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Biochimica et biophysica acta
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7980-2020
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animal models
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- Author:
- Mauricio A. Retamal; Mariana C. Fiori; Ainoa Fernandez-Olivares; Sergio Linsambarth; Francisca Peña; Daisy Quintana; Jimmy Stehberg; Guillermo A. Altenberg
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.8 pp. 158705
- ISSN:
- 1388-1981
- Subject:
- Xenopus laevis; animal models; cataract; connexins; cytoplasm; dithiothreitol; green fluorescent protein; human cell lines; humans; inflammation; ions; lipid peroxides; mutants; oocytes; oxidative stress; probability; rats
- Abstract:
- ... Hemichannels formed by connexins mediate the exchange of ions and signaling molecules between the cytoplasm and the extracellular milieu. Under physiological conditions hemichannels have a low open probability, but in certain pathologies their open probability increases, which can result in cell damage. Pathological conditions are characterized by the production of a number of proinflammatory mole ...
- DOI:
- 10.1016/j.bbalip.2020.158705
- https://doi.org/10.1016/j.bbalip.2020.158705
- Author:
- Satoru Hashimura; Junichi Kido; Risa Matsuda; Miho Yokota; Hirokazu Matsui; Manami Inoue-Fujiwara; Yuji Inagaki; Mayumi Hidaka; Tamotsu Tanaka; Toshihiko Tsutsumi; Toshihiko Nagata; Akira Tokumura
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.7 pp. 158698
- ISSN:
- 1388-1981
- Subject:
- animal models; bacteria; bone resorption; calcium; cell lines; choline; enzyme activity; epithelium; free fatty acids; gingiva; humans; interleukin-6; liquid chromatography; lysophospholipase; neoplasm cells; patients; periodontitis; protective effect; saliva; tandem mass spectrometry
- Abstract:
- ... We previously detected a submicromolar concentration of lysophosphatidic acid (LPA) in human saliva. Here, we compare LPA concentrations in human gingival crevicular fluid (GCF) from patients with periodontitis and healthy controls, and examine how the local LPA levels are regulated enzymatically. The concentrations of LPA and its precursor lysophospholipids in GCF was measured by liquid chromatog ...
- DOI:
- 10.1016/j.bbalip.2020.158698
- https://doi.org/10.1016/j.bbalip.2020.158698
- Author:
- Diwakar Guragain; Pallavi Gurung; Jae-Hoon Chang; Nikita Katila; Hyeun Wook Chang; Byeong-Seon Jeong; Dong-Young Choi; Jung-Ae Kim
- Source:
- Biochimica et biophysica acta 2020 v.1864 no.8 pp. 129631
- ISSN:
- 0304-4165
- Subject:
- AMP-activated protein kinase; NAD(P)H oxidase (H2O2-forming); animal models; anti-inflammatory activity; cell death; colon; dextran sulfate; epithelial cells; epithelium; gene expression regulation; human cell lines; humans; hypoxia-inducible factor 1; inflammation; interleukin-10; interleukin-6; macrophages; mice; oxidative stress; serotonin; signal transduction; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... AMP-activated protein kinase (AMPK) exerts its anti-inflammatory effects by suppressing redox-sensitive nuclear factor kappa B (NF-κB) and pro-inflammatory cytokines including TNF-α. However, it is unclear whether AMPK regulates anti-inflammatory cytokine expressions in the presence of oxidative stress-induced inflammation. We sought to elucidate the mechanisms whereby AMPK regulates inflammatory ...
- DOI:
- 10.1016/j.bbagen.2020.129631
- https://doi.org/10.1016/j.bbagen.2020.129631
- Author:
- Roberto Collu; Julia Maria Post; Maria Scherma; Elisa Giunti; Walter Fratta; Beat Lutz; Paola Fadda; Laura Bindila
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.4 pp. 158578
- ISSN:
- 1388-1981
- Subject:
- abscisic acid; amygdala; animal models; anorexia nervosa; arachidonic acid; biochemical pathways; biomarkers; cognition; cytochrome P-450; genes; hippocampus; hypothalamus; immune system; inflammation; lipoxygenases; messenger RNA; monitoring; phenotype; prefrontal cortex; prostaglandin synthase; prostaglandins; thromboxanes
- Abstract:
- ... Increasing evidence underline the role of inflammation in the behavioral, emotional and cognitive dysregulations displayed in anorexia nervosa (AN). Among the inflammatory mediators acting at both peripheral and central levels, growing attention receives a class of lipids derived from arachidonic acid (AA), called eicosanoids (eiCs), which exert a complex, multifaceted role in a wide range of neur ...
- DOI:
- 10.1016/j.bbalip.2019.158578
- https://doi.org/10.1016/j.bbalip.2019.158578
- Author:
- Robin D. Clugston
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.11 pp. 158597
- ISSN:
- 1388-1981
- Subject:
- animal models; astaxanthin; beta-carotene; beta-cryptoxanthin; enzymes; fatty liver; human nutrition; humans; lipid metabolism; liver; lutein; lycopene; mechanism of action; metabolites; mice; molecular biology; signal transduction; vitamin A; zeaxanthin
- Abstract:
- ... Carotenoids form an important part of the human diet, consumption of which has been associated with many health benefits. With the growing global burden of liver disease, increasing attention has been paid on the possible beneficial role that carotenoids may play in the liver. This review focuses on carotenoid actions in non-alcoholic fatty liver disease (NAFLD), and alcoholic liver disease (ALD). ...
- DOI:
- 10.1016/j.bbalip.2019.158597
- https://doi.org/10.1016/j.bbalip.2019.158597
- Author:
- Vivian Hook; Michael Yoon; Charles Mosier; Gen Ito; Sonia Podvin; Brian P. Head; Robert Rissman; Anthony J. O'Donoghue; Gregory Hook
- Source:
- Biochimica et biophysica acta 2020 v.1868 no.8 pp. 140428
- ISSN:
- 1570-9639
- Subject:
- Alzheimer disease; animal models; biomarkers; brain; brain damage; cathepsin B; cell death; cytosol; drugs; inflammation; lysosomes; neurodegenerative diseases; neuropathology; therapeutics
- Abstract:
- ... Investigations of Alzheimer's disease (AD), traumatic brain injury (TBI), and related brain disorders have provided extensive evidence for involvement of cathepsin B, a lysosomal cysteine protease, in mediating the behavioral deficits and neuropathology of these neurodegenerative diseases. This review integrates findings of cathepsin B regulation in clinical biomarker studies, animal model genetic ...
- DOI:
- 10.1016/j.bbapap.2020.140428
- https://doi.org/10.1016/j.bbapap.2020.140428
- Author:
- David García-Seisdedos; Bohdan Babiy; Milagros Lerma; María E. Casado; Javier Martínez-Botas; Miguel A. Lasunción; Óscar Pastor; Rebeca Busto
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.5 pp. 158638
- ISSN:
- 1388-1981
- Subject:
- Curcuma longa; animal models; ceramides; curcumin; enzyme inhibitors; exosomes; fumonisin B1; hydrophobicity; mice; neuroglia; polyphenols; rhizomes; secretion; serine C-palmitoyltransferase; sphingosine N-acyltransferase
- Abstract:
- ... Curcumin, a hydrophobic polyphenol found in the rhizome of Curcuma longa, has been shown to reduce intracellular lipid accumulation in mouse models of lysosomal storage diseases such as Niemann-Pick type C. Exosomes are small extracellular vesicles secreted by cells in response to changes in intracellular ceramide composition. Curcumin can induce exosome/microvesicle release in cellular models of ...
- DOI:
- 10.1016/j.bbalip.2020.158638
- https://doi.org/10.1016/j.bbalip.2020.158638
- Author:
- Yong Gu; Jing Han; Xin Liu; Yiqing Pan; Xiaoyan Xu; Jichen Sha; Shifang Ren; Jianxin Gu
- Source:
- Biochimica et biophysica acta 2020 v.1864 no.10 pp. 129668
- ISSN:
- 0304-4165
- Subject:
- B-lymphocytes; animal models; blood serum; carcinogenesis; carcinogenicity; colorectal neoplasms; dextran sulfate; fucose; galactose; genetic background; glycosylation; glycosyltransferases; immunoglobulin G; mice; sialic acid; ultra-performance liquid chromatography
- Abstract:
- ... Alternative glycosylation of serum IgG has been shown to be closely associated with colorectal cancer (CRC). Currently, a dynamic study which can not only minimize the influence of genetic background, environment and other interfering factors during cancer development, but also focus on investigating carcinogenic characteristics of IgG glycan is lacking.Serum IgG N-glycans were characterized at fo ...
- DOI:
- 10.1016/j.bbagen.2020.129668
- https://doi.org/10.1016/j.bbagen.2020.129668
- Author:
- Tommaso Nuzzo; Masae Sekine; Daniela Punzo; Mattia Miroballo; Masumi Katane; Yasuaki Saitoh; Alberto Galbusera; Massimo Pasqualetti; Francesco Errico; Alessandro Gozzi; Jean-Pierre Mothet; Hiroshi Homma; Alessandro Usiello
- Source:
- Biochimica et biophysica acta 2020 v.1868 no.12 pp. 140531
- ISSN:
- 1570-9639
- Subject:
- D-aspartate oxidase; animal models; autism; blood serum; gene expression; glutamate receptors; high performance liquid chromatography; hippocampus; messenger RNA; metabolism; mice; neurotransmitters; prefrontal cortex; quantitative polymerase chain reaction; serine; serine racemase; social behavior; stereoselectivity; synapse
- Abstract:
- ... Autism spectrum disorders (ASD) comprise a heterogeneous group of neurodevelopmental conditions characterized by impairment in social interaction, deviance in communication, and repetitive behaviors. Dysfunctional ionotropic NMDA and AMPA receptors, and metabotropic glutamate receptor 5 activity at excitatory synapses has been recently linked to multiple forms of ASD. Despite emerging evidence sho ...
- DOI:
- 10.1016/j.bbapap.2020.140531
- https://doi.org/10.1016/j.bbapap.2020.140531
- Author:
- Rui Liu; Meina Wang; Enjie Li; Yang Yang; Jiaxin Li; Siyu Chen; Wen-Jun Shen; Salman Azhar; Zhigang Guo; Zhigang Hu
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.5 pp. 158640
- ISSN:
- 1388-1981
- Subject:
- animal models; drugs; enzymes; fatty acids; fatty liver; high fat diet; human cell lines; insulin; insulin resistance; lipid metabolism; mice; microRNA; noninsulin-dependent diabetes mellitus; obesity; pathogenesis; risk; therapeutics
- Abstract:
- ... Obesity is associated with an increased risk of developing insulin resistance (IR) and type 2 diabetes (T2D). A diverse group of factors including miRNA has been implicated in the pathogenesis of these two metabolic conditions, although underlying molecular mechanisms involved are not well defined. Here, we provide evidence that hepatic miR-125a levels are diminished in both genetic as well as die ...
- DOI:
- 10.1016/j.bbalip.2020.158640
- https://doi.org/10.1016/j.bbalip.2020.158640
- Author:
- Swetha Pavani Rao; Neelam Sharma; Shasi V. Kalivendi
- Source:
- Biochimica et biophysica acta 2020 v.1861 no.3 pp. 148157
- ISSN:
- 0005-2728
- Subject:
- NAD (coenzyme); Parkinson disease; animal models; antioxidant activity; apoptosis; biogenesis; dopamine; dose response; electron transport chain; mice; mitochondria; neurons; oxidative stress; small interfering RNA; staining; ubiquinones
- Abstract:
- ... Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by the death of dopamine neurons of Substantia nigra pars compacta (SNpc) leading to motor deficits. Amongst the mechanisms proposed, mitochondrial dysfunction, reduced complex-I and PGC1α levels were found to correlate with the pathology of PD. As embelin is a natural product with structural resemblance to ubiquinone, e ...
- DOI:
- 10.1016/j.bbabio.2020.148157
- https://doi.org/10.1016/j.bbabio.2020.148157
- Author:
- Babett Bartling; Katja Zunkel; Samiya Al-Robaiy; Faramarz Dehghani; Andreas Simm
- Source:
- Biochimica et biophysica acta 2020 v.1864 no.1 pp. 129438
- ISSN:
- 0304-4165
- Subject:
- advanced glycation end products; animal models; blood cells; brain; chromosomes; copy number variation; enzymes; females; gene expression regulation; genes; genetic variance; genomics; heart; immune response; kidneys; knockout mutants; ligands; liver; lungs; males; mice; polymerase chain reaction; spleen; tissues; transgenic animals
- Abstract:
- ... The receptor for advanced glycation end-products (RAGE) is a multifunctional protein. Its function as pattern recognition receptor able to interact with various extracellular ligands is well described. Genetically modified mouse models, especially the RAGE knockout (RAGE-KO) mouse, identified the amplification of the immune response as an important function of RAGE. Pro-inflammatory ligands of RAG ...
- DOI:
- 10.1016/j.bbagen.2019.129438
- https://doi.org/10.1016/j.bbagen.2019.129438
13. Immune modulations and survival strategies of evolved hypervirulent Salmonella Typhimurium strains
- Author:
- Diana Pradhan; Jasmin Pradhan; Abtar Mishra; Kapudeep Karmakar; Rohan Dhiman; Dipshikha Chakravortty; Vidya Devi Negi
- Source:
- Biochimica et biophysica acta 2020 v.1864 no.8 pp. 129627
- ISSN:
- 0304-4165
- Subject:
- CD4-positive T-lymphocytes; Salmonella Typhimurium; Western blotting; animal models; antimicrobial peptides; confocal microscopy; flow cytometry; genes; immunomodulation; interleukin-10; interleukin-1beta; lysosomes; mice; microbial load; multiple drug resistance; nitric oxide; polymerase chain reaction; prognosis; salmonellosis; signal transduction; transcription factor NF-kappa B
- Abstract:
- ... Evolving multidrug-resistance and hypervirulence in Salmonella is due to multiple host-pathogen, and non-host environmental interactions. Previously we had studied Salmonella adaptation upon repeated exposure in different in-vitro and in-vivo environmental conditions. This study deals with the mechanistic basis of hypervirulence of the passaged hypervirulent Salmonella strains reported previously. ...
- DOI:
- 10.1016/j.bbagen.2020.129627
- https://doi.org/10.1016/j.bbagen.2020.129627
- Author:
- Eva Knuplez; Sanja Curcic; Anna Theiler; Thomas Bärnthaler; Athina Trakaki; Markus Trieb; Michael Holzer; Akos Heinemann; Robert Zimmermann; Eva M. Sturm; Gunther Marsche
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.7 pp. 158686
- ISSN:
- 1388-1981
- Subject:
- albumins; allergens; animal models; asthma; blood serum; cell membranes; chemotaxis; eosinophils; humans; inflammation; lungs; lysophosphatidylcholine; mice; phospholipases
- Abstract:
- ... Eosinophils are important multifaceted effector cells involved in allergic inflammation. Following allergen challenge, eosinophils and other immune cells release secreted phospholipases, generating lysophosphatidylcholines (LPCs). LPCs are potent lipid mediators, and serum levels of LPCs associate with asthma severity, suggesting a regulatory activity of LPCs in asthma development. As of yet, the ...
- DOI:
- 10.1016/j.bbalip.2020.158686
- https://doi.org/10.1016/j.bbalip.2020.158686
- Author:
- Zall Hirschstein; Gautam Reddy Vanga; Guirong Wang; Zachary M. Novakovic; Patricia Grasso
- Source:
- Biochimica et biophysica acta 2020 v.1864 no.11 pp. 129697
- ISSN:
- 0304-4165
- Subject:
- Alzheimer disease; animal models; blood glucose; blood serum; cerebral cortex; enzyme-linked immunosorbent assay; eosin; glycemic control; hippocampus; histopathology; humans; inflammation; insulin; insulin resistance; insulin-like growth factor I; leptin; males; memory; mice; neurodegenerative diseases; noninsulin-dependent diabetes mellitus; staining; streptozotocin; synthetic peptides; tumor necrosis factor-alpha
- Abstract:
- ... Extracellular beta-amyloid (Aβ), intra-neuronal hyper-phosphorylated tau protein, and chronic inflammation are neuropathological hallmarks of Alzheimer's Disease (AD). A link between AD, insulin dysfunction, and tumor necrosis factor-alpha (TNF-α) in promoting both tau and Aβ pathologies in vivo has been proposed.MA-[D-Leu-4]-OB3 was given, with or without insulin, to streptozotocin (STZ)-treated ...
- DOI:
- 10.1016/j.bbagen.2020.129697
- https://doi.org/10.1016/j.bbagen.2020.129697
- Author:
- Adriana Carino; Michele Biagioli; Silvia Marchianò; Chiara Fiorucci; Martina Bordoni; Rosalinda Roselli; Cristina Di Giorgio; Monia Baldoni; Patrizia Ricci; Maria Chiara Monti; Elva Morretta; Angela Zampella; Eleonora Distrutti; Stefano Fiorucci
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.9 pp. 158733
- ISSN:
- 1388-1981
- Subject:
- S-adenosylmethionine; adverse effects; agonists; animal models; antagonism; bile ducts; cholestasis; genes; hepatocytes; hepatotoxicity; laboratory animals; liver; liver diseases; males; mice; patients; rats; small interfering RNA; sulforaphane; transcription (genetics); transporters
- Abstract:
- ... The farnesoid-X-receptor (FXR) is validated target in the cholestatic disorders treatment. Obeticholic acid (OCA), the first in class of FXR agonist approved for clinical use, causes side effects including acute liver decompensation when administered to cirrhotic patients with primary biliary cholangitis at higher than recommended doses. The V-Maf avian-musculoaponeurotic-fibrosarcoma-oncogene-hom ...
- DOI:
- 10.1016/j.bbalip.2020.158733
- https://doi.org/10.1016/j.bbalip.2020.158733
- Author:
- Yanfeng Xue; Changzheng Guo; Fan Hu; Weiyun Zhu; Shengyong Mao
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.2 pp. 158548
- ISSN:
- 1388-1981
- Subject:
- 3-hydroxybutyric acid; animal models; beta oxidation; blood; body fat; energy; esterification; free fatty acids; genes; growth and development; hepatocytes; homeostasis; humans; lipid metabolism disorders; malnutrition; oxidation; peroxisome proliferator-activated receptor alpha; phospholipids; pregnancy; sequence analysis; signal transduction; triacylglycerols; vitamin A
- Abstract:
- ... Maternal undernutrition during late gestation accelerates body fat mobilization to provide more energy for foetal growth and development, which unbalances metabolic homeostasis and results in serious lipid metabolism disorder. However, detailed regulatory mechanisms are poorly understood. Here, a sheep model was used to explore the regulatory role of PPARA/RXRA signalling in hepatic lipid metaboli ...
- DOI:
- 10.1016/j.bbalip.2019.158548
- https://doi.org/10.1016/j.bbalip.2019.158548
- Author:
- Fabien Lecaille; Thibault Chazeirat; Krzysztof K. Bojarski; Justine Renault; Ahlame Saidi; V. Gangadhara N.V. Prasad; Sergey Samsonov; Gilles Lalmanach
- Source:
- Biochimica et biophysica acta 2020 v.1868 no.2 pp. 140318
- ISSN:
- 1570-9639
- Subject:
- Gibbs free energy; animal models; blood serum; bone resorption; cathepsin K; chondroitin; collagenase; computer simulation; electrostatic interactions; enzyme activity; humans; kininogens; mice; molecular dynamics; osteoclasts; osteoporosis; pH; rats
- Abstract:
- ... Human cathepsin K (hCatK), which is highly expressed in osteoclasts, has the noteworthy ability to cleave type I and II collagens in their helical domain. Its collagenase potency depends strictly on the formation of an oligomeric complex with chondroitin 4-sulfate (C4-S). Accordingly, hCatK is a pivotal protease involved in bone resorption and is an attractive target for the treatment of osteoporo ...
- DOI:
- 10.1016/j.bbapap.2019.140318
- https://doi.org/10.1016/j.bbapap.2019.140318
19. Short-chain fatty acid mitigates adenine-induced chronic kidney disease via FFA2 and FFA3 pathways
- Author:
- Daisuke Mikami; Mamiko Kobayashi; Junsuke Uwada; Takashi Yazawa; Kazuko Kamiyama; Kazuhisa Nishimori; Yudai Nishikawa; Sho Nishikawa; Seiji Yokoi; Hideki Kimura; Ikuo Kimura; Takanobu Taniguchi; Masayuki Iwano
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.6 pp. 158666
- ISSN:
- 1388-1981
- Subject:
- G-protein coupled receptors; acetates; adenine; animal models; butyrates; cytokines; epithelial cells; free fatty acids; gastrointestinal system; genes; humans; immunohistochemistry; in vitro studies; inflammation; intestinal microorganisms; mice; propionic acid; renal failure; renal tubules; short chain fatty acids; therapeutics
- Abstract:
- ... Short-chain fatty acids (SCFAs), including acetate, butyrate, and propionate, are produced when colonic bacteria in the human gastrointestinal tract ferment undigested fibers. Free fatty acid receptor 2 (FFA2) and FFA3 are G-protein-coupled receptors recently identified as SCFA receptors that may modulate inflammation. We previously showed through in vitro experiments that SCFAs activate FFA2 and ...
- DOI:
- 10.1016/j.bbalip.2020.158666
- https://doi.org/10.1016/j.bbalip.2020.158666
- Author:
- Rongjie Yu; Junfeng Li; Zhuochao Lin; Zehua Ouyang; Xiaoling Huang; Dora Reglodi; David Vaudry
- Source:
- Biochimica et biophysica acta 2020 v.1864 no.8 pp. 129626
- ISSN:
- 0304-4165
- Subject:
- Parkinson disease; animal models; bioassays; calorimetry; cyclic AMP; drugs; electrostatic interactions; mice; neuropeptide receptors; neuroprotective effect; polypeptides; titration; vasoactive intestinal peptide
- Abstract:
- ... The cationic Arginine-rich peptide (CARP) TAT had been tagged at the C-terminal end of the vasoactive intestinal peptide (VIP) to construct VIP-TAT in order to improve traversing ability. Interestingly, it was found that TAT may bind the positive allosteric modulation (PAM) site of the N-terminal extracellular domain of neuropeptide receptor PAC1 (PAC1-EC1), imitating the C-terminus part of pituit ...
- DOI:
- 10.1016/j.bbagen.2020.129626
- https://doi.org/10.1016/j.bbagen.2020.129626
- Author:
- Ranganathan Arunkumar; Aruna Gorusupudi; Paul S. Bernstein
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.11 pp. 158617
- ISSN:
- 1388-1981
- Subject:
- absorption; animal models; antioxidants; binding proteins; dietary nutrient sources; enzymes; fruits; green leafy vegetables; humans; light; lutein; metabolism; metabolites; molecular biology; oxidative stress; retina; zeaxanthin
- Abstract:
- ... Among the more than 750 carotenoids identified in nature, only lutein, zeaxanthin, meso-zeaxanthin, and their oxidative metabolites are selectively accumulated in the macula lutea region of the human retina. These retinal carotenoids are collectively referred to as the macular pigment (MP) and are obtained only through dietary sources such as green leafy vegetables and yellow and orange fruits and ...
- DOI:
- 10.1016/j.bbalip.2020.158617
- https://doi.org/10.1016/j.bbalip.2020.158617
- Author:
- Lena Hölzen; Maria Alejandra Parigiani; Thomas Reinheckel
- Source:
- Biochimica et biophysica acta 2020 v.1868 no.7 pp. 140423
- ISSN:
- 1570-9639
- Subject:
- animal models; carcinogenesis; cathepsin L; cell culture; cysteine; genome; human diseases; humans; image analysis; intestines; macrophages; metastasis; mice; neoplasm cells; neoplasms; therapeutics; tissues
- Abstract:
- ... The human genome encodes for 11 papain-like endolysosomal cysteine peptidases, collectively known as the cysteine cathepsins. Based on their biochemical properties and with the help of experiments in cell culture, the cysteine cathepsins have acquired a reputation as promotors of progression and metastasis of various cancer entities. However, tumors are known to be complex tissues in which non-can ...
- DOI:
- 10.1016/j.bbapap.2020.140423
- https://doi.org/10.1016/j.bbapap.2020.140423
- Author:
- Chan-Juan Zhang; Neng Zhu; Zheng Liu; Zhe Shi; Jia Long; Xu-Yu Zu; Zhen-Wang Tang; Zhe-Yu Hu; Duan-Fang Liao; Li Qin
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.2 pp. 158547
- ISSN:
- 1388-1981
- Subject:
- adenosine triphosphate; animal models; apolipoprotein E; atherosclerosis; beta-cyclodextrin; cholesterol; cholesterol homeostasis; cytokines; enzyme-linked immunosorbent assay; in vitro studies; in vivo studies; inflammation; lipopolysaccharides; mice; myocytes; pathogenesis; secretion; smooth muscle; therapeutics; transcription factor NF-kappa B; tyrosine
- Abstract:
- ... Atherosclerosis (AS) is characterized by lipids metabolism disorder and inflammatory response. Accumulating evidence has demonstrated that Wingless type 5a (Wnt5a) is implicated in cardiovascular diseases through non-canonical Wnt cascades. However, its precise role during the pathogenesis of AS is still unclear. Therefore, the present study aims to investigate the role and the underlying mechanis ...
- DOI:
- 10.1016/j.bbalip.2019.158547
- https://doi.org/10.1016/j.bbalip.2019.158547