Jump to Main Content
- Srivastava, Kumkum, et al. Show all 8 Authors
- Biochemistry 2017 v.56 no.51 pp. 6691-6699
- DNA damage; Plasmodium falciparum; Protozoa; antigenic variation; antimalarials; chromatin; death; genes; homeostasis; humans; immune evasion; ligands; malaria; parasites; pathogenesis; pyridines; telomeres; toxicity; toxicity testing; transcription (genetics)
- ... The unique occurrence of G-quadruplexes in the AT-rich genome of human malaria parasite Plasmodium falciparum provides hints about their critical roles in parasite survival, pathogenesis, and host immune evasion. An intriguing question is whether these noncanonical structures can serve as molecular targets for small molecule-based interventions against malaria. In this study, we have investigated ...