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You searched for: Journal name Biochemical and biophysical research communications Remove constraint Journal name: Biochemical and biophysical research communications
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1. (+)-Borneol suppresses conditioned fear recall and anxiety-like behaviors in mice

Author:
Bo Cao; Huan-Yu Ni; Jun Li; Ying Zhou; Xin-Lan Bian; Yan Tao; Cheng-Yun Cai; Cheng Qin; Hai-Yin Wu; Lei Chang; Chun-Xia Luo; Dong-Ya Zhu
Source:
Biochemical and biophysical research communications 2018 v.495 no.2 pp. 1588-1593
ISSN:
0006-291X
Subject:
Artemisia; Dipterocarpaceae; Oriental traditional medicine; anesthesia; antagonists; anxiety; drugs; elevated plus-maze test; fearfulness; hippocampus; monoterpenoids; pain; research; synaptic transmission
Abstract:
... Fear- and anxiety-related psychiatric disorders have been one of the major chronic diseases afflicting patients for decades, and new compounds for treating such disorders remain to be developed. (+)-Borneol, a bicyclic monoterpene found in several species of Artemisia and Dipterocarpaceae, is widely used for anxiety, pain and anesthesia in Chinese medicine. Meanwhile, it can potentiate GABA (γ-ami ...
DOI:
10.1016/j.bbrc.2017.12.025

2. (+)-Nootkatone inhibits tumor necrosis factor α/interferon γ-induced production of chemokines in HaCaT cells

Author:
Hyeon-Jae Choi; Jin-Hwee Lee; Yi-Sook Jung
Source:
Biochemical and biophysical research communications 2014 v.447 pp. 278-284
ISSN:
0006-291X
Subject:
Cyperus rotundus; IKappaB kinase; atopic dermatitis; cell movement; chemokine CCL17; chemokine CCL22; interferon-gamma; messenger RNA; mitogen-activated protein kinase; protein kinase C; signal transduction; thymus gland; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Chemokines are important mediators of cell migration, and thymus and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22) are well-known typical inflammatory chemokines involved in atopic dermatitis (AD). (+)-Nootkatone is the major component of Cyperus rotundus. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. The purpose of this ...
DOI:
10.1016/j.bbrc.2014.03.121

3. (+)-Sesamin, a sesame lignan, is a potent inhibitor of gut bacterial tryptophan indole-lyase that is a key enzyme in chronic kidney disease pathogenesis

Author:
Daiki Oikawa; Satoshi Yamashita; Seiji Takahashi; Toshiyuki Waki; Koichi Kikuchi; Takaaki Abe; Takane Katayama; Toru Nakayama
Source:
Biochemical and biophysical research communications 2022 v.590 pp. 158-162
ISSN:
0006-291X
Subject:
Escherichia coli; active sites; dietary supplements; enzymes; intestines; kidney diseases; kidneys; lignans; mice; morbidity; pathogenesis; phytochemicals; pyridoxal; research; sulfates; therapeutics; toxins; tryptophan
Abstract:
... The progression of chronic kidney disease (CKD) increases the risks of cardiovascular morbidity and end-stage kidney disease. Indoxyl sulfate (IS), which is derived from dietary l-tryptophan by the action of bacterial l-tryptophan indole-lyase (TIL) in the gut, serves as a uremic toxin that exacerbates CKD-related kidney disorder. A mouse model previously showed that inhibition of TIL by 2-aza-l-t ...
DOI:
10.1016/j.bbrc.2021.12.088

4. (-)-Epigallocatechin-3-gallate stimulates myogenic differentiation through TAZ activation

Author:
A Rum Kim; Kyung Min Kim; Mi Ran Byun; Jun-Ha Hwang; Jung Il Park; Ho Taek Oh; Mi Gyeong Jeong; Eun Sook Hwang; Jeong-Ho Hong
Source:
Biochemical and biophysical research communications 2017 v.486 pp. 378-384
ISSN:
0006-291X
Subject:
cytosol; dephosphorylation; genetic markers; green tea; muscle development; muscles; myosin heavy chains; transcription (genetics)
Abstract:
... Muscle loss is a typical process of aging. Green tea consumption is known to slow down the progress of aging. Their underlying mechanisms, however, remain largely unknown. In this study, we investigated the effect of (-)-epigallocatechin-3-gallate (EGCG), a polyphenolic compound of green tea, on myogenic differentiation and found that EGCG significantly increases myogenic differentiation. After EG ...
DOI:
10.1016/j.bbrc.2017.03.049

5. (2S)-7,4′-dihydroxy-8-prenylflavan stimulates adipogenesis and glucose uptake through p38MAPK pathway in 3T3-L1 cells

Author:
Jun Ji; Jingjie Zhu; Xiao Hu; Ting Wang; Xiaodong Zhang; Ai-Jun Hou; Heyao Wang
Source:
Biochemical and biophysical research communications 2015 v.460 pp. 578-582
ISSN:
0006-291X
Subject:
Western blotting; adipogenesis; adiponectin; adipose tissue; genes; glucose; glucose transporters; lipids; mitogen-activated protein kinase; noninsulin-dependent diabetes mellitus; obesity; quantitative polymerase chain reaction; tumor necrosis factor-alpha
Abstract:
... Adipose tissue plays a key role in the development of obesity and diabetes. Natural products are one of the main sources for discovering new lead compounds. In the present study, (2S)-7,4′-dihydroxy-8-prenylflavan (DHPF), a natural prenylated flavan isolated from Morus yunnanensis, was found to significantly promote adipogenesis and increase glucose uptake in 3T3-L1 cells. Real-time PCR results sh ...
DOI:
10.1016/j.bbrc.2015.03.072

6. (EX-4)2-Fc, an effective long-acting GLP-1 receptor agonist, reduces obesity-related inflammation by inhibiting leptin expression

Author:
Bailing Zhou; Chunyan Dong; Binyan Zhao; Xiaoqing Su; Yi Luo; Li Xie; Yaomei Tian; Rui Zhang; Li Yang
Source:
Biochemical and biophysical research communications 2020 v.529 no.3 pp. 562-568
ISSN:
0006-291X
Subject:
adipocytes; adipose tissue; agonists; cytokines; drugs; fatty liver; glucagon-like peptide 1; glucose tolerance; immunity; inflammation; leptin; macrophages; mitogen-activated protein kinase; noninsulin-dependent diabetes mellitus; obesity; research; transcription factor NF-kappa B
Abstract:
... Obesity has been recognized as a low-grade, chronic inflammatory disease that leads to an increase in obesity-associated disorders, including type 2 diabetes (T2D), fatty liver diseases and cancer. Glucagon-like peptide-1 (GLP-1) is an effective drug for T2D, and it not only has glucose-regulating effects but also has anti-inflammatory effects in obesity. In our previous study, we designed a novel ...
DOI:
10.1016/j.bbrc.2020.06.054

7. (Neuro)degenerated Mitochondria-ER contacts

Author:
Agnese De Mario; Rubén Quintana-Cabrera; Denis Martinvalet; Marta Giacomello
Source:
Biochemical and biophysical research communications 2017 v.483 pp. 1096-1109
ISSN:
0006-291X
Subject:
neoplasms; neurodegenerative diseases; neurons; reticulum; stress response
Abstract:
... In the last years, a considerable amount of experimental evidence has highlighted the association between neurodegenerative disorders (NDD) and the biology of mitochondria-Endoplasmic Reticulum contacts (MERCs). In this review, we summarize the most recent findings on this topic. We underline that dysregulation of MERCs can contribute to the neurodegenerative process either by altering directly th ...
DOI:
10.1016/j.bbrc.2016.07.056

8. (−)-menthol increases excitatory transmission by activating both TRPM8 and TRPA1 channels in mouse spinal lamina II layer

Author:
Yuhui Luo; Wuping Sun; Xiaojin Feng; Xiyuan Ba; Tao Liu; Jing Guo; Lizu Xiao; Jin Jiang; Yue Hao; Donglin Xiong; Changyu Jiang
Source:
Biochemical and biophysical research communications 2019 v.516 no.3 pp. 825-830
ISSN:
0006-291X
Subject:
analgesia; analgesics; antagonists; dose response; median effective concentration; menthol; mice; patch-clamp technique; research; spinal cord; synaptic transmission
Abstract:
... (−)-menthol, a major form of menthol, is one of the most commonly used chemicals. Many studies have demonstrated that (−)-menthol produces analgesic action through peripheral mechanisms which are mainly mediated by activation of TRPM8. Moreover, intrathecal injection of menthol induces analgesia as well. However, the central actions and mechanisms of (−)-menthol remain unclear. Here, we have inves ...
DOI:
10.1016/j.bbrc.2019.06.135

9. 1, 25(OH)2D3-induced interaction of vitamin D receptor with p50 subunit of NF-κB suppresses the interaction between KLF5 and p50, contributing to inhibition of LPS-induced macrophage proliferation

Author:
Dong Ma; Ruo-nan Zhang; Ya Wen; Wei-na Yin; Disi Bai; Guo-ying Zheng; Jin-shui Li; Bin Zheng; Jin-kun Wen
Source:
Biochemical and biophysical research communications 2017 v.482 pp. 366-374
ISSN:
0006-291X
Subject:
anti-inflammatory activity; cell cycle; cell proliferation; cyclins; cytokines; gene expression; inflammation; macrophages; transcription factor NF-kappa B; vitamin D
Abstract:
... KLF5 and nuclear factor κB (NF-κB) regulate cell proliferation and inflammation. Vitamin D signaling through vitamin D receptor (VDR) exerts anti-proliferative and anti-inflammatory actions. However, an actual relationship between KLF5, NF-κB and VDR in the inflammation and proliferation of macrophages is still unclear. Here, we showed that LPS and proinflammatory cytokines stimulate KLF5 gene exp ...
DOI:
10.1016/j.bbrc.2016.11.069

10. 1,2-Dilinoleoyl-sn-glycero-3-phosphocholine increases insulin sensitivity in palmitate-treated myotubes and induces lipolysis in adipocytes

Author:
Jinwoo Park; Tae Woo Jung; Yoon Hee Chung; Eon Sub Park; Ji Hoon Jeong
Source:
Biochemical and biophysical research communications 2020 v.533 no.1 pp. 162-167
ISSN:
0006-291X
Subject:
adipocytes; adipose tissue; apoptosis; inflammation; insulin; insulin resistance; lipolysis; muscles; myotubes; noninsulin-dependent diabetes mellitus; obesity; phosphatidylcholines; research
Abstract:
... Obesity causes the development of insulin resistance and type 2 diabetes. Phosphatidylcholine (PPC) has been reported to increase hepatic insulin sensitivity and lipolysis in adipose tissue to resolve local obesity. In this study, we proposed 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC), the main active species of PPC, as an effective substance for the treatment of obesity-mediated disorders ...
DOI:
10.1016/j.bbrc.2020.09.019

11. 1,25(OH)2D3 attenuates TGF-β1/β2-induced increased migration and invasion via inhibiting epithelial–mesenchymal transition in colon cancer cells

Author:
Shanwen Chen; Jing Zhu; Shuai Zuo; Ju Ma; Junling Zhang; Guowei Chen; Xin Wang; Yisheng Pan; Yucun Liu; Pengyuan Wang
Source:
Biochemical and biophysical research communications 2015 v.468 pp. 130-135
ISSN:
0006-291X
Subject:
actin; cadherins; calcitriol; colorectal neoplasms; neoplasm cells; secretion; transcription factors
Abstract:
... 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) has been reported to inhibit proliferation and migration of multiple types of cancer cells. However, the mechanism underlying its anti-metastasis effect is not fully illustrated. In this study, the effect of 1,25(OH)2D3 on TGF-β1/β2-induced epithelial–mesenchymal transition (EMT) is tested in colon cancer cells. The results suggest that 1,25(OH)2D3 inhibited ...
DOI:
10.1016/j.bbrc.2015.10.146

12. 1,25-(OH)2-vitamin D3 prevents activation of hepatic stellate cells in vitro and ameliorates inflammatory liver damage but not fibrosis in the Abcb4−/− model

Author:
Florian P. Reiter; Simon Hohenester; Jutta M. Nagel; Ralf Wimmer; Renate Artmann; Lena Wottke; Marie-Christine Makeschin; Doris Mayr; Christian Rust; Michael Trauner; Gerald U. Denk
Source:
Biochemical and biophysical research communications 2015 v.459 no.2 pp. 227-233
ISSN:
0006-291X
Subject:
ABC transporters; actin; alanine transaminase; blood serum; calcitriol; cholecalciferol; disease course; fibrosis; hydroxyproline; immunoblotting; immunohistochemistry; immunomodulation; inflammation; liver; matrix metalloproteinase 13; mechanism of action; mice; models; muscles; necrosis; patients; staining
Abstract:
... Vitamin D3-deficiency is common in patients with chronic liver-disease and may promote disease progression. Vitamin D3-administration has thus been proposed as a therapeutic approach. Vitamin D3 has immunomodulatory effects and may modulate autoimmune liver-disease such as primary sclerosing cholangitis. Although various mechanisms of action have been proposed, experimental evidence is limited.Her ...
DOI:
10.1016/j.bbrc.2015.02.074

13. 1,25-Dihydroxyvitamin D3 induces human myeloid cell differentiation via the mTOR signaling pathway

Author:
Yongjin Kim; Hee Suk Kim; Jeongwon Sohn; Jong Dae Ji
Source:
Biochemical and biophysical research communications 2019 v.519 no.4 pp. 909-915
ISSN:
0006-291X
Subject:
butanol; calcitriol; cell differentiation; humans; phosphatidic acids; rapamycin; research
Abstract:
... 1,25-Dihydroxyvitamin D3 or 1,25(OH)2D3 is known to play an important role in the differentiation of human myeloid cells. However, the molecular mechanism underlying the 1,25(OH)2D3-mediated differentiation of human myeloid cells is incompletely understood. Here, we report that 1,25(OH)2D3 induces differentiation of human myeloid cell lines such as U937 and THP-1 cells via the mammalian target of ...
DOI:
10.1016/j.bbrc.2019.09.100

14. 1,25-Dihydroxyvitamin D3 preserves intestinal epithelial barrier function from TNF-α induced injury via suppression of NF-kB p65 mediated MLCK-P-MLC signaling pathway

Author:
Shanwen Chen; Jing Zhu; Guowei Chen; Shuai Zuo; Junling Zhang; Ziyi Chen; Xin Wang; Junxia Li; Yucun Liu; Pengyuan Wang
Source:
Biochemical and biophysical research communications 2015 v.460 pp. 873-878
ISSN:
0006-291X
Subject:
calcitriol; electrical resistance; epithelium; fluorescent antibody technique; human cell lines; immunoblotting; myosin light chains; occludins; phosphorylation; protective effect; signal transduction; tight junctions; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Substantial studies have demonstrated the protective effect of 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) on intestinal barrier function, but the mechanisms are not fully illustrated. In this study, the effect of 1,25(OH)2D3 on TNF-α induced barrier dysfunction was further investigated in Caco-2 cell monolayers. The barrier function of Caco-2 monolayers was evaluated by measuring trans-epithelial elec ...
DOI:
10.1016/j.bbrc.2015.03.125

15. 1,25-Dyhydroxyvitamin D3 attenuates rotenone-induced neurotoxicity in SH-SY5Y cells through induction of autophagy

Author:
Wooyoung Jang; Hee Ju Kim; Huan Li; Kwang Deog Jo; Moon Kyu Lee; Sun Hong Song; Hyun Ok Yang
Source:
Biochemical and biophysical research communications 2014 v.451 pp. 142-147
ISSN:
0006-291X
Subject:
Parkinson disease; autophagy; calcitriol; cell viability; cholecalciferol; intracellular signaling peptides and proteins; models; neuroprotective effect; neurotoxicity; pathogenesis; propidium; reactive oxygen species; rotenone; signal transduction
Abstract:
... Dysregulation of the autophagy pathway has been suggested as an important mechanism in the pathogenesis of Parkinson’s disease (PD). Therefore, modulation of autophagy may be a novel strategy for the treatment of PD. Recently, an active form of vitamin D3 has been reported to have neuroprotective properties. Therefore, we investigated the protective, autophagy-modulating effects of 1,25-dyhydroxyv ...
DOI:
10.1016/j.bbrc.2014.07.081

16. 1,25-dihydroxyvitamin D₃ impairs NF-κB activation in human naïve B cells

Author:
Kerstin Geldmeyer-Hilt; Guido Heine; Björn Hartmann; Ria Baumgrass; Andreas Radbruch; Margitta Worm
Source:
Biochemical and biophysical research communications 2011 v.407 no.4 pp. 699-702
ISSN:
0006-291X
Subject:
B-lymphocytes; binding sites; bioactive properties; calcitriol; gene expression; genes; humans; immunoglobulin E; interleukin-4; messenger RNA; metabolites; signal transduction; transcription factor NF-kappa B
Abstract:
... 1α,25-dihydroxyvitamin D₃ (calcitriol), the bioactive metabolite of vitamin D, modulates the activation and inhibits IgE production of anti-CD40 and IL-4 stimulated human peripheral B cells. Engagement of CD40 results in NF-κB p50 activation, which is essential for the class switch to IgE. Herein, we investigated by which mechanism calcitriol modulates NF-κB mediated activation of human naïve B ce ...
DOI:
10.1016/j.bbrc.2011.03.078

17. 1-(2,6-Dibenzyloxybenzoyl)-3-(9H-fluoren-9-yl)-urea: A novel cyclophilin A allosteric activator

Author:
Maosheng Lv; Ting Shi; Xiaona Mao; Xi Li; Yingyi Chen; Jin Zhu; Shuaishuai Ni; Xu Shen; Hualiang Jiang; Jian Li; Jian Zhang; Jin Huang
Source:
Biochemical and biophysical research communications 2012 v.425 no.4 pp. 938-943
ISSN:
0006-291X
Subject:
active sites; binding capacity; binding sites; catalytic activity; cyclophilins; mitogen-activated protein kinase; molecular dynamics; mutagenesis; peptidylprolyl isomerase; phosphorylation; physiology; proteolysis; screening
Abstract:
... Cyclophilin A (CypA) plays an important role in many physiology processes and its overexpression has been involved in many diseases including immune disease, viral infection, neuro-degenerative disease, and cancer. However, the actual role of CypA in the diseases is still far from clear, and a complete understanding of CypA is necessary in order to direct more specific and effective therapeutic st ...
DOI:
10.1016/j.bbrc.2012.08.014

18. 1-, 2- and 3-AG as substrates of the endocannabinoid enzymes and endogenous ligands of the cannabinoid receptor 1

Author:
Shrouq I. Farah; Samantha Hilston; Ngan Tran; Nikolai Zvonok; Alexandros Makriyannis
Source:
Biochemical and biophysical research communications 2022 v.591 pp. 31-36
ISSN:
0006-291X
Subject:
acylglycerol lipase; agonists; amide hydrolases; cannabinoid receptors; cannabinoids; enantiomers; fatty acids; hydrolysis; isomerization; ligands; monoacylglycerols; research; serine; stereochemistry
Abstract:
... 2-Arachidonoylglycerol (2-AG) is the most potent and abundant endocannabinoid that acts as a full agonist at the cannabinoid 1 (CB1) and 2 (CB2) receptors. It serves as a substrate for several serine hydrolases, including monoacylglycerol lipase (MGL), α/β hydrolase domain 6 (ABHD6) and fatty acid amide hydrolase (FAAH). However, 2-AG's rapid conversion to 1-AG (the S stereoisomer) and 3-AG (the R ...
DOI:
10.1016/j.bbrc.2021.12.105

19. 1-o-acetylbritannilactone (ABL) inhibits angiogenesis and lung cancer cell growth through regulating VEGF-Src-FAK signaling

Author:
He Zhengfu; Zhang Hu; Miao Huiwen; Li Zhijun; Zhou Jiaojie; Yan Xiaoyi; Cai Xiujun
Source:
Biochemical and biophysical research communications 2015 v.464 pp. 422-427
ISSN:
0006-291X
Subject:
Inula; angiogenesis; cell growth; endothelial cells; growth retardation; humans; lung neoplasms; mice; non-specific protein-tyrosine kinase; therapeutics; vascular endothelial growth factors
Abstract:
... The search for safe, effective and affordable therapeutics against non-small cell lung cancer (NSCLC) and other lung cancers is important. Here we explored the potential effect of 1-o-acetylbritannilactone (ABL), a novel extract from Inula britannica-F, on angiogenesis and lung cancer cell growth. We demonstrated that ABL dose-dependently inhibited vascular endothelial growth factor (VEGF)-induced ...
DOI:
10.1016/j.bbrc.2015.06.126

20. 1-α,25-dihydroxyvitamin D3 potentiates avian osteoclast activation by increasing the formation of zipper-like structure via Src/Rac1 signaling

Author:
Dong Wang; Jian-Hong Gu; Ling-Ling Feng; Xi-Shuai Tong; Rui-Long Song; Hong-Yan Zhao; Jian-Chun Bian; Xue-Zhong Liu; Yan Yuan; Zong-Ping Liu
Source:
Biochemical and biophysical research communications 2018 v.501 no.2 pp. 576-583
ISSN:
0006-291X
Subject:
bone formation; cytoskeleton; medicine; nutrition; osteoclasts; research; steroid hormones
Abstract:
... Avian bone metabolism diseases affect the development and production of chickens, and many of these diseases can be prevented and controlled by balanced nutrition and hormone medicine. The steroid hormone 1α,25-dihydroxyvitamin D3 plays a key role in maintaining the balance of avian bone metabolism. Clinically, 1α,25-(OH)2D3 has been used to treat several bone diseases. Although several previous s ...
DOI:
10.1016/j.bbrc.2018.05.048