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You searched for: Journal name Biochemical and biophysical research communications Remove constraint Journal name: Biochemical and biophysical research communications
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1. (+)-Sesamin, a sesame lignan, is a potent inhibitor of gut bacterial tryptophan indole-lyase that is a key enzyme in chronic kidney disease pathogenesis

Author:
Daiki Oikawa; Satoshi Yamashita; Seiji Takahashi; Toshiyuki Waki; Koichi Kikuchi; Takaaki Abe; Takane Katayama; Toru Nakayama
Source:
Biochemical and biophysical research communications 2022 v.590 pp. 158-162
ISSN:
0006-291X
Subject:
Escherichia coli; active sites; dietary supplements; enzymes; intestines; kidney diseases; kidneys; lignans; mice; morbidity; pathogenesis; phytochemicals; pyridoxal; research; sulfates; therapeutics; toxins; tryptophan
Abstract:
... The progression of chronic kidney disease (CKD) increases the risks of cardiovascular morbidity and end-stage kidney disease. Indoxyl sulfate (IS), which is derived from dietary l-tryptophan by the action of bacterial l-tryptophan indole-lyase (TIL) in the gut, serves as a uremic toxin that exacerbates CKD-related kidney disorder. A mouse model previously showed that inhibition of TIL by 2-aza-l-t ...
DOI:
10.1016/j.bbrc.2021.12.088

2. 1-, 2- and 3-AG as substrates of the endocannabinoid enzymes and endogenous ligands of the cannabinoid receptor 1

Author:
Shrouq I. Farah; Samantha Hilston; Ngan Tran; Nikolai Zvonok; Alexandros Makriyannis
Source:
Biochemical and biophysical research communications 2022 v.591 pp. 31-36
ISSN:
0006-291X
Subject:
acylglycerol lipase; agonists; amide hydrolases; cannabinoid receptors; cannabinoids; enantiomers; fatty acids; hydrolysis; isomerization; ligands; monoacylglycerols; research; serine; stereochemistry
Abstract:
... 2-Arachidonoylglycerol (2-AG) is the most potent and abundant endocannabinoid that acts as a full agonist at the cannabinoid 1 (CB1) and 2 (CB2) receptors. It serves as a substrate for several serine hydrolases, including monoacylglycerol lipase (MGL), α/β hydrolase domain 6 (ABHD6) and fatty acid amide hydrolase (FAAH). However, 2-AG's rapid conversion to 1-AG (the S stereoisomer) and 3-AG (the R ...
DOI:
10.1016/j.bbrc.2021.12.105

3. IL- 17A promotes vascular calcification in an ex vivo murine aorta culture

Author:
Sumie Hiramatsu-Asano; Tomoyuki Mukai; Takahiko Akagi; Haruhito A. Uchida; Shunichi Fujita; Kazuhisa Nakano; Yoshitaka Morita
Source:
Biochemical and biophysical research communications 2022 v.604 pp. 83-87
ISSN:
0006-291X
Subject:
aorta; calcification; histology; inflammation; interleukin-17; interleukin-6; mice; micro-computed tomography; mineralization; mortality; phosphates; psoriasis; research; risk
Abstract:
... Vascular calcification is characterized by mineral deposition in the vasculature, which is triggered by chronic systemic inflammation, including psoriasis. Psoriasis is an IL-17A-mediated inflammatory skin disease that is associated with exacerbated vascular calcification and high cardiovascular mortality. Although previous studies have shown that IL-17A induces vascular dysfunction in murine psor ...
DOI:
10.1016/j.bbrc.2022.03.051

4. 17β-estradiol inhibits vascular proliferation and inflammation by reducing NF-κB expression induced by increased crosstalk between KLF5 and ERα

Author:
Man-li Zhang; Man-na Zhang; Wen-li Wang; Hui Chen; Xia Wang; Xuan Li; Li Li; Fei Tong
Source:
Biochemical and biophysical research communications 2022 pp. -
ISSN:
0006-291X
Subject:
Western blotting; cardiovascular system; cell proliferation; chromatin immunoprecipitation; fluorescent antibody technique; inflammation; luciferase; research; smooth muscle
Abstract:
... Pathological vascular remodeling and cell proliferation play vital roles in many proliferative vascular diseases. Estrogen can protect the cardiovascular system, but its exact molecular mechanism is unknown. Here we report that 17β-estradiol (E2) suppressed vascular smooth muscle cells (VSMCs) proliferation and inflammation. qRT-PCR and western blot demonstrated that E2 decreased NF-κB p50 express ...
DOI:
10.1016/j.bbrc.2022.07.054

5. IL- 1R1 blockade attenuates liver injury through inhibiting the recruitment of myeloid-derived suppressor cells in sepsis

Author:
Minjie Luo; Hao Wang; Ke Liu; Meidong Liu; Sipin Tan; Yaxi Zhu; Huali Zhang
Source:
Biochemical and biophysical research communications 2022 v.620 pp. 21-28
ISSN:
0006-291X
Subject:
antagonists; bone marrow; humans; liver; macrophages; phenotype; prognosis; protective effect; research
Abstract:
... Myeloid-derived suppressor cells (MDSCs) mobilize and migrate from bone marrow to peripheral tissues or immune organs, which is associated with poor prognosis in sepsis. Intervention of MDSCs might be a potential target for the effective treatment of sepsis. In the present study, we demonstrated that IL-1R1 blockade with either recombinant human IL-1R antagonist Anakinra or IL-1R1 deficiency had a ...
DOI:
10.1016/j.bbrc.2022.06.038

6. 2D-DIGE based urinary proteomics and functional enrichment studies to reveal novel Mycobacterium tuberculosis and human protein biomarker candidates for pulmonary tuberculosis

Author:
Amit Kaushik; Sabyasachi Bandyopadhyay; Chhavi Porwal; Alagiri Srinivasan; Lokesh A. Rukmangadachar; Gururao Hariprasad; Srujana Kola; Jitender Kataria; Urvashi B. Singh
Source:
Biochemical and biophysical research communications 2022 v.619 pp. 15-21
ISSN:
0006-291X
Subject:
Mycobacterium tuberculosis; Streptococcus; adenosinetriphosphatase; biomarkers; cell walls; extracellular space; gel electrophoresis; gene expression regulation; genes; humans; immune response; liquid chromatography; pathogenicity; plasma membrane; pneumonia; protein-protein interactions; proteome; proteomics; research; tandem mass spectrometry; tuberculosis; urine
Abstract:
... In the absence of a sensitive and specific diagnostic modality capable of detecting all forms of tuberculosis (TB), proteomics may identify specific Mycobacterium tuberculosis (M.tb) proteins in urine, with a potential as biomarkers. To identify candidate biomarkers for TB, proteome profile of urine from pulmonary TB patients was compared with non-disease controls (NDC) and disease controls (DC, S ...
DOI:
10.1016/j.bbrc.2022.06.021

7. 3-Hydroxyacyl-CoA dehydratase 2 deficiency confers resistance to diet-induced obesity and glucose intolerance

Author:
Lengyun Wei; Shengmei Weng; Xuyang Lu; Shenglong Zhu; Qin Yang; Yong Q. Chen
Source:
Biochemical and biophysical research communications 2022 v.605 pp. 134-140
ISSN:
0006-291X
Subject:
diabetes; energy expenditure; enzymes; fatty acids; fatty liver; glucose; liver; obesity; pandemic; research; therapeutics
Abstract:
... Obesity and associated complications are becoming a pandemic. Inhibiting fatty acid synthesis and elongation is an important intervention for the treatment of obesity. Despite intensive investigations, many potential therapeutic targets have yet to be discovered. In this study, decreased expression of Hacd2 (a newly found enzyme in fatty acid elongation) was found in HFD induced mice and loss of H ...
DOI:
10.1016/j.bbrc.2022.03.057

8. 3D-cultured small size adipose-derived stem cell spheroids promote bone regeneration in the critical-sized bone defect rat model

Author:
Yutaro Yamada; Tadashi Okano; Kumi Orita; Tomomi Makino; Fumiaki Shima; Hiroaki Nakamura
Source:
Biochemical and biophysical research communications 2022 v.603 pp. 57-62
ISSN:
0006-291X
Subject:
angiogenesis; animal models; apoptosis; cartilage; gene expression; immunohistochemistry; morphogenesis; research; skull; stem cells; therapeutics
Abstract:
... Adipose-derived stem cells (ADSCs), due to their regenerative ability, have beneficial effects on bone and cartilage defects. In addition, spheroid formation of ADSCs obtained using three-dimensional (3D) culture accelerates the regenerative ability of ADSCs. The study investigated the regenerative effect of 3D-cultured small size ADSC spheroids without a scaffold in rats with defects in the criti ...
DOI:
10.1016/j.bbrc.2022.03.027

9. 5-HT and α-m-5-HT attenuate excitatory synaptic transmissions onto the lateral amygdala principal neurons via presynaptic 5-HT1B receptors

Author:
Ryo Yamamoto; Tetsufumi Ito; Takafumi Furuyama; Munenori Ono; Nobuo Kato
Source:
Biochemical and biophysical research communications 2022 pp. -
ISSN:
0006-291X
Subject:
agonists; amygdala; antagonists; rats; research; serotonin; serotonin receptors; therapeutics
Abstract:
... Accumulating evidence suggests that the serotonergic (5-HT) system in the amygdala has significant effects on affective states. Dysregulation of the 5-HT system in the basolateral amygdaloid complex causes affective disorders. To search for therapeutic targets, subtype specification of 5-HT receptors is crucial. The present study was undertaken to identify the 5-HT receptor subtype responsible for ...
DOI:
10.1016/j.bbrc.2022.07.076

10. IL- 6 activates pathologic Th17 cell via STAT 3 phosphorylation in inflammatory joint of Ankylosing Spondylitis

Author:
Hae-in Lee; Hui-Ju Kim; Sungsin Jo; Seung Cheol Shim; Tae-Hwan Kim; Eun Jeong Won; Tae-Jong Kim
Source:
Biochemical and biophysical research communications 2022 v.620 pp. 69-75
ISSN:
0006-291X
Subject:
arthritis; inflammation; interferon-gamma; interleukin-6; mice; phosphorylation; research; skeleton
Abstract:
... Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease, which is characterized by inflammation of the axial skeleton and the peripheral arthritis. An increase in the number of Th17 cells in patients with AS has been reported. Although Th17 cells have been involved in the induction of inflammation, recent data suggest that not all Th17 cells are pathogenic, showing regulatory funct ...
DOI:
10.1016/j.bbrc.2022.06.081

11. IL- 6 protects cardiomyocytes from oxidative stress at the early stage of LPS-induced sepsis

Author:
Yue Peng; Qingchen Yang; Shuya Gao; Zekun Liu; Weixian Kong; Xiaohong Bian; Zhe Li; Junmei Ye
Source:
Biochemical and biophysical research communications 2022 v.603 pp. 144-152
ISSN:
0006-291X
Subject:
antioxidants; cardiomyocytes; histology; homeostasis; interleukin-6; oxidative stress; protective effect; research
Abstract:
... Pro-inflammatory cytokines play important roles in sepsis-induced cardiac injury. Among various cytokines, the function of Interleukin-6 (IL-6) in the regulation of cardiomyocyte injury remains to be elucidated. This study aimed to investigate whether IL-6 plays a key role in the sepsis-induced cardiomyocyte injury and the possible mechanism. Mice deficient for Il-6 exhibited impaired heart rhythm ...
DOI:
10.1016/j.bbrc.2022.03.013

12. 7-aminocephalosporanic acid, a novel HSP90β inhibitor, attenuates HFD-induced hepatic steatosis

Author:
Weitao Zhang; Hanyue Xue; Chen Zhou; Zuguo Zheng; Mingming Xing; Hang Chu; Ping Li; Naixia Zhang; Yongjun Dang; Xiaojun Xu
Source:
Biochemical and biophysical research communications 2022 pp. -
ISSN:
0006-291X
Subject:
adipose tissue; antibiotics; blood serum; cholesterol; fatty liver; heat-shock protein 90; liver; microarray technology; research; triacylglycerols
Abstract:
... Hepatic steatosis is one of the most important causes of liver disease worldwide. Heat shock protein 90 (HSP90) is essential for numerous client proteins. Recently, more attention was focused on increased HSP90 levels in hepatic steatosis, especially HSP90β. Thus, great efforts have been made to develop HSP90β inhibitors, and most natural inhibitors are derived from microorganisms. In this study, ...
DOI:
10.1016/j.bbrc.2022.07.033

13. An 86 amino acids motif in CAPN3 is essential for formation of the nucleolus-localized Def-CAPN3 complex

Author:
Feng Ding; Delai Huang; Mingyun Wang; Jinrong Peng
Source:
Biochemical and biophysical research communications 2022 v.623 pp. 66-73
ISSN:
0006-291X
Subject:
Danio rerio; biogenesis; cell nucleolus; cysteine proteinases; humans; mitosis; neoplasms; research; ribosomes
Abstract:
... Digestive-organ expansion factor (Def) is a nucleolar protein that recruits cysteine proteinase Calpain3 (CAPN3) into the nucleolus to form the Def-CAPN3 complex in both human and zebrafish. This complex mediates the degradation of the tumor suppressor p53 and ribosome biogenesis factor mitotic phosphorylated protein 10 (Mpp10) in nucleolus, demonstrating the importance of this complex in regulati ...
DOI:
10.1016/j.bbrc.2022.06.032

14. ACSL4 is overexpressed in psoriasis and enhances inflammatory responses by activating ferroptosis

Author:
Le Liu; Xiao-xiao Kang
Source:
Biochemical and biophysical research communications 2022 v.623 pp. 1-8
ISSN:
0006-291X
Subject:
apoptosis; ferroptosis; interleukin-17; interleukin-6; interleukin-8; keratinocytes; psoriasis; regression analysis; research; viability
Abstract:
... More and more studies have shown that ferroptosis is closely related to the progression of various diseases, but the significance of ferroptosis in psoriasis is still rarely explored. The detection of plasma and psoriatic lesions found that the contents of MDA and ROS were significantly increased, while the contents of SOD and GSH were significantly decreased, and the trend of increase or decrease ...
DOI:
10.1016/j.bbrc.2022.07.041

15. ACTL6A deficiency induces apoptosis through impairing DNA replication and inhibiting the ATR-Chk1 signaling in glioblastoma cells

Author:
Xiaosong Hu; Dakun Pei; Mingxin Ci; Guanghui Zhang; Benqin Li; Jie Wang; Yue Shen; Xuan Zhai; Ping Liang; Hongjuan Cui
Source:
Biochemical and biophysical research communications 2022 v.599 pp. 148-155
ISSN:
0006-291X
Subject:
DNA damage; DNA replication; apoptosis; chromatin; death; glioblastoma; humans; research; therapeutics; transcription (genetics)
Abstract:
... Actin-like 6A (ACTL6A) is a core subunit of the SWI/SNF chromatin remodeling complex and is highly expressed in several types of human cancers including glioblastoma. Recent studies verified that ACTL6A regulates the proliferation, differentiation, and migration of cancer cells. In this study, we identified ACTL6A as an important regulator of DNA replication. ACTL6A knockdown could impair the DNA ...
DOI:
10.1016/j.bbrc.2022.01.124

16. ADAMTS8 inhibited lung cancer progression through suppressing VEGFA

Author:
Yutian Zhang; Kang Hu; Ziyi Qu; Zhihong Xie; Fei Tian
Source:
Biochemical and biophysical research communications 2022 v.598 pp. 1-8
ISSN:
0006-291X
Subject:
Western blotting; apoptosis; cell proliferation; epithelial cells; flow cytometry; gene expression regulation; immunohistochemistry; lung neoplasms; lungs; neoplasm cells; neoplasm progression; plasmids; research; survival rate; transfection; xenotransplantation
Abstract:
... ADAMTS8 expression has been identified to be low in many cancers including lung cancer. However, the specific functions and regulatory system of ADAMTS8 remain to be unveiled. To study the potential modulatory mechanism of ADAMTS8 in lung cancer in cell and xenograft mice models. Differential expression of ADAMTS8 in lung cancer was analyzed on online tools. So was the overall survival curve in as ...
DOI:
10.1016/j.bbrc.2022.01.110

17. AMPK increases expression of ATM through transcriptional factor Sp1 and induces radioresistance under severe hypoxia in glioblastoma cell lines

Author:
Takuma Hashimoto; Yusuke Urushihara; Yasuhiko Murata; Yohei Fujishima; Yoshio Hosoi
Source:
Biochemical and biophysical research communications 2022 v.590 pp. 82-88
ISSN:
0006-291X
Subject:
DNA damage; cell cycle; energy; glioblastoma; humans; hypoxia; radiation resistance; research; transcription (genetics); transcription factors
Abstract:
... We have previously reported that severe hypoxia increases expression and activity of the DNA damage sensor ATM by activation of the key energy sensor AMPK. Here, to elucidate molecular mechanisms underlying increased expression and activity of ATM by AMPK under severe hypoxia, we investigated roles of transcriptional factors Sp1 and FoxO3a using human glioblastoma cell lines T98G and A172. Severe ...
DOI:
10.1016/j.bbrc.2021.12.076

18. ASPP2 reduction attenuates HBV induced chronic liver damage: A hybrid mouse model study

Author:
Yang Wang; Yang Che; ShanShan Wang; JinMing Wang; Xiaoni Liu; Buxin Kou; Yuanyue Guan; Dexi Chen; Ying Shi
Source:
Biochemical and biophysical research communications 2022 v.610 pp. 61-69
ISSN:
0006-291X
Subject:
Hepatitis B virus; Western blotting; apoptosis; autophagy; blood serum; eosin; humans; hybrids; immune system; immunohistochemistry; inflammation; innate immunity; liver; metabolism; mice; necrosis; progeny; research; transcriptome; transcriptomics
Abstract:
... P53 Apoptosis Stimulating Protein 2 (ASPP2) is confirmed to participate in cellular activities including apoptosis, proliferation, autophagy, injury and so on. However, the role of ASPP2 in Hepatitis B virus (HBV) infection has not been reported in detail. The study explored the role of ASPP2 in HBV induced chronic liver damage. Transcriptome profiling of ASPP2-konckdown mouse liver were analyzed ...
DOI:
10.1016/j.bbrc.2022.03.109

19. AT7519 against lung cancer via the IL6/STAT3 signaling pathway

Author:
Feng Zhou; Fanyun Zhu; Tianru Zhu; Zhucheng Zhao; Luyao Li; Shichong Lin; Haiyang Zhao; Lehe Yang; Chengguang Zhao; Liangxing Wang; Jifa Li; Xiaoying Huang
Source:
Biochemical and biophysical research communications 2022 v.609 pp. 31-38
ISSN:
0006-291X
Subject:
apoptosis; caspase-3; cell cycle; cell viability; cyclin-dependent kinase; flow cytometry; lung neoplasms; models; mortality; research; signal transduction; tetrazolium; transactivators; xenotransplantation
Abstract:
... Lung cancer is a part of the commonest malignancies with the highest mortality rate in cancer-related deaths worldwide. Signal transducer and activator of transcription 3 (STAT3) and cyclin-dependent kinases (CDKs) are promising prognostic marker and therapeutic target in cancers. Our previous study has demonstrated the closely relationship between CDK9 and STAT3 in lung cancer. The inhibition of ...
DOI:
10.1016/j.bbrc.2022.03.147

20. ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors

Author:
Yalin Tong; Jinbei Li; Mengle Peng; Qilan Qian; Wen Shi; Zefeng Chen; Bin Liu
Source:
Biochemical and biophysical research communications 2022 v.594 pp. 146-152
ISSN:
0006-291X
Subject:
DNA damage; adenosinetriphosphatase; androgens; cell proliferation; colorectal neoplasms; estrogens; mutagens; neoplasm cells; neoplasm progression; research; transcription (genetics); ubiquitin; ubiquitin-protein ligase
Abstract:
... ATPase family AAA domain-containing protein 2 (ATAD2) is highly expressed in a variety of cancer types, and acts as a co-activator of androgen and estrogen receptors, as well as MYC and E2F transcription factors, to promote tumor cell proliferation. However, the regulation of ATAD2 and its related mechanisms are still elusive. Here, we show that ATAD2 protein was stabilized during DNA damage respo ...
DOI:
10.1016/j.bbrc.2022.01.036