
DOI:
10.1016/j.bbrc.2022.03.057

7. 5-HT and α-m-5-HT attenuate excitatory synaptic transmissions onto the lateral amygdala principal neurons via presynaptic 5-HT1B receptors

Author:
Ryo Yamamoto; Tetsufumi Ito; Takafumi Furuyama; Munenori Ono; Nobuo Kato
Source:
Biochemical and biophysical research communications 2022 v.624 pp. 28-34
ISSN:
0006-291X
Subject:
agonists; amygdala; antagonists; rats; research; serotonin; serotonin receptors; therapeutics
Abstract:
... Accumulating evidence suggests that the serotonergic (5-HT) system in the amygdala has significant effects on affective states. Dysregulation of the 5-HT system in the basolateral amygdaloid complex causes affective disorders. To search for therapeutic targets, subtype specification of 5-HT receptors is crucial. The present study was undertaken to identify the 5-HT receptor subtype responsible for ...
DOI:
10.1016/j.bbrc.2022.07.076

8. IL- 6 activates pathologic Th17 cell via STAT 3 phosphorylation in inflammatory joint of Ankylosing Spondylitis

Author:
Hae-in Lee; Hui-Ju Kim; Sungsin Jo; Seung Cheol Shim; Tae-Hwan Kim; Eun Jeong Won; Tae-Jong Kim
Source:
Biochemical and biophysical research communications 2022 v.620 pp. 69-75
ISSN:
0006-291X
Subject:
arthritis; inflammation; interferon-gamma; interleukin-6; mice; phosphorylation; research; skeleton
Abstract:
... Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease, which is characterized by inflammation of the axial skeleton and the peripheral arthritis. An increase in the number of Th17 cells in patients with AS has been reported. Although Th17 cells have been involved in the induction of inflammation, recent data suggest that not all Th17 cells are pathogenic, showing regulatory funct ...
DOI:
10.1016/j.bbrc.2022.06.081

9. IL- 6 protects cardiomyocytes from oxidative stress at the early stage of LPS-induced sepsis

Author:
Yue Peng; Qingchen Yang; Shuya Gao; Zekun Liu; Weixian Kong; Xiaohong Bian; Zhe Li; Junmei Ye
Source:
Biochemical and biophysical research communications 2022 v.603 pp. 144-152
ISSN:
0006-291X
Subject:
antioxidants; cardiomyocytes; histology; homeostasis; interleukin-6; oxidative stress; protective effect; research
Abstract:
... Pro-inflammatory cytokines play important roles in sepsis-induced cardiac injury. Among various cytokines, the function of Interleukin-6 (IL-6) in the regulation of cardiomyocyte injury remains to be elucidated. This study aimed to investigate whether IL-6 plays a key role in the sepsis-induced cardiomyocyte injury and the possible mechanism. Mice deficient for Il-6 exhibited impaired heart rhythm ...
DOI:
10.1016/j.bbrc.2022.03.013

10. 7-aminocephalosporanic acid, a novel HSP90β inhibitor, attenuates HFD-induced hepatic steatosis

Author:
Weitao Zhang; Hanyue Xue; Chen Zhou; Zuguo Zheng; Mingming Xing; Hang Chu; Ping Li; Naixia Zhang; Yongjun Dang; Xiaojun Xu
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 184-191
ISSN:
0006-291X
Subject:
adipose tissue; antibiotics; blood serum; cholesterol; fatty liver; heat-shock protein 90; liver; microarray technology; research; triacylglycerols
Abstract:
... Hepatic steatosis is one of the most important causes of liver disease worldwide. Heat shock protein 90 (HSP90) is essential for numerous client proteins. Recently, more attention was focused on increased HSP90 levels in hepatic steatosis, especially HSP90β. Thus, great efforts have been made to develop HSP90β inhibitors, and most natural inhibitors are derived from microorganisms. In this study, ...
DOI:
10.1016/j.bbrc.2022.07.033

11. ACTL6A deficiency induces apoptosis through impairing DNA replication and inhibiting the ATR-Chk1 signaling in glioblastoma cells

Author:
Xiaosong Hu; Dakun Pei; Mingxin Ci; Guanghui Zhang; Benqin Li; Jie Wang; Yue Shen; Xuan Zhai; Ping Liang; Hongjuan Cui
Source:
Biochemical and biophysical research communications 2022 v.599 pp. 148-155
ISSN:
0006-291X
Subject:
DNA damage; DNA replication; apoptosis; chromatin; death; glioblastoma; humans; research; therapeutics; transcription (genetics)
Abstract:
... Actin-like 6A (ACTL6A) is a core subunit of the SWI/SNF chromatin remodeling complex and is highly expressed in several types of human cancers including glioblastoma. Recent studies verified that ACTL6A regulates the proliferation, differentiation, and migration of cancer cells. In this study, we identified ACTL6A as an important regulator of DNA replication. ACTL6A knockdown could impair the DNA ...
DOI:
10.1016/j.bbrc.2022.01.124

12. AMPK increases expression of ATM through transcriptional factor Sp1 and induces radioresistance under severe hypoxia in glioblastoma cell lines

Author:
Takuma Hashimoto; Yusuke Urushihara; Yasuhiko Murata; Yohei Fujishima; Yoshio Hosoi
Source:
Biochemical and biophysical research communications 2022 v.590 pp. 82-88
ISSN:
0006-291X
Subject:
DNA damage; cell cycle; energy; glioblastoma; humans; hypoxia; radiation resistance; research; transcription (genetics); transcription factors
Abstract:
... We have previously reported that severe hypoxia increases expression and activity of the DNA damage sensor ATM by activation of the key energy sensor AMPK. Here, to elucidate molecular mechanisms underlying increased expression and activity of ATM by AMPK under severe hypoxia, we investigated roles of transcriptional factors Sp1 and FoxO3a using human glioblastoma cell lines T98G and A172. Severe ...
DOI:
10.1016/j.bbrc.2021.12.076

13. AT7519 against lung cancer via the IL6/STAT3 signaling pathway

Author:
Feng Zhou; Fanyun Zhu; Tianru Zhu; Zhucheng Zhao; Luyao Li; Shichong Lin; Haiyang Zhao; Lehe Yang; Chengguang Zhao; Liangxing Wang; Jifa Li; Xiaoying Huang
Source:
Biochemical and biophysical research communications 2022 v.609 pp. 31-38
ISSN:
0006-291X
Subject:
apoptosis; caspase-3; cell cycle; cell viability; cyclin-dependent kinase; flow cytometry; lung neoplasms; models; mortality; research; signal transduction; tetrazolium; transactivators; xenotransplantation
Abstract:
... Lung cancer is a part of the commonest malignancies with the highest mortality rate in cancer-related deaths worldwide. Signal transducer and activator of transcription 3 (STAT3) and cyclin-dependent kinases (CDKs) are promising prognostic marker and therapeutic target in cancers. Our previous study has demonstrated the closely relationship between CDK9 and STAT3 in lung cancer. The inhibition of ...
DOI:
10.1016/j.bbrc.2022.03.147

14. ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors

Author:
Yalin Tong; Jinbei Li; Mengle Peng; Qilan Qian; Wen Shi; Zefeng Chen; Bin Liu
Source:
Biochemical and biophysical research communications 2022 v.594 pp. 146-152
ISSN:
0006-291X
Subject:
DNA damage; adenosinetriphosphatase; androgens; cell proliferation; colorectal neoplasms; estrogens; mutagens; neoplasm cells; neoplasm progression; research; transcription (genetics); ubiquitin; ubiquitin-protein ligase
Abstract:
... ATPase family AAA domain-containing protein 2 (ATAD2) is highly expressed in a variety of cancer types, and acts as a co-activator of androgen and estrogen receptors, as well as MYC and E2F transcription factors, to promote tumor cell proliferation. However, the regulation of ATAD2 and its related mechanisms are still elusive. Here, we show that ATAD2 protein was stabilized during DNA damage respo ...
DOI:
10.1016/j.bbrc.2022.01.036

15. Abemaciclib and Vacuolin-1 induce vacuole-like autolysosome formation – A new tool to study autophagosome-lysosome fusion

Author:
Yoshinori Tanaka; Hirotsugu Hino; Kosuke Takeya; Masumi Eto
Source:
Biochemical and biophysical research communications 2022 v.614 pp. 191-197
ISSN:
0006-291X
Subject:
autophagosomes; breast neoplasms; endosomes; lysosomes; macroautophagy; rapamycin; research; vacuoles
Abstract:
... Macroautophagy (hereafter autophagy) is a conserved cellular degradation system, impairments in which have been implicated in the development of a wide range of diseases, including cancer and neurodegenerative diseases. Autophagy is mainly comprised of two processes: the formation of autophagosomes and autolysosomes. A detailed understanding of the formation of autophagosomes has been obtained in ...
DOI:
10.1016/j.bbrc.2022.05.027

16. Abietic acid alleviates endoplasmic reticulum stress and lipid accumulation in human primary hepatocytes through the AMPK/ORP150 signaling

Author:
Tae Woo Jung; Ju-Cheol Jeong; Seung Yeon Park; Wonjun Cho; Heeseung Oh; Hyun Jung Lee; Ahmet Hacimuftuoglu; A.M. Abd El-Aty; Joon Seok Bang; Ji Hoon Jeong
Source:
Biochemical and biophysical research communications 2022 v.608 pp. 142-148
ISSN:
0006-291X
Subject:
abietic acid; apoptosis; endoplasmic reticulum; endoplasmic reticulum stress; fatty liver; hepatocytes; humans; lipids; lipogenesis; medicine; obesity; palmitates; research
Abstract:
... Abietic acid (AA), the main component of pine resin that has been traditionally used as Asian medicine, has been reported to demonstrate anti-inflammatory activities. Despite this, little is known about the effects of AA on hepatic endoplasmic reticulum (ER) stress and lipid metabolism. This study investigated the impacts of AA on ER stress and steatosis in in vitro obesity models. We found that T ...
DOI:
10.1016/j.bbrc.2022.04.010

17. Abnormal histidine metabolism promotes macrophage lipid accumulation under Ox-LDL condition

Author:
Baoling Zhu; Zhiwei Zhang; Xiangfei Wang; Weiwei Zhang; Hongyu Shi; Zhifeng Song; Suling Ding; Xiangdong Yang
Source:
Biochemical and biophysical research communications 2022 v.588 pp. 161-167
ISSN:
0006-291X
Subject:
antagonists; cholesterol; esterification; fat intake; genes; high fat diet; histamine; histidine; histidine decarboxylase; hydrolases; lipid metabolism; low density lipoprotein; macrophages; metabolic diseases; microarray technology; models; oxidation; oxidative stress; research
Abstract:
... Distinct macrophage populations exert highly heterogeneity and perform various functions, among which, a crucial function of lipid metabolism is highlighted. However, the role of histidine metabolism disorder in macrophage lipid metabolism remains elusive. Addressed this question, we sorted and cultured the bone marrow-derived macrophages (BMDMs) of histidine decarboxylase (Hdc) knockout (Hdc⁻/⁻) ...
DOI:
10.1016/j.bbrc.2021.12.069

18. Activated cell-cycle CDK4/CyclinD1-pRB-E2F1 signaling pathway is involved in the apoptosis of dorsal raphe nucleus in the rat model of PTSD

Author:
Xiaojing Wang; Linchuan Ma; Jingmin Li; Fanzhen Kong
Source:
Biochemical and biophysical research communications 2022 v.602 pp. 142-148
ISSN:
0006-291X
Subject:
acute exposure; animal models; apoptosis; cell cycle; cognition; memory; pathogenesis; research; signal transduction
Abstract:
... Dysregulation of the dorsal raphe nucleus (DRN) has been revealed to contribute to cognitive and arousal impairments associated with post-traumatic stress disorder (PTSD) in an animal model. In our research an acute exposure to single prolonged stress (SPS) was used to establish PTSD rat model and the effects related to cell-cycle signaling pathway in DRN were examined. Apoptosis in DRN was detect ...
DOI:
10.1016/j.bbrc.2022.02.108

19. Activated glia cells cause bioenergetic impairment of neurons that can be rescued by knock-down of the mitochondrial calcium uniporter

Author:
Angela Maria Casaril; Athanasios Katsalifis; Rolf M. Schmidt; Carlos Bas-Orth
Source:
Biochemical and biophysical research communications 2022 v.608 pp. 45-51
ISSN:
0006-291X
Subject:
astrocytes; calcium; cell culture; cell death; cytokines; disease progression; glutamic acid; inflammation; lipopolysaccharides; membrane potential; mitochondria; mitochondrial membrane; models; neurodegenerative diseases; neurons; neuroprotective effect; oxidation; rats; reactive oxygen species; research; viability
Abstract:
... Neuroinflammation is a hallmark of various neurological disorders including autoimmune-, neurodegenerative and neuropsychiatric diseases. In neuroinflammation, activated microglia and astrocytes release soluble mediators such as cytokines, glutamate, and reactive oxygen species that negatively affect neuronal function and viability, and thus contribute to neurodegeneration during disease progressi ...
DOI:
10.1016/j.bbrc.2022.03.120

20. Activation of TLR4 induces inflammatory muscle injury via mTOR and NF-κB pathways in experimental autoimmune myositis mice

Author:
Hongya Zhang; Fangyuan He; Linfu Zhou; Ming Shi; Fangming Li; Hongge Jia
Source:
Biochemical and biophysical research communications 2022 v.603 pp. 29-34
ISSN:
0006-291X
Subject:
animal models; antagonists; autoimmune diseases; blood serum; complement; etiology; inflammation; interleukin-17; mice; muscle strength; muscles; myositis; pathogenesis; rapamycin; research; skeletal muscle; transcription factor NF-kappa B
Abstract:
... Idiopathic inflammatory myopathy (IIM) is an autoimmune disease that invades skeletal muscle; however, the etiology of IIM is still poorly understood. Toll-like receptor (TLR) 4 has been widely reported to take part in the autoimmune inflammation of IIMs. The mammalian target of rapamycin, mTOR, is a key central substance which mediates immune responses and metabolic changes, and also has been con ...
DOI:
10.1016/j.bbrc.2022.03.004

21. Actl7a deficiency in mice leads to male infertility and fertilization failure

Author:
Xiaopei Zhou; Zhenxing Liu; Weimin Jia; Meiqi Hou; Xianqin Zhang
Source:
Biochemical and biophysical research communications 2022 v.623 pp. 154-161
ISSN:
0006-291X
Subject:
acrosome; calcium; gene targeting; genes; homozygosity; intracytoplasmic sperm injection; male sterility; males; oocytes; research; zona pellucida
Abstract:
... Mutations in the Actl7a gene have been reported to lead to male infertility; however, the detailed mechanism of this phenomenon remains unknown. In this study, we constructed Actl7a gene knockout (KO) mice and found that Actl7a deficiency led to malformed formation of sperm acrosomes, male infertility, fertilization failure during in vitro fertilization (IVF) and intracytoplasmic sperm injection ( ...
DOI:
10.1016/j.bbrc.2022.07.065

22. Acute stress promotes brain oscillations and hippocampal-cortical dialog in emotional processing

Author:
Xin Lv; Xiaolin Zhang; Qian Zhao; Chunbo Li; Tianhong Zhang; Xiangyu Yang
Source:
Biochemical and biophysical research communications 2022 v.598 pp. 55-61
ISSN:
0006-291X
Subject:
cognition; electroencephalography; electrophysiology; hippocampus; mental depression; pathological processes and conditions; prefrontal cortex; research; stress response
Abstract:
... Hippocampal-cortical circuit oscillations in local field potential (LFP) represent network-level signals which promotes behavior. Investigating these signals promote our understanding on how the brain process cognition and emotion, and provide further perspectives into electroencephalogram endophenotypes, especially under the pathological state. The physiological adaptive stress responses to threa ...
DOI:
10.1016/j.bbrc.2022.01.116

23. Aging-associated susceptibility to stress-induced ventricular arrhythmogenesis is attenuated by tetrodotoxin

Author:
Ekhson L. Holmuhamedov; Praloy Chakraborty; Andrew Oberlin; Xiaoke Liu; Mohammed Yousufuddin; Win K. Shen; Andre Terzic; Arshad Jahangir
Source:
Biochemical and biophysical research communications 2022 v.623 pp. 44-50
ISSN:
0006-291X
Subject:
4-aminopyridine; action potentials; cardiomyocytes; catecholamines; ischemia; isoproterenols; males; research; sodium; tetrodotoxin
Abstract:
... Aging is associated with increased prevalence of life-threatening ventricular arrhythmias, but mechanisms underlying higher susceptibility to arrhythmogenesis and means to prevent such arrhythmias under stress are not fully defined. We aimed to define differences in aging-associated susceptibility to ventricular fibrillation (VF) induction between young and aged hearts. VF induction was attempted ...
DOI:
10.1016/j.bbrc.2022.07.040

24. Alcoholic fatty liver is blunted by rFGF21 administration in mice lacking adipose FGFR1: The role of FGF21 in PPARα-mediated regulation of adipose tissue mass

Author:
Yunhui Xu; Yongke Lu
Source:
Biochemical and biophysical research communications 2022 v.619 pp. 84-89
ISSN:
0006-291X
Subject:
adipose tissue; agonists; atrophy; blood serum; ethanol; fatty liver; fibroblast growth factor receptor 1; fibroblast growth factors; free fatty acids; lipid metabolism; liver; mice; models; protective effect; research; triacylglycerols
Abstract:
... Fibroblast growth factor 21 (FGF21) is regulated by peroxisome proliferator activated receptor α (PPARα) in the liver. FGF21 regulates lipid metabolism via fibroblast growth factor receptor 1 (FGFR1). FGF21 protect against alcoholic fatty liver (AFL), however, FGF21 does not exert protective effect through liver FGFR1. We have previously shown that PPARα agonist WY-14,643 induces FGF21 and adipose ...
DOI:
10.1016/j.bbrc.2022.05.099

25. Allograft inflammatory factor-1 enhances inflammation and oxidative stress via the NF-κB pathway in diabetic kidney disease

Author:
Yuting Fu; Xingzhi Wang; Lei Zhang; Yiqun Ren; Lirong Hao
Source:
Biochemical and biophysical research communications 2022 v.614 pp. 63-69
ISSN:
0006-291X
Subject:
allografting; animal models; caudal vein; endothelial cells; inflammation; kidney diseases; kidneys; oxidative stress; research; transfection
Abstract:
... Inflammation and glomerular endothelial dysfunction promote diabetic kidney disease (DKD) progression, but the mechanisms are not fully understood. Allograft inflammatory factor-1 (AIF-1) is a protein that regulates inflammatory reactions and immune responses. This study aimed to explore the mechanism of AIF-1 in a DKD animal model and mouse renal glomerular endothelial cells (MRGECs). We injected ...
DOI:
10.1016/j.bbrc.2022.04.089

26. Alpha-crystallin B chains in trastuzumab-resistant breast cancer cells promote endothelial cell tube formation through activating mTOR

Author:
Lili Yang; Kazuma Higashisaka; Masafumi Shimoda; Yuya Haga; Naoki Sekine; Hirofumi Tsujino; Kazuya Nagano; Kenzo Shimazu; Yasuo Tsutsumi
Source:
Biochemical and biophysical research communications 2022 v.588 pp. 175-181
ISSN:
0006-291X
Subject:
adjuvants; angiogenesis; breast neoplasms; cell lines; endothelial cells; erbB-2 receptor; metastasis; monoclonal antibodies; proteomics; rapamycin; relapse; research
Abstract:
... The specific human epidermal growth factor receptor 2 (HER2)-targeting monoclonal antibody trastuzumab shows considerable clinical efficacy in patients with HER2-overexpressing breast cancer. However, about 20% of patients who receive trastuzumab in the adjuvant setting relapse, and approximately half of patients with metastatic HER2-positive breast cancer develop resistance to trastuzumab within ...
DOI:
10.1016/j.bbrc.2021.12.056

27. Alpha-synuclein/MPP+ mediated activation of NLRP3 inflammasome through microtubule-driven mitochondrial perinuclear transport

Author:
Xueping Yang; Huihan Ma; Qingyun Yv; Fanlong Ye; Zhang He; Sheng Chen; Alimu Keram; Wenwei Li; Min Zhu
Source:
Biochemical and biophysical research communications 2022 v.594 pp. 161-167
ISSN:
0006-291X
Subject:
NAD (coenzyme); Parkinson disease; adenine; homeostasis; inflammasomes; leucine; metabolites; mitochondria; oligomerization; oxidoreductases; phosphates; research; toxicity
Abstract:
... 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can activate nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) inflammasome in Parkinson's disease (PD) mice, while 1-methyl-4-phenyl- 1, 2, 3, 6-tetrahydropyridinium ion (MPP⁺), the toxic metabolite of MPTP was not enough to achieve it in vitro. We hypothesized that the accumulation of Alpha-sy ...
DOI:
10.1016/j.bbrc.2022.01.047

28. Alterations of RNAs in the insula related to cocaine-induced condition place preference in adolescent mice

Author:
Wenchao Li; Chun Zhang; Yang yang Wang; Lifei Xiao; Yan Feng; Xianhao Huo; Chaofan Wang; Yu Sun; Feng Wang; Tao Sun
Source:
Biochemical and biophysical research communications 2022 v.621 pp. 109-115
ISSN:
0006-291X
Subject:
adolescence; adolescents; biomarkers; brain; catabolism; cocaine; drug resistance; drugs; gene expression regulation; messenger RNA; microRNA; mitogen-activated protein kinase; neurotransmitters; research; synaptic transmission; transcriptome
Abstract:
... Cocaine as a highly addictive psychostimulant can cause changes in the body at the cellular and molecular levels over a long period of time. It reminds us that cocaine may have a potential role in post-transcriptional regulation, but the alteration of insula-expression profile in adolescent cocaine use disorder (CUD) has not been reported. To reveal the mechanisms underlying the post-transcription ...
DOI:
10.1016/j.bbrc.2022.06.080

29. Alternaria alternata-induced airway epithelial signaling and inflammatory responses via protease-activated receptor-2 expression

Author:
Candy M. Rivas; Hillary V. Schiff; Aubin Moutal; Rajesh Khanna; Pawel R. Kiela; Gregory Dussor; Theodore J. Price; Josef Vagner; Kathryn A. DeFea; Scott Boitano
Source:
Biochemical and biophysical research communications 2022 v.591 pp. 13-19
ISSN:
0006-291X
Subject:
Alternaria alternata; acute exposure; agonists; allergens; asthma; breathing; chemokines; elastase; epithelial cells; epithelium; fungi; humans; inflammation; liquid-air interface; mucus; pathophysiology; research; risk; trypsin
Abstract:
... Inhalation of the fungus Alternaria alternata is associated with an increased risk of allergic asthma development and exacerbations. Recent work in acute exposure animal models suggests that A. alternata-induced asthma symptoms, which include inflammation, mucus overproduction and airway hyperresponsiveness, are due to A. alternata proteases that act via protease-activated receptor-2 (PAR2). Howev ...
DOI:
10.1016/j.bbrc.2021.12.090

30. Amentoflavone impairs the reconsolidated fear memories through inhibition of ERK pathway

Author:
Kuisheng Sun; Ruizhu Xie; Zhengjun Yi; Liqian Yin; Yan Guan; Lujuan Wang; Ying Wang; Xiaoyan Ding; Yaning Luan; Huijie Liu; Yuhan Fan
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 8-14
ISSN:
0006-291X
Subject:
Western blotting; amygdala; animal behavior; fearfulness; inflammation; memory; pathophysiology; research
Abstract:
... Post-traumatic stress disorder (PTSD) is a pathological fear memory-related disease. The persistence of pathological fearful memories is one of the most characteristic symptoms of PTSD. However, this can be eliminated by intervening in reconsolidation. Inflammation is intimately involved in the pathophysiologic progression of PTSD. Amentoflavone (AF) has anti-inflammatory effects. However, the eff ...
DOI:
10.1016/j.bbrc.2022.07.024

31. Amiloride is a suitable fluorescent substrate for the study of the drug transporter human multidrug and toxin extrusion 1 (MATE1)

Author:
Tatsuya Kawasaki; Chisa Kaneko; Ryosuke Nakanishi; Yoshinori Moriyama; Tomohiro Nabekura
Source:
Biochemical and biophysical research communications 2022 v.592 pp. 113-118
ISSN:
0006-291X
Subject:
acidification; ammonium; cation pumps; detergents; drug development; fluorescence; humans; hypertension; liver; metformin; pH; physiology; pyrimethamine; research; sodium dodecyl sulfate; solvents; tetraethylammonium compounds
Abstract:
... Human multidrug and toxin extrusion 1 (MATE1; SLC47A1) is highly expressed in the kidneys and the liver. It plays a significant role in drug and endogenous compound disposition, and therefore, a rapid evaluation of its inhibition is important for drug development and for the understanding of renal and hepatic physiology. Amiloride is a potassium-sparing diuretic used for treating hypertension; it ...
DOI:
10.1016/j.bbrc.2022.01.014

32. Amygdalin protects against acetaminophen-induced acute liver failure by reducing inflammatory response and inhibiting hepatocyte death

Author:
Congcong Zhang; Jiacheng Lin; Chao Zhen; Fang Wang; Xuehua Sun; Xiaoni Kong; Yueqiu Gao
Source:
Biochemical and biophysical research communications 2022 v.602 pp. 105-112
ISSN:
0006-291X
Subject:
acetaminophen; acetylcysteine; amygdalin; anti-inflammatory activity; death; hepatocytes; histology; inflammation; interleukin-6; intraperitoneal injection; liver; liver failure; macrophages; medicine; neutrophils; phosphorylation; protective effect; protein synthesis; research
Abstract:
... Amygdalin is a natural compound from Bitter Apricot Seed which is reported to have anti-inflammatory activity. Acetaminophen (APAP) resulted in drug-induced liver injury is the main cause of acute liver failure (ALI) worldwide and only N-acetylcysteine is the accepted detoxification drug. However, there is no effective medicine to perfect the hepatocyte death and secondary inflammation injury. In ...
DOI:
10.1016/j.bbrc.2022.03.011

33. Angiopoietin-like protein 4 promotes hyperlipidemia-induced renal injury by down-regulating the expression of ACTN4

Author:
Yue Li; Wangqiu Gong; Jing Liu; Xingxing Chen; Yanhong Suo; Huabing Yang; Xia Gao
Source:
Biochemical and biophysical research communications 2022 v.595 pp. 69-75
ISSN:
0006-291X
Subject:
albumins; blood; blood lipids; genes; high fat diet; hyperlipidemia; kidneys; lipid metabolism; proteinuria; research
Abstract:
... The molecular mechanism of in hyperlipidemia-induced renal injury has not been elucidated. Angiogenin-like protein 4 (ANGPTL4) is a key regulator of lipid metabolism. The role of ANGPTL4 hyperlipidemia-induced renal injury has not been reported. Wild type C57 mice and gene angptl4 knockout mice were fed with 60% high fat diet or normal diet respectively. The serum lipid, urinary albumin and renal ...
DOI:
10.1016/j.bbrc.2022.01.061

34. Antagonistic action of a synthetic androgen ligand mediated by chromatin remodeling in a human prostate cancer cell line

Author:
Takahiro Sawada; Yoshiaki Kanemoto; Rei Amano; Akira Hayakawa; Tomohiro Kurokawa; Jinichi Mori; Shigeaki Kato
Source:
Biochemical and biophysical research communications 2022 v.612 pp. 110-118
ISSN:
0006-291X
Subject:
androgen receptors; androgens; antagonists; cell proliferation; chromatin; dihydrotestosterone; gene expression; genes; humans; ligands; neoplasm cells; prostatic neoplasms; remission; research; transcriptional activation
Abstract:
... The clinical use of androgen receptor (AR) antagonists has been successful in treating prostate cancer patients, inducing remission of androgen-dependent tumors. However, a couple of years after treatment, prostate tumors transition into an androgen-independent state with altered gene expression profiles, but the molecular basis is not understood. Since the AR antagonists trigger this transition, ...
DOI:
10.1016/j.bbrc.2022.04.109

35. Anti-VEGFR2 monoclonal antibody(MSB0254) inhibits angiogenesis and tumor growth by blocking the signaling pathway mediated by VEGFR2 in glioblastoma

Author:
Sansong Chen; Xuetao Li; Hao Wang; Guangliang Chen; Youxin Zhou
Source:
Biochemical and biophysical research communications 2022 v.604 pp. 158-164
ISSN:
0006-291X
Subject:
angiogenesis; bioinformatics; glioblastoma; immunohistochemistry; monoclonal antibodies; prognosis; research; therapeutics; vascular endothelial growth factor receptor-2
Abstract:
... Angiogenesis is a key physiological process that plays a key role in glioblastoma (GBM) progression and displays therapeutic resistance to antiangiogenic therapies. In this study, we aimed to identify whether vascular endothelial growth factor receptor 2(VEGFR2)monoclonal antibodies(mab)could inhibit tumorigenicity and the formation of vascular mimicry (VM) in GBM. The bioinformatic analysis from ...
DOI:
10.1016/j.bbrc.2022.03.045

36. Antibacterial activity and mechanism of slightly acidic electrolyzed water against Shewanella putrefaciens and Staphylococcus saprophytic

Author:
Lin Liu; Weiqing Lan; Yanbo Wang; Jing Xie
Source:
Biochemical and biophysical research communications 2022 v.592 pp. 44-50
ISSN:
0006-291X
Subject:
DNA; Shewanella putrefaciens; antibacterial properties; cell structures; chlorine; death; electrolyzed water; membrane permeability; mortality; reactive oxygen species; research; saprophytes
Abstract:
... The purpose of this study was to investigate the antimicrobial effect and mechanism of slightly acidic electrolyzed water (SAEW) against Shewanella putrefaciens (S. putrefaciens) and Staphylococcus saprophytic (S. saprophyticus). The results showed that SAEW exhibited strong antimicrobial activity against tested bacteria, which was positively correlated to the available chlorine concentration (ACC ...
DOI:
10.1016/j.bbrc.2022.01.013

37. Antibacterial effect of synthetic ultra-short lipopeptide on Streptococcus agalactiae and its active on bacterial mastitis in mice

Author:
Jie Peng; Qiangsheng Lu; Xuming Liu; Yuanjie Deng; Tiantian Shang; Lvfeng Yuan; Hecheng Zhang; Qiaoying Zeng
Source:
Biochemical and biophysical research communications 2022 v.601 pp. 153-159
ISSN:
0006-291X
Subject:
Streptococcus agalactiae; antibacterial properties; antibiotics; chemical structure; dairy cows; lipopeptides; mice; milk industry; research
Abstract:
... Streptococcus agalactiae mastitis is one of the significant threats to the milk industry. The traditional antibiotic treatment method is easy to cause the emergence of resistant strains, and the problem of drug residue is increasingly severe. In this study, we designed and synthesized five lipopeptides. The antibacterial activity of different molecular structure lipopeptides against Streptococcus ...
DOI:
10.1016/j.bbrc.2022.02.061

38. Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells

Author:
Shilpa Kuttikrishnan; Ajaz A. Bhat; Jericha M. Mateo; Fareed Ahmad; Feras Q. Alali; Tamam El-Elimat; Nicholas H. Oberlies; Cedric J. Pearce; Shahab Uddin
Source:
Biochemical and biophysical research communications 2022 v.601 pp. 59-64
ISSN:
0006-291X
Subject:
antineoplastic activity; apoptosis; caspases; cell viability; fungi; leukemia; meroterpenoids; mitochondria; oncogenes; pro-apoptotic proteins; research; secondary metabolites; therapeutics
Abstract:
... Neosetophomone B (NSP–B), a meroterpenoid fungal secondary metabolite, was investigated for its anticancer potential in leukemic cell lines (K562 and U937). NSP-B treatment of leukemic cells suppressed cell viability by triggering apoptotic cell death. Apoptosis induced by NSP-B is triggered by mitochondrial signaling and caspase activation. Additionally, NSP-B treatment of leukemic cells causes A ...
DOI:
10.1016/j.bbrc.2022.02.071

39. Antitumor effects of pyrrole-imidazole polyamide modified with alkylating agent on prostate cancer cells

Author:
Daigo Funakoshi; Daisuke Obinata; Kyoko Fujiwara; Shinichiro Yamamoto; Kenichi Takayama; Makoto Hara; Satoru Takahashi; Satoshi Inoue
Source:
Biochemical and biophysical research communications 2022 v.623 pp. 9-16
ISSN:
0006-291X
Subject:
DNA; DNA repair; alkylation agents; androgen receptors; androgens; castration; cell proliferation; colorectal neoplasms; drug delivery systems; epithelium; gene expression; inhibitory concentration 50; models; neoplasm cells; neoplasm progression; oncogenes; pancreatic neoplasms; polyamides; prostatic neoplasms; research; transcription (genetics); xenotransplantation
Abstract:
... Androgens and androgen receptor (AR) have a central role in prostate cancer progression by regulating its downstream signaling. Although androgen depletion therapy (ADT) is the primary treatment for most prostate cancers, they acquires resistance to ADT and become castration resistant prostate cancers (CRPC). AR complex formation with multiple transcription factors is important for enhancer activi ...
DOI:
10.1016/j.bbrc.2022.07.042

40. Apis mellifera RidA, a novel member of the canonical YigF/YER057c/UK114 imine deiminase superfamily of enzymes pre-empting metabolic damage

Author:
Cristina Visentin; Giulia Rizzi; Genny Degani; Stefania Digiovanni; Giovanni Robecchi; Alberto Barbiroli; Laura Popolo; Maria Antonietta Vanoni; Stefano Ricagno
Source:
Biochemical and biophysical research communications 2022 v.616 pp. 70-75
ISSN:
0006-291X
Subject:
Apis mellifera; ammonia; circular dichroism spectroscopy; crystal structure; enamines; hydrolases; imines; invertebrates; metabolism; pyruvic acid; research; substrate specificity; tautomers; thermal stability
Abstract:
... The Reactive intermediate deiminase (Rid) protein family is a group of enzymes widely distributed in all Kingdoms of Life. RidA is one of the eight known Rid subfamilies, and its members act by preventing the accumulation of 2-aminoacrylate, a highly reactive enamine generated during the metabolism of some amino acids, by hydrolyzing the 2-iminopyruvate tautomer to pyruvate and ammonia. RidA membe ...
DOI:
10.1016/j.bbrc.2022.05.062

41. Apoptosis triggered by cytolethal distending toxin B subunit of Helicobacter hepaticus is aggravated by autophagy inhibition in mouse hepatocytes

Author:
Miao Qian; Shuyang Cao; Tao Wang; Xiangming Xu; Quan Zhang
Source:
Biochemical and biophysical research communications 2022 v.598 pp. 40-46
ISSN:
0006-291X
Subject:
DNA damage; Helicobacter hepaticus; apoptosis; autophagy; caspase-3; caspase-9; cell viability; chloroquine; dose response; hepatocytes; interleukin-6; liver; mice; pathogenesis; phosphorylation; research; toxins; virulence
Abstract:
... Hepatocytes injury caused by cytolethal distending toxin (CDT) are major events during helicobacter hepaticus (H.hepaticus) infection. Recent study showed that pre-survival autophagy was promoted against CdtB subunit induced DNA damage. In the present study, we demonstrated that inflammatory cytokines IL-6, IL-1β, TNF-α, IFN-α, IFN-γ expression and STAT phosphorylation were promoted by CdtB. Besid ...
DOI:
10.1016/j.bbrc.2022.01.121

42. Apple polyphenols exhibits chondroprotective changes of synovium and prevents knee osteoarthritis

Author:
Marina Kobayashi; Seiyu Harada; Naoki Fujimoto; Yoshihiro Nomura
Source:
Biochemical and biophysical research communications 2022 v.614 pp. 120-124
ISSN:
0006-291X
Subject:
antioxidants; blood serum; cell proliferation; hyaluronic acid; inflammation; metalloproteinases; osteoarthritis; oxidative stress; procyanidins; research
Abstract:
... Apple polyphenols (AP) have strong antioxidant and anti-inflammatory properties. We examined the effects of AP on the progression of osteoarthritis (OA) AP was administered to surgically-induced OA model rats for 4 or 8 weeks. This treatment suppressed inflammation and oxidative stress in the synovium, resulting in a decrease in the OA severity score, and the expression of tumor necrosis factor (T ...
DOI:
10.1016/j.bbrc.2022.05.016

43. Application of CRISPR/Cas9 system and the preferred no-indel end-joining repair in tardigrades

Author:
Hitomi Kumagai; Koyuki Kondo; Takekazu Kunieda
Source:
Biochemical and biophysical research communications 2022 v.623 pp. 196-201
ISSN:
0006-291X
Subject:
CRISPR-Cas systems; Tardigrada; adults; electroporation; genes; heterologous gene expression; models; research; ribonucleoproteins
Abstract:
... Tardigrades are small aquatic animals known for the tolerant ability against various extreme stresses. Recent studies identified several tardigrade-unique proteins as protective factors of biomolecules from extreme stresses. Due to the limitation of the technique available in tardigrades, the function of these protective molecules has largely been studied utilizing the systems of in vitro and the ...
DOI:
10.1016/j.bbrc.2022.07.060

44. Arabidopsis PDI11 interacts with lectin molecular chaperons calreticulin 1 and 2 through its D domain

Author:
Yuanyuan Zhou; Fenggui Fan; Yongfeng Han; Dongping Lu
Source:
Biochemical and biophysical research communications 2022 v.588 pp. 55-60
ISSN:
0006-291X
Subject:
Arabidopsis thaliana; calreticulin; disulfides; endoplasmic reticulum; glycoproteins; mammals; protein disulfide-isomerase; research
Abstract:
... The endoplasmic reticulum (ER) is equipped with protein disulfide isomerases (PDIs), molecular chaperons, and other folding enzymes to ensure that newly synthesized proteins in the ER are properly folded. Molecular chaperons and PDIs can form complex to promote protein folding in the ER of mammalian cells. In plants, many PDIs associate with each other and function cooperatively in oxidative prote ...
DOI:
10.1016/j.bbrc.2021.12.045

45. Arabidopsis exocyst subunit SEC6 is involved in cell plate formation during Microgametogenesis

Author:
Xiaoyun Tan; Haoyue Xu; Jie Ye; Jin Wang; Wenlong Liu; Feng Liu; Qingchen Rui; Yiqun Bao
Source:
Biochemical and biophysical research communications 2022 v.598 pp. 100-106
ISSN:
0006-291X
Subject:
Arabidopsis; cytokinesis; cytoplasm; gametophytes; males; mitosis; mutants; mutation; pollen; research
Abstract:
... Cytokinesis during pollen mitosis I is critical for cell division and differentiation in the male gametophyte development, but the vesicle trafficking mechanisms in this process are largely unknown. Exocyst is an octameric tethering complex which plays multiple important roles in plant cell vesicle trafficking. Here we report the characterization of exocyst subunit SEC6 in the cytokinesis during p ...
DOI:
10.1016/j.bbrc.2022.01.092

46. Arachidonic acid supplementation attenuates adipocyte inflammation but not adiposity in high fat diet induced obese mice

Author:
Sourav Roy; Md Abdur Rahman Ripon; Rahima Begum; Dipty Rani Bhowmik; Mohammad Tohidul Amin; Md Aminul Islam; Firoz Ahmed; Mohammad Salim Hossain
Source:
Biochemical and biophysical research communications 2022 v.608 pp. 90-95
ISSN:
0006-291X
Subject:
adipocytes; adiposity; albino; arachidonic acid; blood lipids; blood serum; colorimetry; food intake; gene expression; high fat diet; histology; inflammation; lipid composition; males; metabolism; obesity; pathophysiology; research; visceral fat; white adipose tissue
Abstract:
... Obesity is associated with low-grade chronic inflammation and has a remarkable role in the pathophysiology of metabolic complications. In triggering these inflammatory responses, the arachidonic acid (AA) cascade plays a key role. However, there is a lack of data on how supplementary AA would affect obesity, adipose tissue inflammation, and the AA cascade in obesity. This study aims to investigate ...
DOI:
10.1016/j.bbrc.2022.03.089

47. Artificial aptamer that inhibits interleukin-23/interleukin-23 receptor interaction discovered via SELEX

Author:
Yukio Takamori; Takehiro Ando; Masashi Sato; Santhana Vedi; Daisuke Fuji; Takumi Yokoyama; Keita Tsukamoto; Mizuki Yamamoto; Takashi Kawakami
Source:
Biochemical and biophysical research communications 2022 v.614 pp. 17-21
ISSN:
0006-291X
Subject:
Crohn disease; RNA; autoimmune diseases; chemiluminescence; fluorescence; humans; interleukin-23; nucleotide sequences; oligonucleotides; polymerase chain reaction; psoriasis; research; systematic evolution of ligands by exponential enrichment; therapeutics
Abstract:
... Interaction between the pro-inflammatory cytokine interleukin-23 (IL-23) and IL-23 receptor (IL-23R) is related to the development of inflammatory autoimmune diseases such as psoriasis, inflammatory bowel disease, and Crohn's disease. In this study, we conducted systematic evolution of ligands by exponential enrichment (SELEX) for in vitro selection against human IL-23 and observed RNA sequence en ...
DOI:
10.1016/j.bbrc.2022.05.012

48. Assembly of LHCA5 into PSI blue shifts the far-red fluorescence emission in higher plants

Author:
Fenghua Wu; Xiuxiu Li; Gongxian Yang; Jince Song; Xiaoyu Zhao; Lixia Zhu; Xiaochun Qin
Source:
Biochemical and biophysical research communications 2022 v.612 pp. 77-83
ISSN:
0006-291X
Subject:
Arabidopsis thaliana; absorbance; chlorophyll; fluorescence; immunoblotting; light harvesting complex; mosses and liverworts; mutants; phenotype; photosynthesis; research; temperature
Abstract:
... In higher plants, the PSI core complex is associated with light-harvesting complex I (LHCI), forming the PSI-LHCI super-complex. In vascular plants, four major antenna proteins (LHCA1-4) are assembled in the order of LHCA1, LHCA4, LHCA2, and LHCA3 into a crescent-shaped LHCI, while LHCA5 and LHCA6 are minor antenna proteins. By contrast, in moss and green algae, LHCA5 or LHCA5-like protein functio ...
DOI:
10.1016/j.bbrc.2022.04.102

49. Auditory independent low-intensity ultrasound stimulation of mouse brain is associated with neuronal ERK phosphorylation and an increase of Tbr2 marked neuroprogenitors

Author:
Jormay Lim; Ya-Cherng Chu; Hsiao-Hsin Tai; Andy Chien; Shao-Shiang Huang; Chih-Cheng Chen; Jaw-Lin Wang
Source:
Biochemical and biophysical research communications 2022 v.613 pp. 113-119
ISSN:
0006-291X
Subject:
brain; energy; mice; neurons; phosphorylation; research; toxicity; ultrasonics
Abstract:
... Transcranial ultrasound stimulation is an emerging technique for the development of a non-invasive neuromodulation device for the treatment of various types of neurodegenerations and brain damages. However, there are very few studies that have quantified the optimal ultrasound dosage and the long-term associated effects of transcranial ultrasound treatments of brain diseases. In this study, we use ...
DOI:
10.1016/j.bbrc.2022.04.123

50. Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation

Author:
Chun-xiao Wang; Li-hua Chen; Hai-bin Zhuang; Ze-sheng Shi; Zhi chuan Chen; Jian-peng Pan; Zhong-shi Hong
Source:
Biochemical and biophysical research communications 2022 v.587 pp. 99-106
ISSN:
0006-291X
Subject:
Flemingia; antineoplastic activity; apoptosis; cell viability; colorectal neoplasms; digestive system; ferroptosis; herbal medicines; mitochondria; neoplasm cells; phosphorylation; reactive oxygen species; research; shrinkage
Abstract:
... Colorectal cancer (CRC) is one of the most common malignant tumors in the digestive system, and Chinese herbal medicine plays an important role in tumor treatment. The in-depth study of auriculasin isolated from Flemingia philippinensis showed that auriculasin promoted reactive oxygen species (ROS) generation in a concentration-dependent manner; when ROS scavenger NAC was added, the effects of aur ...
DOI:
10.1016/j.bbrc.2021.11.101

51. BMP4 signaling plays critical roles in self-renewal of R2i mouse embryonic stem cells

Author:
Sara Taleahmad; Ali Salari; Azam Samadian; Se Hyun Chae; Daehee Hwang; Bonghee Lee; Delger Bayarsaikhan; Govigerel Bayarsaikhan; Jaesuk Lee; Ji Hwan Park; Seyedeh-Nafiseh Hassani; Hossein Baharvand; Ghasem Hosseini Salekdeh
Source:
Biochemical and biophysical research communications 2022 v.617 pp. 8-15
ISSN:
0006-291X
Subject:
adhesion; apoptosis; bone morphogenetic proteins; cell adhesion; death; loss-of-function mutation; mice; mitochondria; research; transcriptomics
Abstract:
... Mouse embryonic stem cells (mESCs) can be maintained in a pluripotent state under R2i culture conditions that inhibit the TGF-β and ERK signaling pathways. BMP4 is another member of the TGF-β family that plays a crucial role in maintaining the pluripotency state of mESCs. It has been reported that inhibition of BMP4 caused the death of R2i-grown cells. In this study, we used the loss-of-function a ...
DOI:
10.1016/j.bbrc.2022.05.036

52. The BRCA2 missense mutation K2497R suppressed self-degradation and increased ATP production and cell proliferation

Author:
Gerelmaa Enkhbat; Akira Nakanishi; Yoshio Miki
Source:
Biochemical and biophysical research communications 2022 v.590 pp. 27-33
ISSN:
0006-291X
Subject:
breast neoplasms; cell proliferation; centrosomes; cycloheximide; cytokinesis; genes; heat shock proteins; interphase; lysine; missense mutation; research; tumor suppressor proteins; ubiquitination
Abstract:
... Breast cancer susceptibility gene 2 (BRCA2) mediates genome maintenance during the S phase of the cell cycle, with important roles in replication stress, centrosome replication, and cytokinesis. In this study, we showed that a small heat shock protein, HSP27, interacted with and participated in the degradation of BRCA2 in estrogen-treated MCF-7 cells. BRCA2 degradation reportedly requires ubiquiti ...
DOI:
10.1016/j.bbrc.2021.12.073

53. BRCA2 represses the transcriptional activity of pS2 by E2-ERα

Author:
Mio Fukuda; Yo Tojo; Ami Sato; Hiroko Saito; Akira Nakanishi; Yoshio Miki
Source:
Biochemical and biophysical research communications 2022 v.588 pp. 75-82
ISSN:
0006-291X
Subject:
DNA repair; DNA replication; breast neoplasms; estradiol; estrogen receptors; genes; germ cells; interphase; plasmids; promoter regions; research; transcription (genetics); tumor suppressor proteins
Abstract:
... Germline mutations to the breast cancer 2 (BRCA2) gene have been associated with hereditary breast cancer. In addition to estrogen uptake, BRCA2 expression increases in the S phase of the cell cycle and largely contributes to DNA damage repair associated with DNA replication. However, the role of BRCA2 in estrogen induction remains unclear. An expression plasmid was created to induce BRCA2 activat ...
DOI:
10.1016/j.bbrc.2021.12.054

54. BRD4 inhibitor MZ1 exerts anti-cancer effects by targeting MYCN and MAPK signaling in neuroblastoma

Author:
Xianbing Zhang; Xinyi Guo; Ran Zhuo; Yanfang Tao; Wenxia Liang; Randong Yang; Yanling Chen; Haibo Cao; Siqi Jia; Juanjuan Yu; Xinmei Liao; Xiaolu Li; Fang Fang; Gen Li; Di Wu; Yunyun Xu; Zhiheng Li; Jian Pan; Jian Wang
Source:
Biochemical and biophysical research communications 2022 v.604 pp. 63-69
ISSN:
0006-291X
Subject:
antineoplastic activity; apoptosis; cell cycle; cell proliferation; childhood; gene amplification; neoplasms; prognosis; research; therapeutics
Abstract:
... Neuroblastoma(NB) is a common childhood solid tumor, and most patients in the high-risk group with MYCN gene amplification have a poor prognosis. Inhibition of bromodomain and extra terminal (BET) proteins has shown considerable promise in the investigation of MYCN-driven malignancies in recent years. MZ1 is a novel BET inhibitor that employs proteolytic-targeting chimera (PROTAC) technology for p ...
DOI:
10.1016/j.bbrc.2022.03.039

55. A BTB/POZ domain-containing protein negatively regulates plant immunity in Nicotiana benthamiana

Author:
Mengwei Zhao; Yu Ge; Zhangyan Xu; Xue Ouyang; Yuling Jia; Jiangtao Liu; Meixiang Zhang; Yuyan An
Source:
Biochemical and biophysical research communications 2022 v.600 pp. 54-59
ISSN:
0006-291X
Subject:
Nicotiana benthamiana; Phytophthora nicotianae var. parasitica; Pseudomonas syringae; Ralstonia solanacearum; hypersensitive response; immunity; pathogens; research; ubiquitin; ubiquitin-protein ligase
Abstract:
... Plants have evolved immune systems to fight against pathogens. However, it is still largely unknown how the plant immunity is finely regulated. Here we identified a BTB/POZ domain-containing protein, namely NbBTB, which is predicted to be a member of the ubiquitin E3 ligase complex. The NbBTB expression is downregulated upon the oomycete pathogen Phytophthora parasitica infection. Overexpression o ...
DOI:
10.1016/j.bbrc.2022.02.050

56. Baicalin promotes antibacterial defenses by modulating mitochondrial function

Author:
Dongjiu Zhao; Binhao Du; Jihao Xu; Qinzi Xie; Zhe Lu; Yanhua Kang
Source:
Biochemical and biophysical research communications 2022 v.621 pp. 130-136
ISSN:
0006-291X
Subject:
Staphylococcus aureus; antimicrobial properties; bacterial infections; baicalin; biogenesis; macrophages; membrane potential; mitochondria; mitochondrial membrane; reactive oxygen species; research; rotenone; therapeutics
Abstract:
... Natural flavonoids, such as baicalin, have been extensively studied for their role in bacterial infection. However, the underlying mechanisms remain poorly understood. We demonstrated that baicalin coordinates mitochondrial function and dynamics to promote antibacterial response. Baicalin protected against Staphylococcus aureus infections and alleviates inflammatory responses in vivo and in vitro. ...
DOI:
10.1016/j.bbrc.2022.06.084

57. Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARα in ApoE−/− mice

Author:
Bin Man; Cuilin Hu; Guangyan Yang; Jiaqing Xiang; Shu Yang; Chuanrui Ma
Source:
Biochemical and biophysical research communications 2022 v.624 pp. 59-67
ISSN:
0006-291X
Subject:
atherogenesis; atherosclerosis; berberine; diabetes; glucose; hyperglycemia; hyperinsulinemia; hyperlipidemia; inflammation; lipids; metabolism; morbidity; mortality; oxidative stress; research; risk factors
Abstract:
... Cardiovascular disease caused by atherosclerosis is a leading cause of morbidity and mortality worldwide. Diabetes is a major independent risk factor for the development of atherosclerotic cardiovascular diseases. Diabetic atherosclerosis is characterized by hyperglycemia, hyperinsulinemia, and dyslipidemia. These multiple pathological factors can induce oxidative stress, inflammation, and vascula ...
DOI:
10.1016/j.bbrc.2022.07.072

58. Berberine inhibits glioma cell migration and invasion by suppressing TGF-β1/COL11A1 pathway

Author:
Yuxue Sun; Haiyan Huang; Zhixin Zhan; Haijun Gao; Chaochao Zhang; Jiacheng Lai; Junguo Cao; Chaoyue Li; Yong Chen; Ziqiang Liu
Source:
Biochemical and biophysical research communications 2022 v.625 pp. 38-45
ISSN:
0006-291X
Subject:
arthritis; berberine; blood-brain barrier; cell movement; cell proliferation; collagen; cytotoxicity; diabetic nephropathy; glioma; mice; microfilaments; mitochondria; models; mutants; prognosis; pulmonary fibrosis; research; xenotransplantation
Abstract:
... Glioma is a clinically heterogeneous disease with a poor prognosis. Berberine (BBR), as a multi-target anti-tumor alkaloid, has the ability to penetrate the blood-brain barrier and shows cytotoxicity to glioma cells. In previous studies, we demonstrated that berberine inhibits glioma cell proliferation by inhibiting mutant p53 protein and promoting mitochondrial damage. In addition, berberine has ...
DOI:
10.1016/j.bbrc.2022.07.101

59. Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI promotes neuronal rejuvenation in aged mice

Author:
Hongwon Kim; Jaein Shin; Sumin Kim; Siyoung Kim; Byounggook Cho; Sang-jun Park; Gwoncheol Park; Hakdong Shin; Myeong Soo Park; Jongpil Kim
Source:
Biochemical and biophysical research communications 2022 v.603 pp. 41-48
ISSN:
0006-291X
Subject:
Bifidobacterium bifidum; Bifidobacterium longum; DNA damage; apoptosis; brain; brain damage; cognition; histones; intestinal microorganisms; lysine; memory; neurons; probiotics; protective effect; research
Abstract:
... An increasing number of studies have indicated that alterations in gut microbiota affect brain function, including cognition and memory ability, via the gut-brain axis. In this study, we aimed to determine the protective effect of Bifidobacterium bifidum BGN4 (B. bifidum BGN4) and Bifidobacterium longum BORI (B. longum BORI) on age-related brain damage in mice. We found that administration of B. b ...
DOI:
10.1016/j.bbrc.2022.03.024

60. Bilirubin oxidation end product B prevents CoCl2-induced primary cortical neuron apoptosis by promoting cell survival Akt/mTOR/p70S6K signaling pathway

Author:
Jingting Liu; Lingxuan Kong; Dongxin Chen; Huirong Tang; Yinzhong Lu; Yao Yuan; Feng Qian; Shangwei Hou; Wenjuan Zhao; Man Zhang
Source:
Biochemical and biophysical research communications 2022 v.602 pp. 27-34
ISSN:
0006-291X
Subject:
4',6-diamidino-2-phenylindole; apoptosis; bilirubin; caspase-3; cell viability; hemorrhage; hypoxia; neurites; neuroprotective effect; oxidation; protein content; research
Abstract:
... Bilirubin oxidation end products (BOXes) are associated with the late-developing neurological deficits after subarachnoid hemorrhage (SAH) possibly by direct constricting the cerebral arteries, but their specific impacts on neurons especially in the state of hypoxia, a prominent feature during the late stage of SAH, remain unclear. Here, we explored the effects of BOXes on the primary cortical neu ...
DOI:
10.1016/j.bbrc.2022.02.063

61. Binding characteristics of calpastatin domain L to NaV1.5 sodium channel and its IQ motif mutants

Author:
Fenghui Zhang; Yingchun Xue; Jingyang Su; Xingrong Xu; Yifan Zhao; Yan Liu; Huiyuan Hu; Liying Hao
Source:
Biochemical and biophysical research communications 2022 pp. -
ISSN:
0006-291X
Subject:
amino acid sequences; calcium; calpastatin; genes; humans; mutation; research; sodium channels
Abstract:
... NaV1.5 channel is an integral membrane protein involved in the initiation and conduction of action potentials. IQ motif is located in the C-terminal domain of NaV1.5 sodium channel, which is highly conserved in human sodium channel subtypes. IQ motif is involved in the Ca2+-dependent regulation through interaction with the regulatory proteins such as calpastatin domain L (CSL). Mutations in SCN5A, ...
DOI:
10.1016/j.bbrc.2022.07.056

62. Binding mode of brazzein to the taste receptor based on crystal structure and docking simulation

Author:
Tae-Yeon Kim; Eui-jeon Woo; Tae-Sung Yoon
Source:
Biochemical and biophysical research communications 2022 v.592 pp. 119-124
ISSN:
0006-291X
Subject:
alanine; crystal structure; cysteine; databases; disulfides; hydrogen; lysine; models; protein structure; protein sweeteners; research; sugars; sweetness; taste; taste receptors
Abstract:
... Several natural substances including protein produce sweet taste. Brazzein, derived from the plant Pentadipladra brazzeana, is one of the sweet proteins that bind to the taste receptor with stronger sweetness than sugar. Mutations of this protein affect its flavour, yielding higher sweetness in D29K and lower sweetness in R43A. To elucidate its sweet mechanism in the taste receptor, we determined ...
DOI:
10.1016/j.bbrc.2022.01.004

63. Biochemical and NMR studies reveal specific interaction between STIMATE C-tail and PI(4,5)P2 or PI(3,4,5)P3-containing membrane

Author:
Chongxu Liu; Youjia Zhang; Liang Ge; Ling Li; Bo Wu; Junfeng Wang
Source:
Biochemical and biophysical research communications 2022 v.597 pp. 16-22
ISSN:
0006-291X
Subject:
calcium; endoplasmic reticulum; membrane proteins; mutational analysis; research; titration
Abstract:
... STIMATE is an endoplasmic reticulum (ER) resident membrane protein that plays key roles in regulating calcium signaling occurring at ER-plasma membrane (PM) junctions. It is also involved in the regulation of ER-PM junction maintenance. STIMATE contains multiple putative transmembrane domains with a polybasic C tail (STIMATE-CT) that directly interacts with stromal interaction molecule 1 (STIM1) t ...
DOI:
10.1016/j.bbrc.2022.01.100

64. Bioinformatics-based screening of key genes between maternal preeclampsia and offspring schizophrenia

Author:
Jiashuo Zhang; Yangxue Yin; Yijie Gao; Mengting Zhang
Source:
Biochemical and biophysical research communications 2022 v.615 pp. 1-8
ISSN:
0006-291X
Subject:
blood pressure; data collection; databases; gene expression; gene expression regulation; humans; metabolism; neurodevelopment; patients; pre-eclampsia; pregnancy; progeny; research; risk; schizophrenia
Abstract:
... Converging lines of evidence suggest an association between schizophrenia and prenatal neurodevelopmental disorders. Preeclampsia is a multisystem disease based on the coexistence of pregnancy and elevated blood pressure, which increases the risk for offspring abnormal neurodevelopment. Previous studies have showed maternal preeclampsia is associated with an increased risk of offspring schizophren ...
DOI:
10.1016/j.bbrc.2022.05.026

65. Biophysical characterization of the interaction of Atg8 with a disordered region of Nup159 involved in selective autophagy of the nuclear pore complex

Author:
RyeongHyeon Kim; Junseock Koh
Source:
Biochemical and biophysical research communications 2022 v.604 pp. 172-178
ISSN:
0006-291X
Subject:
autophagy; biogenesis; calorimetry; enthalpy; heat; nuclear pore; nucleocytoplasmic transport; proteome; research; temperature; titration; yeasts
Abstract:
... A functional proteome in the cell is maintained by coordinate regulation of biogenesis, folding, and degradation of cellular proteins. Although the degradation pathways have been extensively characterized for various substrates, it remains elusive how large multiprotein complexes are selectively degraded. Recent investigations have discovered selective autophagic degradation of the yeast Nuclear P ...
DOI:
10.1016/j.bbrc.2022.03.056

66. Blocking protease-activated receptor 4 alleviates liver injury induced by brain death

Author:
Hongbo Fang; Zibo Yuan; Yaohua Zhu; Hongwei Tang; Chun Pang; Jie Li; Jihua Shi; Wenzhi Guo; Shuijun Zhang
Source:
Biochemical and biophysical research communications 2022 v.595 pp. 47-53
ISSN:
0006-291X
Subject:
animal models; antagonists; apoptosis; blood platelets; blood serum; brain; death; inflammation; liver; platelet activation; protein synthesis; research; thrombin
Abstract:
... Brain death (BD) induces a systemic inflammatory response that influences donor liver quality. Protease-activated receptor 4 (PAR4) is a thrombin receptor that mediates platelet activation and is involved in inflammatory and apoptotic processes. Therefore, we investigated the role of PAR4 blockade in liver injury induced by BD and its associated mechanisms. In this study, we constructed a BD rat m ...
DOI:
10.1016/j.bbrc.2022.01.074

67. Bone mesenchymal stem cell-derived extracellular vesicles inhibit DAPK1-mediated inflammation by delivering miR-191 to macrophages

Author:
Hui Liu; Luming Zhang; Meilian Li; Fengzhi Zhao; Fan Lu; Feng Zhang; Sida Chen; Juntao Guo; Rui Zhang; Haiyan Yin
Source:
Biochemical and biophysical research communications 2022 v.598 pp. 32-39
ISSN:
0006-291X
Subject:
apoptosis; humans; inflammation; lungs; macrophage activation; macrophages; mesenchymal stromal cells; protein kinases; research
Abstract:
... Alveolar macrophage activation and apoptosis are vital contributors to sepsis-associated acute lung injury (ALI). However, the mechanisms of alveolar macrophage activation are yet to be clarified. Death-associated protein kinase 1 (DAPK1) is one of the potential candidates that play crucial roles in regulating alveolar macrophage inflammation. Herein, we found that primary human bone mesenchymal s ...
DOI:
10.1016/j.bbrc.2022.02.009

68. C9orf72 knockdown alleviates hepatic insulin resistance by promoting lipophagy

Author:
Xiaomin Cang; Yu Wang; Jia Zeng; Jingwen Gao; Qianqian Yu; Chunfeng Lu; Feng Xu; Jiaxi Lin; Jinzhou Zhu; Xueqin Wang
Source:
Biochemical and biophysical research communications 2022 v.588 pp. 15-22
ISSN:
0006-291X
Subject:
autophagy; cell division; chromosomes; glucose; hepatocytes; insulin resistance; liver; research; therapeutics
Abstract:
... Insulin resistance (IR) attributed by the deficiency of lipophagy, is an abnormal state of downregulation of insulin-mediated glucose uptake and use into the liver. Chromosome 9 open reading frame 72 (C9orf72) variously modulates autophagy. We investigated the role and the downstream pathway of C9orf72 in hepatic IR. We found that C9orf72 knockdown alleviated hepatic IR by lipophagy promotion in T ...
DOI:
10.1016/j.bbrc.2021.12.018

69. CD4+ T cells play an essential role in chronic MC903-induced skin inflammation

Author:
Mi Hye Song; Anupriya Gupta; Varun Sasidharan Nair; Kwonik Oh
Source:
Biochemical and biophysical research communications 2022 v.612 pp. 8-14
ISSN:
0006-291X
Subject:
atopic dermatitis; humans; inflammation; mice; research
Abstract:
... MC903 skin inflammation model is one of well-characterized murine models of atopic dermatitis and driven by TSLP-mediated type 2 inflammation. Since it can be prepared simply by repetitive applications of MC903 and shows consistent clinical results, this model has been widely used. However, in contrast to human atopic dermatitis which is chronic and closely related to TH2 cells, MC903 induces infl ...
DOI:
10.1016/j.bbrc.2022.04.106

70. CD81 inhibition with the cytoplasmic RNA vector producing anti-CD81 antibodies suppresses arthritis in a rat CIA model

Author:
Yuta Fujii; Yuji Arai; Shuji Nakagawa; Tsutomu Yamasaki; Minoru Iijima; Naofumi Yamada; Kenji Takahashi; Mahito Nakanishi; Tohru Nakanishi
Source:
Biochemical and biophysical research communications 2022 v.604 pp. 22-29
ISSN:
0006-291X
Subject:
RNA; body weight; cartilage; eosin; histology; membrane proteins; models; rats; research; rheumatoid arthritis; therapeutics
Abstract:
... Cluster of differentiation 81 (CD81) is a tetraspanin membrane protein consisting of 4 transmembrane domains and 2 outer membrane loops. CD81 inhibition is a potential treatment for rheumatoid arthritis (RA). Here, we investigated the therapeutic effects of the cytoplasmic RNA vector expressing anti-CD81 antibodies (the anti-CD81 vector) on the ankle joint synovium in collagen-induced arthritis (C ...
DOI:
10.1016/j.bbrc.2022.02.081

71. The CDK4/6-UCHL5-BRD4 axis confers resistance to BET inhibitors in MLL-rearranged leukemia cells by suppressing BRD4 protein degradation

Author:
Keigo Amari; Satoru Sasagawa; Natsuki Imayoshi; Yuki Toda; Shigekuni Hosogi; Toshihiko Imamura; Eishi Ashihara
Source:
Biochemical and biophysical research communications 2022 v.588 pp. 147-153
ISSN:
0006-291X
Subject:
apoptosis; biomarkers; cell proliferation; cyclin-dependent kinase; isozymes; leukemia; prognosis; protein degradation; research; therapeutics; ubiquitinyl hydrolase 1
Abstract:
... Among acute leukemias, mixed-lineage leukemia-rearranged (MLL-r) leukemia is associated with poor prognosis. Bromodomain and extra-terminal inhibitors (BETi) are promising agents for treatment of hematological malignancies; however, the mechanisms underlying sensitivity to BETi and biomarkers to predict sensitivity are yet to be clarified. Here, we established OTX015-resistant MLL-r cell lines (OT ...
DOI:
10.1016/j.bbrc.2021.12.063

72. The CLOCK protein regulates insulin secretion related with L-type calcium channels in rat pancreatic beta cells

Author:
Linlin Tian; Xiaodong Li; Yi Ding; Minli Li; Yunzhao Tang; Daiqing Li
Source:
Biochemical and biophysical research communications 2022 v.589 pp. 116-122
ISSN:
0006-291X
Subject:
calcium; calcium channels; chromatin immunoprecipitation; circadian rhythm; fluorescence; glucose; homeostasis; insulin; insulin secretion; islets of Langerhans; luciferase; rats; reporter genes; research
Abstract:
... Circadian locomotor output cycles kaput protein (CLOCK) plays a crucial role in glucose homeostasis and controlling insulin secretion. However, the mechanism of the CLOCK regulating rhythmic insulin secretion has not been fully understood.Rhythmic expression of the CLOCK in rat pancreatic beta cell was detected. INS-1 cells were transfected with siRNAs to knockdown the CLOCK before the cells were ...
DOI:
10.1016/j.bbrc.2021.12.016

73. CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemia

Author:
Natsuki Imayoshi; Makoto Yoshioka; Kuniaki Tanaka; Shyh-Ming Yang; Koshi Akahane; Yuki Toda; Shigekuni Hosogi; Takeshi Inukai; Seiji Okada; David J. Maloney; Tatsutoshi Nakahata; Junko Takita; Itaru Kato; Eishi Ashihara
Source:
Biochemical and biophysical research communications 2022 v.590 pp. 49-54
ISSN:
0006-291X
Subject:
acetyltransferases; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; cyclic AMP; genes; histones; interphase; ligands; luminescence; lymphocytic leukemia; mice; protein synthesis; research; xenotransplantation
Abstract:
... Acute lymphoblastic leukemia with chromosomal rearrangements involving the mixed-lineage leukemia (MLL) gene (MLL-r ALL) remains an incurable disease. Thus, development of a safe and effective therapeutic agent to treat this disease is crucial to address this unmet medical need. BRD4, a member of the bromodomain and extra-terminal domain (BET) protein family, and cyclic AMP response element bindin ...
DOI:
10.1016/j.bbrc.2021.12.078

74. COBL9 and COBL7 synergistically regulate root hair tip growth via controlling apical cellulose deposition

Author:
Zhengzheng Li; Tao Zhou; Pengyue Sun; Xinhang Chen; Luping Gong; Peng Sun; Shengchao Ge; Yun-Kuan Liang
Source:
Biochemical and biophysical research communications 2022 v.596 pp. 6-13
ISSN:
0006-291X
Subject:
Arabidopsis; Liliopsida; cell walls; cellulose; mutants; research; rice; root epidermis; root hairs; salt tolerance
Abstract:
... Root hairs are cylindrical extensions of root epidermal cells that are important for the acquisition of water and minerals, interactions between plant and microbes. The deposition of cell wall materials in the tip enables root hairs to maintain elongation constantly. To date, our knowledge of the regulators that connect the architecture of cell wall and the root hair development remains very limit ...
DOI:
10.1016/j.bbrc.2022.01.096

75. CRL4-DCAF8L2 E3 ligase promotes ubiquitination and degradation of BARD1

Author:
Jingcheng Deng; Ting Zhang; Fei Liu; Qianying Han; Qin Li; Xueyuan Guo; Yanfang Ma; Li Li; Genze Shao
Source:
Biochemical and biophysical research communications 2022 v.611 pp. 107-113
ISSN:
0006-291X
Subject:
DNA; DNA damage; breast neoplasms; dimerization; homologous recombination; neoplasm cells; pathogenesis; research; tumor suppressor proteins; ubiquitin-protein ligase; ubiquitination
Abstract:
... BARD1 is a tumor suppressor that is necessary for the functioning and stability of BRCA1, with which it forms a heterodimer and participates in the repair of DNA double-strand breaks. The cellular level of BARD1 and its interaction with BRCA1 are crucial for BRCA1/BARD1 function in homologous recombination and tumor suppression. However, the regulatory mechanism underpinning the stability of BARD1 ...
DOI:
10.1016/j.bbrc.2022.04.100

76. CTSB+ macrophage repress memory immune hub in the liver metastasis site of colorectal cancer patient revealed by multi-omics analysis

Author:
Caizhao Lin; Hanjin Yang; Wenquan Zhao; Weibing Wang
Source:
Biochemical and biophysical research communications 2022 pp. -
ISSN:
0006-291X
Subject:
colorectal neoplasms; immunohistochemistry; liver; macrophages; memory; metastasis; multiomics; patients; prognosis; research
Abstract:
... Colorectal cancer (CRC) is a lethal malignant tumor and 25–30% of CRC patients develop liver metastasis (LM) with a worse prognosis, but the metastasis mechanism is yet elucidated. To identify the potential immune regulatory mechanism of CRC liver metastasis, single-cell sequencing and multiplex immunohistochemistry were applied to identify key cell populations of the tumor microenvironment (TME) ...
DOI:
10.1016/j.bbrc.2022.06.037

77. Calcium influx through TRPV4 channels involve in hyperosmotic stress-induced epithelial-mesenchymal transition in tubular epithelial cells

Author:
Takashi Miyano; Atsushi Suzuki; Naoya Sakamoto
Source:
Biochemical and biophysical research communications 2022 v.617 pp. 48-54
ISSN:
0006-291X
Subject:
actin; agonists; antagonists; cadherins; calcium; epithelium; fluorescence microscopy; kidneys; muscles; pathogenesis; rats; research; transient receptor potential vanilloid channels
Abstract:
... The epithelial-mesenchymal transition (EMT) is a biological process that occurs in the pathogenesis of kidney diseases in which injured tubular epithelial cells transform into myofibroblasts. We previously showed that mannitol-mediated hyperosmotic stress induces EMT of tubular epithelial cells. Although Ca²⁺ signaling is essential for the induction of EMT in tubular epithelial cells, the role of ...
DOI:
10.1016/j.bbrc.2022.06.003

78. Cancer cells targeting with genetically engineered constructs based on a pH-dependent membrane insertion peptide and fluorescent protein

Author:
Anastasiya Yu. Frolova; Alexey A. Pakhomov; Dmitry L. Kakuev; Anna S. Sungurova; Sergey M. Deyev; Vladimir I. Martynov
Source:
Biochemical and biophysical research communications 2022 v.612 pp. 141-146
ISSN:
0006-291X
Subject:
cell membranes; endocytosis; fluorescence; fluorescent proteins; human cell lines; medicine; molecular weight; neoplasm cells; pH; peptides; research
Abstract:
... The targeted delivery of nanodrugs to malignant neoplasm is one of the most pressing challenges in the development of modern medicine. It was reported earlier that a bacteriorhodopsin-derived pH low insertion peptide (pHLIP) targets acidic tumors and has the ability to translocate low molecular weight cargoes across the cancer cell membrane. Here, to better understand the potential of pHLIP-relate ...
DOI:
10.1016/j.bbrc.2022.04.112

79. Capparis zeylanica L. conjugated TiO2 nanoparticles as bio-enhancers for antimicrobial and chronic wound repair

Author:
M. Nilavukkarasi; S. Vijayakumar; Mohan Kalaskar; Nilambari Gurav; Shailendra Gurav; P.K. Praseetha
Source:
Biochemical and biophysical research communications 2022 v.623 pp. 127-132
ISSN:
0006-291X
Subject:
Capparis zeylanica; Fourier transform infrared spectroscopy; X-ray diffraction; agar; albino; ambient temperature; antimicrobial properties; drugs; excision; lighting; models; research; titanium dioxide; ultraviolet-visible spectroscopy
Abstract:
... Chronic, non-healable wounds have been a threat throughout history and have consumed centuries of traditional and modern research. In wound repair, a growing variety of novel treatments have been developed. At various stages of wound healing, nanostructure systems are employed. The drug may be synthesized at the nanoscale to act as a “provider,” or nanomaterial could be employed as biomedical devi ...
DOI:
10.1016/j.bbrc.2022.07.064

80. Carbonic anhydrase amyloid fibrils composed of laterally associated protofilaments show reduced cytotoxicity

Author:
Natalya Ryabova; Liliia Fakhranurova; Vitaly Balobanov; Victor Marchenkov; Anatoly Glukhov; Nelly Ilyina; Alexey Kochetov; Mariya Suvorina; Alexey Surin; Natalya Katina
Source:
Biochemical and biophysical research communications 2022 v.593 pp. 46-51
ISSN:
0006-291X
Subject:
amyloid; carbonate dehydratase; cattle; cell viability; cytotoxicity; hydrophobicity; mass spectrometry; mutation; proteolysis; research; solvents
Abstract:
... Cytotoxicity of amyloid fibrils has been shown to depend on their structure. However, specific features of toxic and non-toxic amyloids remain unclear. Here we focus on the relationship between structural characteristics of the fibrils and their cytotoxicity. Bovine carbonic anhydrase B (BCAB) serves as the object of this study because its amyloids reduce cell viability. Limited proteolysis and ma ...
DOI:
10.1016/j.bbrc.2022.01.040

81. Cellular concentrations of plasmalogen species containing a polyunsaturated fatty acid significantly increase under hypoxia in human colorectal cancer, Caco2 cells

Author:
Keiko Tamiya-Koizumi; Yurika Otoki; Kiyotaka Nakagawa; Reiji Kannagi; Naoki Mizutani; Motoshi Suzuki; Mamoru Kyogashima; Soichiro Iwaki; Mineyoshi Aoyama; Takashi Murate; Kazuyuki Kitatani; Takahisa Kuga; Yasuyoshi Mizutani; Akira Tokumura
Source:
Biochemical and biophysical research communications 2022 v.611 pp. 1-7
ISSN:
0006-291X
Subject:
biosynthesis; choline; colorectal neoplasms; ethanolamine; humans; hypoxia; liquid chromatography; phospholipases; polyunsaturated fatty acids; research; tandem mass spectrometry
Abstract:
... Plasmalogen localized in the raft of mammalian cell membranes plays a role in the storage of polyunsaturated fatty acid (PUFA), and exists to a higher extent in malignant cells that survive, and even grow in hypoxic conditions. The biosynthesis of plasmalogen in mammalian cells has been reported to depend on aerobic conditions. Using liquid chromatography-tandem mass spectrometry, we found that th ...
DOI:
10.1016/j.bbrc.2022.04.061

82. Change of motifs in C. elegans reveals developmental principle of neural network

Author:
Jian Liu; Ye Yuan; Peng Zhao; Gaofeng Liu; Hong Huo; Zhaoyu Li; Tao Fang
Source:
Biochemical and biophysical research communications 2022 v.624 pp. 112-119
ISSN:
0006-291X
Subject:
neural networks; neurophysiology; research
Abstract:
... Revealing the organizing principles of developing neural networks is a difficult but significant task in neuroscience. As a creature with a rather compact and well-studied neural network, C. elegans is an ideal subject for neuroscience study. However, the researches on its developing neural network remain challenging. The changes in specific properties of neural network across development may unco ...
DOI:
10.1016/j.bbrc.2022.07.108

83. Changes in the properties of membrane tethers in response to HP1α depletion in MCF7 cells

Author:
Susav Pradhan; Martin A.K. Williams; Tracy K. Hale
Source:
Biochemical and biophysical research communications 2022 v.587 pp. 126-130
ISSN:
0006-291X
Subject:
breast neoplasms; plasma membrane; research
Abstract:
... Plasma membrane tension is known to regulate many cell functions, such as motility and membrane trafficking. Membrane tether pulling is an effective method for measuring the apparent membrane tension of cells and exploring membrane-cytoskeleton interactions. In this article, the mechanical properties of HP1α-depleted MCF7 breast cancer cells are explored in comparison to controls, by pulling membr ...
DOI:
10.1016/j.bbrc.2021.11.081

84. Characteristics of alpha smooth muscle actin-positive peritubular cells in prepubertal bovine testes

Author:
Yusuke Kawabe; Takashi Numabe; Kentaro Tanemura; Kenshiro Hara
Source:
Biochemical and biophysical research communications 2022 v.609 pp. 48-53
ISSN:
0006-291X
Subject:
actin; adults; elastin; immatures; puberty; research; smooth muscle
Abstract:
... Characteristics of peritubular myoid cells (PMCs) in sexually immature cattle remain largely unknown. Here, we report the character and behavior of peritubular cells expressing alpha smooth muscle actin (αSMA), a marker of PMCs in adult testes, in prepubertal testes procured from 5-months-old bulls. Elastin distribution around αSMA + PMCs was dim and discontinuous in prepubertal testes, but strong ...
DOI:
10.1016/j.bbrc.2022.03.149

85. Characterization of differentiated autoregulation of LuxI/LuxR-type quorum sensing system in Pseudoalteromonas

Author:
Shuangjia Li; Shijun Wu; Yixuan Ren; Qiu Meng; Jianhua Yin; Zhiliang Yu
Source:
Biochemical and biophysical research communications 2022 v.590 pp. 177-183
ISSN:
0006-291X
Subject:
Pseudoalteromonas; Santalum yasi; autoregulation; lactones; research
Abstract:
... Gram-negative bacteria usually use acyl-homoserine lactones (AHLs)-mediated LuxI/LuxR-type quorum sensing (QS) systems for cell-cell cooperation and/or bacteria-environment communication. LuxI and LuxR are AHLs synthase and receptor, respectively. These two parts could form a positive regulatory feedback loop, controlling various types of group behaviors. However, the autoregulation mechanisms bet ...
DOI:
10.1016/j.bbrc.2021.12.107

86. Characterization of the membrane penetration-enhancing peptide S19 derived from human syncytin-1 for the intracellular delivery of TAT-fused proteins

Author:
Mayuko Suzuki; Kouta Iwaki; Moeki Kikuchi; Kei Fujiwara; Nobuhide Doi
Source:
Biochemical and biophysical research communications 2022 v.586 pp. 63-67
ISSN:
0006-291X
Subject:
dimerization; endocytosis; endosomes; humans; mutagenesis; mutants; peptides; research; therapeutics
Abstract:
... Although cell-penetrating peptides such as the HIV-derived TAT peptide have been used as tools for the intracellular delivery of therapeutic peptides and proteins, a problem persists: the endosomal escape efficiency is low. Previously, we found that the fusogenic peptide S19, derived from the human protein syncytin-1, enhance the endosomal escape efficiency of proteins that incorporated by endocyt ...
DOI:
10.1016/j.bbrc.2021.11.065

87. Characterization of the modification of Kelch-like ECH-associated protein 1 by different fumarates

Author:
Lingzhi Qu; Ming Guo; Huajun Zhang; Xiaojuan Chen; Hudie Wei; Longying Jiang; Jun Li; Zhuchu Chen; Shuyan Dai; Yongheng Chen
Source:
Biochemical and biophysical research communications 2022 v.605 pp. 9-15
ISSN:
0006-291X
Subject:
cysteine; dimethyl fumarate; fluorescence; fumaric acid; psoriasis; research; sclerosis; thermal stability
Abstract:
... Fumarates (fumaric acid esters), primarily dimethyl fumarate (DMF) and monoethyl fumarate (MEF) and its salts, are orally administered systemic agents used for the treatment of psoriasis and multiple sclerosis. It is widely believed that the pharmaceutical activities of fumarates are exerted through the Keap1-Nrf2 pathway. Although it has been revealed that DMF and MEF differentially modify specif ...
DOI:
10.1016/j.bbrc.2022.03.059

88. Chlorambucil-conjugated PI-polyamides (Chb-M’), a transcription inhibitor of RUNX family, has an anti-tumor activity against SHH-type medulloblastoma with p53 mutation

Author:
Yasuzumi Matsui; Yohei Mineharu; Yuki Noguchi; Etsuko Yamamoto Hattori; Hirohito Kubota; Masahiro Hirata; Susumu Miyamoto; Hiroshi Sugiyama; Yoshiki Arakawa; Yasuhiko Kamikubo
Source:
Biochemical and biophysical research communications 2022 v.620 pp. 150-157
ISSN:
0006-291X
Subject:
antineoplastic activity; apoptosis; computer simulation; consensus sequence; drugs; growth retardation; models; mutation; neoplasms; phosphorylation; research; serine; therapeutics; transcription (genetics)
Abstract:
... Malignancy of medulloblastoma depends on its molecular classification. Sonic Hedgehog (SHH)-type medulloblastoma with p53 mutation was recognized as one of the most aggressive types of tumors. We developed a novel drug, chlorambucil-conjugated PI-polyamides (Chb-M′), which was designed to compete with the RUNX consensus DNA-binding site. Chb-M′ specifically recognizes this consensus sequence and a ...
DOI:
10.1016/j.bbrc.2022.06.090

89. Chromogranin A-derived peptide CGA47-66 protects against septic brain injury by reducing blood-brain barrier damage through the PI3K/AKT pathway

Author:
FengLin Wang; Yan Zeng; Xian Liu; JiaJun Cao; ShengNan Kang; WuShuang Zhou; XiaoYing Chen; JingLun Liu; Dan Zhang
Source:
Biochemical and biophysical research communications 2022 v.605 pp. 162-170
ISSN:
0006-291X
Subject:
actin; blood-brain barrier; brain damage; cell lines; cognitive disorders; lipopolysaccharides; peptides; phosphatidylinositol 3-kinase; protective effect; research; therapeutics; tight junctions
Abstract:
... CGA₄₇₋₆₆ (Chromofungin, CHR), is a peptide derived from the N-terminus of chromogranin A (CgA), has been proven to inhibit the lipopolysaccharide (LPS)-induced brain injury. However, the underlying mechanism is still unknown. We found that CGA₄₇₋₆₆ exerted a protective effect on cognitive impairment by inhibiting the destruction of the blood-brain barrier (BBB) in the LPS-induced sepsis mice model ...
DOI:
10.1016/j.bbrc.2022.03.046

90. Chronic microglial inflammation promotes neuronal lactate supply but impairs its utilization in primary rat astrocyte-neuron co-cultures

Author:
Yi Wang; Jie Li; Meng-Yue Wang; Zhi-Yong Pan; Zhi-Qiang Li; Ze-Fen Wang
Source:
Biochemical and biophysical research communications 2022 v.607 pp. 28-35
ISSN:
0006-291X
Subject:
adenosine triphosphate; astrocytes; coculture; cytoskeleton; energy; energy metabolism; glucose; inflammation; lactic acid; lipopolysaccharides; neurons; neurotoxicity; oxidation; rats; research
Abstract:
... Neuronal activity is closely associated with energy metabolism. In addition to glucose, astrocyte-derived lactate serves as an energy source for neurons. Chronic inflammation is a common pathological event that is associated with aging and neurodegenerative diseases. However, the mechanisms underlying inflammation-induced neuronal injury are not fully understood. Both microglia and astrocytes part ...
DOI:
10.1016/j.bbrc.2022.03.122

91. CircPDHX promotes prostate cancer cell progression in vitro and tumor growth in vivo via miR-497-5p/ACSL1 axis

Author:
Jia Chen; Qitong Xie; Weixian Miao; Jianrui Fan; Xiaobo Zhou; Maozhang Li
Source:
Biochemical and biophysical research communications 2022 v.620 pp. 35-41
ISSN:
0006-291X
Subject:
Western blotting; apoptosis; bioluminescence assay; cell movement; cell proliferation; fatty acids; flow cytometry; long-chain-fatty-acid-CoA ligase; metabolites; microRNA; neoplasm cells; prostatic neoplasms; pyruvate dehydrogenase (lipoamide); quantitative polymerase chain reaction; research
Abstract:
... Circular RNAs (circRNAs) have been proved could regulate many cancers, including prostate cancer (PCa). In this paper, we reconnoitered the roles of circRNA pyruvate dehydrogenase complex component X (circPDHX) in PCa. The circPDHX, microRNA (miR)-497-5p and acyl-CoA synthetase long chain family member 1 (ACSL1) contents were detected by quantitative real-time PCR and Western blot analysis. Cell p ...
DOI:
10.1016/j.bbrc.2022.06.012

92. CircRNA608-microRNA222-PINK1 axis regulates the mitophagy of hepatic stellate cells in NASH related fibrosis

Author:
Zi-Xin Xu; Jing-Ze Li; Qin Li; Ming-Yi Xu; Hui-Yi Li
Source:
Biochemical and biophysical research communications 2022 v.610 pp. 35-42
ISSN:
0006-291X
Subject:
bioinformatics; computer software; fatty liver; fibrosis; fluorescent antibody technique; liver cirrhosis; microRNA; mitochondria; mitophagy; research
Abstract:
... Increasing evidences have confirmed the relationship between mitophagy and nonalcoholic steatohepatitis (NASH). The exact mechanism of upstream circular RNAs (circRNAs) regulating PTEN-induced putative kinase 1 (PINK1) mediated mitophagy and its contribution to NASH-related liver fibrosis was explored in our study. Primary hepatic stellate cells (PHSCs) from C57BL/6 mice transfected with small int ...
DOI:
10.1016/j.bbrc.2022.04.008

93. Circ_0000591 served as endogenous RNA for miR-326 to promote progression of cholangiocarcinoma via the TLR4/MyD88/IL6 axis

Author:
Fenqiang Xiao; Fei Xu; Hua Zhang; Xiaoming Shuai
Source:
Biochemical and biophysical research communications 2022 v.600 pp. 101-108
ISSN:
0006-291X
Subject:
carcinogenesis; hepatoma; liver; prognosis; research
Abstract:
... Cholangiocarcinoma (CCA) is the second most common liver malignancy with poor prognosis after hepatocellular carcinoma (HCC). Emerging evidences have proved that circular RNAs (circRNAs) are involved in the progression of multiple cancers, while their roles in tumorigenesis of CCA remains largely unclear. In the present study, we found circ_0000591 was upregulated in CCA cells and tissues. The hig ...
DOI:
10.1016/j.bbrc.2022.02.073

94. Circ_LPAR3 promotes the progression of oral squamous cell carcinoma (OSCC)

Author:
Li Li; Ye Yin; Fanglong Nan; Zeyu Ma
Source:
Biochemical and biophysical research communications 2022 v.589 pp. 215-222
ISSN:
0006-291X
Subject:
RNA; Western blotting; angiogenesis; apoptosis; bioinformatics; cell viability; flow cytometry; gene expression regulation; immunohistochemistry; luciferase; oncogenes; research; squamous cell carcinoma; transfection
Abstract:
... circ_LPAR3 is an oncogene in esophageal squamous cell carcinoma. However, its role in oral squamous cell carcinoma (OSCC) is unknown.To reveal the functions of circ_LPAR3 in OSCC.Online bioinformatic analysis was performed to disclose the differential expression of circ_LPAR3, VEGFC, AKT1 in OSCC and also the target predictions of miR-513b-5p. Transfection was applied in OSCC cells. RT-qPCR was us ...
DOI:
10.1016/j.bbrc.2021.12.012

95. Circular RNA circRNF169 functions as a miR-30c-5p sponge to promote cellular senescence

Author:
Dingyuan Zhang; Yuting Li; Yiting Lei; Haiqing Yang; Linying Huang; Xue Chen; Zhihao Zhou; Cuiyi Huang; Yantao Zhou; Ruolan Feng; Xing-dong Xiong; Yuan Yuan; Hongjing Cui; Hui-ling Zheng; Xuerong Sun; Xinguang Liu; Shun Xu
Source:
Biochemical and biophysical research communications 2022 v.604 pp. 88-95
ISSN:
0006-291X
Subject:
bioluminescence assay; cell proliferation; cell senescence; circular RNA; fibroblasts; mice; research
Abstract:
... Circular RNAs (circRNAs), characterized as single-stranded closed circular RNA molecules, have been established to exert pivotal functions in various biological or pathological processes. Nonetheless, the effects and underlying mechanisms concerning circRNAs on the aging and aging-related diseases remain elusive. We herein compared the expression patterns of circRNAs in young and senescent mouse e ...
DOI:
10.1016/j.bbrc.2022.03.041

96. Circular RNA circ_0047744 suppresses the metastasis of pancreatic ductal adenocarcinoma by regulating the miR-21/SOCS5 axis

Author:
Haoran Xie; Qiuyan Zhao; Lanting Yu; Jiawei Lu; Kui Peng; Ni Xie; Jianbo Ni; Baiwen Li
Source:
Biochemical and biophysical research communications 2022 v.605 pp. 154-161
ISSN:
0006-291X
Subject:
adenocarcinoma; cell movement; circular RNA; lymph nodes; metastasis; microRNA; research; therapeutics
Abstract:
... There is increasing evidence that circular RNAs (circRNAs) can serve as microRNA (miRNA) sponges to regulate metastasis of multiple tumors, including pancreatic ductal adenocarcinoma (PDAC). However, the role of the circRNA/miRNA regulatory network in metastasis of PDAC has not been elucidated. The purpose of this study is to explore the role of circ_0047744/miR-21/SOCS5 in the metastasis of PDAC. ...
DOI:
10.1016/j.bbrc.2022.03.082

97. Clathrin-mediated trafficking of phospholipid flippases is required for local plasma membrane/cell wall damage repair in budding yeast

Author:
Yuta Yamazaki; Keiko Kono
Source:
Biochemical and biophysical research communications 2022 v.606 pp. 156-162
ISSN:
0006-291X
Subject:
cell walls; clathrin; phospholipids; plasma membrane; protein kinase C; research; yeasts
Abstract:
... Plasma membrane damage and repair frequently happen in cells. A critical process underlying plasma membrane repair is to redirect repair factors, such as protein kinase C and the exocyst complex, from the polarized site to the damage site. However, the mechanism underlying the repair factor delivery to the damage site remains unknown. Here, we demonstrate that clathrin-mediated trafficking of repa ...
DOI:
10.1016/j.bbrc.2022.03.129

98. Cleavage stimulating factor 64 depletion mitigates cardiac fibrosis through alternative polyadenylation

Author:
Rahul Neupane; Keith Youker; Hari Krishna Yalamanchili; Katarzyna A. Cieslik; Harry Karmouty-quintana; Ashrith Guha; Rajarajan A. Thandavarayan
Source:
Biochemical and biophysical research communications 2022 v.597 pp. 109-114
ISSN:
0006-291X
Subject:
3' untranslated regions; fibroblasts; fibrosis; gene expression; heart failure; humans; protein synthesis; research; therapeutics
Abstract:
... Alternative polyadenylation (APA) regulates gene expression by cleavage and addition of poly(A) sequence at different polyadenylation sites (PAS) in 3′UTR, thus, generating transcript isoforms with different lengths. Cleavage stimulating factor 64 (CstF64) is an APA regulator which plays a role in PAS selection and determines the length of 3′UTR. CstF64 favors the use of proximal PAS, resulting in ...
DOI:
10.1016/j.bbrc.2022.01.093

99. Coculture in vitro with endothelial cells induces cytarabine resistance of acute myeloid leukemia cells in a VEGF-A/VEGFR-2 signaling–independent manner

Author:
Shuichiro Okamoto; Kei Miyano; Keisuke Kitakaze; Hitomi Kato; Akira Yamauchi; Mizuho Kajikawa; Momoe Itsumi; Chikage Kawai; Futoshi Kuribayashi
Source:
Biochemical and biophysical research communications 2022 v.587 pp. 78-84
ISSN:
0006-291X
Subject:
CRISPR-Cas systems; antineoplastic agents; apoptosis; bone marrow; cell movement; coculture; endothelial cells; humans; myeloid leukemia; phosphorylation; research; vascular endothelial growth factor A; vascular endothelial growth factor receptor-2
Abstract:
... An interaction between acute myeloid leukemia (AML) cells and endothelial cells in the bone marrow seems to play a critical role in chemosensitivity on leukemia treatment. The endothelial niche reportedly enhances the paracrine action of the soluble secretory proteins responsible for chemoresistance in a vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 (VEGFR-2) signaling pathway–depe ...
DOI:
10.1016/j.bbrc.2021.11.090

100. Colchicine prevents ventricular arrhythmias vulnerability in diet-induced obesity rats

Author:
Zhiyang Lv; Xiaodi Chen; Ping Chen; Qianyuan Li; Zhuli Guo; Qing Lu; Shifang Ding
Source:
Biochemical and biophysical research communications 2022 v.610 pp. 127-132
ISSN:
0006-291X
Subject:
Western blotting; calcium-calmodulin-dependent protein kinase; colchicine; electrophysiology; fibrosis; high fat diet; histology; males; obesity; research
Abstract:
... This study aimed to assess the role of colchicine in ventricular arrhythmias (VAs) induced by high fat diet (HFD)-fed rats. Male rats were divided into four groups: CTL, normal diet plus saline; CTC, normal diet plus colchicine; HFD, HFD plus saline; HFC: HFD plus colchicine. Metabolic parameters, ECG parameters, ventricular electrophysiological parameters, ventricular histology, Western blot and ...
DOI:
10.1016/j.bbrc.2022.03.114