Jump to Main Content
- Liu, Wenshe R., et al. Show all 6 Authors
- Biochemistry 2012 v.51 no.26 pp. 5232-5234
- acetylation; histones; lysine; methylation; phosphorylation; post-translational modification; serine; thiols
- ... Using an evolved pyrrolysyl-tRNA synthetase-tRNAᴾʸˡ pair, a Se-alkylselenocysteine was genetically incorporated into histone H3 with a high protein expression yield. Quantitative oxidative elimination of Se-alkylselenocysteine followed by Michael addition reactions with various thiol nucleophiles generated biologically active mimics of H3 with posttranslational modifications including lysine methy ...
- PubMed Central: