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You searched for: Journal Biochemistry Remove constraint Journal: Biochemistry Publication Year 2018 Remove constraint Publication Year: 2018 Source 2018 v.57 no.46 Remove constraint Source: 2018 v.57 no.46
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1. Dynamics and Molecular Mechanisms of p53 Transcriptional Activation

Author:
Offutt, Tavina L.; Ieong, Pek U.; Demir, Özlem; Amaro, Rommie E.
Source:
Biochemistry 2018 v.57 no.46 pp. 6528-6537
ISSN:
1520-4995
Subject:
DNA; DNA damage; DNA-binding domains; apoptosis; asymmetry; cell cycle checkpoints; crystal structure; drug resistance; genome; genomics; humans; hypoxia; models; molecular dynamics; mutants; neoplasms; site-directed mutagenesis; transcription factors; transcriptional activation
Abstract:
... The “guardian of the genome”, p53, functions as a tumor suppressor that responds to cell stressors such as DNA damage, hypoxia, and tumor formation by inducing cell-cycle arrest, senescence, or apoptosis. Mutation of p53 disrupts its tumor suppressor function, leading to various types of human cancers. One particular mutant, R175H, is a structural mutant that inactivates the DNA damage response pa ...
DOI:
10.1021/acs.biochem.8b01005

2. Structural Changes Induced by the Binding of the Calcium Desensitizer W7 to Cardiac Troponin

Author:
Cai, Fangze; Hwang, Peter M.; Sykes, Brian D.
Source:
Biochemistry 2018 v.57 no.46 pp. 6461-6469
ISSN:
1520-4995
Subject:
calcium; chemical bonding; electrostatic interactions; heart diseases; hydrophobicity; mice; naphthalene; nuclear magnetic resonance spectroscopy; peptides; regulatory proteins; sarcomeres; solvents; transgenic animals; troponin C; troponin I
Abstract:
... Compounds that directly modulate the affinity of the thin filament calcium regulatory proteins in cardiac muscle have potential for treating heart disease. A recent “proof of concept” study showed that the desensitizer W7 can correct hyper-calcium-sensitive sarcomeres from RCM R193H inhibitory subunit troponin I (cTnI) transgenic mice. We have determined the high-resolution nuclear magnetic resona ...
DOI:
10.1021/acs.biochem.8b00882

3. Structural Polymorphs Suggest Competing Pathways for the Formation of Amyloid Fibrils That Diverge from a Common Intermediate Species

Author:
Buchanan, Lauren E.; Maj, Michał; Dunkelberger, Emily B.; Cheng, Pin-Nan; Nowick, James S.; Zanni, Martin T.
Source:
Biochemistry 2018 v.57 no.46 pp. 6470-6478
ISSN:
1520-4995
Subject:
Gibbs free energy; amyloid; cytotoxicity; drugs; humans; infrared spectroscopy; noninsulin-dependent diabetes mellitus; polypeptides; seeds
Abstract:
... It is now recognized that many amyloid-forming proteins can associate into multiple fibril structures. Here, we use two-dimensional infrared spectroscopy to study two fibril polymorphs formed by human islet amyloid polypeptide (hIAPP or amylin), which is associated with type 2 diabetes. The polymorphs exhibit different degrees of structural organization near the loop region of hIAPP fibrils. The r ...
DOI:
10.1021/acs.biochem.8b00997

4. Novel Amphiphilic G-Quadruplex Binding Synthetic Derivative of TMPyP4 and Its Effect on Cancer Cell Proliferation and Apoptosis Induction

Author:
Chilakamarthi, Ushasri; Koteshwar, Devulapally; Jinka, Sudhakar; Vamsi Krishna, Narra; Sridharan, Kathyayani; Nagesh, Narayana; Giribabu, Lingamallu
Source:
Biochemistry 2018 v.57 no.46 pp. 6514-6527
ISSN:
1520-4995
Subject:
DNA; adverse effects; antineoplastic agents; apoptosis; binding capacity; cell cycle checkpoints; cell lines; cell proliferation; cytotoxicity; drug therapy; fluorescence; irradiation; melting; neoplasm cells; neoplasms; porphyrins; spectroscopy; tissues
Abstract:
... Porphyrins are well-known anticancer agents because of their high binding affinity for G-quadruplex DNA and excellent photophysical properties. Several studies carried out using TMPyP4 established it as an efficient chemotherapeutic and a photodynamic therapeutic (PDT) agent, but its use as a lead molecule has been restricted because of its high level of binding to double-stranded DNA (dsDNA), whi ...
DOI:
10.1021/acs.biochem.8b00843

5. A Quantitative Model for BicD2/Cargo Interactions

Author:
Noell, Crystal R.; Loftus, Kyle M.; Cui, Heying; Grewer, Christof; Kizer, Megan; Debler, Erik W.; Solmaz, Sozanne R.
Source:
Biochemistry 2018 v.57 no.46 pp. 6538-6550
ISSN:
1520-4995
Subject:
brain; dynein ATPase; humans; interphase; models; nuclear pore; prediction; proteins; synapse
Abstract:
... Dynein adaptor proteins such as Bicaudal D2 (BicD2) are integral components of the dynein transport machinery, as they recognize cargoes for cell cycle-specific transport and link them to the motor complex. Human BicD2 switches from selecting secretory and Golgi-derived vesicles for transport in G1 and S phase (by recognizing Rab6ᴳᵀᴾ), to selecting the nucleus for transport in G2 phase (by recogni ...
DOI:
10.1021/acs.biochem.8b00987

6. α-Amine Desaturation of d-Arginine by the Iron(II)- and 2-(Oxo)glutarate-Dependent l-Arginine 3-Hydroxylase, VioC

Author:
Dunham, Noah P.; Mitchell, Andrew J.; Del Río Pantoja, José M.; Krebs, Carsten; Bollinger, J. Martin; Boal, Amie K.
Source:
Biochemistry 2018 v.57 no.46 pp. 6479-6488
ISSN:
1520-4995
Subject:
ammonia; arginine; carbon; catalytic activity; chemical bonding; cleavage (chemistry); deamination; deuterium; enantiomers; formaldehyde; hydroxylation; iron; moieties; oxygen; oxygenases; solvents; stable isotopes
Abstract:
... When challenged with substrate analogues, iron(II)- and 2-(oxo)glutarate-dependent (Fe/2OG) oxygenases can promote transformations different from those they enact upon their native substrates. We show here that the Fe/2OG enzyme, VioC, which is natively an l-arginine 3-hydroxylase, catalyzes an efficient oxidative deamination of its substrate enantiomer, d-Arg. The reactant complex with d-Arg reta ...
DOI:
10.1021/acs.biochem.8b00901

7. Endocannabinoid Virodhamine Is an Endogenous Inhibitor of Human Cardiovascular CYP2J2 Epoxygenase

Author:
Carnevale, Lauren N.; Arango, Andres S.; Arnold, William R.; Tajkhorshid, Emad; Das, Aditi
Source:
Biochemistry 2018 v.57 no.46 pp. 6489-6499
ISSN:
1520-4995
Subject:
arachidonic acid; bioactive compounds; blood pressure; cannabinoids; catalytic activity; constitutional isomers; cytochrome P-450; enzymes; epoxides; ethanolamine; heart; humans; metabolism; molecular dynamics; swine
Abstract:
... The human body contains endogenous cannabinoids (endocannabinoids) that elicit effects similar to those of Δ⁹-tetrahydrocanabinol, the principal bioactive component of cannabis. The endocannabinoid virodhamine (O-AEA) is the constitutional isomer of the well-characterized cardioprotective and anti-inflammatory endocannabinoid anandamide (AEA). The chemical structures of O-AEA and AEA contain arach ...
DOI:
10.1021/acs.biochem.8b00691

8. Reduction of Cisplatin-Induced Ototoxicity without Compromising Its Antitumor Activity

Author:
Surnar, Bapurao; Kolishetti, Nagesh; Basu, Uttara; Ahmad, Anis; Goka, Erik; Marples, Brian; Kolb, David; Lippman, Marc E.; Dhar, Shanta
Source:
Biochemistry 2018 v.57 no.46 pp. 6500-6513
ISSN:
1520-4995
Subject:
DNA; DNA damage; adverse effects; antineoplastic activity; aspirin; cisplatin; drug therapy; in vitro studies; models; nausea; nephrotoxicity; neurotoxicity; patients; urinary bladder neoplasms
Abstract:
... Cisplatin is a major chemotherapeutic that continues to have a significant impact in the treatment of more than 50% of all cancers. Since its Food and Drug Administration approval in 1978 for the treatment of advanced ovarian and bladder cancer, this chemotherapeutic has made significant strides and its application has been extended to a large variety of other cancers. However, the vast majority o ...
DOI:
10.1021/acs.biochem.8b00712