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- Xu, Ningning; Ma, Chao; Ou, Jianfa; Sun, Wanqi Wendy; Zhou, Lufang; Hu, Hui; Liu, Xiaoguang Margaret
- Biochemical engineering journal 2017 v.124 pp. 122-129
- Chinese hamsters; animal ovary; biopharmaceutical industry; biopharmaceuticals; cell engineering; cell growth; dihydrofolate reductase; genes; glycolysis; glycosylation; liquid chromatography; mass spectrometry; proteins; proteomics; translation (genetics); tricarboxylic acid cycle
- ... Chinese hamster ovary (CHO)¹1CHO: Chinese hamster ovary, DHFR: dihydrofolate reductase, LC–MS/MS: Liquid chromatography tandem–mass spectrometry cells have been widely used to express heterologous genes and produce therapeutic proteins in biopharmaceutical industry. Different CHO host cells have distinct cell growth rates and protein expression characteristics. In this study, the expression of abo ...
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