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- Chilakamarthi, Ushasri; Koteshwar, Devulapally; Jinka, Sudhakar; Vamsi Krishna, Narra; Sridharan, Kathyayani; Nagesh, Narayana; Giribabu, Lingamallu
- Biochemistry 2018 v.57 no.46 pp. 6514-6527
- DNA; adverse effects; antineoplastic agents; apoptosis; binding capacity; cell cycle checkpoints; cell lines; cell proliferation; cytotoxicity; drug therapy; fluorescence; irradiation; melting; neoplasm cells; neoplasms; porphyrins; spectroscopy; tissues
- ... Porphyrins are well-known anticancer agents because of their high binding affinity for G-quadruplex DNA and excellent photophysical properties. Several studies carried out using TMPyP4 established it as an efficient chemotherapeutic and a photodynamic therapeutic (PDT) agent, but its use as a lead molecule has been restricted because of its high level of binding to double-stranded DNA (dsDNA), whi ...