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- Abdelmagid, Walid M.; Adak, Taniya; Freeman, Jon O.; Tanner, Martin E.
- Biochemistry 2018 v.57 no.38 pp. 5591-5601
- Staphylococcus aureus; active sites; catalytic activity; dimerization; dissociation; electrostatic interactions; enzymes; guanidinium; humans; ionization; lipids; moieties; squalene; urea
- ... Dehydrosqualene and squalene synthases catalyze the redox neutral and the reductive, head-to-head dimerization of farnesyl diphosphate, respectively. In each case, the reaction is thought to proceed via an initial dissociation of farnesyl diphosphate to form an allylic carbocation-pyrophosphate ion pair. This work describes the synthesis and testing of inhibitors in which a guanidinium or amidiniu ...
- Rohde, Michael; Sippel, Daniel; Trncik, Christian; Andrade, Susana L. A.; Einsle, Oliver
- Biochemistry 2018 v.57 no.38 pp. 5497-5504
- active sites; catalytic activity; chemical bonding; hydrides; hydrogen; nitrogen; nitrogenase
- ... The reaction catalyzed by the nitrogenase enzyme involves breaking the stable triple bond of the dinitrogen molecule and is consequently considered among the most challenging reactions in biology. While many aspects regarding its atomic mechanism remain to be elucidated, a kinetic scheme established by David Lowe and Roger Thorneley has remained a gold standard for functional studies of the enzyme ...