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You searched for: Journal name Biochemistry Remove constraint Journal name: Biochemistry Publication year rev 7982-2018 Remove constraint Publication year rev: 7982-2018 Source 2018 v.57 no.46 Remove constraint Source: 2018 v.57 no.46 Subject term adverse effects Remove constraint Subject term: adverse effects
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1. Novel Amphiphilic G-Quadruplex Binding Synthetic Derivative of TMPyP4 and Its Effect on Cancer Cell Proliferation and Apoptosis Induction

Author:
Ushasri Chilakamarthi; Devulapally Koteshwar; Sudhakar Jinka; Narra Vamsi Krishna; Kathyayani Sridharan; Narayana Nagesh; Lingamallu Giribabu
Source:
Biochemistry 2018 v.57 no.46 pp. 6514-6527
ISSN:
1520-4995
Subject:
DNA; adverse effects; antineoplastic agents; apoptosis; binding capacity; cell cycle checkpoints; cell lines; cell proliferation; cytotoxicity; drug therapy; fluorescence; irradiation; melting; neoplasm cells; neoplasms; porphyrins; spectroscopy; tissues
Abstract:
... Porphyrins are well-known anticancer agents because of their high binding affinity for G-quadruplex DNA and excellent photophysical properties. Several studies carried out using TMPyP4 established it as an efficient chemotherapeutic and a photodynamic therapeutic (PDT) agent, but its use as a lead molecule has been restricted because of its high level of binding to double-stranded DNA (dsDNA), whi ...
DOI:
10.1021/acs.biochem.8b00843

2. Reduction of Cisplatin-Induced Ototoxicity without Compromising Its Antitumor Activity

Author:
Bapurao Surnar; Nagesh Kolishetti; Uttara Basu; Anis Ahmad; Erik Goka; Brian Marples; David Kolb; Marc E. Lippman; Shanta Dhar
Source:
Biochemistry 2018 v.57 no.46 pp. 6500-6513
ISSN:
1520-4995
Subject:
DNA; DNA damage; adverse effects; antineoplastic activity; aspirin; cisplatin; drug therapy; in vitro studies; models; nausea; nephrotoxicity; neurotoxicity; patients; urinary bladder neoplasms
Abstract:
... Cisplatin is a major chemotherapeutic that continues to have a significant impact in the treatment of more than 50% of all cancers. Since its Food and Drug Administration approval in 1978 for the treatment of advanced ovarian and bladder cancer, this chemotherapeutic has made significant strides and its application has been extended to a large variety of other cancers. However, the vast majority o ...
DOI:
10.1021/acs.biochem.8b00712