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You searched for: Subject "peracetic acid" Remove constraint Subject: "peracetic acid" Journal Biochemistry Remove constraint Journal: Biochemistry
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1. Reactions of Ferrous Coproheme Decarboxylase (HemQ) with O2 and H2O2 Yield Ferric Heme b

Author:
Streit, Bennett R.; Celis, Arianna I.; Shisler, Krista; Rodgers, Kenton R.; Lukat-Rodgers, Gudrun S.; DuBois, Jennifer L.
Source:
Biochemistry 2017 v.56 no.1 pp. 189-201
ISSN:
1520-4995
Subject:
peracetic acid,   etc   ; Raman spectroscopy; active sites; aerobic conditions; biosynthesis; cations; heme; heme proteins; hydrogen peroxide; iron; isotopes; oxidants; oxygen; pH; reaction kinetics;     Show all 15 Subjects
Abstract:
... A recently discovered pathway for the biosynthesis of heme b ends in an unusual reaction catalyzed by coproheme decarboxylase (HemQ), where the Fe(II)-containing coproheme acts as both substrate and cofactor. Because both O₂ and H₂O₂ are available as cellular oxidants, pathways for the reaction involving either can be proposed. Analysis of reaction kinetics and products showed that, under aerobic ...
DOI:
10.1021/acs.biochem.6b00958
PubMed:
27982566
PubMed Central:
PMC5368639

2. Unusual Peroxide-Dependent, Heme-Transforming Reaction Catalyzed by HemQ

Author:
Celis, Arianna I.; Streit, Bennett R.; Moraski, Garrett C.; Kant, Ravi; Lash, Timothy D.; Lukat-Rodgers, Gudrun S.; Rodgers, Kenton R.; DuBois, Jennifer L.
Source:
Biochemistry 2015 v.54 no.26 pp. 4022-4032
ISSN:
1520-4995
Subject:
peracetic acid,   etc   ; Staphylococcus aureus; active sites; bacteria; biosynthesis; decarboxylation; heme; hydrogen peroxide; isomers; oxidants; peroxidase; propionates;     Show all 12 Subjects
Abstract:
... A recently proposed pathway for heme b biosynthesis, common to diverse bacteria, has the conversion of two of the four propionates on coproheme III to vinyl groups as its final step. This reaction is catalyzed in a cofactor-independent, H₂O₂-dependent manner by the enzyme HemQ. Using the HemQ from Staphylococcus aureus (SaHemQ), the initial decarboxylation step was observed to rapidly and obligate ...
DOI:
10.1021/acs.biochem.5b00492
PubMed:
26083961
PubMed Central:
PMC4950513

3. Interaction with the Redox Cofactor MYW and Functional Role of a Mobile Arginine in Eukaryotic Catalase-Peroxidase

Author:
Gasselhuber, Bernhard; Graf, Michael M. H.; Jakopitsch, Christa; Zamocky, Marcel; Nicolussi, Andrea; Furtmüller, Paul G.; Oostenbrink, Chris; Carpena, Xavi; Obinger, Christian
Source:
Biochemistry 2016 v.55 no.25 pp. 3528-3541
ISSN:
1520-4995
Subject:
peracetic acid,   etc   ; Magnaporthe grisea; active sites; arginine; catalase; crystal structure; cyanides; fungi; hydrogen peroxide; molecular dynamics; mutants; mutation; oxidation; pH; reaction mechanisms; thermal stability;     Show all 16 Subjects
Abstract:
... Catalase-peroxidases (KatGs) are unique bifunctional heme peroxidases with an additional posttranslationally formed redox-active Met-Tyr-Trp cofactor that is essential for catalase activity. On the basis of studies of bacterial KatGs, controversial mechanisms of hydrogen peroxide oxidation were proposed. The recent discovery of eukaryotic KatGs with differing pH optima of catalase activity now all ...
DOI:
10.1021/acs.biochem.6b00436
PubMed:
27293030
PubMed Central:
PMC4928148

4. Peroxidase-Type Reactions Suggest a Heterolytic/Nucleophilic O–O Joining Mechanism in the Heme-Dependent Chlorite Dismutase

Author:
Mayfield, Jeffrey A.; Blanc, Béatrice; Rodgers, Kenton R.; Lukat-Rodgers, Gudrun S.; DuBois, Jennifer L.
Source:
Biochemistry 2013 v.52 no.40 pp. 6982-6994
ISSN:
1520-4995
Subject:
peracetic acid,   etc   ; Dechloromonas; biochemistry; cations; chemical bonding; heme; hydrogen peroxide; pH;     Show all 8 Subjects
Abstract:
... Heme-containing chlorite dismutases (Clds) catalyze a highly unusual O–O bond-forming reaction. The O–O cleaving reactions of hydrogen peroxide and peracetic acid (PAA) with the Cld from Dechloromonas aromatica (DaCld) were studied to better understand the Cl–O cleavage of the natural substrate and subsequent O–O bond formation. While reactions with H₂O₂ result in slow destruction of the heme, at ...
DOI:
10.1021/bi4005599
PubMed:
24001266
PubMed Central:
PMC4390081

5. Spectroscopic and Kinetic Investigation of the Reactions of Peroxyacetic Acid with Burkholderia pseudomallei Catalase-Peroxidase, KatG

Author:
Ivancich, Anabella; Donald, Lynda J.; Villanueva, Jacylyn; Wiseman, Ben; Fita, Ignacio; Loewen, Peter C.
Source:
Biochemistry 2013 v.52 no.41 pp. 7271-7282
ISSN:
1520-4995
Subject:
peracetic acid,   etc   ; Burkholderia pseudomallei; acetic acid; ambient temperature; catalase; crosslinking; cysteine; electron paramagnetic resonance spectroscopy; electrons; hydrogen peroxide; mass spectrometry; methionine; oxygen; peptides; peroxidase; spectral analysis; tryptophan;     Show all 17 Subjects
Abstract:
... Catalase-peroxidases or KatGs can utilize organic peroxyacids and peroxides instead of hydrogen peroxide to generate the high-valent ferryl-oxo intermediates involved in the catalase and peroxidase reactions. In the absence of peroxidatic one-electron donors, the ferryl intermediates generated with a low excess (10-fold) of peroxyacetic acid (PAA) slowly decay to the ferric resting state after sev ...
DOI:
10.1021/bi400963j