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- Fang, Chongye; Cai, Xianbin; Hayashi, Shuhei; Hao, Shumei; Sakiyama, Haruhiko; Wang, Xuanjun; Yang, Qin; Akira, Shizuo; Nishiguchi, Shuhei; Fujiwara, Noriko; Tsutsui, Hiroko; Sheng, Jun
- Biochimica et biophysica acta 2019 v.1864 no.3 pp. 271-280
- adipocytes; caffeine; fatty liver; hepatocytes; hepatoprotective effect; interleukin-6; knockout mutants; liver; macrophages; messenger RNA; mice; muscles; myotubes; oxygen consumption; risk reduction
- ... Caffeine intake is associated with a reduced risk developing non-alcoholic fatty liver disease (NAFLD), but the underlying molecular mechanisms remain to be fully elucidated. We report here that caffeine markedly improved high fat diet-induced NAFLD in mice resulting in a 10-fold increase in circulating IL-6 levels, leading to STAT3 activation in the liver. Interestingly, the expression of IL-6 mR ...
- Alvares, Danielle; Hoffman, Simon; Stankovic, Bogdan; Adeli, Khosrow
- Biochimica et biophysica acta 2019 v.1864 no.3 pp. 326-334
- agonists; fatty liver; glucagon-like peptide 1; glucagon-like peptide 2; homeostasis; inflammation; insulin resistance; lipogenesis; lipoproteins; liver; metabolic diseases; pathogenesis; pathophysiology; protein metabolism; reactive oxygen species; receptors
- ... Non-alcoholic fatty liver disease (NAFLD) is a continuum of disorders that can range from simple steatosis to non-alcoholic steatohepatitis (NASH). As a complex metabolic disorder, the pathophysiology of NAFLD is incompletely understood. Recently glucagon-like peptide (GLP)-1 and -2 signalling has been implicated in the pathogenesis of NAFLD. The role of these gut hormones in the hepatic abnormali ...