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- García-Seisdedos, David; Babiy, Bohdan; Lerma, Milagros; Casado, María E.; Martínez-Botas, Javier; Lasunción, Miguel A.; Pastor, Óscar; Busto, Rebeca
- Biochimica et biophysica acta 2020 v.1865 no.5 pp. 158638
- serine C-palmitoyltransferase, etc ; Curcuma longa; animal models; ceramides; curcumin; enzyme inhibitors; exosomes; fumonisin B1; hydrophobicity; mice; neuroglia; polyphenols; rhizomes; secretion; sphingosine N-acyltransferase; Show all 15 Subjects
- ... Curcumin, a hydrophobic polyphenol found in the rhizome of Curcuma longa, has been shown to reduce intracellular lipid accumulation in mouse models of lysosomal storage diseases such as Niemann-Pick type C. Exosomes are small extracellular vesicles secreted by cells in response to changes in intracellular ceramide composition. Curcumin can induce exosome/microvesicle release in cellular models of ...