Journal name: Biochimica et biophysica acta / Publication Year: 2011 / Subject term: pyridoxal phosphate / Text availability: Citation in PubAg

Author:: Hans-Heinrich Limbach; Monique Chan-Huot; Shasad Sharif; Peter M. Tolstoy; Ilya G. Shenderovich; Gleb S. Denisov; Michael D. Toney
Source:: Biochimica et biophysica acta 2011 v.1814 no.11 pp. 1426-1437
ISSN:: 1878-1454
Subject:: aqueous solutions; aspartate transaminase; aspartic acid; correlation; enzymatic reactions; enzymology; histidine; hydrogen bonding; models; nitrogen; nuclear magnetic resonance spectroscopy; proteins; pyridoxal; pyridoxal phosphate; schiff bases; solvents; stable isotopes; zwitterions
Abstract:: ... In this contribution we review recent NMR studies of protonation and hydrogen bond states of pyridoxal 5′-phosphate (PLP) and PLP model Schiff bases in different environments, starting from aqueous solution, the organic solid state to polar organic solution and finally to enzyme environments. We have established hydrogen bond correlations that allow one to estimate hydrogen bond geometries from ¹⁵ ...
DOI:: 10.1016/j.bbapap.2011.06.004
: https://doi.org/10.1016/j.bbapap.2011.06.004

Author:: Hiroko Ikushiro; Hideyuki Hayashi
Source:: Biochimica et biophysica acta 2011 v.1814 no.11 pp. 1474-1480
ISSN:: 1878-1454
Subject:: biosynthesis; pyridoxal phosphate; sphingolipids; spectroscopy; enzymology; serine C-palmitoyltransferase
Abstract:: ... Serine palmitoyltransferase, which is one of the α-oxamine synthase family enzymes, catalyzes the condensation reaction of L-serine and palmitoyl-CoA to form 3-ketodihydrosphingosine, the first and rate-determining step of the sphingolipid biosynthesis. As with other α-oxamine synthase family enzymes, the catalytic reaction is composed of multiple elementary steps, and the mechanism to control the ...
DOI:: 10.1016/j.bbapap.2011.02.005
: https://doi.org/10.1016/j.bbapap.2011.02.005

Author:: Barbara Kappes; Ivo Tews; Alexandra Binter; Peter Macheroux
Source:: Biochimica et biophysica acta 2011 v.1814 no.11 pp. 1567-1576
ISSN:: 1878-1454
Subject:: Protozoa; drugs; enzymatic reactions; enzymes; enzymology; parasites; physicochemical properties; pyridoxal phosphate; pyridoxine
Abstract:: ... The chemical properties of the B₆ vitamers are uniquely suited for wide use as cofactors in essential reactions, such as decarboxylations and transaminations. This review addresses current efforts to explore vitamin B₆ dependent enzymatic reactions as drug targets. Several current targets are described that are found amongst these enzymes. The focus is set on diseases caused by protozoan parasites ...
DOI:: 10.1016/j.bbapap.2011.07.018
: https://doi.org/10.1016/j.bbapap.2011.07.018

Author:: Tathagata Mukherjee; Jeremiah Hanes; Ivo Tews; Steven E. Ealick; Tadhg P. Begley
Source:: Biochimica et biophysica acta 2011 v.1814 no.11 pp. 1585-1596
ISSN:: 1878-1454
Subject:: biosynthesis; chemical reactions; enzymes; enzymology; fungi; oxidative stress; protective effect; pyridoxal phosphate; pyridoxine; singlet oxygen
Abstract:: ... Vitamin B₆ is an essential cofactor that participates in a large number of biochemical reactions. Pyridoxal phosphate is biosynthesized de novo by two different pathways (the DXP dependent pathway and the R5P pathway) and can also be salvaged from the environment. It is one of the few cofactors whose catabolic pathway has been comprehensively characterized. It is also known to function as a single ...
DOI:: 10.1016/j.bbapap.2011.06.018
: https://doi.org/10.1016/j.bbapap.2011.06.018

Author:: Rita Florio; Martino Luigi di Salvo; Mirella Vivoli; Roberto Contestabile
Source:: Biochimica et biophysica acta 2011 v.1814 no.11 pp. 1489-1496
ISSN:: 1878-1454
Subject:: enzymology; glycine hydroxymethyltransferase; metabolism; mutants; pyridoxal; pyridoxal phosphate; serine
Abstract:: ... Serine hydroxymethyltransferase is a ubiquitous representative of the family of fold type I, pyridoxal 5′-phosphate-dependent enzymes. The reaction catalyzed by this enzyme, the reversible transfer of the Cβ of serine to tetrahydropteroylglutamate, represents a link between amino acid and folates metabolism and operates as a major source of one-carbon units for several essential biosynthetic proce ...
DOI:: 10.1016/j.bbapap.2010.10.010
: https://doi.org/10.1016/j.bbapap.2010.10.010

Author:: Susan M. Aitken; Pratik H. Lodha; Dominique J.K. Morneau
Source:: Biochimica et biophysica acta 2011 v.1814 no.11 pp. 1511-1517
ISSN:: 1878-1454
Subject:: active sites; animals; anti-infective agents; bacteria; cystathionine; cystathionine beta-synthase; cystathionine gamma-lyase; cysteine; engineering; enzymology; pyridoxal; pyridoxal phosphate; therapeutics; yeasts
Abstract:: ... The diversity of reactions catalyzed by enzymes reliant on pyridoxal 5′-phosphate (PLP) demonstrates the catalytic versatility of this cofactor and the plasticity of the protein scaffolds of the major fold types of PLP-dependent enzymes. The enzymes of the transsulfuration (cystathionine γ-synthase and cystathionine β-lyase) and reverse transsulfuration (cystathionine β-synthase and cystathionine ...
DOI:: 10.1016/j.bbapap.2011.03.006
: https://doi.org/10.1016/j.bbapap.2011.03.006

Author:: Martino Luigi di Salvo; Roberto Contestabile; Martin K. Safo
Source:: Biochimica et biophysica acta 2011 v.1814 no.11 pp. 1597-1608
ISSN:: 1570-9639
Subject:: animals; enzymatic reactions; enzymes; enzymology; homeostasis; metabolism; pyridoxal; pyridoxal phosphate; pyridoxamine; pyridoxine
Abstract:: ... Vitamin B₆ is a generic term referring to pyridoxine, pyridoxamine, pyridoxal and their related phosphorylated forms. Pyridoxal 5′-phosphate is the catalytically active form of vitamin B₆, and acts as cofactor in more than 140 different enzyme reactions. In animals, pyridoxal 5′-phosphate is recycled from food and from degraded B₆-enzymes in a “salvage pathway”, which essentially involves two ubiq ...
DOI:: 10.1016/j.bbapap.2010.12.006
: https://doi.org/10.1016/j.bbapap.2010.12.006

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