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- Singh, Amar Bahadur; Dong, Bin; Xu, Yanyong; Zhang, Yanqiao; Liu, Jingwen
- Biochimica et biophysica acta 2019 v.1864 no.3 pp. 358-371
- Adenoviridae; acute effects; acyl coenzyme A; adipose tissue; adults; agonists; beta oxidation; bile; bile acids; biochemical pathways; biosynthesis; blood serum; cholesterol metabolism; fatty acids; free fatty acids; gene expression regulation; heart; high fat diet; hypercholesterolemia; knockout mutants; liver; long-chain-fatty-acid-CoA ligase; low density lipoprotein cholesterol; low density lipoprotein receptors; messenger RNA; mice; phenotype; phospholipids; protein content; skeletal muscle; triacylglycerols
- ... Long-chain acyl-CoA synthetase 1 (ACSL1) plays a pivotal role in fatty acid β‑oxidation in heart, adipose tissue and skeletal muscle. However, key functions of ACSL1 in the liver remain largely unknown. We investigated acute effects of hepatic ACSL1 deficiency on lipid metabolism in adult mice under hyperlipidemic and normolipidemic conditions. We knocked down hepatic ACSL1 expression using adenov ...