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- Barsegov, Valeri, et al. Show all 7 Authors
- Biochemistry 2017 v.56 no.13 pp. 1932-1942
- Gibbs free energy; fibrin; fibrinogen; integrins; molecular models; peptides; platelet aggregation
- ... Binding of soluble fibrinogen to the activated conformation of the integrin αIIbβ3 is required for platelet aggregation and is mediated exclusively by the C-terminal AGDV-containing dodecapeptide (γC-12) sequence of the fibrinogen γ chain. However, peptides containing the Arg-Gly-Asp (RGD) sequences located in two places in the fibrinogen Aα chain inhibit soluble fibrinogen binding to αIIbβ3 and m ...
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