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- Celis, Arianna
I.; Streit, Bennett R.; Moraski, Garrett C.; Kant, Ravi; Lash, Timothy D.; Lukat-Rodgers, Gudrun S.; Rodgers, Kenton R.; DuBois, Jennifer L.
- Biochemistry 2015 v.54 no.26 pp. 4022-4032
- peracetic acid, etc ; Staphylococcus aureus; active sites; bacteria; biosynthesis; decarboxylation; heme; hydrogen peroxide; isomers; oxidants; peroxidase; propionates; Show all 12 Subjects
- ... A recently proposed pathway for heme b biosynthesis, common to diverse bacteria, has the conversion of two of the four propionates on coproheme III to vinyl groups as its final step. This reaction is catalyzed in a cofactor-independent, H₂O₂-dependent manner by the enzyme HemQ. Using the HemQ from Staphylococcus aureus (SaHemQ), the initial decarboxylation step was observed to rapidly and obligate ...
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