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- Zucconi, Beth E.; Luef, Birgit; Xu, Wei; Henry, Ryan A.; Nodelman, Ilana M.; Bowman, Gregory D.; Andrews, Andrew J.; Cole, Philip A.
- Biochemistry 2016 v.55 no.27 pp. 3727-3734
- Western blotting; acetylation; histone acetyltransferase; histones; leukemia; ligands; mass spectrometry; neoplasm cells; nucleosomes; pharmacology; prostatic neoplasms; transcription (genetics)
- ... The histone acetyltransferase (HAT) enzymes p300 and CBP are closely related paralogs that serve as transcriptional coactivators and have been found to be dysregulated in cancer and other diseases. p300/CBP is a multidomain protein and possesses a highly conserved bromodomain that has been shown to bind acetylated Lys residues in both proteins and various small molecules, including I-CBP112 and CB ...
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