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Biochimica et biophysica acta
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7980-2020
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2020
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Subject term
ceramides
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- Author:
- Davide Noto; Francesca Di Gaudio; Ida Grazia Altieri; Angelo Baldassare Cefalù; Sergio Indelicato; Francesca Fayer; Rossella Spina; Chiara Scrimali; Antonina Giammanco; Alessandro Mattina; Serena Indelicato; Massimiliano Greco; David Bongiorno; Maurizio Averna
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.6 pp. 158656
- ISSN:
- 1388-1981
- Subject:
- algorithms; automation; biomarkers; cell culture; ceramides; glucose; hepatocytes; hepatoma; insulin resistance; isotope labeling; lipid metabolism; long chain triacylglycerols; models; palmitates; palmitic acid; sphingomyelins; stable isotopes
- Abstract:
- ... Untargeted lipidomics is a powerful tool to discover new biomarkers and to understand the physiology and pathology of lipids. The use of stable isotopes as tracers to investigate the kinetics of lipids is another tool able to supply dynamic information on lipid synthesis and catabolism. Coupling the two methodology is then very appealing in the study of lipid metabolism. The main issue to face is ...
- DOI:
- 10.1016/j.bbalip.2020.158656
- https://doi.org/10.1016/j.bbalip.2020.158656
- Author:
- David García-Seisdedos; Bohdan Babiy; Milagros Lerma; María E. Casado; Javier Martínez-Botas; Miguel A. Lasunción; Óscar Pastor; Rebeca Busto
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.5 pp. 158638
- ISSN:
- 1388-1981
- Subject:
- Curcuma longa; animal models; ceramides; curcumin; enzyme inhibitors; exosomes; fumonisin B1; hydrophobicity; mice; neuroglia; polyphenols; rhizomes; secretion; serine C-palmitoyltransferase; sphingosine N-acyltransferase
- Abstract:
- ... Curcumin, a hydrophobic polyphenol found in the rhizome of Curcuma longa, has been shown to reduce intracellular lipid accumulation in mouse models of lysosomal storage diseases such as Niemann-Pick type C. Exosomes are small extracellular vesicles secreted by cells in response to changes in intracellular ceramide composition. Curcumin can induce exosome/microvesicle release in cellular models of ...
- DOI:
- 10.1016/j.bbalip.2020.158638
- https://doi.org/10.1016/j.bbalip.2020.158638
- Author:
- Aline Bayerle; Christian Marsching; Mariona Rabionet; Shaalee Dworski; Mustafa A. Kamani; Chandramohan Chitraju; Nina L. Gluchowski; Katlyn R. Gabriel; Silke Herzer; Richard Jennemann; Thierry Levade; Jeffrey A. Medin; Roger Sandhoff
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.9 pp. 158741
- ISSN:
- 1388-1981
- Subject:
- brain; ceramide glucosyltransferase; ceramides; colon; diet; esterification; glucosylceramides; heart; kidneys; lipid metabolism; liver; lungs; lymph; mice; small intestine; spleen
- Abstract:
- ... Except for epidermis and liver, little is known about endogenous expression of 1-O-acylceramides (1-OACs) in mammalian tissue. Therefore, we screened several organs (brain, lung, liver, spleen, lymph nodes, heart, kidney, thymus, small intestine, and colon) from mice for the presence of 1-OACs by LC-MS². In most organs, low levels of about 0.25–1.3 pmol 1-OACs/mg wet weight were recorded. Higher l ...
- DOI:
- 10.1016/j.bbalip.2020.158741
- https://doi.org/10.1016/j.bbalip.2020.158741
- Author:
- Renata Martins Cardoso; Eline Creemers; Samira Absalah; Menno Hoekstra; Gert S. Gooris; Joke A. Bouwstra; Miranda Van Eck
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.3 pp. 158592
- ISSN:
- 1388-1981
- Subject:
- apolipoprotein B; benzoic acids; ceramides; cholesteremic effect; cholesteryl esters; free fatty acids; gene expression regulation; genes; high density lipoprotein cholesterol; hypercholesterolemia; knockout mutants; lipid composition; mice; permeability
- Abstract:
- ... Scavenger receptor class B type I (SR-BI) mediates the selective uptake of cholesteryl esters (CE) from high-density lipoproteins (HDL). An impaired SR-BI function leads to hyperalphalipoproteinemia with elevated levels of cholesterol transported in the HDL fraction. Accumulation of cholesterol in apolipoprotein B (apoB)-containing lipoproteins has been shown to alter skin lipid composition and ba ...
- DOI:
- 10.1016/j.bbalip.2019.158592
- https://doi.org/10.1016/j.bbalip.2019.158592
- Author:
- Satoshi Tomizawa; Mizuki Tamori; Ai Tanaka; Naoya Utsumi; Hiromi Sato; Hiroto Hatakeyama; Akihiro Hisaka; Takafumi Kohama; Kazuyuki Yamagata; Takuya Honda; Hiroyuki Nakamura; Toshihiko Murayama
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.6 pp. 158675
- ISSN:
- 1388-1981
- Subject:
- breast neoplasms; cell movement; ceramides; enzymes; epidermal growth factor; fibroblasts; intravenous injection; lung neoplasms; lungs; metastasis; mice; neoplasm cells; pseudopodia
- Abstract:
- ... Ceramide kinase (CerK) phosphorylates ceramide to ceramide-1-phosphate (C1P), a bioactive sphingolipid. Since the mechanisms responsible for regulating the proliferation and migration/metastasis of cancer cells by the CerK/C1P pathway remain unclear, we conducted the present study. The knockdown of CerK in A549 lung and MCF-7 breast cancer cells (shCerK cells) increased the formation of lamellipod ...
- DOI:
- 10.1016/j.bbalip.2020.158675
- https://doi.org/10.1016/j.bbalip.2020.158675
- Author:
- Felipe Macedo; Gabriel Loureiro Martins; Luis A. Luévano-Martínez; Gustavo Monteiro Viana; Karin A. Riske; Alex Inague; Marcos Y. Yoshinaga; Hugo Aguilaniu; Sayuri Miyamoto; Isaias Glezer; Fernanda Marques da Cunha
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.2 pp. 158539
- ISSN:
- 1388-1981
- Subject:
- Caenorhabditis elegans; carboxylic ester hydrolases; cardiolipins; ceramides; fatty acids; food deprivation; gastric acid; genes; humans; lipid composition; mitochondria; mutants; starvation
- Abstract:
- ... The C. elegans lipase-like 5 (lipl-5) gene is predicted to code for a lipase homologous to the human gastric acid lipase. Its expression was previously shown to be modulated by nutritional or immune cues, but nothing is known about its impact on the lipid landscape and ensuing functional consequences. In the present work, we used mutants lacking LIPL-5 protein and found that lipl-5 is important fo ...
- DOI:
- 10.1016/j.bbalip.2019.158539
- https://doi.org/10.1016/j.bbalip.2019.158539
- Author:
- Romain Magny; Karima Kessal; Anne Regazzetti; Asma Ben Yedder; Christophe Baudouin; Stéphane Mélik Parsadaniantz; Françoise Brignole-Baudouin; Olivier Laprévote; Nicolas Auzeil
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.9 pp. 158728
- ISSN:
- 1388-1981
- Subject:
- ammonium salts; benzalkonium chloride; biomarkers; ceramides; cornea; droplets; epithelium; eye diseases; glycerophospholipids; humans; inflammation; lipid metabolism; lipidomics; lysophospholipids; quaternary ammonium compounds; therapeutics; triacylglycerols
- Abstract:
- ... Dry eye disease (DED) is a multifactorial chronic inflammatory disease of the ocular surface characterized by tear film instability, hyperosmolarity, cell damage and inflammation. Hyperosmolarity is strongly established as the core mechanism of the DED. Benzalkonium chloride (BAK) - a quaternary ammonium salt commonly used in eye drops for its microbicidal properties - is well known to favor the o ...
- DOI:
- 10.1016/j.bbalip.2020.158728
- https://doi.org/10.1016/j.bbalip.2020.158728
- Author:
- Natalia Presa; Ana Gomez-Larrauri; Asier Dominguez-Herrera; Miguel Trueba; Antonio Gomez-Muñoz
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.4 pp. 158630
- ISSN:
- 1388-1981
- Subject:
- adipocytes; adipogenesis; adipose tissue; anti-inflammatory activity; apoptosis; arachidonic acid; cell growth; cell movement; cell viability; ceramides; fibroblasts; inflammation; interleukin-10; lungs; macrophages; mammals; monocytes; neoplasms; phospholipase A2; phospholipases; pulmonary emphysema; transcription factor NF-kappa B
- Abstract:
- ... The bioactive sphingolipid ceramide 1-phosphate (C1P) regulates key physiologic cell functions and is implicated in a number of metabolic alterations and pathological processes. Initial studies using different types of fibroblasts and monocytes/macrophages revealed that C1P was mitogenic and that it promoted cell survival through inhibition of apoptosis. Subsequent studies implicated C1P in inflam ...
- DOI:
- 10.1016/j.bbalip.2020.158630
- https://doi.org/10.1016/j.bbalip.2020.158630
- Author:
- Sara Ghezzal; Barbara Graziela Postal; Elodie Quevrain; Loic Brot; Philippe Seksik; Armelle Leturque; Sophie Thenet; Véronique Carrière
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.2 pp. 158530
- ISSN:
- 1388-1981
- Subject:
- Clostridium leptum; bacteria; ceramides; cytokines; epithelium; humans; inflammation; intestines; metabolic diseases; mice; obesity; oleic acid; palm oils; palmitic acid; permeability; proteins
- Abstract:
- ... The mechanisms leading to the low-grade inflammation observed during obesity are not fully understood. Seeking the initiating events, we tested the hypothesis that the intestine could be damaged by repeated lipid supply and therefore participate in inflammation. In mice, 1–5 palm oil gavages increased intestinal permeability via decreased expression and mislocalization of junctional proteins at th ...
- DOI:
- 10.1016/j.bbalip.2019.158530
- https://doi.org/10.1016/j.bbalip.2019.158530
- Author:
- Christa Buechler; Charalampos Aslanidis
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.5 pp. 158658
- ISSN:
- 1388-1981
- Subject:
- apoptosis; biomarkers; carcinogenicity; cell proliferation; ceramides; cholesterol; early diagnosis; hepatoma; homeostasis; lipid composition; lipid metabolism; liver; liver cirrhosis; metabolites; oxidative stress; pathophysiology; patients; risk; therapeutics; tissues
- Abstract:
- ... Hepatocellular carcinoma (HCC) is an aggressive and widespread cancer. Patients with liver cirrhosis of different aetiologies are at a risk to develop HCC. It is important to know that in approximately 20% of cases primary liver tumors arise in a non-cirrhotic liver. Lipid metabolism is variable in patients with chronic liver diseases, and lipid metabolites involved therein do play a role in the d ...
- DOI:
- 10.1016/j.bbalip.2020.158658
- https://doi.org/10.1016/j.bbalip.2020.158658
- Author:
- Nadine Hagen-Euteneuer; Shah Alam; Hannah Rindsfuesser; Dagmar Meyer zu Heringdorf; Gerhild van Echten-Deckert
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.8 pp. 158708
- ISSN:
- 1388-1981
- Subject:
- angiogenesis; biosynthesis; cell viability; ceramides; fibroblasts; gangliosides; glucosylceramides; immunity; lipid metabolism; mice; neurons
- Abstract:
- ... Sphingosine-1-phosphate (S1P) is not only a catabolic intermediate of all sphingolipids but also an evolutionary conserved bioactive lipid with critical functions in cell survival, differentiation, and migration as well as in immunity and angiogenesis. S1P-lyase (SGPL1) irreversibly cleaves S1P in the final step of sphingolipid catabolism. As sphingoid bases and their 1-phosphates are not only met ...
- DOI:
- 10.1016/j.bbalip.2020.158708
- https://doi.org/10.1016/j.bbalip.2020.158708
- Author:
- Daphne E.C. Boer; Jeroen van Smeden; Hanin Al-Khakany; Elizaveta Melnik; Rianne van Dijk; Samira Absalah; Rob J. Vreeken; Caroline C.P. Haenen; Adriana P.M. Lavrijsen; Herman S. Overkleeft; Johannes M.F.G. Aerts; Joke A. Bouwstra
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.6 pp. 158673
- ISSN:
- 1388-1981
- Subject:
- antimicrobial peptides; atopic dermatitis; biomarkers; ceramides; chemokines; enzyme activity; free fatty acids; glucosylceramidase; lipid composition; patients
- Abstract:
- ... Patients with Atopic Dermatitis (AD) suffer from inflamed skin and skin barrier defects. Proper formation of the outermost part of the skin, the stratum corneum (SC), is crucial for the skin barrier function. In this study we analyzed the localization and activity of lipid enzymes β-glucocerebrosidase (GBA) and acid sphingomyelinase (ASM) in the skin of AD patients and controls. Localization of bo ...
- DOI:
- 10.1016/j.bbalip.2020.158673
- https://doi.org/10.1016/j.bbalip.2020.158673
- Author:
- Iris D. Zelnik; Ana E. Ventura; Jiyoon L. Kim; Liana C. Silva; Anthony H. Futerman
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.1 pp. 158489
- ISSN:
- 1388-1981
- Subject:
- Golgi apparatus; apoptosis; ceramides; endoplasmic reticulum
- Abstract:
- ... Sphingolipids (SLs) are an important class of membrane lipids containing a long chain sphingoid base backbone. SL synthesis is compartmentalized between two major cell organelles, the endoplasmic reticulum (ER) and the Golgi apparatus. The initial steps of sphingolipid synthesis take place in the ER, where the simplest SL, ceramide, is synthesized. Although ceramide is a critical membrane componen ...
- DOI:
- 10.1016/j.bbalip.2019.06.015
- https://doi.org/10.1016/j.bbalip.2019.06.015