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1. Functional Annotation and Structural Characterization of a Novel Lactonase Hydrolyzing d-Xylono-1,4-lactone-5-phosphate and l-Arabino-1,4-lactone-5-phosphate

Author:
Korczynska, Magdalena; Xiang, Dao Feng; Zhang, Zhening; Xu, Chengfu; Narindoshvili, Tamari; Kamat, Siddhesh S.; Williams, Howard J.; Chang, Shawn S.; Kolb, Peter; Hillerich, Brandan; Sauder, J. Michael; Burley, Stephen K.; Almo, Steven C.; Swaminathan, Subramanyam; Shoichet, Brian K.; Raushel, Frank M.
Source:
Biochemistry 2014 v.53 no.28 pp. 4727-4738
ISSN:
1520-4995
Subject:
Mycoplasma synoviae,   etc   ; Mycoplasma agalactiae; active sites; biochemistry; crystal structure; genes; hydrogen bonding; hydrolysis; molecular models; phosphates; protein structure; screening; zinc;     Show all 13 Subjects
Abstract:
... A novel lactonase from Mycoplasma synoviae 53 (MS53_0025) and Mycoplasma agalactiae PG2 (MAG_6390) was characterized by protein structure determination, molecular docking, gene context analysis, and library screening. The crystal structure of MS53_0025 was determined to a resolution of 2.06 Å. This protein adopts a typical amidohydrolase (β/α)₈-fold and contains a binuclear zinc center located at ...
DOI:
10.1021/bi500595c
PubMed:
24955762
PubMed Central:
PMC4108184