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- Giudice, Emmanuel; Molza, Anne-Elisabeth; Laurin, Yoann; Nicolas, Aurélie; Le Rumeur, Elisabeth; Delalande, Olivier
- Biochemistry 2013 v.52 no.44 pp. 7777-7784
- neuronal nitric oxide synthase, etc ; blood; dystrophin; exercise; hydrophobicity; in vivo studies; models; molecular dynamics; muscle protein; mutation; myocytes; patients; phenotype; phospholipids; physical properties; plasma membrane; skeletal muscle; Show all 17 Subjects
- ... Dystrophin is a large skeletal muscle protein located at the internal face of the plasma membrane and interacting with membrane phospholipids and a number of cytosolic proteins. Binding of neuronal nitric oxide synthase (nNOS) to dystrophin appears to be crucial for exercise-induced increases in blood supply in muscle cells. By contrast, utrophin, the developmental homologous protein of dystrophin ...
- Jansen Labby, Kristin; Li, Huiying; Roman, Linda J.; Martásek, Pavel; Poulos, Thomas L.; Silverman, Richard B.
- Biochemistry 2013 v.52 no.18 pp. 3062-3073
- neuronal nitric oxide synthase, etc ; active sites; arginine; catalytic activity; citrulline; crystal structure; cytochrome P-450; guanidinium; heme; mammals; methanol; nitric oxide; radiolabeling; Show all 13 Subjects
- ... Nitric oxide synthase (NOS) catalyzes the conversion of l-arginine to l-citrulline through the intermediate Nω-hydroxy-l-arginine (NHA), producing nitric oxide, an important mammalian signaling molecule. Several disease states are associated with improper regulation of nitric oxide production, making NOS a therapeutic target. The first step of the NOS reaction has been well-characterized and is pr ...
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