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- Yang, Jian-hui; Wu, Qiong; Lv, Jian-guo; Nie, Hui-Yong
- Biochemical and biophysical research communications 2016
- Gleditsia sinensis, etc ; transcription factor NF-kappa B; osteoclasts; fruits; macrophages; signal transduction; ovariectomy; bone density; bone marrow; triterpenoids; osteoporosis; rats; phosphorylation; mitogen-activated protein kinase; Show all 14 Subjects
- ... Receptor activator of nuclear factor-κB ligand (RANKL) is a key factor in the differentiation and activation of osteoclasts. Echinocystic acid (EA), a pentacyclic triterpene isolated from the fruits of Gleditsia sinensis Lam, was reported to prevent reduction of bone mass and strength and improve the cancellous bone structure and biochemical properties in ovariectomy rats. However, the molecular m ...