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You searched for: Subject "muscular atrophy" Remove constraint Subject: "muscular atrophy" Journal Biochemical and biophysical research communications Remove constraint Journal: Biochemical and biophysical research communications
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1. Muscle fiber-type selective propensity to pathology in the nmd mouse model of SMARD1

Author:
Villalón, Eric; Lee, Naomi N.; Marquez, Jose; Lorson, Christian L.
Source:
Biochemical and biophysical research communications 2019 v.516 no.1 pp. 313-319
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; animal models; disease models; distress; gene expression regulation; genes; mice; motor neurons; muscle fibers; muscles; neurodegenerative diseases; therapeutics; transcriptomics;     Show all 13 Subjects
Abstract:
... Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is an autosomal recessive disease that causes distal limb muscle atrophy, due to motor neuron degeneration. Similar to other motor neuron diseases, SMARD1 shows differential vulnerability to denervation in various muscle groups, which is recapitulated in the nmd mouse, a model of SMARD1. In multiple neurodegenerative disease models, ...
DOI:
10.1016/j.bbrc.2019.06.117

2. New evidence of exercise training benefits in myostatin-deficient mice: Effect on lipidomic abnormalities

Author:
Baati, Narjes; Feillet-Coudray, Christine; Fouret, Gilles; Vernus, Barbara; Goustard, Bénédicte; Jollet, Maxence; Bertrand-Gaday, Christelle; Coudray, Charles; Lecomte, Jérôme; Bonnieu, Anne; Koechlin-Ramonatxo, Christelle
Source:
Biochemical and biophysical research communications 2019 v.516 no.1 pp. 89-95
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; cardiolipins; citrate (si)-synthase; exercise; gene expression regulation; genes; lipid composition; lipid metabolism; mice; mitochondria; mitochondrial membrane; muscle tissues; muscles; myostatin; protein content;     Show all 15 Subjects
Abstract:
... Myostatin (Mstn) inactivation or inhibition is considered as a promising treatment for various muscle-wasting disorders because it promotes muscle growth. However, myostatin-deficient hypertrophic muscles show strong fatigability associated with abnormal mitochondria and lipid metabolism. Here, we investigated whether endurance training could improve lipid metabolism and mitochondrial membrane lip ...
DOI:
10.1016/j.bbrc.2019.06.014

3. Interaction between alpha-COP and SMN ameliorates disease phenotype in a mouse model of spinal muscular atrophy

Author:
Custer, Sara K.; Astroski, Jacob W.; Li, Hong Xia; Androphy, Elliot J.
Source:
Biochemical and biophysical research communications 2019 v.514 no.2 pp. 530-537
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; animal models; brain; exons; gene expression; genetically modified organisms; mice; muscles; mutants; neurites; phenotype; protein content; skeletal muscle; spinal cord; stem cells; testes; therapeutics;     Show all 17 Subjects
Abstract:
... We report that expression of the α-COP protein rescues disease phenotype in a severe mouse model of Spinal Muscular Atrophy (SMA). Lentiviral particles expressing α-COP were injected directly into the testes of genetically pure mouse strain of interest resulting in infection of the spermatagonial stem cells. α-COP was stably expressed in brain, skeletal muscle, and spinal cord without altering SMN ...
DOI:
10.1016/j.bbrc.2019.04.176

4. Constant light exposure aggravates POMC-mediated muscle wasting associated with hypothalamic alteration of circadian clock and SIRT1 in endotoxemia rats

Author:
Chen, Yan; Cheng, Minhua; Su, Ting; Gao, Tao; Yu, Wenkui
Source:
Biochemical and biophysical research communications 2019 v.508 no.3 pp. 811-817
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; adults; circadian clocks; circadian rhythm; cytokines; endotoxemia; genes; hypothalamus; lipopolysaccharides; males; metabolic diseases; muscles; neuropeptides; patients; photoperiod; pro-opiomelanocortin; prognosis; rats; skeletal muscle; sleep disorders; tyrosine;     Show all 21 Subjects
Abstract:
... Constant light exposure is widespread in the intensive care unit (ICU) and could increase the rate of brain dysfunction as delirium and sleep disorders in critical patients. And the activation of hypothalamic neuropeptides is proved to play a crucial role in regulating hypercatabolism, especially skeletal muscle wasting in critical patients, which could lead to serious complications and poor progn ...
DOI:
10.1016/j.bbrc.2018.12.020

5. Effect of skeletal muscle phenotype and gender on fasting-induced myokine expression in mice

Author:
Jia, Wei-hua; Wang, Nuo-qi; Yin, Lin; Chen, Xi; Hou, Bi-yu; Qiang, Gui-fen; Chan, Chi Bun; Yang, Xiu-ying; Du, Guan-hua
Source:
Biochemical and biophysical research communications 2019 v.514 no.2 pp. 407-414
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; databases; fasting; females; gender differences; gene expression; genetic markers; interleukin-6; males; metabolism; mice; muscle development; muscle fibers; muscles; peroxisome proliferator-activated receptor alpha; peroxisome proliferator-activated receptor gamma; phenotype; sequence analysis; skeletal muscle;     Show all 19 Subjects
Abstract:
... Skeletal muscle secretes myokines, which are involved in metabolism and muscle function regulation. The role of fasting on myokine expression in skeletal muscle is largely unknown. In this study, we used gastrocnemius skeletal muscle RNA sequencing data from fasting male mice in the Gene Expression Omnibus (GEO) database. Adopted male and female C57BL/6J mice that fasted for 24 h were included to ...
DOI:
10.1016/j.bbrc.2019.04.155

6. Neuromuscular electrical stimulation improves muscle atrophy induced by chronic hypoxia-hypercapnia through the MicroRNA-486/PTEN/FoxO1 pathway

Author:
Shen, Jie; Nie, Xue; Huang, Shi-Yuan; Qin, Yan-Qing; Pan, Lu-Lu; Wang, Xiao-Tong
Source:
Biochemical and biophysical research communications 2019 v.509 no.4 pp. 1021-1027
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; Western blotting; electrical treatment; immunohistochemistry; laboratory animals; males; muscle protein; muscles; protein content; protein synthesis; quantitative polymerase chain reaction; rats; respiratory tract diseases; reverse transcriptase polymerase chain reaction; skeletal muscle; staining; therapeutics; tumor necrosis factor-alpha;     Show all 18 Subjects
Abstract:
... Previous work has confirmed that the chronic hypoxia-hypercapnia (CHH) associated with chronic obstructive pulmonary disease contributes to the development of skeletal muscle atrophy. Neuromuscular Electrical Stimulation (NMES) has shown some efficacy when used as a treatment to reduce skeletal muscle atrophy. The present study focuses on the MicroRNA-486/PTEN/FoxO1 pathway with the goal of identi ...
DOI:
10.1016/j.bbrc.2018.12.147

7. Morin suppresses cachexia-induced muscle wasting by binding to ribosomal protein S10 in carcinoma cells

Author:
Yoshimura, Tomohiro; Saitoh, Kanae; Sun, Luchuanyang; Wang, Yao; Taniyama, Shigeto; Yamaguchi, Kenichi; Uchida, Takayuki; Ohkubo, Tsutomu; Higashitani, Atsushi; Nikawa, Takeshi; Tachibana, Katsuyasu; Hirasaka, Katsuya
Source:
Biochemical and biophysical research communications 2018 v.506 no.4 pp. 773-779
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; cachexia; cell viability; daidzein; diet; energy; genistein; lung neoplasms; magnetism; mice; muscles; myotubes; neoplasm cells; patients; ribosomal proteins;     Show all 15 Subjects
Abstract:
... Cachexia, observed in most cancer patients, is a syndrome that includes wasting of bodily energy reserves and is characterized by muscle atrophy and fat loss. We have previously demonstrated that isoflavones, such as genistein and daidzein, prevent muscle wasting in tumor-bearing mice. In this study, we examined the effect of morin, a flavonoid, on cachexia. The wet weight and myofiber size of mus ...
DOI:
10.1016/j.bbrc.2018.10.184

8. Adipose tissue browning in cancer-associated cachexia can be attenuated by inhibition of exosome generation

Author:
Hu, Wenjun; Ru, Zeyuan; Xiao, Wen; Xiong, Zhiyong; Wang, Cheng; Yuan, Changfei; Zhang, Xiaoping; Yang, Hongmei
Source:
Biochemical and biophysical research communications 2018 v.506 no.1 pp. 122-129
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; adipocytes; adipose tissue; cachexia; enzyme inhibitors; exosomes; lipolysis; lung neoplasms; mice; neoplasm cells; skeletal muscle; weight loss;     Show all 12 Subjects
Abstract:
... Cancer-associated cachexia (CAC) is a disorder characterized by unintended weight loss due to skeletal muscle wasting and adipose tissue loss. Although muscle atrophy in this condition has been well studied, the mechanisms underlying adipose tissue loss, which include browning, have not been investigated in detail. In this respect, though recent studies have shown that exosomes from cancer cells c ...
DOI:
10.1016/j.bbrc.2018.09.139

9. Glucocorticoid-induced CREB activation and myostatin expression in C2C12 myotubes involves phosphodiesterase-3/4 signaling

Author:
Xie, Yang; Perry, Ben D.; Espinoza, Daniel; Zhang, Peng; Price, S. Russ
Source:
Biochemical and biophysical research communications 2018 v.503 no.3 pp. 1409-1414
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; cAMP-dependent protein kinase; dexamethasone; diabetes; insulin; kidney diseases; messenger RNA; myostatin; myotubes; phosphorylation; quantitative polymerase chain reaction; transcription factors;     Show all 12 Subjects
Abstract:
... Muscle atrophy in metabolic conditions like chronic kidney disease (CKD) and diabetes are associated with glucocorticoid production, dysfunctional insulin/Akt/FoxO3 signaling and increased myostatin expression. We recently found that CREB, a transcription factor proposed to regulate myostatin expression, is highly phosphorylated in some wasting conditions. Based on a novel Akt-PDE3/4 signaling par ...
DOI:
10.1016/j.bbrc.2018.07.056

10. Myostatin inhibits eEF2K-eEF2 by regulating AMPK to suppress protein synthesis

Author:
Deng, Zhao; Luo, Pei; Lai, Wen; Song, Tongxing; Peng, Jian; Wei, Hong-Kui
Source:
Biochemical and biophysical research communications 2017
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; myostatin; myotubes; protein synthesis; recombinant proteins; skeletal muscle; transforming growth factor beta;     Show all 7 Subjects
Abstract:
... Growth of skeletal muscle is dependent on the protein synthesis, and the rate of protein synthesis is mainly regulated in the stage of translation initiation and elongation. Myostatin, a member of the transforming growth factor-β (TGF-β) superfamily, is a negative regulator of protein synthesis. C2C12 myotubes was incubated with 0, 0.01, 0.1, 1, 2, 3 μg/mL myostatin recombinant protein, and then w ...
DOI:
10.1016/j.bbrc.2017.10.040

11. Tribbles 3 regulates protein turnover in mouse skeletal muscle

Author:
Choi, Ran Hee; McConahay, Abigail; Jeong, Ha-Won; McClellan, Jamie L.; Hardee, Justin P.; Carson, James A.; Hirshman, Michael F.; Goodyear, Laurie J.; Koh, Ho-Jin
Source:
Biochemical and biophysical research communications 2017
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; genetically modified organisms; knockout mutants; mice; muscles; protein degradation; protein synthesis; skeletal muscle;     Show all 8 Subjects
Abstract:
... Skeletal muscle atrophy is associated with a disruption in protein turnover involving increased protein degradation and suppressed protein synthesis. Although it has been well studied that the IGF-1/PI3K/Akt pathway plays an essential role in the regulation of the protein turnover, molecule(s) that triggers the change in protein turnover still remains to be elucidated. TRB3 has been shown to inhib ...
DOI:
10.1016/j.bbrc.2017.09.134

12. Resveratrol attenuates skeletal muscle atrophy induced by chronic kidney disease via MuRF1 signaling pathway

Author:
Sun, Li-Jing; Sun, Yan-Ni; Chen, Shun-Jie; Liu, Shuang; Jiang, Geng-Ru
Source:
Biochemical and biophysical research communications 2017 v.487 pp. 83-89
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; developmental stages; kidney diseases; models; myotubes; phosphorylation; resveratrol; signal transduction; skeletal muscle; transcription factor NF-kappa B;     Show all 10 Subjects
Abstract:
... Skeletal muscle atrophy is an important clinical characteristic of chronic kidney disease (CKD); however, at present, the therapeutic approaches to muscle atrophy induced by CKD are still at an early stage of development. Resveratrol is used to attenuate muscle atrophy in other experimental models, but the effects on a CKD model are largely unknown. Here, we showed that resveratrol prevented an in ...
DOI:
10.1016/j.bbrc.2017.04.022

13. Microgravity influences maintenance of the human muscle stem/progenitor cell pool

Author:
Hosoyama, Tohru; Ichida, Shunji; Kanno, Masatsugu; Ishihara, Reiichi; Hatashima, Toshikatsu; Ueno, Koji; Hamano, Kimikazu
Source:
Biochemical and biophysical research communications 2017
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; apoptosis; humans; microgravity; mitogen-activated protein kinase; muscles; myotubes; phosphorylation; proteasome inhibitors; skeletal muscle; stem cells;     Show all 11 Subjects
Abstract:
... Microgravity induces skeletal muscle atrophy; however, the underlying mechanism is not clarified. In particular, the influence of microgravity on human skeletal muscle stem/progenitor cells (SMPCs) is not well understood. In this study, we used induced pluripotent stem cell-derived human SMPCs to investigate the effect of microgravity on maintenance of the stem/progenitor cell pool. Human SMPCs we ...
DOI:
10.1016/j.bbrc.2017.09.103

14. Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development

Author:
Van Alstyne, Meaghan; Lotti, Francesco; Dal Mas, Andrea; Area-Gomez, Estela; Pellizzoni, Livio
Source:
Biochemical and biophysical research communications 2018 v.506 no.3 pp. 463-470
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; Danio rerio; Drosophila; animal models; axons; childhood; embryo (animal); embryogenesis; endoplasmic reticulum; fractionation; knockout mutants; larvae; mass spectrometry; mice; microscopy; mitochondria; mitochondrial membrane; neurodegenerative diseases; phenotype; physiological transport; precipitin tests; transmembrane proteins;     Show all 22 Subjects
Abstract:
... Stasimon (also known as Tmem41b) is an evolutionarily conserved transmembrane protein first identified for its contribution to motor system dysfunction in animal models of the childhood neurodegenerative disease spinal muscular atrophy (SMA). Stasimon was shown to be required for normal neurotransmission in the motor circuit of Drosophila larvae and proper development of motor axons in zebrafish e ...
DOI:
10.1016/j.bbrc.2018.10.073

15. Conformational modulation mediated by polyglutamine expansion in CAG repeat expansion disease-associated proteins

Author:
Verani, Margherita; Bustamante, Maria; Martufi, Paola; Daldin, Manuel; Cariulo, Cristina; Azzollini, Lucia; Fodale, Valentina; Puglisi, Francesca; Weiss, Andreas; Macdonald, Douglas; Petricca, Lara; Caricasole, Andrea
Source:
Biochemical and biophysical research communications 2016 v.478 no.2 pp. 949-955
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; androgen receptors; antibodies; ataxia (disorder); binding proteins; epitopes; immunoassays;     Show all 7 Subjects
Abstract:
... We have previously reported TR-FRET based immunoassays to detect a conformational change imparted on huntingtin protein by the polyglutamine expansion, which we confirmed using biophysical methodologies. Using these immunoassays, we now report that polyglutamine expansion influences the conformational properties of other polyglutamine disease proteins, exemplified by the androgen receptor (associa ...
DOI:
10.1016/j.bbrc.2016.08.057

16. Ibandronate concomitantly blocks immobilization-induced bone and muscle atrophy

Author:
Watanabe, Ryuichi; Fujita, Nobuyuki; Takeda, Satoshi; Sato, Yuiko; Kobayashi, Tami; Morita, Mayu; Oike, Takatsugu; Miyamoto, Kana; Matsumoto, Yoshihiro; Matsumoto, Morio; Nakamura, Masaya; Miyamoto, Takeshi
Source:
Biochemical and biophysical research communications 2016 v.480 pp. 662-668
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; animal models; blood serum; bone resorption; drugs; muscles; proteasome endopeptidase complex; skeletal muscle; starvation; ubiquitin;     Show all 10 Subjects
Abstract:
... Both bone and muscle volume is concomitantly reduced under immobilization conditions; however, no single drug is currently available to block these outcomes simultaneously. Bisphosphonates are utilized clinically to inhibit osteoclast-dependent bone resorption, but their effects on muscle are largely unknown. Here we show that skeletal muscle is a direct target of the bisphosphonate ibandronate (I ...
DOI:
10.1016/j.bbrc.2016.10.112

17. Placental development in a mouse model of spinal muscular atrophy

Author:
Van Gronigen Caesar, Gerialisa; Dale, Jeffrey M.; Osman, Erkan Y.; Garcia, Michael L.; Lorson, Christian L.; Schulz, Laura C.
Source:
Biochemical and biophysical research communications 2016 v.470 no.1 pp. 82-87
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; animal models; birth weight; diet; fetal development; genes; infants; mice; mothers; motor neurons; nutrients; placenta; pups; transcription factors;     Show all 14 Subjects
Abstract:
... Spinal Muscular Atrophy (SMA) is an autosomal recessive disorder, leading to fatal loss of motor neurons. It is caused by loss of function of the SMN gene, which is expressed throughout the body, and there is increasing evidence of dysfunction in non-neuronal tissues. Birthweight is one of most powerful prognostic factors for infants born with SMA, and intrauterine growth restriction is common. In ...
DOI:
10.1016/j.bbrc.2015.12.120
PubMed:
26748185
PubMed Central:
PMC4755490

18. G7731A mutation in mouse mitochondrial tRNALys regulates late-onset disorders in transmitochondrial mice

Author:
Shimizu, Akinori; Mito, Takayuki; Hashizume, Osamu; Yonekawa, Hiromichi; Ishikawa, Kaori; Nakada, Kazuto; Hayashi, Jun-Ichi
Source:
Biochemical and biophysical research communications 2015 v.459 pp. 66-70
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; acidosis; anemia; body length; genes; mice; mitochondria; mitochondrial DNA; models; muscles; mutation; patients;     Show all 12 Subjects
Abstract:
... We previously generated mito-mice-tRNALys7731 as a model for primary prevention of mitochondrial diseases. These mice harbour a G7731A mtDNA mutation in the tRNALys gene, but express only muscle weakness and short body length by four months. Here, we examined the effects of their aging on metabolic and histologic features. Unlike young mito-mice-tRNALys7731, aged mito-mice-tRNALys7731 developed mu ...
DOI:
10.1016/j.bbrc.2015.02.070

19. Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders

Author:
Mito, Takayuki; Ishizaki, Hikari; Suzuki, Michiko; Morishima, Hitomi; Ota, Azusa; Ishikawa, Kaori; Nakada, Kazuto; Maeno, Akiteru; Shiroishi, Toshihiko; Hayashi, Jun-Ichi
Source:
Biochemical and biophysical research communications 2015 v.456 pp. 933-937
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; animal models; elderly; mice; mitochondria; mitochondrial DNA; osteoporosis; phenotype;     Show all 8 Subjects
Abstract:
... The spectra of phenotypes associated with aging and mitochondrial diseases sometimes appear to overlap with each other. We used aged mice and a mouse model of mitochondrial diseases (transmitochondrial mito-miceΔ with deleted mtDNA) to study whether premature aging phenotypes observed in mtDNA mutator mice are associated with aging or mitochondrial diseases. Here, we provide convincing evidence th ...
DOI:
10.1016/j.bbrc.2014.12.009

20. ALDH2 restores exhaustive exercise-induced mitochondrial dysfunction in skeletal muscle

Author:
Zhang, Qiuping; Zheng, Jianheng; Qiu, Jun; Wu, Xiahong; Xu, Yangshuo; Shen, Weili; Sun, Mengwei
Source:
Biochemical and biophysical research communications 2017
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; acetaldehyde; aldehyde dehydrogenase; antioxidants; autophagy; biogenesis; biomarkers; cardioprotective effect; exercise; heart; ischemia; males; messenger RNA; mice; mitochondria; oxidative stress; proteins; skeletal muscle; superoxide dismutase; toxicity; transgenic animals;     Show all 21 Subjects
Abstract:
... Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is highly expressed in heart and skeletal muscles, and is the major enzyme that metabolizes acetaldehyde and toxic aldehydes. The cardioprotective effects of ALDH2 during cardiac ischemia/reperfusion injury have been recognized. However, less is known about the function of ALDH2 in skeletal muscle. This study was designed to evaluate the effect of ALD ...
DOI:
10.1016/j.bbrc.2017.02.124

21. Mild hypothermia ameliorates muscle wasting in septic rats associated with hypothalamic AMPK-induced autophagy and neuropeptides

Author:
Cao, Chun; Gao, Tao; Cheng, Minhua; Xi, Fengchan; Zhao, Chenyan; Yu, Wenkui
Source:
Biochemical and biophysical research communications 2017
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; adults; anesthesia; autophagy; cocaine; gene expression; genes; hypothalamus; hypothermia; lipopolysaccharides; males; messenger RNA; mortality; muscles; neuropeptides; patients; pro-opiomelanocortin; prognosis; protective effect; rats; sepsis (infection); skeletal muscle; tyrosine;     Show all 23 Subjects
Abstract:
... Sepsis, always developing muscle wasting, contributes to serious complications and mortality. Mild hypothermia has been reported to have protective effects on the prognosis of septic patients. However, the underlying mechanisms remain unclear. We therefore hypothesized that mild hypothermia could ameliorate muscle wasting during sepsis and whether it was associated with hypothalamus AMPK-induced a ...
DOI:
10.1016/j.bbrc.2017.06.135

22. TLR2 deficiency attenuates skeletal muscle atrophy in mice

Author:
Kim, Dae-Sung; Cha, Hye-Na; Jo, Hye Jun; Song, In-Hwan; Baek, Suk-Hwan; Dan, Jin-Myoung; Kim, Yong-Woon; Kim, Jong-Yeon; Lee, In-Kyu; Seo, Jae-Sung; Park, So-Young
Source:
Biochemical and biophysical research communications 2015 v.459 pp. 534-540
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; Toll-like receptor 2; genes; inflammation; interleukin-6; mice; muscles; oxidative stress; phosphorylation; skeletal muscle; weight loss;     Show all 11 Subjects
Abstract:
... Oxidative stress and inflammation are associated with skeletal muscle atrophy. Because the activation of toll-like receptor (TLR) 2 induces oxidative stress and inflammation, TLR2 may be directly linked to skeletal muscle atrophy. This study examined the role of TLR2 in skeletal muscle atrophy in wild-type (WT) and TLR2 knockout (KO) mice. Immobilization for 2 weeks increased the expression of cyt ...
DOI:
10.1016/j.bbrc.2015.02.144

23. β-Hydroxy-β-methylbutyrate (HMB) prevents dexamethasone-induced myotube atrophy

Author:
Aversa, Zaira; Alamdari, Nima; Castillero, Estibaliz; Muscaritoli, Maurizio; Fanelli, Filippo Rossi; Hasselgren, Per-Olof
Source:
Biochemical and biophysical research communications 2012 v.423 no.4 pp. 739-743
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; dexamethasone; glucocorticoids; muscles; protein degradation; protein synthesis;     Show all 6 Subjects
Abstract:
... High levels of glucocorticoids result in muscle wasting and weakness. β-hydroxy-β-methylbutyrate (HMB) attenuates the loss of muscle mass in various catabolic conditions but the influence of HMB on glucocorticoid-induced muscle atrophy is not known. We tested the hypothesis that HMB prevents dexamethasone-induced atrophy in cultured myotubes. Treatment of cultured L6 myotubes with dexamethasone re ...
DOI:
10.1016/j.bbrc.2012.06.029
PubMed:
22705301
PubMed Central:
PMC3399026

24. Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle

Author:
Khayrullin, Andrew; Smith, Lauren; Mistry, Dhwani; Dukes, Amy; Pan, Y. Albert; Hamrick, Mark W.
Source:
Biochemical and biophysical research communications 2016 v.479 pp. 590-595
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; Danio rerio; adults; alcohol abuse; antagonists; ethanol; fish; humans; mice; microRNA; microarray technology; models; muscle development; muscle fibers; muscles; muscular diseases; polymerase chain reaction; sequence homology; signal transduction; skeletal muscle;     Show all 20 Subjects
Abstract:
... Muscle wasting is estimated to affect 40–60% of alcoholics, and is more common than cirrhosis among chronic alcohol abusers. The molecular and cellular mechanisms underlying alcohol-related musculoskeletal dysfunction are, however, poorly understood. Muscle-specific microRNAs (miRNAs) referred to as myoMirs are now known to play a key role in both myogenesis and muscle atrophy. Yet, no studies hav ...
DOI:
10.1016/j.bbrc.2016.09.117

25. Comparative decline of the protein profiles of nebulin in response to denervation in skeletal muscle

Author:
Wei, Jih-Hua; Chang, Nen-Chung; Chen, Sy-Ping; Geraldine, Pitchairaj; Jayakumar, Thanasekaran; Fong, Tsorng-Harn
Source:
Biochemical and biophysical research communications 2015 v.466 pp. 95-102
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; Western blotting; actin; densitometry; electron microscopy; models; muscles; myosin heavy chains; polyacrylamide gel electrophoresis; rats; sarcomeres; signal transduction; skeletal muscle; sodium dodecyl sulfate;     Show all 14 Subjects
Abstract:
... The sliding filament model of the sarcomere was developed more than half a century ago. This model, consisting only of thin and thick filaments, has been efficacious in elucidating many, but not all, features of skeletal muscle. Work during the 1980s revealed the existence of two additional filaments: the giant filamentous proteins titin and nebulin. Nebulin, a giant myofibrillar protein, acts as ...
DOI:
10.1016/j.bbrc.2015.08.114

26. Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1-dependent mechanism

Author:
Alamdari, Nima; Aversa, Zaira; Castillero, Estibaliz; Gurav, Aniket; Petkova, Victoria; Tizio, Steven; Hasselgren, Per-Olof
Source:
Biochemical and biophysical research communications 2012 v.417 no.1 pp. 528-533
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; acetylation; dexamethasone; muscles; protective effect; protein degradation; resveratrol; small interfering RNA; ubiquitin-protein ligase;     Show all 9 Subjects
Abstract:
... Resveratrol (3,5,4′-trihydroxystilbene) has been ascribed multiple beneficial biological effects but the influence of resveratrol on glucocorticoid-induced muscle atrophy is not known. We examined the effects of resveratrol on dexamethasone-induced atrogin-1 and MuRF1 expression, FOXO1 acetylation, protein degradation and atrophy in cultured L6 myotubes. In addition, the role of the deacetylase SI ...
DOI:
10.1016/j.bbrc.2011.11.154
PubMed:
22166204
PubMed Central:
PMC3261799

27. Cancer cachexia decreases specific force and accelerates fatigue in limb muscle

Author:
Roberts, B.M.; Frye, G.S.; Ahn, B.; Ferreira, L.F.; Judge, A.R.
Source:
Biochemical and biophysical research communications 2013 v.435 pp. 488-492
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; cachexia; carcinoma; diaphragm; glycolysis; locomotion; metabolic syndrome; mice; models; mortality; muscle fibers; quality of life; skeletal muscle;     Show all 13 Subjects
Abstract:
... Cancer cachexia is a complex metabolic syndrome that is characterized by the loss of skeletal muscle mass and weakness, which compromises physical function, reduces quality of life, and ultimately can lead to mortality. Experimental models of cancer cachexia have recapitulated this skeletal muscle atrophy and consequent decline in muscle force generating capacity. However, more recently, we provid ...
DOI:
10.1016/j.bbrc.2013.05.018
PubMed:
23673294
PubMed Central:
PMC3708303

28. An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19

Author:
Velasco, Kelly; Zhao, Bin; Callegari, Simone; Altun, Mikael; Liu, Haiyin; Hassink, Gerco; Masucci, Maria G.; Lindsten, Kristina
Source:
Biochemical and biophysical research communications 2013 v.433 pp. 390-395
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; cell cycle; hypoxia; proteinases; two hybrid system techniques; ubiquitin; ubiquitin-protein ligase; unfolded protein response;     Show all 8 Subjects
Abstract:
... The Ubiquitin Specific Protease-19 (USP19) regulates cell cycle progression and is involved in the cellular response to different types of stress, including the unfolded protein response (UPR), hypoxia and muscle atrophy. Using the unique N-terminal domain as bait in a yeast-two hybrid screen we have identified the ubiquitin ligases Seven In Absentia Homolog (SIAH)-1 and SIAH2 as binding partners ...
DOI:
10.1016/j.bbrc.2013.02.094

29. A novel evaluation method of survival motor neuron protein as a biomarker of spinal muscular atrophy by imaging flow cytometry

Author:
Arakawa, Masayuki; Arakawa, Reiko; Tatsumi, Shinichi; Aoki, Ryoko; Saito, Kayoko; Nomoto, Akio
Source:
Biochemical and biophysical research communications 2014 v.453 pp. 368-374
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; acid treatment; biomarkers; clinical trials; enzyme-linked immunosorbent assay; fibroblasts; flow cytometry; genes; humans; image analysis; motor neurons; mutation; protein synthesis; therapeutics; valproic acid; Germany;     Show all 16 Subjects
Abstract:
... Spinal muscular atrophy (SMA) is caused by mutations within the survival motor neuron 1 (SMN1) gene. These mutations result in the reduction of survival motor neuron (SMN) protein expression and SMN complex in spinal motor neurons and other tissues. SMN protein has been used as a therapeutic biomarker in recent SMA clinical studies using enzyme-linked immunosorbent assay (ELISA). Here, we investig ...
DOI:
10.1016/j.bbrc.2014.09.087

30. Identification of functional glucocorticoid response elements in the mouse FoxO1 promoter

Author:
Qin, Weiping; Pan, Jiangping; Qin, Yiwen; Lee, David N.; Bauman, William A.; Cardozo, Christopher
Source:
Biochemical and biophysical research communications 2014 v.450 pp. 979-983
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; dexamethasone; gels; gene expression regulation; glucocorticoid receptors; glucocorticoids; messenger RNA; mice; muscle protein; myoblasts; protein synthesis; reporter genes; response elements; skeletal muscle;     Show all 14 Subjects
Abstract:
... Glucocorticoids stimulate muscle atrophy through a cascade of signals that includes activation of FoxO transcription factors which then upregulate multiple genes to promote degradation of myofibrillar and other muscle proteins and inhibit protein synthesis. Our previous finding that glucocorticoids upregulate mRNA levels for FoxO1 in skeletal muscle led us to hypothesize that the FoxO1 gene contai ...
DOI:
10.1016/j.bbrc.2014.06.080

31. Neuronal cells but not muscle cells are resistant to oxidative stress mediated protein misfolding and cell death: Role of molecular chaperones

Author:
Bhattacharya, Arunabh; Wei, Rochelle; Hamilton, Ryan T.; Chaudhuri, Asish R.
Source:
Biochemical and biophysical research communications 2014 v.446 pp. 1250-1254
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; animal models; cell death; disease course; heat shock proteins; mice; motor neurons; muscle protein; mutants; myocytes; oxidative stress; protein folding; sclerosis; skeletal muscle; spinal cord; toxicity;     Show all 16 Subjects
Abstract:
... Our recent study in a mouse model of familial-Amyotrophic Lateral Sclerosis (f-ALS) revealed that muscle proteins are equally sensitive to misfolding as spinal cord proteins despite the presence of low mutant CuZn-superoxide dismutase, which is considered to be the key toxic element for initiation and progression of f-ALS. More importantly, we observed differential level of heat shock proteins (Hs ...
DOI:
10.1016/j.bbrc.2014.03.097

32. Overexpression of hepatocyte growth factor in SBMA model mice has an additive effect on combination therapy with castration

Author:
Ding, Ying; Adachi, Hiroaki; Katsuno, Masahisa; Huang, Zhe; Jiang, Yue-Mei; Kondo, Naohide; Iida, Madoka; Tohnai, Genki; Nakatsuji, Hideaki; Funakoshi, Hiroshi; Nakamura, Toshikazu; Sobue, Gen
Source:
Biochemical and biophysical research communications 2015 v.468 pp. 677-683
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; additive effect; androgen receptors; animal models; brain stem; castration; disease course; gene overexpression; genes; hepatocyte growth factor; mice; motor neurons; mutants; neuroprotective effect; nuclear inclusions; phosphorylation; polypeptides; spinal cord; transgenic animals;     Show all 19 Subjects
Abstract:
... Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine (polyQ)-encoding tract within the androgen receptor (AR) gene. The pathologic features of SBMA are motor neuron loss in the spinal cord and brainstem and diffuse nuclear accumulation and nuclear inclusions of mutant AR in residual motor neurons and certain visceral organs. Hepa ...
DOI:
10.1016/j.bbrc.2015.11.015

33. ANKRD1 modulates inflammatory responses in C2C12 myoblasts through feedback inhibition of NF-κB signaling activity

Author:
Liu, Xin-Hua; Bauman, William A.; Cardozo, Christopher
Source:
Biochemical and biophysical research communications 2015 v.464 pp. 208-213
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; binding sites; cell viability; chromatin; gene overexpression; immunity; inflammation; messenger RNA; muscles; myoblasts; paralysis; precipitin tests; skeletal muscle; transcription (genetics); transcription factor NF-kappa B; transcriptional activation; tumor necrosis factor-alpha;     Show all 17 Subjects
Abstract:
... Transcription factors of the nuclear factor-kappa B (NF-κB) family play a pivotal role in inflammation, immunity and cell survival responses. Recent studies revealed that NF-κB also regulates the processes of muscle atrophy. NF-κB activity is regulated by various factors, including ankyrin repeat domain 2 (AnkrD2), which belongs to the muscle ankyrin repeat protein family. Another member of this f ...
DOI:
10.1016/j.bbrc.2015.06.118

34. Validation of trans-acting elements that promote exon 7 skipping of SMN2 in SMN2-GFP stable cell line

Author:
Cho, Sunghee; Moon, Heegyum; Yang, Xiaoming; Zhou, Jianhua; Kim, Hye-Ran; Shin, Myung-Geun; Loh, Tiing Jen; Zheng, Xuexiu; Shen, Haihong
Source:
Biochemical and biophysical research communications 2012 v.423 no.3 pp. 531-535
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; microscopy; immunoblotting; alternative splicing; reverse transcriptase polymerase chain reaction; genetic disorders; patients; exons; small interfering RNA;     Show all 9 Subjects
Abstract:
... Spinal muscular atrophy is a genetic disease in which the SMN1 gene is deleted. The SMN2 gene exists in all of the patients. Alternative splicing of these two genes are different. More than 90% of exon 7 included form is produced from SMN1 pre-mRNA, whereas only ∼20% of exon 7 included form is produced from SMN2 pre-mRNA. Only exon 7 inclusion form produces functional protein. Exon 7 skipped SMN i ...
DOI:
10.1016/j.bbrc.2012.05.161

35. The gemin2-binding site on SMN protein: Accessibility to antibody

Author:
Lam, Le Thanh; Fuller, Heidi R.; Morris, Glenn E.
Source:
Biochemical and biophysical research communications 2013 v.438 pp. 624-627
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; amino acids; binding sites; childhood; epitopes; genetic disorders; humans; immune response; mice; monoclonal antibodies; motor neurons; peptide libraries; proteins; spliceosomes;     Show all 14 Subjects
Abstract:
... Reduced levels of SMN (survival-of-motor-neurons) protein are the cause of spinal muscular atrophy, an inherited disorder characterised by loss of motor neurons in early childhood. SMN associates with more than eight other proteins to form an RNA-binding complex involved in assembly of the spliceosome. Two monoclonal antibodies (mAbs), MANSMA1 and MANSMA12, have been widely-used in studies of SMN ...
DOI:
10.1016/j.bbrc.2013.08.005

36. The progression of comorbidity in IL-18 transgenic chronic obstructive pulmonary disease mice model

Author:
Takenaka, Shin-ichi; Kawayama, Tomotaka; Imaoka, Haruki; Sakazaki, Yuki; Oda, Hanako; Kaku, Yoichiro; Matsuoka, Masanobu; Okamoto, Masaki; Kato, Seiya; Yamada, Kentaro; Hoshino, Tomoaki
Source:
Biochemical and biophysical research communications 2014 v.445 pp. 597-601
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; animal models; bone density; comorbidity; complementary DNA; diabetes mellitus; emaciation; females; genetically modified organisms; glucose tolerance; heart failure; humans; hyperlipidemia; hypertension; interleukin-13; interleukin-18; lungs; mice; muscles; osteoporosis; pathogenesis; patients; respiratory tract diseases; sclerosis; surfactants; weight loss;     Show all 26 Subjects
Abstract:
... Patients with severe COPD are known to have comorbidities such as emaciation, cor pulmonale and right heart failure, muscle weakness, hyperlipemia, diabetes mellitus, osteoporosis, muscle atrophy, arterial sclerosis, hypertension, and depression. Therefore, treatment for COPD needs to focus on these comorbidities as well as the lungs. We previously reported a new mouse model of COPD utilizing the ...
DOI:
10.1016/j.bbrc.2014.02.052

37. Direct central nervous system delivery provides enhanced protection following vector mediated gene replacement in a severe model of Spinal Muscular Atrophy

Author:
Glascock, Jacqueline J.; Shababi, Monir; Wetz, Mary J.; Krogman, Megan M.; Lorson, Christian L.
Source:
Biochemical and biophysical research communications 2012 v.417 no.1 pp. 376-381
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; animal models; central nervous system; complementary DNA; gene therapy; genes; homozygosity; infant mortality; intravenous injection; longevity; mice; motor neurons; viruses;     Show all 13 Subjects
Abstract:
... Spinal Muscular Atrophy (SMA), an autosomal recessive neuromuscular disorder, is the leading genetic cause of infant mortality. SMA is caused by the homozygous loss of Survival Motor Neuron-1 (SMN1). SMA, however, is not due to complete absence of SMN, rather a low level of functional full-length SMN is produced by a nearly identical copy gene called SMN2. Despite SMN’s ubiquitous expression, moto ...
DOI:
10.1016/j.bbrc.2011.11.121
PubMed:
22172949
PubMed Central:
PMC3259227

38. Differential regulation of the SMN2 gene by individual HDAC proteins

Author:
Evans, Matthew C.; Cherry, Jonathan J.; Androphy, Elliot J.
Source:
Biochemical and biophysical research communications 2011 v.414 no.1 pp. 25-30
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; quantitative polymerase chain reaction; proteins; alternative splicing; neurons; sequence deletion; neurodegenerative diseases; therapeutics; disease severity; transcription (genetics); death; homozygosity; exons;     Show all 13 Subjects
Abstract:
... Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disorder that is the leading genetic cause of infantile death. SMA is caused by homozygous deletion or mutation of the survival of motor neuron 1 gene (SMN1). The SMN2 gene is nearly identical to SMN1, however is alternatively spliced. The close relationship to SMN1 results in SMN2 being a very power genetic modifier of SMA ...
DOI:
10.1016/j.bbrc.2011.09.011

39. Therapeutic potential of ghrelin treatment for unloading-induced muscle atrophy in mice

Author:
Koshinaka, Keiichi; Toshinai, Koji; Mohammad, Arif; Noma, Kenji; Oshikawa, Miki; Ueno, Hiroaki; Yamaguchi, Hideki; Nakazato, Masamitsu
Source:
Biochemical and biophysical research communications 2011 v.412 no.2 pp. 296-301
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; animal models; energy; food intake; gene expression; ghrelin; homeostasis; insulin-like growth factor I; messenger RNA; mice; muscles; phosphorylation; signal transduction; somatotropin; stomach; transcription factors;     Show all 16 Subjects
Abstract:
... Ghrelin is a growth hormone (GH) secretagogue secreted mainly from the stomach that functions in controlling muscle volume and energy homeostasis. We here studied the effects of ghrelin on unloading-induced muscle atrophy using a mouse model of hindlimb suspension (HS). Ghrelin administration during 2-week HS alleviated reductions of muscle mass in the fast-twitch fiber-rich plantaris muscle and t ...
DOI:
10.1016/j.bbrc.2011.07.086

40. Angiotensin II induced catabolic effect and muscle atrophy are redox dependent

Author:
Semprun-Prieto, Laura C.; Sukhanov, Sergiy; Yoshida, Tadashi; Rezk, Bashir M.; Gonzalez-Villalobos, Romer A.; Vaughn, Charlotte; Michael Tabony, A.; Delafontaine, Patrice
Source:
Biochemical and biophysical research communications 2011 v.409 no.2 pp. 217-221
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; NAD(P)H oxidase (H2O2-forming); NADP (coenzyme); angiotensin II; metabolism; mice; muscles; proteasome endopeptidase complex; reactive oxygen species; skeletal muscle;     Show all 10 Subjects
Abstract:
... Angiotensin II (Ang II) causes skeletal muscle wasting via an increase in muscle catabolism. To determine whether the wasting effects of Ang II were related to its ability to increase NADPH oxidase-derived reactive oxygen species (ROS) we infused wild-type C57BL/6J or p47ᵖʰᵒˣ ⁻/⁻ mice with vehicle or Ang II for 7days. Superoxide production was increased 2.4-fold in the skeletal muscle of Ang II in ...
DOI:
10.1016/j.bbrc.2011.04.122
PubMed:
21570954
PubMed Central:
PMC3109128

41. Inhibition of IkappaB kinase alpha (IKKα) or IKKbeta (IKKβ) plus forkhead box O (Foxo) abolishes skeletal muscle atrophy

Author:
Reed, S.A.; Senf, S.M.; Cornwell, E.W.; Kandarian, S.C.; Judge, A.R.
Source:
Biochemical and biophysical research communications 2011 v.405 no.3 pp. 491-496
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; IKappaB kinase; additive effect; gene expression; muscle fibers; muscles; mutants; plasmids; skeletal muscle; transcription (genetics); transcription factor NF-kappa B;     Show all 11 Subjects
Abstract:
... Two transcription factor families that are activated during multiple conditions of skeletal muscle wasting are nuclear factor κB (NF-κB) and forkhead box O (Foxo). There is clear evidence that both NF-κB and Foxo activation are sufficient to cause muscle fiber atrophy and they are individually required for at least half of the fiber atrophy during muscle disuse, but there is no work determining th ...
DOI:
10.1016/j.bbrc.2011.01.059
PubMed:
21256828
PubMed Central:
PMC3056397

42. Acupuncture ameliorated skeletal muscle atrophy induced by hindlimb suspension in mice

Author:
Onda, Akiko; Jiao, Qibin; Nagano, Yasuharu; Akimoto, Takayuki; Miyamoto, Toshikazu; Minamisawa, Susumu; Fukubayashi, Toru
Source:
Biochemical and biophysical research communications 2011 v.410 no.3 pp. 434-439
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; acupuncture; adenosine; elderly; electrical treatment; exercise; gene expression; messenger RNA; mice; muscles; myostatin; patients; phosphatidylinositol 3-kinase; protein degradation; protein synthesis; quality of life; skeletal muscle; ubiquitin-protein ligase;     Show all 18 Subjects
Abstract:
... Preventing skeletal muscle atrophy is critical for maintaining quality of life, but it is often a challenging goal for the elderly and patients with severe conditions. We hypothesized that acupuncture in place of exercise training is an alternative non-pharmacological intervention that can help to prevent muscle atrophy. To elucidate the effects of acupuncture on skeletal muscle atrophy caused by ...
DOI:
10.1016/j.bbrc.2011.05.152

43. Proteomic analysis of muscle affected by motor neuron degeneration: The wobbler mouse model of amyotrophic lateral sclerosis

Author:
Staunton, Lisa; Jockusch, Harald; Ohlendieck, Kay
Source:
Biochemical and biophysical research communications 2011 v.406 no.4 pp. 595-600
ISSN:
0006-291X
Subject:
muscular atrophy,   etc   ; adults; animal models; biochemical pathways; biomarkers; cerebrospinal fluid; electrophoresis; fluorescence; genotype; glyceraldehyde-3-phosphate dehydrogenase; glycolysis; humans; immunoblotting; intermediate filaments; mass spectrometry; mice; muscles; neurons; paralysis; patients; phenotype; proteins; proteome; proteomics; sclerosis; skeletal muscle; spinal cord; stress response;     Show all 28 Subjects
Abstract:
... Amyotrophic lateral sclerosis is the most common form of motor neuron disease in adult patients and characterized by progressive paralysis. The wobbler mouse (phenotype WR, genotype wr/wr) is an established animal model of human motor neuron disease and is characterized by a large variety of cellular abnormalities including muscular atrophy. In analogy to recent proteomic studies of cerebrospinal ...
DOI:
10.1016/j.bbrc.2011.02.099