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Biochimica et biophysica acta
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7981-2019
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absorption
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- Author:
- Xue Li; Shuyue Wang; Xiaogang Xun; Mengran Zhang; Shi Wang; Hengde Li; Liang Zhao; Qiang Fu; Huizhen Wang; Tingting Li; Shanshan Lian; Qiang Xing; Xu Li; Wei Wu; Lingling Zhang; Xiaoli Hu; Zhenmin Bao
- Source:
- Biochimica et biophysica acta 2019 v.1864 no.7 pp. 966-975
- ISSN:
- 1388-1981
- Subject:
- Mizuhopecten yessoensis; absorption; beta-carotene; bioavailability; chromosomes; color; digestion; enzymes; gene expression regulation; genes; genomics; hepatopancreas; humans; lipids; meat quality; metabolism; models; muscles; nutrients; scallops
- Abstract:
- ... As lipid microconstituents mainly of plant origin, carotenoids are essential nutrients for humans and animals, and carotenoid coloration represents an important meat quality parameter for many farmed animals. Currently, the mechanism of carotenoid bioavailability in animals is largely unknown mainly due to the limited approaches applied, the shortage of suitable model systems and the restricted ta ...
- DOI:
- 10.1016/j.bbalip.2019.03.003
- https://doi.org/10.1016/j.bbalip.2019.03.003
- Author:
- Simona la Gatta; Francesco Milano; Gianluca M. Farinola; Angela Agostiano; Mariangela Di Donato; Andrea Lapini; Paolo Foggi; Massimo Trotta; Roberta Ragni
- Source:
- Biochimica et biophysica acta 2019 v.1860 no.4 pp. 350-359
- ISSN:
- 0005-2728
- Subject:
- Rhodobacter sphaeroides; absorption; energy conversion; energy transfer; fluorescence; infrared spectroscopy; optical properties; photosynthetic reaction centers; solar energy; white light
- Abstract:
- ... The photosynthetic Reaction Center (RC) from the purple bacterium Rhodobacter sphaeroides has unique photoconversion capabilities, that can be exploited in assembly biohybrid devices for applications in solar energy conversion. Extending the absorption cross section of isolated RC through covalent functionalization with ad-hoc synthesized artificial antennas is a successful strategy to outperform ...
- DOI:
- 10.1016/j.bbabio.2019.01.009
- https://doi.org/10.1016/j.bbabio.2019.01.009
- Author:
- Yu-Han Hung; Kimberly K. Buhman
- Source:
- Biochimica et biophysica acta 2019 v.1864 no.4 pp. 587-595
- ISSN:
- 1388-1981
- Subject:
- absorption; acidification; acyl coenzyme A; diacylglycerol acyltransferase; dietary fat; droplets; enterocytes; hydrolysis; lysosomes; mice; obesity; oils; phenotype; secretion; small intestine; triacylglycerols
- Abstract:
- ... Enterocytes, the absorptive cells of the small intestine, mediate the process of dietary fat absorption by secreting triacylglycerol (TAG) into circulation. When levels of dietary fat are high, TAG is stored in cytoplasmic lipid droplets (CLDs) and sequentially hydrolyzed for ultimate secretion. Mice with deficiency in acyl CoA: diacylglycerol acyltransferase 1 (Dgat1−/− mice) were previously repo ...
- DOI:
- 10.1016/j.bbalip.2018.10.007
- PubMed:
- 30342099
- PubMed Central:
- PMC7024568
- https://doi.org/10.1016/j.bbalip.2018.10.007
- Author:
- Ruoqi Li; Yi Liu; Jingjing Shi; Yantong Yu; Haifei Lu; Lu Yu; Yanqiang Liu; Fengxia Zhang
- Source:
- Biochimica et biophysica acta 2019 v.1864 no.8 pp. 1124-1133
- ISSN:
- 1388-1981
- Subject:
- absorption; animal models; atherosclerosis; blood serum; body weight; cholesterol metabolism; diosgenin; excretion; fatty liver; high fat diet; homeostasis; hypercholesterolemia; intestines; liver; low density lipoprotein cholesterol; messenger RNA; protein synthesis; rats; risk factors; transporters; triacylglycerols
- Abstract:
- ... Hypercholesterolemia is a preventable risk factor for atherosclerosis and cardiovascular disease. However, the mechanisms of diosgenin (DG) that promote cholesterol homeostasis and alleviate hypercholesterolemia remain elusive. To investigate the effects and molecular mechanisms of the promotion of cholesterol metabolism by DG, a rat model of hypercholesterolemia was induced by providing a high-fa ...
- DOI:
- 10.1016/j.bbalip.2019.04.010
- https://doi.org/10.1016/j.bbalip.2019.04.010
- Author:
- David Bína; Milan Durchan; Valentyna Kuznetsova; František Vácha; Radek Litvín; Tomáš Polívka
- Source:
- Biochimica et biophysica acta 2019 v.1860 no.2 pp. 111-120
- ISSN:
- 0005-2728
- Subject:
- Eustigmatophyceae; Rhodophyta; absorption; chlorophyll; energy flow; energy transfer; eukaryotic cells; fluorescence; habitats; light harvesting complex; photosynthesis; plastids; solar energy; symbiosis; violaxanthin
- Abstract:
- ... Photosynthetic eukaryotes whose cells harbor plastids originating from secondary endosymbiosis of a red alga include species of major ecological and economic importance. Since utilization of solar energy relies on the efficient light-harvesting, one of the critical factors for the success of the red lineage in a range of environments is to be found in the adaptability of the light-harvesting machi ...
- DOI:
- 10.1016/j.bbabio.2018.11.006
- https://doi.org/10.1016/j.bbabio.2018.11.006
- Author:
- David J.K. Swainsbury; Kaitlyn M. Faries; Dariusz M. Niedzwiedzki; Elizabeth C. Martin; Adam J. Flinders; Daniel P. Canniffe; Gaozhong Shen; Donald A. Bryant; Christine Kirmaier; Dewey Holten; C. Neil Hunter
- Source:
- Biochimica et biophysica acta 2019 v.1860 no.3 pp. 209-223
- ISSN:
- 0005-2728
- Subject:
- Rhodobacter sphaeroides; absorption; bacteriochlorophyll; binding sites; biosynthesis; energy transfer; engineering; fluorescence emission spectroscopy; hydrogen bonding; light harvesting complex; moieties; photosynthetic bacteria; pigments; polypeptides
- Abstract:
- ... The light-harvesting 2 complex (LH2) of the purple phototrophic bacterium Rhodobacter sphaeroides is a highly efficient, light-harvesting antenna that allows growth under a wide-range of light intensities. In order to expand the spectral range of this antenna complex, we first used a series of competition assays to measure the capacity of the non-native pigments 3-acetyl chlorophyll (Chl) a, Chl d ...
- DOI:
- 10.1016/j.bbabio.2018.11.008
- PubMed:
- 30414933
- PubMed Central:
- PMC6358721
- https://doi.org/10.1016/j.bbabio.2018.11.008
- Author:
- David Y. Hui
- Source:
- Biochimica et biophysica acta 2019 v.1864 no.6 pp. 784-788
- ISSN:
- 1388-1981
- Subject:
- absorption; atherosclerosis; catalytic activity; hyperinsulinemia; hyperlipidemia; inflammation; lungs; moieties; neoplasms; obesity; pancreas; phospholipase A2; phospholipases; phospholipids; respiratory tract diseases
- Abstract:
- ... The group 1B phospholipase A2 (PLA2G1B) is a secreted phospholipase that catalyzes the hydrolytic removal of the sn-2 fatty acyl moiety from phospholipids. This enzyme is synthesized most abundantly in the pancreas and is also expressed in the lung. The first part of this review article focuses on the role of pancreatic-derived PLA2G1B in mediating lipid absorption and discusses how the PLA2G1B-de ...
- DOI:
- 10.1016/j.bbalip.2018.07.001
- PubMed:
- 30003964
- PubMed Central:
- PMC6328335
- https://doi.org/10.1016/j.bbalip.2018.07.001
- Author:
- Petr Herman; Aleš Holoubek; Barbora Brodska
- Source:
- Biochimica et biophysica acta 2019 v.1863 no.1 pp. 266-277
- ISSN:
- 0304-4165
- Subject:
- T-lymphocytes; absorption; biomedical research; cell lines; fluorescence; fluorescent proteins; image analysis; irradiation; mutants; photochemistry; solvents; viscosity
- Abstract:
- ... EGFP is a fluorescent tag extensively used in biological and biomedical research. Over the years many researches have gathered collections of cell lines bearing specific EGFP-tagged proteins. Despite its popularity some photochemical properties of EGFP remain undocumented and unused. We report on so far unexplored lifetime photoconversion of EGFP usable in FLIM.Fluorescence lifetime imaging and sp ...
- DOI:
- 10.1016/j.bbagen.2018.10.016
- https://doi.org/10.1016/j.bbagen.2018.10.016
- Author:
- Kostas Stamatakis; Panayiotis-Ilias Broussos; Angeliki Panagiotopoulou; Rebecca J. Gast; Maria Pelecanou; George C. Papageorgiou
- Source:
- Biochimica et biophysica acta 2019 v.1860 no.1 pp. 102-110
- ISSN:
- 0005-2728
- Subject:
- Bacillariophyceae; Chlorophyta; Cyanobacteria; Miozoa; Phaeocystis; Rhodophyta; absorption; algae; amino acids; autotrophs; chlorophyll; circular dichroism spectroscopy; fluorescence; kleptoplasts; photosynthesis; ultraviolet radiation; Antarctica
- Abstract:
- ... Light state transitions (STs) is a reversible physiological process that oxygenic photosynthetic organisms use in order to minimize imbalances in the electronic excitation delivery to the reaction centers of Photosystems I and II, and thus to optimize photosynthesis. STs have been studied extensively in plants, green algae, red algae and cyanobacteria, but sparsely in algae with secondary red alga ...
- DOI:
- 10.1016/j.bbabio.2018.11.016
- https://doi.org/10.1016/j.bbabio.2018.11.016
- Author:
- Dariusz M. Niedzwiedzki; Shira Bar-Zvi; Robert E. Blankenship; Noam Adir
- Source:
- Biochimica et biophysica acta 2019 v.1860 no.4 pp. 286-296
- ISSN:
- 0005-2728
- Subject:
- Acaryochloris marina; absorption; ambient temperature; energy; fluorescence; fluorescence emission spectroscopy; kinetics; models; phosphates; phycobilisome; spectral analysis; white light
- Abstract:
- ... In this study, we use ultrafast time-resolved absorption and fluorescence spectroscopies to examine A. marina phycobilisomes isolated from cells grown under light of different intensities and spectral regimes. Investigations were performed at room temperature and at 77 K. The study demonstrates that if complexes are stabilized by high phosphate (900 mM) buffer, there are no differences between the ...
- DOI:
- 10.1016/j.bbabio.2019.01.002
- https://doi.org/10.1016/j.bbabio.2019.01.002
- Author:
- Pablo A. Nogara; Cláudia S. Oliveira; Gabriela L. Schmitz; Paulo C. Piquini; Marcelo Farina; Michael Aschner; João B.T. Rocha
- Source:
- Biochimica et biophysica acta 2019 pp. -
- ISSN:
- 0304-4165
- Subject:
- Animalia; absorption; acetyl coenzyme A; albumins; brain; cysteine; excretion; fish; hemoglobin; homocysteine; humans; methylmercury compounds; models; molecular weight; neurotoxicity; neurotoxins; rice; selenoproteins; thiols
- Abstract:
- ... Methylmercury is a neurotoxicant that is found in fish and rice. MeHg's toxicity is mediated by blockage of -SH and -SeH groups of proteins. However, the identification of MeHg's targets is elusive. Here we focus on the chemistry of MeHg in the abiotic and biotic environment. The toxicological chemistry of MeHg is complex in metazoans, but at the atomic level it can be explained by exchange reacti ...
- DOI:
- 10.1016/j.bbagen.2019.01.006
- https://doi.org/10.1016/j.bbagen.2019.01.006
- Author:
- M. Marziano; S. Tonello; E. Cantù; G. Abate; M. Vezzoli; W. Rungratanawanich; M. Serpelloni; N.F. Lopomo; M. Memo; E. Sardini; D. Uberti
- Source:
- Biochimica et biophysica acta 2019 v.1863 no.5 pp. 893-902
- ISSN:
- 0304-4165
- Subject:
- absorption; aerosols; carcinogenesis; cell differentiation; cell growth; electric impedance; enterocytes; human cell lines; in vitro studies; metabolism; models; monitoring; neoplasm cells; neoplasms; nondestructive methods; principal component analysis; sensors (equipment)
- Abstract:
- ... Colorectal adenocarcinoma cells (Caco-2) are a widely used model of intestinal barrier to study cancer development, toxicological assessments, absorption and metabolism in food science or drug discovery. Caco-2 spontaneously differentiate into a monolayer expressing several specific characteristics, typically showed by mature enterocytes. For in vitro experiments, it is crucial to identify non-inv ...
- DOI:
- 10.1016/j.bbagen.2019.02.008
- https://doi.org/10.1016/j.bbagen.2019.02.008
- Author:
- Yuki Takegawa; Makoto Nakamura; Shin Nakamura; Takumi Noguchi; Julien Sellés; A. William Rutherford; Alain Boussac; Miwa Sugiura
- Source:
- Biochimica et biophysica acta 2019 v.1860 no.4 pp. 297-309
- ISSN:
- 0005-2728
- Subject:
- Thermosynechococcus elongatus; absorption; bleaching; chlorophyll; hydrogen bonding; magnesium; mutants; mutation; photoinhibition; photosystem II; singlet oxygen; thermoluminescence; wavelengths
- Abstract:
- ... The monomeric chlorophyll, ChlD1, which is located between the PD1PD2 chlorophyll pair and the pheophytin, PheoD1, is the longest wavelength chlorophyll in the heart of Photosystem II and is thought to be the primary electron donor. Its central Mg2+ is liganded to a water molecule that is H-bonded to D1/T179. Here, two site-directed mutants, D1/T179H and D1/T179V, were made in the thermophilic cya ...
- DOI:
- 10.1016/j.bbabio.2019.01.008
- https://doi.org/10.1016/j.bbabio.2019.01.008
- Author:
- Jie Chang; Yun Zhou; Qiang Wang; Michael Aschner; Rongzhu Lu
- Source:
- Biochimica et biophysica acta 2019 pp. -
- ISSN:
- 0304-4165
- Subject:
- absorption; biochemical mechanisms; demethylation; drugs; excretion; intestines; mercury; methylmercury compounds; nervous system; neurotoxicity; plant extracts; pollutants; protective effect; therapeutics; tissues
- Abstract:
- ... Methylmercury (MeHg) is a ubiquitous environmental pollutant, with the nervous system as its main target; however, the neurotoxic mechanisms of MeHg have not been fully elucidated, and no effective therapeutic and preventive drugs are available to mitigate its toxicity. Recent evidence suggests a reduction in the toxicity of MeHg by natural plant extracts.The aim of this review is to provide an ov ...
- DOI:
- 10.1016/j.bbagen.2019.01.012
- https://doi.org/10.1016/j.bbagen.2019.01.012
- Author:
- Shinji Kato; Haruhi Tobe; Hiroki Matsubara; Mariko Sawada; Yasuko Sasaki; Satoru Fukiya; Naoki Morita; Atsushi Yokota
- Source:
- Biochimica et biophysica acta 2019 v.1864 no.3 pp. 403-412
- ISSN:
- 1388-1981
- Subject:
- Lactobacillus gasseri; absorption; acid tolerance; antimicrobial properties; cardiolipins; cholic acid; detergents; genes; glycolipids; humans; lactic acid bacteria; lipid composition; lipid metabolism; models; mutants; solubilization
- Abstract:
- ... Bile acids exhibit strong antimicrobial activity as natural detergents, and are involved in lipid digestion and absorption. We investigated the mechanism of bile acid adaptation in Lactobacillus gasseri JCM1131ᵀ. Exposure to sublethal concentrations of cholic acid (CA), a major bile acid in humans, resulted in development of resistance to otherwise-lethal concentrations of CA by this intestinal la ...
- DOI:
- 10.1016/j.bbalip.2018.06.004
- https://doi.org/10.1016/j.bbalip.2018.06.004
- Author:
- I. Iachina; I.E. Antonescu; J. Dreier; J.A. Sørensen; J.R. Brewer
- Source:
- Biochimica et biophysica acta 2019 v.1863 no.7 pp. 1226-1233
- ISSN:
- 0304-4165
- Subject:
- absorption; confocal microscopy; drug delivery systems; drugs; dyes; energy transfer; lipid bilayers; lipids; lipophilicity; models; skin (animal); water solubility
- Abstract:
- ... Knowledge regarding the barrier properties of human skin is important for understanding skin pathology, developing of transdermal drug delivery systems and computational skin absorption models; however, the molecular pathways through human skin remains to be fully investigated on a nanoscopic level. In particular the nanoscopic pathway of molecules passing the intercellular lipid bilayers separati ...
- DOI:
- 10.1016/j.bbagen.2019.04.012
- https://doi.org/10.1016/j.bbagen.2019.04.012
- Author:
- Yingyue Tang; Jingyi Zhang; Jing Li; Xiaohong Lei; Dongke Xu; Yang Wang; Chunmin Li; Xiaobo Li; Yimin Mao
- Source:
- Biochimica et biophysica acta 2019 v.1864 no.10 pp. 1293-1304
- ISSN:
- 1388-1981
- Subject:
- Bacteroidetes; Firmicutes; Verrucomicrobia; absorption; bile; blood serum; cecum; cholic acid; cytochrome P-450; dysbiosis; fatty liver; gene expression; genes; hepatocytes; high fat diet; inflammation; insulin resistance; lipids; liver; metabolomics; microorganisms; models; rats; ribosomal RNA; sequence analysis; taurocholic acid; ursodeoxycholic acid
- Abstract:
- ... Bile acids (BAs) participate in lipid absorption and serve as metabolic regulatory factors in gut-liver communication. To date, there are no studies on the systemic patterns of BAs in the serum, liver, and gut in the same non-alcoholic fatty liver disease (NAFLD) model.A targeted metabolomics approach and 16S rRNA sequencing were used to identify the profile of BAs and connection between BAs and m ...
- DOI:
- 10.1016/j.bbalip.2019.05.016
- https://doi.org/10.1016/j.bbalip.2019.05.016