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- Bapurao Surnar; Nagesh Kolishetti; Uttara Basu; Anis Ahmad; Erik Goka; Brian Marples; David Kolb; Marc E. Lippman; Shanta Dhar
- Biochemistry 2018 v.57 no.46 pp. 6500-6513
- DNA; DNA damage; adverse effects; antineoplastic activity; aspirin; cisplatin; drug therapy; in vitro studies; models; nausea; nephrotoxicity; neurotoxicity; patients; urinary bladder neoplasms
- ... Cisplatin is a major chemotherapeutic that continues to have a significant impact in the treatment of more than 50% of all cancers. Since its Food and Drug Administration approval in 1978 for the treatment of advanced ovarian and bladder cancer, this chemotherapeutic has made significant strides and its application has been extended to a large variety of other cancers. However, the vast majority o ...
- Yadav Kranthikumar; Meka Penchala Narasimha Rao; Sadhu Sudeshna; Guggilapu Sravanthi Devi; Kovvuri Jeshma; Kamal Ahmed; Srinivas Ragampeta; Devayani Panuganti; Babu Bathini Nagendra; Nagesh Narayana
- Biochemistry 2017 v.56 no.33 pp. 4392-4404
- DNA; DNA replication; antineoplastic activity; apoptosis; benzimidazole; cell cycle checkpoints; electrospray ionization mass spectrometry; fluorescence microscopy; guanine; humans; models; neoplasm cells; neoplasms; polymerase chain reaction; stoichiometry; telomerase; telomeres
- ... Guanine rich regions in DNA, which can form highly stable secondary structures, namely, G-quadruplex or G4 DNA structures, affect DNA replication and transcription. Molecules that stabilize G4 DNA have become important in recent years. In this study, G4 DNA stabilization, inhibition of telomerase, and anticancer activity of synthetic β-carboline–benzimidazole derivatives (5a, 5d, 5h, and 5r) were ...