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- Li, Huiying; Evenson, Ryan J.; Chreifi, Georges; Silverman, Richard B.; Poulos, Thomas L.
- Biochemistry 2018 v.57 no.44 pp. 6319-6325
- neuronal nitric oxide synthase, etc ; Gibbs free energy; active sites; bioavailability; brain; computational methodology; crystallography; endothelial nitric oxide synthase; enzyme inhibition; humans; neurodegenerative diseases; nitric oxide; therapeutics; Show all 13 Subjects
- ... The overproduction of nitric oxide in the brain by neuronal nitric oxide synthase (nNOS) is associated with a number of neurodegenerative diseases. Although inhibiting nNOS is an important therapeutic goal, it is important not to inhibit endothelial NOS (eNOS) because of the critical role played by eNOS in maintaining vascular tone. While it has been possible to develop nNOS selective aminopyridin ...