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- Tidemand, Kasper
D.; Peters, Günther H.; Harris, Pernille; Stensgaard, Eva; Christensen, Hans E. M.
- Biochemistry 2017 v.56 no.46 pp. 6155-6164
- active sites; biosynthesis; brain; humans; irritable bowel syndrome; molecular dynamics; point mutation; sequence analysis; serotonin; tryptophan
- ... Tryptophan hydroxylase (TPH) catalyzes the initial and rate-limiting step in the biosynthesis of serotonin, which is associated with a variety of disorders such as depression and irritable bowel syndrome. TPH exists in two isoforms: TPH1 and TPH2. TPH1 catalyzes the initial step in the synthesis of serotonin in the peripheral tissues, while TPH2 catalyzes this step in the brain. In this study, the ...
- Lu, Chang; Liu, Xin; Zhang, Chen-Song; Gong, Haipeng; Wu, Jia-Wei; Wang, Zhi-Xin
- Biochemistry 2017 v.56 no.46 pp. 6165-6175
- active sites; catalytic activity; mitogen-activated protein kinase; molecular dynamics; signal transduction
- ... The mitogen-activated protein kinases (MAPKs) are key components of cellular signal transduction pathways, which are down-regulated by the MAPK phosphatases (MKPs). Catalytic activity of the MKPs is controlled both by their ability to recognize selective MAPKs and by allosteric activation upon binding to MAPK substrates. Here, we use a combination of experimental and computational techniques to el ...