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- Kolbanovskiy, Marina; Chowdhury, Moinuddin A.; Nadkarni, Aditi; Broyde, Suse; Geacintov, Nicholas E.; Scicchitano, David A.; Shafirovich, Vladimir
- Biochemistry 2017 v.56 no.24 pp. 3008-3018
- DNA; DNA repair; DNA-directed RNA polymerase; RNA; humans; mutagens; polyacrylamide gel electrophoresis; transcription (genetics)
- ... The most common, oxidatively generated lesion in cellular DNA is 8-oxo-7,8-dihydroguanine, which can be oxidized further to yield highly mutagenic spiroiminodihydantoin (Sp) and 5-guanidinohydantoin (Gh) in DNA. In human cell-free extracts, both lesions can be excised by base excision repair and global genomic nucleotide excision repair. However, it is not known if these lesions can be removed by ...
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