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- Li, Xiaohong; He, Qinghao; Li, Haiyun; Gao, Xia; Hu, Mancheng; Li, Shuni; Zhai, Quanguo; Jiang, Yucheng; Wang, Xiaotang
- Biochemical engineering journal 2017 v.120 pp. 7-16
- Chlorella; activated sludge; arthritis; bioremediation; biotransformation; chemical oxygen demand; chloride peroxidase; diclofenac; heme; high performance liquid chromatography; humans; mass spectrometry; median effective concentration; muscles; nonsteroidal anti-inflammatory agents; nuclear magnetic resonance spectroscopy; pH; pain; toxicity; waste treatment; wastewater
- ... Non-steroidal anti-inflammatory drugs diclofenac and naproxen are widely used for the treatment of arthritis, ankylosing spondylitis, and acute muscle pain. However, most of them are usually not metabolized and simply pass through human body. These drugs are difficult to be decomposed by general waste treatment strategies and have caused serious environmental concerns. We report a rapid and effici ...
- Bruder, Stefan; Boles, Eckhard
- Biochemical engineering journal 2017 v.120 pp. 103-112
- NADP (coenzyme); Saccharomyces cerevisiae; acetaldehyde; alkaloids; benzaldehyde; benzoic acid; benzyl alcohol; biotransformation; byproducts; ephedrine; heterologous gene expression; mutants; pyruvate decarboxylase; yeasts
- ... (R)-phenylacetylcarbinol (PAC) is a precursor of the pharmaceutical alkaloid ephedrine. It is produced in biotransformations with the yeast Saccharomyces cerevisiae via condensation of benzaldehyde and fermentation-derived acetaldehyde mediated by pyruvate decarboxylase (Pdc). To improve PAC formation with S. cerevisiae various Pdc isoforms isolated from an industrial PAC producing yeast strain an ...