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- Author:
- Vuitika, L.; Chaves-Moreira, D.; Caruso, I.; Lima, M.A.; Matsubara, F.H.; Murakami, M.T.; Takahashi, H.K.; Toledo, M.S.; Coronado, M.A.; Nader, H.B.; Senff-Ribeiro, A.; Chaim, O.M.; Arni, R.K.; Veiga, S.S.
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 970-979
- ISSN:
- 1388-1981
- Subject:
- Loxosceles; active sites; antibodies; bioactive properties; blood serum; circular dichroism spectroscopy; differential scanning calorimetry; hemolysis; inflammation; mutants; permeability; phospholipase D; phospholipases; phospholipids; renal failure; toxins; venoms
- Abstract:
- ... Brown spider phospholipases D from Loxosceles venoms are among the most widely studied toxins since they induce dermonecrosis, triggering inflammatory responses, increase vascular permeability, cause hemolysis, and renal failure. The catalytic (H12 and H47) and metal-ion binding (E32 and D34) residues in Loxosceles intermedia phospholipase D (LiRecDT1) were mutated to understand their roles in the ...
- DOI:
- 10.1016/j.bbalip.2016.05.009
-
https://dx.doi.org/10.1016/j.bbalip.2016.05.009
- Author:
- Allen, Doug K.
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1226-1242
- ISSN:
- 1388-1981
- Subject:
- acetyl coenzyme A; biochemical pathways; biosynthesis; cytosol; experimental design; fatty acids; instrumentation; lipid metabolism; metabolites; organelles; radiolabeling; radionuclides; spatial variation; stable isotopes; tissue distribution; tissues
- Abstract:
- ... Metabolism in plants takes place across multiple cell types and within distinct organelles. The distributions equate to spatial heterogeneity; though the limited means to experimentally assess metabolism frequently involve homogenizing tissues and mixing metabolites from different locations. Most current isotope investigations of metabolism therefore lack the ability to resolve spatially distinct ...
- Handle:
- 10113/62904
- DOI:
- 10.1016/j.bbalip.2016.03.017
- Chorus Open Access:
- 10.1016/j.bbalip.2016.03.017
-
https://dx.doi.org/10.1016/j.bbalip.2016.03.017
- Author:
- Abd-El-Haliem, Ahmed M.; Vossen, Jack H.; van Zeijl, Arjan; Dezhsetan, Sara; Testerink, Christa; Seidl, Michael F.; Beck, Martina; Strutt, James; Robatzek, Silke; Joosten, Matthieu H.A.J.
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1365-1378
- ISSN:
- 1388-1981
- Subject:
- Arabidopsis thaliana; Solanum lycopersicum; abiotic stress; calcium; diacylglycerols; flagellin; genome; immunity; ions; nucleotide sequences; pH; phospholipase C; recombinant proteins; substrate specificity; tomatoes
- Abstract:
- ... Plants possess effective mechanisms to quickly respond to biotic and abiotic stresses. The rapid activation of phosphatidylinositol-specific phospholipase C (PLC) enzymes occurs early after the stimulation of plant immune-receptors. Genomes of different plant species encode multiple PLC homologs belonging to one class, PLCζ. Here we determined whether all tomato homologs encode active enzymes and ...
- DOI:
- 10.1016/j.bbalip.2016.01.017
-
https://dx.doi.org/10.1016/j.bbalip.2016.01.017
- Author:
- Sirobhushanam, Sirisha; Galva, Charitha; Sen, Suranjana; Wilkinson, Brian J.; Gatto, Craig
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1102-1110
- ISSN:
- 1388-1981
- Subject:
- Listeria monocytogenes; acetyl coenzyme A; acyl coenzyme A; additives; amino acids; biosynthesis; branched chain fatty acids; butyrates; catalytic activity; chemical structure; enzymes; foodborne illness; listeriosis; mutants; operon; substrate specificity
- Abstract:
- ... Listeria monocytogenes, the causative organism of the serious food-borne disease listeriosis, has a membrane abundant in branched-chain fatty acids (BCFAs). BCFAs are normally biosynthesized from branched-chain amino acids via the activity of branched chain α-keto acid dehydrogenase (Bkd), and disruption of this pathway results in reduced BCFA content in the membrane. Short branched-chain carboxyl ...
- DOI:
- 10.1016/j.bbalip.2016.06.003
- PubMed:
- 27320015
- PubMed Central:
- PMC4947441
-
https://dx.doi.org/10.1016/j.bbalip.2016.06.003
- Author:
- Machida, Shuntaro; Shiraiwa, Yoshihiro; Suzuki, Iwane
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 980-987
- ISSN:
- 1388-1981
- Subject:
- Escherichia coli; Synechocystis sp. PCC 6714; Synechocystis sp. PCC 6803; biofuels; fatty acids; genes; microalgae; oxidation; photosynthesis; temperature
- Abstract:
- ... Microalgae have received much attention as a next-generation source of biomass energy. However, most of the fatty acids (FAs) from microalgae are multiply unsaturated; thus, the biofuels derived from them are fluid, but vulnerable to oxidation. In this study, we attempted to synthesize cyclopropane FAs in the cyanobacterium Synechocystis sp. PCC 6803 by expressing the cfa gene for cyclopropane FA ...
- DOI:
- 10.1016/j.bbalip.2016.05.012
-
https://dx.doi.org/10.1016/j.bbalip.2016.05.012
- Author:
- Peña, Lucía; Meana, Clara; Astudillo, Alma M.; Lordén, Gema; Valdearcos, Martín; Sato, Hiroyasu; Murakami, Makoto; Balsinde, Jesús; Balboa, María A.
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1083-1095
- ISSN:
- 1388-1981
- Subject:
- adipocytes; adipogenesis; adipose tissue; animals; arachidonic acid; cell cycle; comorbidity; high fat diet; obesity; phospholipase A2; stem cells; transcription factors
- Abstract:
- ... Adipogenesis is the process of differentiation of immature mesenchymal stem cells into adipocytes. Elucidation of the mechanisms that regulate adipocyte differentiation is key for the development of novel therapies for the control of obesity and related comorbidities. Cytosolic group IVA phospholipase A2 (cPLA2α) is the pivotal enzyme in receptor-mediated arachidonic acid (AA) mobilization and att ...
- DOI:
- 10.1016/j.bbalip.2016.06.004
-
https://dx.doi.org/10.1016/j.bbalip.2016.06.004
- Author:
- Maida, Eri; Awai, Koichiro
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1309-1314
- ISSN:
- 1388-1981
- Subject:
- Chloroflexus aurantiacus; Synechococcus sp. PCC 7942; autotrophs; biochemical pathways; galactose; genes; lipid composition; lipids; photosynthesis; plants (botany); thylakoids
- Abstract:
- ... Digalactosyldiacylglycerol (DGDG) is a major component of thylakoid membranes, occupying approximately 20% of the membrane system. This lipid composition is conserved from cyanobacteria to the chloroplasts of terrestrial plants, suggesting that DGDG is important for the function of photosynthetic membranes. Here we isolated the gene for DGDG synthase in the cyanobacterium Synechococcus elongatus P ...
- DOI:
- 10.1016/j.bbalip.2016.03.011
-
https://dx.doi.org/10.1016/j.bbalip.2016.03.011
- Author:
- Lemarié, F.; Cavalier, J.-F.; Garcia, C.; Boissel, F.; Point, V.; Catheline, D.; Legrand, P.; Carrière, F.; Rioux, V.
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1111-1120
- ISSN:
- 1388-1981
- Subject:
- absorption; carboxylic ester hydrolases; digestion; emulsions; gastric mucosa; ghrelin; ghrelin receptors; ligands; lipolysis; octanoic acid; rats; suckling; triolein
- Abstract:
- ... Part of medium chain fatty acids (MCFAs) coming from dietary triglycerides (TGs) can be directly absorbed through the gastric mucosa after the action of preduodenal lipase (lingual lipase in the rat). MCFA gastric absorption, particularly that of octanoic acid (C8:0), may have a physiological importance in the octanoylation of ghrelin, the orexigenic gastric peptide acting as an endogenous ligand ...
- DOI:
- 10.1016/j.bbalip.2016.06.009
-
https://dx.doi.org/10.1016/j.bbalip.2016.06.009
- Author:
- Lee, Gi Young; Lee, Sora; Lee, Hye-Ra; Yoo, Young Do
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1096-1101
- ISSN:
- 1388-1981
- Subject:
- Hepatitis C virus; adhesion; ion channels; lipids; pH
- Abstract:
- ... Viroporin p7 of the hepatitis C virus (HCV) acts as an ion channel for pH equilibration to stabilize HCV particles; most studies of p7 have focused on this role. However, pH equilibration by p7 via its ion channel activity does not fully explain the importance of p7 in HCV particle production. Indeed, several researchers have suggested p7 to have an unidentified ion channel-independent function. H ...
- DOI:
- 10.1016/j.bbalip.2016.06.011
-
https://dx.doi.org/10.1016/j.bbalip.2016.06.011
- Author:
- Casado, María E.; Pastor, Oscar; García-Seisdedos, David; Huerta, Lydia; Kraemer, Fredric B.; Lasunción, Miguel A.; Martín-Hidalgo, Antonia; Busto, Rebeca
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1142-1150
- ISSN:
- 1388-1981
- Subject:
- acylglycerols; carboxylic ester hydrolases; cholesterol; fractionation; lipid composition; male fertility; males; mice; monounsaturated fatty acids; phosphatidylcholines; phosphatidylethanolamines; phosphatidylserines; plasma membrane; proteins; signal transduction; sphingolipids; testes
- Abstract:
- ... Hormone-sensitive lipase (HSL) is an intracellular neutral lipase capable of hydrolyzing acylglycerols, as well as cholesteryl and retinyl esters. In mice, HSL deficiency results in male sterility. Lipid rafts, a plasma membrane microdomain enriched in cholesterol, sphingolipids and saturated glycerophospholipids, comprise a highly dynamic clustering of proteins and lipids that play a central role ...
- DOI:
- 10.1016/j.bbalip.2016.06.018
-
https://dx.doi.org/10.1016/j.bbalip.2016.06.018
- Author:
- Simpson, Jeffrey P.; Thrower, Nicholas; Ohlrogge, John B.
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1243-1252
- ISSN:
- 1388-1981
- Subject:
- Morella caroliniensis; amino acid sequences; biosynthesis; cherries; cutin; diacylglycerols; esterification; evolution; gene expression; gene expression regulation; genes; leaves; lipid metabolism; mesocarp; microscopy; saturated fatty acids; secretion; seeds; tissues; tomatoes; triacylglycerols
- Abstract:
- ... Bayberry (Myrica pensylvanica) fruits are covered with a remarkably thick layer of crystalline wax consisting of triacylglycerol (TAG) and diacylglycerol (DAG) esterified exclusively with saturated fatty acids. As the only plant known to accumulate soluble glycerolipids as a major component of surface waxes, Bayberry represents a novel system to investigate neutral lipid biosynthesis and lipid sec ...
- DOI:
- 10.1016/j.bbalip.2016.01.022
-
https://dx.doi.org/10.1016/j.bbalip.2016.01.022
- Author:
- Estruch, Montserrat; Sanchez-Quesada, Jose Luis; Ordoñez-Llanos, Jordi; Benitez, Sonia
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 963-969
- ISSN:
- 1388-1981
- Subject:
- Toll-like receptor 4; cyclic AMP; enzyme-linked immunosorbent assay; interleukin-10; interleukin-6; low density lipoprotein; mitogen-activated protein kinase; monocytes; phosphatidylinositol 3-kinase; phosphorylation; transcription factor NF-kappa B
- Abstract:
- ... Electronegative LDL (LDL(−)) is a plasma LDL subfraction that induces cytokine release in monocytes through toll-like receptor 4 (TLR4) activation. However, the intracellular pathways induced by LDL(−) downstream TLR4 activation are unknown. We aimed to identify the pathways activated by LDL(−) leading to cytokine release in monocytes.We determined LDL(−)-induced activation of several intracellula ...
- DOI:
- 10.1016/j.bbalip.2016.05.010
-
https://dx.doi.org/10.1016/j.bbalip.2016.05.010
- Author:
- Jia, Feng; Howlader, Md. Amran; Cairo, Christopher W.
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1170-1179
- ISSN:
- 1388-1981
- Subject:
- adhesion; cell movement; cytoskeleton; enzyme activity; gangliosides; humans; integrins; isozymes; phosphorylation; receptors; sialidase
- Abstract:
- ... Integrins are critical receptors in cell migration and adhesion. A number of mechanisms are known to regulate the function of integrins, including phosphorylation, conformational change, and cytoskeletal anchoring. We investigated whether native neuraminidase (Neu, or sialidase) enzymes which modify glycolipids could play a role in regulating integrin-mediated cell migration. Using a scratch assay ...
- DOI:
- 10.1016/j.bbalip.2016.06.013
-
https://dx.doi.org/10.1016/j.bbalip.2016.06.013
- Author:
- Hung, Chun-Hsien; Kanehara, Kazue; Nakamura, Yuki
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1282-1293
- ISSN:
- 1388-1981
- Subject:
- Chlamydomonas reinhardtii; acetates; acetyl coenzyme A; beta-galactosidase; biodiesel; biosynthesis; culture media; fatty acid composition; fructose 6-phosphate; fuel production; genes; glucose 6-phosphate; glycolysis; hydrolysis; metabolites; metabolomics; mutants; nitrogen; photosynthesis; starch granules; starvation; triacylglycerols; tricarboxylic acid cycle
- Abstract:
- ... Triacylglycerol (TAG), a major source of biodiesel production, accumulates in nitrogen-starved Chlamydomonas reinhardtii. However, the metabolic pathway of starch-to-TAG conversion remains elusive because an enzyme that affects the starch degradation is unknown. Here, we isolated a new class of mutant bgal1, which expressed an overaccumulation of starch granules and defective photosynthetic growth ...
- DOI:
- 10.1016/j.bbalip.2016.04.001
-
https://dx.doi.org/10.1016/j.bbalip.2016.04.001
- Author:
- Leamy, Alexandra K.; Hasenour, Clinton M.; Egnatchik, Robert A.; Trenary, Irina A.; Yao, Cong-Hui; Patti, Gary J.; Shiota, Masakazu; Young, Jamey D.
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1005-1014
- ISSN:
- 1388-1981
- Subject:
- diacylglycerol acyltransferase; esterification; hepatocytes; lipotoxicity; oleic acid; palmitates; phospholipids; protective effect; rats; saturated fatty acids; toxicity; triacylglycerols
- Abstract:
- ... Experiments in a variety of cell types, including hepatocytes, consistently demonstrate the acutely lipotoxic effects of saturated fatty acids, such as palmitate (PA), but not unsaturated fatty acids, such as oleate (OA). PA+OA co-treatment fully prevents PA lipotoxicity through mechanisms that are not well defined but which have been previously attributed to more efficient esterification and sequ ...
- DOI:
- 10.1016/j.bbalip.2016.05.013
- PubMed:
- 27249207
- PubMed Central:
- PMC4947436
-
https://dx.doi.org/10.1016/j.bbalip.2016.05.013
- Author:
- Siebers, Meike; Brands, Mathias; Wewer, Vera; Duan, Yanjiao; Hölzl, Georg; Dörmann, Peter
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1379-1395
- ISSN:
- 1388-1981
- Subject:
- bacteria; ceramides; diacylglycerols; free fatty acids; fungi; jasmonic acid; oxylipins; phospholipids; systemic acquired resistance
- Abstract:
- ... Bacteria and fungi can undergo symbiotic or pathogenic interactions with plants. Membrane lipids and lipid-derived molecules from the plant or the microbial organism play important roles during the infection process. For example, lipids (phospholipids, glycolipids, sphingolipids, sterol lipids) are involved in establishing the membrane interface between the two organisms. Furthermore, lipid-derive ...
- DOI:
- 10.1016/j.bbalip.2016.02.021
-
https://dx.doi.org/10.1016/j.bbalip.2016.02.021
- Author:
- Ischebeck, Till
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1315-1328
- ISSN:
- 1388-1981
- Subject:
- Arabidopsis; droplets; evolution; fatty acids; galactolipids; gametophytes; lipid composition; males; mutants; ovules; phenotype; pollen; pollen tubes; proteins; spermatozoa; sphingolipids; stigma; triacylglycerols
- Abstract:
- ... During evolution, the male gametophyte of Angiosperms has been severely reduced to the pollen grain, consisting of a vegetative cell containing two sperm cells.This vegetative cell has to deliver the sperm cells from the stigma through the style to the ovule. It does so by producing a pollen tube and elongating it to many centimeters in length in some species, requiring vast amounts of fatty acid ...
- DOI:
- 10.1016/j.bbalip.2016.03.023
-
https://dx.doi.org/10.1016/j.bbalip.2016.03.023
- Author:
- Yang, Fan; Du, Yu; Zhang, Jin; Jiang, Zhibo; Wang, Li; Hong, Bin
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1066-1075
- ISSN:
- 1388-1981
- Subject:
- acetylation; blood lipids; cardiovascular diseases; genes; hepatocytes; high density lipoprotein cholesterol; histone acetyltransferase; histone deacetylase; histones; lipid content; low density lipoprotein; mass spectrometry; phosphorylation; precipitin tests; promoter regions; risk; site-directed mutagenesis; transcription factors
- Abstract:
- ... Scavenger receptor class B type I (SR-BI) is one of the key proteins in the process of reverse cholesterol transport (RCT), and its major function is to uptake high density lipoprotein (HDL) cholesterol from plasma into liver cells. The regulation of SR-BI expression is important for controlling serum lipid content and reducing the risks of cardiovascular diseases. Here we found that SR-BI express ...
- DOI:
- 10.1016/j.bbalip.2016.06.001
-
https://dx.doi.org/10.1016/j.bbalip.2016.06.001
- Author:
- Linscott, Kristin B.; Niehaus, Thomas D.; Zhuang, Xun; Bell, Stephen A.; Chappell, Joe
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1049-1057
- ISSN:
- 1388-1981
- Subject:
- Saccharomyces cerevisiae; active sites; animals; biosynthesis; chimerism; enzymes; ergosterol; eukaryotic cells; genes; growth retardation; knockout mutants; mutation; phenotype; plants (botany); squalene; toxicity; yeasts
- Abstract:
- ... Squalene synthase catalyzes the first committed step in sterol biosynthesis and consists of both an amino-terminal catalytic domain and a carboxy-terminal domain tethering the enzyme to the ER membrane. While the overall architecture of this enzyme is identical in eukaryotes, it was previously shown that plant and animal genes cannot complement a squalene synthase knockout mutation in yeast unless ...
- DOI:
- 10.1016/j.bbalip.2016.06.008
-
https://dx.doi.org/10.1016/j.bbalip.2016.06.008
- Author:
- Ning, Li-Jun; He, An-Yuan; Li, Jia-Min; Lu, Dong-Liang; Jiao, Jian-Gang; Li, Ling-Yu; Li, Dong-Liang; Zhang, Mei-Ling; Chen, Li-Qiao; Du, Zhen-Yu
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1036-1048
- ISSN:
- 1388-1981
- Subject:
- DNA; Oreochromis niloticus; agonists; beta oxidation; blood glucose; brain; carbohydrate metabolism; carnitine; cytochrome b; dephosphorylation; energy; fasting; fatty acids; fenofibrate; fish; gene expression; heart; hepatocytes; homeostasis; insulin; lactic acid; lipemic effect; liver; mammals; messenger RNA; mitochondria; nutrients; palmitates; peroxisome proliferator-activated receptors; phosphorylation; protein synthesis; tissues; transcriptomics; triacylglycerols
- Abstract:
- ... Although the key metabolic regulatory functions of mammalian peroxisome proliferator-activated receptor α (PPARα) have been thoroughly studied, the molecular mechanisms and metabolic regulation of PPARα activation in fish are less known. In the first part of the present study, Nile tilapia (Nt)PPARα was cloned and identified, and high mRNA expression levels were detected in the brain, liver, and h ...
- DOI:
- 10.1016/j.bbalip.2016.06.005
-
https://dx.doi.org/10.1016/j.bbalip.2016.06.005