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- Fan, Hang, et al. Show all 7 Authors
- Biochemical and biophysical research communications 2018 v.498 no.3 pp. 409-415
- T-lymphocytes; Western blotting; adenocarcinoma; biomarkers; enzyme-linked immunosorbent assay; exosomes; galectins; immune response; immunoglobulins; ligands; lung neoplasms; lungs; lymph nodes; metastasis; mucins; neoplasm cells; patients; protein content; squamous cell carcinoma; transmission electron microscopy; viruses
- ... Exosomes are membrane-bound, virus-sized vesicles present in circulating blood. Tumor cells are avid producers of exosomes, which are thought to mimic molecular features of parent tumor cells. T-cell immunoglobulin- and mucin-domain-containing molecule 3 (Tim-3) is a the next-generation immune checkpoint that can be activated by its ligand Galectin-9 to negatively regulate the anti-tumor immune re ...