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- Bouley, Renee A.; Hinkovska-Galcheva, Vania; Shayman, James A.; Tesmer, John J. G.
- Biochemistry 2019 v.58 no.13 pp. 1709-1717
- histidine, etc ; active sites; calcium; cations; enzyme activity; enzyme inhibition; homeostasis; lipids; lysosomes; magnesium; pH; phospholipase A2; phospholipases; serine; zinc; Show all 15 Subjects
- ... Lysosomal phospholipase A₂ (LPLA₂/PLA2G15) is a key enzyme involved in lipid homeostasis and is characterized by both phospholipase A2 and transacylase activity and by an acidic pH optimum. Divalent cations such as Ca²⁺ and Mg²⁺ have previously been shown to have little effect on the activity of LPLA₂, but the discovery of a novel crystal form of LPLA₂ with Zn²⁺ bound in the active site suggested ...